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Volumn 2, Issue 1, 2003, Pages 15-28

Scientific and therapeutic advances in antiplatelet therapy

Author keywords

[No Author keywords available]

Indexed keywords

ABCIXIMAB; ACETYLSALICYLIC ACID; ANTITHROMBOCYTIC AGENT; C REACTIVE PROTEIN; CD40 LIGAND; CLOPIDOGREL; ENOXAPARIN; EPTIFIBATIDE; FIBRINOGEN RECEPTOR ANTAGONIST; FIBRINOLYTIC AGENT; IMMUNOGLOBULIN F(AB) FRAGMENT; LAMIFIBAN; LOW MOLECULAR WEIGHT HEPARIN; MONOCLONAL ANTIBODY; NITRIC OXIDE; NITRIC OXIDE DONOR; ORBOFIBAN; PLACEBO; PROSTAGLANDIN ENDOPEROXIDE; PROSTAGLANDIN RECEPTOR BLOCKING AGENT; PROSTAGLANDIN SYNTHASE; RIDOGREL; TERBOGREL; THROMBOXANE A2; THROMBOXANE A2 RECEPTOR BLOCKING AGENT; TICLOPIDINE; TIROFIBAN; UNCLASSIFIED DRUG; UNINDEXED DRUG; WARFARIN; XEMILOFIBAN; ADENOSINE DIPHOSPHATE; FIBRINOGEN RECEPTOR;

EID: 0037271306     PISSN: 14741776     EISSN: None     Source Type: Journal    
DOI: 10.1038/nrd985     Document Type: Review
Times cited : (416)

References (173)
  • 1
    • 0025694966 scopus 로고
    • History of aspirin and its mechanism of action
    • Vane, J. R., Flower, R. J. & Botting, R. M. History of aspirin and its mechanism of action. Stroke 21, IV12-23 (1990).
    • (1990) Stroke , vol.21
    • Vane, J.R.1    Flower, R.J.2    Botting, R.M.3
  • 2
    • 0032573187 scopus 로고    scopus 로고
    • Frontiers in interventional cardiology
    • Topol, E. J. & Serruys, P. W. Frontiers in interventional cardiology. Circulation 98, 1802-1820 (1998).
    • (1998) Circulation , vol.98 , pp. 1802-1820
    • Topol, E.J.1    Serruys, P.W.2
  • 3
    • 0033983526 scopus 로고    scopus 로고
    • Antiplatelet and anticoagulant therapy in the secondary prevention of ischemic heart disease
    • Bhatt, D. L. & Topol, E. J. Antiplatelet and anticoagulant therapy in the secondary prevention of ischemic heart disease. Med. Clin. North Am. 84, 163-179 (2000).
    • (2000) Med. Clin. North Am. , vol.84 , pp. 163-179
    • Bhatt, D.L.1    Topol, E.J.2
  • 4
    • 0028120906 scopus 로고
    • Collaborative overview of randomised trials of antiplatelet therapy-I: Prevention of death, myocardial infarction, and stroke by prolonged antiplatelet therapy in various categories of patients. Antiplatelet Trialists' Collaboration
    • Collaborative overview of randomised trials of antiplatelet therapy-I: Prevention of death, myocardial infarction, and stroke by prolonged antiplatelet therapy in various categories of patients. Antiplatelet Trialists' Collaboration. BMJ 308, 81-106 (1994).
    • (1994) BMJ , vol.308 , pp. 81-106
  • 5
    • 0023805341 scopus 로고
    • Randomised trial of intravenous streptokinase, oral aspirin, both, or neither among 17,187 cases of suspected acute myocardial infarction: ISIS-2
    • ISIS-2 (Second International Study of Infarct Survival) Collaborative Group
    • Randomised trial of intravenous streptokinase, oral aspirin, both, or neither among 17,187 cases of suspected acute myocardial infarction: ISIS-2. ISIS-2 (Second International Study of Infarct Survival) Collaborative Group. Lancet 2, 349-360 (1988).
    • (1988) Lancet , vol.2 , pp. 349-360
  • 6
    • 0037065502 scopus 로고    scopus 로고
    • Collaborative meta-analysis of randomised trials of antiplatelet therapy for prevention of death, myocardial infarction, and stroke in high risk patients
    • Collaborative meta-analysis of randomised trials of antiplatelet therapy for prevention of death, myocardial infarction, and stroke in high risk patients. BMJ 324, 71-86 (2002).
    • (2002) BMJ , vol.324 , pp. 71-86
  • 7
    • 0034763373 scopus 로고    scopus 로고
    • Aspirin for primary prevention of coronary heart disease: Safety and absolute benefit related to coronary risk derived from meta-analysis of randomised trials
    • Sanmuganathan, P. S., Ghahramani, P., Jackson, P. R., Wallis, E. J. & Ramsay, L. E. Aspirin for primary prevention of coronary heart disease: safety and absolute benefit related to coronary risk derived from meta-analysis of randomised trials. Heart 85, 265-271 (2001 ).
    • (2001) Heart , vol.85 , pp. 265-271
    • Sanmuganathan, P.S.1    Ghahramani, P.2    Jackson, P.R.3    Wallis, E.J.4    Ramsay, L.E.5
  • 8
    • 0037080429 scopus 로고    scopus 로고
    • Aspirin for the primary prevention of cardiovascular events: Recommendation and rationale
    • Aspirin for the primary prevention of cardiovascular events: recommendation and rationale. Ann. Intern. Med. 136, 157-160 (2002).
    • (2002) Ann. Intern. Med. , vol.136 , pp. 157-160
  • 9
    • 0037080065 scopus 로고    scopus 로고
    • Aspirin for the primary prevention of cardiovascular events: A summary of the evidence for the U. S. Preventive Services Task Force
    • Hayden, M., Pignone, M., Phillips, C. & Mulrow, C. Aspirin for the primary prevention of cardiovascular events: a summary of the evidence for the U. S. Preventive Services Task Force. Ann. Intern. Med. 136, 161-172 (2002).
    • (2002) Ann. Intern. Med. , vol.136 , pp. 161-172
    • Hayden, M.1    Pignone, M.2    Phillips, C.3    Mulrow, C.4
  • 10
    • 0035850414 scopus 로고    scopus 로고
    • Aspirin use and all-cause mortality among patients being evaluated for known or suspected coronary artery disease: A propensity analysis
    • Gum, P. A., Thamilarasan, M., Watanabe, J., Blackstone, E. H. & Lauer, M. S. Aspirin use and all-cause mortality among patients being evaluated for known or suspected coronary artery disease: A propensity analysis. JAMA 286, 1187-1194 (2001).
