G13-mediated signaling as a potential target for antiplatelet drugs

Drug News and Perspectives

Volumn 17, Issue 8, 2004, Pages 493-498

  Moers, Alexandra ^a   Wettschureck, Nina ^a   Offermanns, Stefan ^a,b  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b NONE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE DIPHOSPHATE; ADRENALIN; ANTITHROMBOCYTIC AGENT; G13 PROTEIN; GUANINE NUCLEOTIDE BINDING PROTEIN; HETEROTRIMERIC GUANINE NUCLEOTIDE BINDING PROTEIN; PROTEIN; RHO FACTOR; RHO KINASE; THROMBIN; THROMBIN RECEPTOR; THROMBOXANE A2; THROMBOXANE A2 RECEPTOR; UNCLASSIFIED DRUG; ACETYLSALICYLIC ACID; CLOPIDOGREL; DRUG DERIVATIVE; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; TICLOPIDINE;

ARTERY THROMBOSIS; BLOOD VESSEL INJURY; DRUG TARGETING; HEART INFARCTION; HEMOSTASIS; RECEPTOR BINDING; REGULATORY MECHANISM; REVIEW; SIGNAL TRANSDUCTION; STROKE; THROMBOCYTE; THROMBOCYTE ACTIVATION; THROMBOCYTE AGGREGATION INHIBITION; ANIMAL; DRUG EFFECT; FORECASTING; GERMANY; HUMAN; METABOLISM; PHYSIOLOGY;

ANIMALS; ASPIRIN; BLOOD PLATELETS; FORECASTING; GERMANY; GTP-BINDING PROTEIN ALPHA SUBUNITS, G12-G13; HUMANS; PLATELET ACTIVATION; PLATELET AGGREGATION INHIBITORS; SIGNAL TRANSDUCTION; TICLOPIDINE;

EID: 10444240971     PISSN: 02140934     EISSN: None     Source Type: Journal    
DOI: 10.1358/dnp.2004.17.8.863692     Document Type: Review

References (36)