    • (2001) JAMA , vol.286 , pp. 1187-1194
    • Gum, P.A.1    Thamilarasan, M.2    Watanabe, J.3    Blackstone, E.H.4    Lauer, M.S.5
  • 11
    • 0035899289 scopus 로고    scopus 로고
    • Effects of clopidogrel in addition to aspirin in patients with acute coronary syndromes without ST-segment elevation
    • Yusuf, S. et al. Effects of clopidogrel in addition to aspirin in patients with acute coronary syndromes without ST-segment elevation. N. Engl. J. Med. 345, 494-502 (2001).
    • (2001) N. Engl. J. Med. , vol.345 , pp. 494-502
    • Yusuf, S.1
  • 12
    • 0033606533 scopus 로고    scopus 로고
    • Low-dose and high-dose acetylsalicylic acid for patients undergoing carotid endarterectomy: A randomized controlled trial
    • ASA and Carotid Endarterectomy (ACE) Trial Collaborators
    • Taylor, D. W. et al. Low-dose and high-dose acetylsalicylic acid for patients undergoing carotid endarterectomy: a randomized controlled trial. ASA and Carotid Endarterectomy (ACE) Trial Collaborators. Lancet 353, 2179-2184 (1999).
    • (1999) Lancet , vol.353 , pp. 2179-2184
    • Taylor, D.W.1
  • 13
    • 0033679411 scopus 로고    scopus 로고
    • Update on clinical trials of antiplatelet therapy for cerebrovascular diseases
    • Bhatt, D. L., Kapadia, S. R., Yadav, J. S. & Topol, E. J. Update on clinical trials of antiplatelet therapy for cerebrovascular diseases. Cerebrovasc. Dis. 10 (Suppl S5), 34-40 (2000).
    • (2000) Cerebrovasc. Dis. , vol.10 , Issue.SUPPL. S5 , pp. 34-40
    • Bhatt, D.L.1    Kapadia, S.R.2    Yadav, J.S.3    Topol, E.J.4
  • 14
    • 0028140168 scopus 로고
    • Randomized trial of ridogrel, a combined thromboxane A2 synthase inhibitor and thromboxane A2/prostaglandin endoperoxide receptor antagonist, versus aspirin as adjunct to thrombolysis in patients with acute myocardial infarction
    • The RAPT Trial Investigators. The Ridogrel Versus Aspirin Patency Trial (RAPT)
    • The RAPT Trial Investigators. Randomized trial of ridogrel, a combined thromboxane A2 synthase inhibitor and thromboxane A2/prostaglandin endoperoxide receptor antagonist, versus aspirin as adjunct to thrombolysis in patients with acute myocardial infarction. The Ridogrel Versus Aspirin Patency Trial (RAPT). Circulation 89, 588-595 (1994).
    • (1994) Circulation , vol.89 , pp. 588-595
  • 15
    • 0034294087 scopus 로고    scopus 로고
    • Terbogrel, a dual-acting agent for thromboxane receptor antagonism and thromboxane synthase inhibition
    • Michaux, C. et al. Terbogrel, a dual-acting agent for thromboxane receptor antagonism and thromboxane synthase inhibition. Acta Crystallogr. C 56, 1265-1266 (2000).
    • (2000) Acta Crystallogr. C , vol.56 , pp. 1265-1266
    • Michaux, C.1
  • 16
    • 0033535613 scopus 로고    scopus 로고
    • Guanidine derivatives as combined thromboxane A2 receptor antagonists and synthase inhibitors
    • Soyka, R., Guth, B. D., Weisenberger, H. M., Luger, P. & Muller T. H. Guanidine derivatives as combined thromboxane A2 receptor antagonists and synthase inhibitors. J. Med. Chem. 42, 1235-1249 (1999).
    • (1999) J. Med. Chem. , vol.42 , pp. 1235-1249
    • Soyka, R.1    Guth, B.D.2    Weisenberger, H.M.3    Luger, P.4    Muller, T.H.5
  • 17
    • 20244386797 scopus 로고    scopus 로고
    • Effects of the thromboxane synthetase inhibitor and receptor antagonist terbogrel in patients with primary pulmonary hypertension
    • Langleben, D. et al. Effects of the thromboxane synthetase inhibitor and receptor antagonist terbogrel in patients with primary pulmonary hypertension. Am. Heart. J. 143, E4 (2002).
    • (2002) Am. Heart. J. , vol.143
    • Langleben, D.1
  • 18
    • 0037126075 scopus 로고    scopus 로고
    • Chronic treatment with nitric oxide-releasing aspirin reduces plasma low-density lipoprotein oxidation and oxidative stress, arterial oxidation-specific epitopes, and atherogenesis in hypercholesterolemic mice
    • Napoli, C. et al. Chronic treatment with nitric oxide-releasing aspirin reduces plasma low-density lipoprotein oxidation and oxidative stress, arterial oxidation-specific epitopes, and atherogenesis in hypercholesterolemic mice. Proc. Natl Acad. Sci. USA 99, 12467-12470 (2002).
    • (2002) Proc. Natl Acad. Sci. USA , vol.99 , pp. 12467-12470
    • Napoli, C.1
  • 19
    • 0037022334 scopus 로고    scopus 로고
    • Efficacy and age-related effects of nitric oxide-releasing aspirin on experimental
    • Napoli, C. et al. Efficacy and age-related effects of nitric oxide-releasing aspirin on experimental restenosis. Proc. Natl Acad. Sci. USA 99, 1689-1694 (2002).
    • (2002) Restenosis Proc. Natl Acad. Sci. USA , vol.99 , pp. 1689-1694
    • Napoli, C.1
  • 20
    • 0035956891 scopus 로고    scopus 로고
    • Effects of nitric oxide-releasing aspirin versus aspirin on restenosis in hypercholesterolemic mice
    • Napoli, C. et al. Effects of nitric oxide-releasing aspirin versus aspirin on restenosis in hypercholesterolemic mice. Proc. Natl Acad. Sci. USA 98, 2860-2864 (2001).
    • (2001) Proc. Natl Acad. Sci. USA , vol.98 , pp. 2860-2864
    • Napoli, C.1
  • 21
    • 0037085951 scopus 로고    scopus 로고
    • Underuse of aspirin in a referral population with documented coronary artery disease
    • Califf, R. M. et al. Underuse of aspirin in a referral population with documented coronary artery disease. Am. J. Cardiol. 89, 653-661 (2002).
    • (2002) Am. J. Cardiol. , vol.89 , pp. 653-661
    • Califf, R.M.1
  • 22
    • 0033561482 scopus 로고    scopus 로고
    • Prior aspirin use predicts worse outcomes in patients with non-ST-elevation acute coronary syndromes
    • PURSUIT Investigators. Platelet IIb/IIIa in Unstable angina: Receptor Suppression Using Integrilin Therapy
    • Alexander, J. H. et al. Prior aspirin use predicts worse outcomes in patients with non-ST-elevation acute coronary syndromes. PURSUIT Investigators. Platelet IIb/IIIa in Unstable angina: Receptor Suppression Using Integrilin Therapy. Am. J. Cardiol. 83, 1147-1151 (1999).
    • (1999) Am. J. Cardiol. , vol.83 , pp. 1147-1151
    • Alexander, J.H.1
  • 23
    • 0035421783 scopus 로고    scopus 로고
    • Profile and prevalence of aspirin resistance in patients with cardiovascular disease
    • Gum, P. A. et al. Profile and prevalence of aspirin resistance in patients with cardiovascular disease. Am. J. Cardiol. 88, 230-235 (2001).
    • (2001) Am. J. Cardiol. , vol.88 , pp. 230-235
    • Gum, P.A.1
  • 24
    • 0242356828 scopus 로고    scopus 로고
    • Clinical consequences of aspirin resistance
    • (in the press)
    • Gum, P. A. et al. Clinical consequences of aspirin resistance. J. Am. Coll. Cardiol (in the press).
    • J. Am. Coll. Cardiol
    • Gum, P.A.1
  • 25
    • 0037046196 scopus 로고    scopus 로고
    • Aspirin-resistant thromboxane biosynthesis and the risk of myocardial infarction, stroke, or cardiovascular death in patients at high risk for cardiovascular events
    • Eikelboom, J. W. et al. Aspirin-resistant thromboxane biosynthesis and the risk of myocardial infarction, stroke, or cardiovascular death in patients at high risk for cardiovascular events. Circulation 105, 1650-1655 (2002).
    • (2002) Circulation , vol.105 , pp. 1650-1655
    • Eikelboom, J.W.1
  • 26
    • 0030614495 scopus 로고    scopus 로고
    • PIA1/A2 polymorphism of platelet glycoprotein IIIa and risks of myocardial infarction, stroke, and venous thrombosis
    • Ridker, P. M., Hennekens, C. H., Schmitz, C., Stampfer, M. J. & Lindpaintner, K. PIA1/A2 polymorphism of platelet glycoprotein IIIa and risks of myocardial infarction, stroke, and venous thrombosis. Lancet 349, 385-388 (1997).
    • (1997) Lancet , vol.349 , pp. 385-388
    • Ridker, P.M.1    Hennekens, C.H.2    Schmitz, C.3    Stampfer, M.J.4    Lindpaintner, K.5
  • 27
    • 0033761053 scopus 로고    scopus 로고
    • Relationship between bleeding time, aspirin and the PIA1/A2 polymorphism of platelet glycoprotein IIIa
    • Szczeklik, A., Undas, A., Sanak, M., Frolow, M. & Wegrzyn, W. Relationship between bleeding time, aspirin and the PIA1/A2 polymorphism of platelet glycoprotein IIIa. Br. J. Haematol. 110, 965-967 (2000).
    • (2000) Br. J. Haematol. , vol.110 , pp. 965-967
    • Szczeklik, A.1    Undas, A.2    Sanak, M.3    Frolow, M.4    Wegrzyn, W.5
  • 28
    • 0033760129 scopus 로고    scopus 로고
    • Defective platelet response to arachidonic acid and thromboxane A(2) in subjects with PI(A2) polymorphism of β(3) subunit (glycoprotein IIIa)
    • Andrioli, G. et al. Defective platelet response to arachidonic acid and thromboxane A(2) in subjects with PI(A2) polymorphism of β(3) subunit (glycoprotein IIIa). Br. J. Haematol. 110, 911-918 (2000).
    • (2000) Br. J. Haematol. , vol.110 , pp. 911-918
    • Andrioli, G.1
  • 29
    • 18244414272 scopus 로고    scopus 로고
    • Platelet GP IIIa PI(A) polymorphisms display different sensitivities to agonists
    • Michelson, A. D. et al. Platelet GP IIIa PI(A) polymorphisms display different sensitivities to agonists. Circulation 101, 1013-1018 (2000).
    • (2000) Circulation , vol.101 , pp. 1013-1018
    • Michelson, A.D.1
  • 30
    • 0035960620 scopus 로고    scopus 로고
    • PI(A2) polymorphism of β(3) integrins is associated with enhanced thrombin generation and impaired antithrombotic action of aspirin at the site of microvascular injury
    • Undas, A., Brummel, K., Musial, J., Mann, K. G. & Szczeklik, A. PI(A2) polymorphism of β(3) integrins is associated with enhanced thrombin generation and impaired antithrombotic action of aspirin at the site of microvascular injury. Circulation 104, 2666-2672 (2001).
    • (2001) Circulation , vol.104 , pp. 2666-2672
    • Undas, A.1    Brummel, K.2    Musial, J.3    Mann, K.G.4    Szczeklik, A.5
  • 31
    • 0035199930 scopus 로고    scopus 로고
    • Common variations in platelet glycoproteins: Pharmacogenomic implications
    • Topol, E. J. & Quinn, M. J. Common variations in platelet glycoproteins: pharmacogenomic implications. Pharmacogenomics 2, 341-352 (2001).
    • (2001) Pharmacogenomics , vol.2 , pp. 341-352
    • Topol, E.J.1    Quinn, M.J.2
  • 32
    • 0345040152 scopus 로고    scopus 로고
    • Cyclooxygenase-2 in human platelets as a possible factor in aspirin resistance
    • Weber, A. A., Zimmermann, K. C., Meyer-Kirchrath, J. & Schror, K. Cyclooxygenase-2 in human platelets as a possible factor in aspirin resistance. Lancet 353, 900 (1999).
    • (1999) Lancet , vol.353 , pp. 900
    • Weber, A.A.1    Zimmermann, K.C.2    Meyer-Kirchrath, J.3    Schror, K.4
  • 33
    • 0033573790 scopus 로고    scopus 로고
    • Platelet GPIIb-IIIa blockers
    • Topol, E. J., Byzova, T. V. & Plow, E. F. Platelet GPIIb-IIIa blockers. Lancet 353, 227-231 (1999).
    • (1999) Lancet , vol.353 , pp. 227-231
    • Topol, E.J.1    Byzova, T.V.2    Plow, E.F.3
  • 34
    • 0028807209 scopus 로고
    • Differential inhibition of platelet aggregation induced by adenosine diphosphate or a thrombin receptor-activating peptide in patients treated with bolus chimeric 7E3 Fab: Implications for inhibition of the internal pool of GPIIb/IIIa receptors
    • Kleiman, N. S. et al. Differential inhibition of platelet aggregation induced by adenosine diphosphate or a thrombin receptor-activating peptide in patients treated with bolus chimeric 7E3 Fab: implications for inhibition of the internal pool of GPIIb/IIIa receptors. J. Am. Coll. Cardiol. 26, 1665-1671 (1995).