1. Ruggeri, Z.M. Platelets in atherothrombosis. Nat Med 2002, 8: 1227-34.
2. Bhatt, D.L. and Topol, E.J. Scientific and therapeutic advances in antiplatelet therapy. Nat Rev Drug Discov 2003, 2: 15-28.
3. Antithrombotic Trialists' Collaboration. Collaborative meta-analysis of randomised trials of antiplatelet therapy for prevention of death, myocardial infarction, and stroke in high risk patients. Br Med J 2002, 324: 71-86.
4. A randomised, blinded, trial of clopidogrel versus aspirin in patients at risk of ischaemic events (CAPRIE). CAPRIE Steering Committee. Lancet 1996, 348: 1329-39.
5. Bhatt, D.L. and Topol, E.J. Current role of platelet glycoprotein IIb/IIIa inhibitors in acute coronary syndromes. JAMA 2000, 284: 1549-58.
6. Jackson, S.P., Nesbitt, W.S. and Kulkarni, S. Signaling events underlying thrombus formation. J Thromb Haemost 2003, 7: 1602-12.
7. Nieswandt, B. and Watson, S.P. Platelet-collagen interaction: Is GPVI the central receptor? Blood 2003, 102: 449-61.
8. Abrams C.S. and Brass L.F. Platelet signal transduction. In: Hemostasis and Thrombosis. R.W. Colman, J. Hirsh, V.J. Marder, A.W. Clowes and J.N. George (Eds.). Lippincott William & Wilkins, Philadelphia 2001, 541-59.
9. Offermanns, S., Toombs, C.F., Hu, Y.-H. and Simon, M.I. Defective platelet activation in Galphaq deficient mice. Nature 1997, 389: 183-6.
10. Jantzen, H.M., Milstone, D.S., Gousset, L., Conley, P.B. and Mortensen, R.M. Impaired activation of murine platelets lacking G alpha(12). J Clin Invest 2001, 108: 477-83.
11. Yang, J. et al. Signaling through Gi family members in platelets. Redundancy and specificity in the regulation of adenylyl cyclase and other effectors. J Biol Chem 2002, 277: 46035-42.
12. Hechler, B., Leon, C., Vial, C. et al. The P2Y1 receptor is necessary for adenosine 5′-diphosphate-induced platelet aggregation. Blood 1998, 92: 152-9
13. Jin, J. and Kunapuli, S.P. Coactivation of two different G protein-coupled receptors is essential for ADP-induced platelet aggregation. Proc Natl Acad Sci USA 1998, 95: 8070-4.
14. Savi, P., Beauverger, P., Labouret, C. et al. Role of P2Y1 purinoceptor in ADP-induced platelet activation. FEBS Lett 1998, 422: 291-5.
15. Fabre, J.E., Nguyen, M., Latour, A. et al. Decreased platelet aggregation, increased bleeding time and resistance to thromboembolism in P2Y1-deficient mice. Nat Med 1999, 5: 1199-202.
16. Leon, C., Hechler, B., Freund, M. et al. Defective platelet aggregation and increased resistance to thrombosis in purinergic P2Y(1) receptor-null mice. J Clin Invest 1999, 104: 1731-7.
17. Foster, C.J., Presser, D.M., Agans, J.M. et al. Molecular identification and characterization of the platelet ADP receptor targeted by thienopyridine antithrombotic drugs. J Clin Invest 2001, 107: 1591-8.
18. Savi, P., Pflieger, A.M., and Herbert, J.M. cAMP is not an important messenger for ADP-induced platelet aggregation. Blood Coagul Fibrinolysis 1996, 7: 249-52.
19. Pulcinelli, F.M., Pesciotti, M., Pignatelli, P., Riondino, S. and Gazzaniga, P.P. Concomitant activation of Gi and Gq protein-coupled receptors does not require an increase in cytosolic calcium for platelet aggregation. FEBS Lett 1998, 435: 5-8.
20. Daniel, J.L., Dangelmaier, C., Jin, J., Kim, Y.B. and Kunapuli, S.P. Role of intracellular signaling events in ADP-induced platelet aggregation. Thromb Haemost 1999, 82: 1322-6.
21. Fukuhara, S., Chikumi, H. and Gutkind, J.S. RGS-containing RhoGEFs: The missing link between transforming G proteins and Rho? Oncogene 2001, 20: 1661-8.
22. Sah, V.P., Seasholtz, T.M., Sagi, S.A. and Brown, J.H. The role of Rho in G protein-coupled receptor signal transduction. Annu Rev Pharmacol Toxicol 2000, 40: 459-89.
23. Etienne-Manneville, S. and Hall, A. Rho GTPases in cell biology. Nature 2002, 420: 629-35.
24. Offermanns, S., Laugwitz, K.L., Spicher, K. and Schultz, G. G proteins of the G12 family are activated via thromboxane A2 and thrombin receptors in human platelets. Proc Natl Acad Sci USA 1994, 91: 504-8.
25. Klages, B., Brandt, U., Simon, M.I., Schultz, G. and Offermanns, S. Activation of G12/G13 results in shape change and Rho/Rho-kinase-mediated myosin light chain phosphorylation in mouse platelets. J Cell Biol 1999, 144: 745-54.
26. Nieswandt, B., Schulte, V., Zywietz, A., Gratacap, M.-P. and Offermanns, S. Co-stimulation of Gi- and G12/G13-mediated signaling pathways induces integrin alpha IIbbeta 3 activation in platelets. J Biol Chem 2002, 277: 39493-8.
27. Dorsam, R.T., Kim, S., Jin, J. and Kunapuli, S.P. Coordinated signaling through both G12/13 and G(i) pathways is sufficient to activate GPIIb/IIIa in human platelets. J Biol Chem 2002, 277: 47588-95.
28. Moers, A., Nieswandt, B., Massberg, S. et al. G13 is an essential mediator of platelet activation in hemostasis and thrombosis. Nat Med 2003 11: 1418-22.
29. Paul, B.Z., Daniel, J.L. and Kunapuli, S.P. Platelet shape change is mediated by both calcium-dependent and -independent signaling pathways. Role of p160 Rho-associated coiled-coil-containing protein kinase in platelet shape change. J Biol Chem 1999, 274: 28293-300.
30. Bauer, M., Retzer, M., Wilde, J.I. et al. Dichotomous regulation of myosin phosphorylation and shape change by Rho-kinase and calcium in intact human platelets. Blood 1999, 94: 1665-72.
31. Missy, K., Plantavid, M., Pacaud, P., Viala, C., Chap, H. and Payrastre, B. Rho-kinase is involved in the sustained phosphorylation of myosin and the irreversible platelet aggregation induced by PARI activating peptide. Thromb Haemost 2001, 85: 514-20.
32. Schoenwaelder, S.M., Hughan, S.C., Boniface, K. et al. RhoA sustains integrin alpha IIbbeta 3 adhesion contacts under high shear. J Biol Chem 2002, 277: 14738-46.
33. Gratacap, M.P., Payrastre, B., Nieswandt, B. and Offermanns, S. Differential regulation of Rho and Rac through heterotrimeric G-proteins and cyclic nucleotides. J Biol Chem 2001, 276: 47906-13.
34. Woulfe, D., Yang, J., Prevost, N., O'Brien, P. and Brass, L.F. Signal transduction during initiation, extension and perpetuation of platelet plug formation. In: Platelets. A.D. Michelson (Ed.). Academic Press, San Diego 2002, 197-214.
35. Yang, J., Wu, J., Kowalska, M.A. et al. Loss of signaling through the G protein, Gz, results in abnormal platelet activation and altered responses to psychoactive drugs. Proc Natl Acad Sci USA 2000, 97: 9984-9.
36. Kelleher, K.L., Matthaei, K.I. and Hendry, I.A. Targeted disruption of the mouse Gz-alpha gene: A role for Gz in platelet function? Thromb Haemost 2001, 85: 529-32.