    • (1995) J. Am. Coll. Cardiol. , vol.26 , pp. 1665-1671
    • Kleiman, N.S.1
  • 35
    • 0033104925 scopus 로고    scopus 로고
    • Labeling of the internal pool of GP IIb-IIIa in platelets by c7E3 Fab fragments (abciximab): Flow and endocytic mechanisms contribute to the transport
    • Nurden, P. et al. Labeling of the internal pool of GP IIb-IIIa in platelets by c7E3 Fab fragments (abciximab): flow and endocytic mechanisms contribute to the transport. Blood 93, 1622-1633 (1999).
    • (1999) Blood , vol.93 , pp. 1622-1633
    • Nurden, P.1
  • 36
    • 0034089122 scopus 로고    scopus 로고
    • Incomplete inhibition of platelet aggregation and glycoprotein IIb-IIIa receptor blockade by abciximab: Importance of internal pool of glycoprotein IIb-IIIa receptors
    • Gawaz, M. et al. Incomplete inhibition of platelet aggregation and glycoprotein IIb-IIIa receptor blockade by abciximab: importance of internal pool of glycoprotein IIb-IIIa receptors. Thromb. Haemost. 83, 915-922 (2000).
    • (2000) Thromb. Haemost. , vol.83 , pp. 915-922
    • Gawaz, M.1
  • 37
    • 0035028123 scopus 로고    scopus 로고
    • Occupancy of the internal and external pools of glycoprotein IIb/IIIa following abciximab bolus and infusion
    • Quinn, M. J., Murphy, R. T., Dooley, M., Foley, J. B. & Fitzgerald, D. J. Occupancy of the internal and external pools of glycoprotein IIb/IIIa following abciximab bolus and infusion. J. Pharmacol. Exp. Ther. 297, 496-500 (2001).
    • (2001) J. Pharmacol. Exp. Ther. , vol.297 , pp. 496-500
    • Quinn, M.J.1    Murphy, R.T.2    Dooley, M.3    Foley, J.B.4    Fitzgerald, D.J.5
  • 38
    • 0034721399 scopus 로고    scopus 로고
    • Current role of platelet glycoprotein IIb/IIIa inhibitors in acute coronary syndromes
    • Bhatt, D. L. & Topol, E. J. Current role of platelet glycoprotein IIb/IIIa inhibitors in acute coronary syndromes. JAMA 284, 1549-1558 (2000).
    • (2000) JAMA , vol.284 , pp. 1549-1558
    • Bhatt, D.L.1    Topol, E.J.2
  • 39
    • 0036067568 scopus 로고    scopus 로고
    • Multi-year follow-up of abciximab therapy in three randomized, placebo- controlled trials of percutaneous coronary revascularization
    • Topol, E. J. et al. Multi-year follow-up of abciximab therapy in three randomized, placebo- controlled trials of percutaneous coronary revascularization. Am. J. Med. 113, 1-6 (2002).
    • (2002) Am. J. Med. , vol.113 , pp. 1-6
    • Topol, E.J.1
  • 40
    • 0035897706 scopus 로고    scopus 로고
    • Platelet glycoprotein IIb/IIIa integrin blockade with eptifibatide in coronary stent intervention: The ESPRIT trial: A randomized controlled trial
    • O'Shea, J. C. et al. Platelet glycoprotein IIb/IIIa integrin blockade with eptifibatide in coronary stent intervention: the ESPRIT trial: a randomized controlled trial. JAMA 285, 2468-2473 (2001).
    • (2001) JAMA , vol.285 , pp. 2468-2473
    • O'Shea, J.C.1
  • 41
    • 0035927988 scopus 로고    scopus 로고
    • Comparison of two platelet glycoprotein IIb/IIIa inhibitors, tirofiban and abciximab, for the prevention of ischemic events with percutaneous coronary revascularization
    • Topol, E. J. et al. Comparison of two platelet glycoprotein IIb/IIIa inhibitors, tirofiban and abciximab, for the prevention of ischemic events with percutaneous coronary revascularization. N. Engl. J. Med. 344, 1888-1894 (2001).
    • (2001) N. Engl. J. Med. , vol.344 , pp. 1888-1894
    • Topol, E.J.1
  • 42
    • 0036380962 scopus 로고    scopus 로고
    • Optimizing glycoprotein IIb/IIIa inhibition: Lessons from recent randomized controlled trials
    • Chew, D. P. & Bhatt, D. L. Optimizing glycoprotein IIb/IIIa inhibition: lessons from recent randomized controlled trials. Intern. Med. J. 32, 338-345 (2002).
    • (2002) Intern. Med. J. , vol.32 , pp. 338-345
    • Chew, D.P.1    Bhatt, D.L.2
  • 43
    • 1842497857 scopus 로고    scopus 로고
    • (ed. Topol, E. J.) (Marcel Dekker, New York,)
    • Bhatt, D. L. & Topol, E. J. in Acute Coronary Syndromes (ed. Topol, E. J.) 79-110 (Marcel Dekker, New York, 2000).
    • (2000) Acute Coronary Syndromes , pp. 79-110
    • Bhatt, D.L.1    Topol, E.J.2
  • 44
    • 0033609314 scopus 로고    scopus 로고
    • Benefit of abciximab in patients with refractory unstable angina in relation to serum troponin T levels
    • c7E3 Fab Antiplatelet Therapy in Unstable Refractory Angina (CAPTURE) Study Investigators
    • Hamm, C. W. et al. Benefit of abciximab in patients with refractory unstable angina in relation to serum troponin T levels. c7E3 Fab Antiplatelet Therapy in Unstable Refractory Angina (CAPTURE) Study Investigators. N. Engl. J. Med. 340, 1623-1629 (1999).
    • (1999) N. Engl. J. Med. , vol.340 , pp. 1623-1629
    • Hamm, C.W.1
  • 45
    • 0006858359 scopus 로고    scopus 로고
    • Benefit of Tirofiban in High-Risk Patients with Unstable Angina Identified by Troponins in the PRISM Trial
    • Hamm, C. W., Heeschen, C., Goldmann, B. U. & White, H. D. Benefit of Tirofiban in High-Risk Patients with Unstable Angina Identified by Troponins in the PRISM Trial. Circulation 100, 1-775 (1999).
    • (1999) Circulation , vol.100 , pp. 1-775
    • Hamm, C.W.1    Heeschen, C.2    Goldmann, B.U.3    White, H.D.4
  • 46
    • 0034654627 scopus 로고    scopus 로고
    • Abciximab reduces mortality in diabetics following percutaneous coronary intervention
    • Bhatt, D. L. et al. Abciximab reduces mortality in diabetics following percutaneous coronary intervention. J. Am. Coll. Cardiol. 35, 922-928 (2000).
    • (2000) J. Am. Coll. Cardiol. , vol.35 , pp. 922-928
    • Bhatt, D.L.1
  • 47
    • 0035808028 scopus 로고    scopus 로고
    • Platelet glycoprotein IIb/IIIa inhibitors reduce mortality in diabetic patients with non-ST-segment-elevation acute coronary syndromes
    • Roffi, M. et al. Platelet glycoprotein IIb/IIIa inhibitors reduce mortality in diabetic patients with non-ST-segment-elevation acute coronary syndromes. Circulation 104, 2767-2771 (2001).
    • (2001) Circulation , vol.104 , pp. 2767-2771
    • Roffi, M.1
  • 48
    • 0030945072 scopus 로고    scopus 로고
    • Deutsche Nikotinamid Interventionsstudie
    • DENIS Study Group
    • Tschoepe, D., Driesch, E., Schwippert, B. & Lampeter, E. F. Activated platelets in subjects at increased risk of IDDM. DENIS Study Group. Deutsche Nikotinamid Interventionsstudie. Diabetologia 40, 573-577 (1997).
    • (1997) Diabetologia , vol.40 , pp. 573-577
    • Tschoepe, D.1    Driesch, E.2    Schwippert, B.3    Lampeter, E.F.4
  • 49
    • 0031453235 scopus 로고    scopus 로고
    • Platelet-leukocyte-cross-talk in diabetes mellitus
    • Tschoepe, D., Rauch, U. & Schwippert, B. Platelet-leukocyte-cross-talk in diabetes mellitus. Horm. Metab. Res. 29, 631-635 (1997).
    • (1997) Horm. Metab. Res. , vol.29 , pp. 631-635
    • Tschoepe, D.1    Rauch, U.2    Schwippert, B.3
  • 50
    • 0035227860 scopus 로고    scopus 로고
    • Oral glycoprotein IIb/IIIa antagonists in coronary artery disease
    • Chew, D. P. & Bhatt, D. L. Oral glycoprotein IIb/IIIa antagonists in coronary artery disease. Curr. Cardiol. Rep. 3, 63-71 (2001).
    • (2001) Curr. Cardiol. Rep. , vol.3 , pp. 63-71
    • Chew, D.P.1    Bhatt, D.L.2
  • 51
    • 0035895332 scopus 로고    scopus 로고
    • Increased mortality with oral platelet glycoprotein IIb/IIIa antagonists: A meta-analysis of phase III multicenter randomized trials
    • Chew, D. P., Bhatt, D. L., Sapp, S. & Topol, E. J. Increased mortality with oral platelet glycoprotein IIb/IIIa antagonists: A meta-analysis of phase III multicenter randomized trials. Circulation 103, 201-206 (2001).
    • (2001) Circulation , vol.103 , pp. 201-206
    • Chew, D.P.1    Bhatt, D.L.2    Sapp, S.3    Topol, E.J.4
  • 52
    • 0035897893 scopus 로고    scopus 로고
    • Effect of glycoprotein IIb/IIIa receptor blocker abciximab on outcome in patients with acute coronary syndromes without early coronary revascularisation: The GUSTO IV-ACS randomised trial
    • Simoons, M. L. Effect of glycoprotein IIb/IIIa receptor blocker abciximab on outcome in patients with acute coronary syndromes without early coronary revascularisation: the GUSTO IV-ACS randomised trial. Lancet 357, 1915-1924 (2001).
    • (2001) Lancet , vol.357 , pp. 1915-1924
    • Simoons, M.L.1
  • 53
    • 0035967496 scopus 로고    scopus 로고
    • Point-of-care measured platelet inhibition correlates with a reduced risk of an adverse cardiac event after percutaneous coronary intervention: Results of the GOLD (AU-Assessing Ultegra) multicenter study
    • Steinhubl, S. R. et al. Point-of-care measured platelet inhibition correlates with a reduced risk of an adverse cardiac event after percutaneous coronary intervention: results of the GOLD (AU-Assessing Ultegra) multicenter study. Circulation 103, 2572-2578 (2001).
    • (2001) Circulation , vol.103 , pp. 2572-2578
    • Steinhubl, S.R.1
  • 54
    • 0034332785 scopus 로고    scopus 로고
    • Evidence of platelet activation during treatment with a GPIIb/IIIa antagonist in patients presenting with acute coronary syndromes
    • Cox, D. et al. Evidence of platelet activation during treatment with a GPIIb/IIIa antagonist in patients presenting with acute coronary syndromes. J. Am. Coll. Cardiol. 36, 1514-1519 (2000).
    • (2000) J. Am. Coll. Cardiol. , vol.36 , pp. 1514-1519
    • Cox, D.1
  • 55
    • 0037118664 scopus 로고    scopus 로고
    • Platelet glycoprotein IIb/IIIa inhibitors: Recognition of a two-edged sword?
    • Quinn, M. J., Plow, E. F. & Topol, E. J. Platelet glycoprotein IIb/IIIa inhibitors: recognition of a two-edged sword? Circulation 106, 379-385 (2002).
    • (2002) Circulation , vol.106 , pp. 379-385
    • Quinn, M.J.1    Plow, E.F.2    Topol, E.J.3
  • 56
    • 0035760865 scopus 로고    scopus 로고
    • Genetic variation in glycoprotein IIb/IIIa (GPIIb/IIIa) as a determinant of the responses to an oral GPIIb/IIIa antagonist in patients with unstable coronary syndromes
    • O'Connor, F. F. et al. Genetic variation in glycoprotein IIb/IIIa (GPIIb/IIIa) as a determinant of the responses to an oral GPIIb/IIIa antagonist in patients with unstable coronary syndromes. Blood 98, 3256-3260 (2001).
    • (2001) Blood , vol.98 , pp. 3256-3260
    • O'Connor, F.F.1
  • 57
    • 0033956763 scopus 로고    scopus 로고
    • Paradoxical inhibition of fibrinogen binding and potentiation of α-granule release by specific types of inhibitors of glycoprotein IIb-IIIa
    • Schneider, D. J., Taatjes, D. J. & Sobel, B. E. Paradoxical inhibition of fibrinogen binding and potentiation of α-granule release by specific types of inhibitors of glycoprotein IIb-IIIa. Cardiovasc Res 45, 437-446 (2000).
    • (2000) Cardiovasc Res , vol.45 , pp. 437-446
    • Schneider, D.J.1    Taatjes, D.J.2    Sobel, B.E.3
  • 58
    • 0036220890 scopus 로고    scopus 로고
    • Clopidogrel, but not abciximab, reduces platelet leukocyte conjugates and P-selectin expression in a human ex vivo in vitro model
    • Klinkhardt, U., Graff, J. & Harder, S. Clopidogrel, but not abciximab, reduces platelet leukocyte conjugates and P-selectin expression in a human ex vivo in vitro model. Clin. Pharmacol. Ther. 71, 176-185 (2002).
    • (2002) Clin. Pharmacol. Ther. , vol.71 , pp. 176-185
    • Klinkhardt, U.1    Graff, J.2    Harder, S.3
  • 59
    • 0035838353 scopus 로고    scopus 로고
    • Abciximab suppresses the rise in levels of circulating inflammatory markers after percutaneous coronary revascularization
    • Lincoff, A. M. et al. Abciximab suppresses the rise in levels of circulating inflammatory markers after percutaneous coronary revascularization. Circulation 104, 163-167 (2001).
    • (2001) Circulation , vol.104 , pp. 163-167
    • Lincoff, A.M.1
  • 60
    • 0034081573 scopus 로고    scopus 로고
    • Assessing the optimal level of platelet inhibition with GPIIb/IIIa inhibitors in patients undergoing coronary intervention. Rationale and design of the GOLD study
    • Steinhubl, S. R. Assessing the optimal level of platelet inhibition with GPIIb/IIIa inhibitors in patients undergoing coronary intervention. Rationale and design of the GOLD study. J. Thromb. Thrombolysis 9, 199-205 (2000).
    • (2000) J. Thromb. Thrombolysis , vol.9 , pp. 199-205
    • Steinhubl, S.R.1
  • 61
    • 0034091791 scopus 로고    scopus 로고
    • Glycoprotein IIb/IIIa antagonists induce apoptosis in rat cardiomyocytes by caspase-3 activation
    • Adderley, S. R. & Fitzgerald, D. J. Glycoprotein IIb/IIIa antagonists induce apoptosis in rat cardiomyocytes by caspase-3 activation. J. Biol. Chem. 275, 5760-5766 (2000).
    • (2000) J. Biol. Chem. , vol.275 , pp. 5760-5766
    • Adderley, S.R.1    Fitzgerald, D.J.2
  • 62
    • 0035912912 scopus 로고    scopus 로고
    • Benefit of glycoprotein IIb/IIIa inhibition in patients with acute coronary syndromes and troponin t-positive status: The paragon-B troponin T substudy
    • Newby, L. K. et al. Benefit of glycoprotein IIb/IIIa inhibition in patients with acute coronary syndromes and troponin t-positive status: the paragon-B troponin T substudy. Circulation 103, 2891-2896 (2001).
    • (2001) Circulation , vol.103 , pp. 2891-2896
    • Newby, L.K.1
  • 63
    • 3543081983 scopus 로고    scopus 로고
    • The CRUSADE Registry of high risk acute coronary syndrome patients
    • Bhatt, D. L. The CRUSADE Registry of high risk acute coronary syndrome patients. Circulation 106, II-494 (2002).
    • (2002) Circulation , vol.106
    • Bhatt, D.L.1
  • 64
    • 85009017764 scopus 로고    scopus 로고
    • Safety of concomitant therapy with eptifibatide and enoxaparin in patients undergoing percutaneous coronary intervention - Results of the CRUISE study
    • (in the press)
    • Bhatt, D. L. et al. Safety of concomitant therapy with eptifibatide and enoxaparin in patients undergoing percutaneous coronary intervention - Results of the CRUISE study. J. Am. Coll. Cardiol. (in the press).
    • J. Am. Coll. Cardiol.
    • Bhatt, D.L.1
  • 65
    • 0037046221 scopus 로고    scopus 로고
    • Enoxaparin as adjunctive antithrombin therapy for ST-elevation myocardial infarction: Results of the ENTIRE-Thrombolysis in Myocardial Infarction (TIMI) 23 Trial
    • Antman, E. M. et al. Enoxaparin as adjunctive antithrombin therapy for ST-elevation myocardial infarction: results of the ENTIRE-Thrombolysis in Myocardial Infarction (TIMI) 23 Trial. Circulation 105, 1642-1649 (2002).
    • (2002) Circulation , vol.105 , pp. 1642-1649
    • Antman, E.M.1
  • 66
    • 0035897888 scopus 로고    scopus 로고
    • Reperfusion therapy for acute myocardial infarction with fibrinolytic therapy or combination reduced fibrinolytc therapy and platelet glycoprotein IIb/IIIa inhibition: The GUSTO V randomised trial
    • Topol, E. J. Reperfusion therapy for acute myocardial infarction with fibrinolytic therapy or combination reduced fibrinolytc therapy and platelet glycoprotein IIb/IIIa inhibition: the GUSTO V randomised trial. Lancet 357, 1905-1914 (2001).
    • (2001) Lancet , vol.357 , pp. 1905-1914
    • Topol, E.J.1
  • 67
    • 0035949117 scopus 로고    scopus 로고
    • Efficacy and safety of tenecteplase in combination with enoxaparin, abciximab, or unfractionated heparin: The ASSENT-3 randomised trial in acute myocardial infarction
    • Efficacy and safety of tenecteplase in combination with enoxaparin, abciximab, or unfractionated heparin: the ASSENT-3 randomised trial in acute myocardial infarction. Lancet 358, 605-613 (2001).
    • (2001) Lancet , vol.358 , pp. 605-613
  • 68
    • 0029742679 scopus 로고    scopus 로고
    • The STIMS trial: The ticlopidine experience and its clinical applications. Swedish Ticlopidine Multicenter Study
    • Janzon, L. The STIMS trial: the ticlopidine experience and its clinical applications. Swedish Ticlopidine Multicenter Study. Vasc. Med. 1, 141-143 (1996).
    • (1996) Vasc. Med. , vol.1 , pp. 141-143
    • Janzon, L.1
  • 69
    • 0025345221 scopus 로고
    • Antiplatelet treatment with ticlopidine in unstable angina. A controlled multicenter clinical trial
    • The Studio della Ticlopidina nell'Angina Instabile Group
    • Balsano, F. et al. Antiplatelet treatment with ticlopidine in unstable angina. A controlled multicenter clinical trial. The Studio della Ticlopidina nell'Angina Instabile Group. Circulation 82, 17-26 (1990).
    • (1990) Circulation , vol.82 , pp. 17-26
    • Balsano, F.1
  • 70
    • 0021339039 scopus 로고
    • Effect of ticlopidine on saphenous vein bypass patency rates: A double-blind study
    • Chevigne, M., David, J. L., Rigo, P. & Limet, R. Effect of ticlopidine on saphenous vein bypass patency rates: a double-blind study. Ann. Thorac. Surg. 37, 371-378 (1984).
    • (1984) Ann. Thorac. Surg. , vol.37 , pp. 371-378
    • Chevigne, M.1    David, J.L.2    Rigo, P.3    Limet, R.4
  • 71
    • 0023634779 scopus 로고
    • Prevention of aorta-coronary bypass graft occlusion. Beneficial effect of ticlopidine on early and late patency rates of venous coronary bypass grafts: A double-blind study
    • Limet, R., David, J. L., Magotteaux, P., Larock, M. P. & Rigo, P. Prevention of aorta-coronary bypass graft occlusion. Beneficial effect of ticlopidine on early and late patency rates of venous coronary bypass grafts: a double-blind study. J. Thorac. Cardiovasc. Surg. 94, 773-783 (1987).
    • (1987) J. Thorac. Cardiovasc. Surg. , vol.94 , pp. 773-783
    • Limet, R.1    David, J.L.2    Magotteaux, P.3    Larock, M.P.4    Rigo, P.5
  • 72
    • 0030658097 scopus 로고    scopus 로고
    • Effect of ticlopidine on the long-term patency of saphenous-vein bypass grafts in the legs
    • Etude de la Ticlopidine apres Pontage Femoro- Poplite and the Association Universitaire de Recherche en Chirurgie
    • Becquemin, J. P. Effect of ticlopidine on the long-term patency of saphenous-vein bypass grafts in the legs. Etude de la Ticlopidine apres Pontage Femoro- Poplite and the Association Universitaire de Recherche en Chirurgie. N. Engl. J. Med. 337, 1726-1731 (1997).
    • (1997) N. Engl. J. Med. , vol.337 , pp. 1726-1731
    • Becquemin, J.P.1
  • 73
    • 0024396437 scopus 로고
    • A randomized trial comparing ticlopidine hydrochloride with aspirin for the prevention of stroke in high-risk patients
    • Ticlopidine Aspirin Stroke Study Group
    • Hass, W. K. et al. A randomized trial comparing ticlopidine hydrochloride with aspirin for the prevention of stroke in high-risk patients. Ticlopidine Aspirin Stroke Study Group. N. Engl. J. Med. 321, 501-507 (1989).
    • (1989) N. Engl. J. Med. , vol.321 , pp. 501-507
    • Hass, W.K.1
  • 74
    • 0024411823 scopus 로고
    • The Canadian American Ticlopidine Study (CATS) in thromboembolic stroke
    • Gent, M. et al. The Canadian American Ticlopidine Study (CATS) in thromboembolic stroke. Lancet 1, 1215-1220 (1989).
    • (1989) Lancet , vol.1 , pp. 1215-1220
    • Gent, M.1
  • 75
    • 0033518847 scopus 로고    scopus 로고
    • Incidence and clinical course of thrombotic thrombocytopenic purpura due to ticlopidine following coronary stenting
    • EPISTENT Investigators. Evaluation of Platelet IIb/IIIa Inhibitor for Stenting
    • Steinhubl, S. R., Tan, W. A., Foody, J. M. & Topol, E. J. Incidence and clinical course of thrombotic thrombocytopenic purpura due to ticlopidine following coronary stenting. EPISTENT Investigators. Evaluation of Platelet IIb/IIIa Inhibitor for Stenting. JAMA 281, 806-810 (1999).
    • (1999) JAMA , vol.281 , pp. 806-810
    • Steinhubl, S.R.1    Tan, W.A.2    Foody, J.M.3    Topol, E.J.4
  • 77
    • 0037014999 scopus 로고    scopus 로고
    • A new name in thrombosis, ADAMTS13
    • Sadler, J. E. A new name in thrombosis, ADAMTS13. Proc. Natl Acad. Sci. USA 99, 11552-11554 (2002).
    • (2002) Proc. Natl Acad. Sci. USA , vol.99 , pp. 11552-11554
    • Sadler, J.E.1
  • 78
    • 0030590746 scopus 로고    scopus 로고
    • A randomised, blinded, trial of clopidogrel versus aspirin in patients at risk of ischaemic events (CAPRIE)
    • CAPRIE Steering Committee
    • CAPRIE Steering Committee. A randomised, blinded, trial of clopidogrel versus aspirin in patients at risk of ischaemic events (CAPRIE). Lancet 348, 1329-1339 (1996).
    • (1996) Lancet , vol.348 , pp. 1329-1339
  • 79
    • 0033941958 scopus 로고    scopus 로고
    • Reduction in the need for hospitalization for recurrent ischemic events and bleeding with clopidogrel instead of aspirin
    • Bhatt, D. L., Hirsch, A. T., Ringleb, P. A., Hacke, W. & Topol, E. J. Reduction in the need for hospitalization for recurrent ischemic events and bleeding with clopidogrel instead of aspirin. Am. Heart J. 140, 67-73 (2000).
    • (2000) Am. Heart J. , vol.140 , pp. 67-73
    • Bhatt, D.L.1    Hirsch, A.T.2    Ringleb, P.A.3    Hacke, W.4    Topol, E.J.5
  • 80
    • 0035936484 scopus 로고    scopus 로고
    • Superiority of clopidogrel versus aspirin in patients with prior cardiac surgery
    • Bhatt, D. L. et al. Superiority of clopidogrel versus aspirin in patients with prior cardiac surgery. Circulation 103, 363-368 (2001).
    • (2001) Circulation , vol.103 , pp. 363-368
    • Bhatt, D.L.1
  • 81
    • 0037106972 scopus 로고    scopus 로고
    • Amplified benefit of clopidogrel versus aspirin in patients with diabetes mellitus
    • Bhatt, D. et al. Amplified benefit of clopidogrel versus aspirin in patients with diabetes mellitus. Am. J. Cardiol. 90, 625-628 (2002).
    • (2002) Am. J. Cardiol. , vol.90 , pp. 625-628
    • Bhatt, D.1
  • 82
    • 0242356827 scopus 로고    scopus 로고
    • The benefit of clopidogrel over aspirin is amplified in high-risk subgroups of patients with a prior history of ischemic events
    • (in the press)
    • Ringleb, P. A. et al. The benefit of clopidogrel over aspirin is amplified in high-risk subgroups of patients with a prior history of ischemic events. Stroke (in the press).
    • Stroke
    • Ringleb, P.A.1
  • 83
    • 0031727053 scopus 로고    scopus 로고
    • The antiaggregating and antithrombotic activity of clopidogrel is potentiated by aspirin in several experimental models in the rabbit
    • Herbert, J. M. et al. The antiaggregating and antithrombotic activity of clopidogrel is potentiated by aspirin in several experimental models in the rabbit. Thromb. Haemost. 80, 512-518 (1998).
    • (1998) Thromb. Haemost. , vol.80 , pp. 512-518
    • Herbert, J.M.1
  • 84
    • 0032189692 scopus 로고    scopus 로고
    • Effects of clopidogrel, aspirin and combined therapy in a porcine ex vivo model of high-shear induced stent thrombosis
    • Makkar, R. R. et al. Effects of clopidogrel, aspirin and combined therapy in a porcine ex vivo model of high-shear induced stent thrombosis. Eur. Heart. J. 19, 1538-1546 (1998).
    • (1998) Eur. Heart. J. , vol.19 , pp. 1538-1546
    • Makkar, R.R.1
  • 85
    • 0033866804 scopus 로고    scopus 로고
    • Antiplatelet effects of clopidogrel compared with aspirin after myocardial infarction: Enhanced inhibitory effects of combination therapy
    • Moshfegh, K. et al. Antiplatelet effects of clopidogrel compared with aspirin after myocardial infarction: enhanced inhibitory effects of combination therapy. J. Am. Coll. Cardiol. 36, 699-705 (2000).
    • (2000) J. Am. Coll. Cardiol. , vol.36 , pp. 699-705
    • Moshfegh, K.1
  • 86
    • 0032562266 scopus 로고    scopus 로고
    • Comparison of antiplatelet effects of aspirin, ticlopidine, or their combination after stent implantation
    • Rupprecht, H. J. et al. Comparison of antiplatelet effects of aspirin, ticlopidine, or their combination after stent implantation. Circulation 97, 1046-1052 (1998).
    • (1998) Circulation , vol.97 , pp. 1046-1052
    • Rupprecht, H.J.1
  • 87
    • 7844220998 scopus 로고    scopus 로고
    • Randomized multicenter comparison of conventional anticoagulation versus antiplatelet therapy in unplanned and elective coronary stenting. The full anticoagulation versus aspirin and ticlopidine (FANTASTIC) study
    • Bertrand, M. E. et al. Randomized multicenter comparison of conventional anticoagulation versus antiplatelet therapy in unplanned and elective coronary stenting. The full anticoagulation versus aspirin and ticlopidine (FANTASTIC) study. Circulation 98, 1597-1603 (1998).
    • (1998) Circulation , vol.98 , pp. 1597-1603
    • Bertrand, M.E.1
  • 88
    • 0032481092 scopus 로고    scopus 로고
    • A clinical trial comparing three antithrombotic-drug regimens after coronary-artery stenting
    • Stent Anticoagulation Restenosis Study Investigators
    • Leon, M. B. et al. A clinical trial comparing three antithrombotic-drug regimens after coronary-artery stenting. Stent Anticoagulation Restenosis Study Investigators. N. Engl. J. Med. 339, 1665-1671 (1998).
    • (1998) N. Engl. J. Med. , vol.339 , pp. 1665-1671
    • Leon, M.B.1
  • 89
    • 0037005777 scopus 로고    scopus 로고
    • Meta-analysis of randomized and registry comparisons of ticlopidine with clopidogrel after stenting
    • Bhatt, D. L. et al. Meta-analysis of randomized and registry comparisons of ticlopidine with clopidogrel after stenting. J. Am. Coll. Cardiol. 39, 9-14 (2002).
    • (2002) J. Am. Coll. Cardiol. , vol.39 , pp. 9-14
    • Bhatt, D.L.1
  • 90
    • 0034622539 scopus 로고    scopus 로고
    • Double-blind study of the safety of clopidogrel with and without a loading dose in combination with aspirin compared with ticlopidine in combination with aspirin after coronary stenting: The clopidogrel aspirin stent international cooperative study (CLASSICS)
    • Investigators F
    • Bertrand, M. E., Rupprecht, H. J., Urban, P., Gershlick, A. H. & Investigators, f. Double-blind study of the safety of clopidogrel with and without a loading dose in combination with aspirin compared with ticlopidine in combination with aspirin after coronary stenting: the clopidogrel aspirin stent international cooperative study (CLASSICS). Circulation 102, 624-629 (2000).
    • (2000) Circulation , vol.102 , pp. 624-629
    • Bertrand, M.E.1    Rupprecht, H.J.2    Urban, P.3    Gershlick, A.H.4
  • 91
    • 0031028221 scopus 로고    scopus 로고
    • Elective stenting of the extracranial carotid arteries
    • Yadav, J. S. et al. Elective stenting of the extracranial carotid arteries. Circulation 95, 376-381 (1997).
    • (1997) Circulation , vol.95 , pp. 376-381
    • Yadav, J.S.1
  • 92
    • 0035654565 scopus 로고    scopus 로고
    • Dual antiplatelet therapy with clopidogrel and aspirin after carotid artery stenting
    • Bhatt, D. L. et al. Dual antiplatelet therapy with clopidogrel and aspirin after carotid artery stenting. J. Invasive. Cardiol. 13, 767-771 (2001).
    • (2001) J. Invasive. Cardiol. , vol.13 , pp. 767-771
    • Bhatt, D.L.1
  • 93
    • 0035908781 scopus 로고    scopus 로고
    • Effects of pretreatment with clopidogrel and aspirin followed by long- term therapy in patients undergoing percutaneous coronary intervention: The PCI-CURE study
    • Mehta, S. R. et al. Effects of pretreatment with clopidogrel and aspirin followed by long- term therapy in patients undergoing percutaneous coronary intervention: the PCI-CURE study. Lancet 358, 527-533 (2001).
    • (2001) Lancet , vol.358 , pp. 527-533
    • Mehta, S.R.1
  • 94
    • 0037145863 scopus 로고    scopus 로고
    • Early and sustained dual oral antiplatelet therapy following percutaneous coronary intervention: A randomized controlled trial
    • Steinhubl, S. R. et al. Early and sustained dual oral antiplatelet therapy following percutaneous coronary intervention: a randomized controlled trial. JAMA 288, 2411-2420 (2002).
    • (2002) JAMA , vol.288 , pp. 2411-2420
    • Steinhubl, S.R.1
  • 95
    • 0017252864 scopus 로고
    • Platelets, acute inflammation and inflammatory mediators
    • Ferreira, S. H., Ubatuba, F. B. & Vane, J. R. Platelets, acute inflammation and inflammatory mediators. Agents Actions 6, 313-317 (1976).
    • (1976) Agents Actions , vol.6 , pp. 313-317
    • Ferreira, S.H.1    Ubatuba, F.B.2    Vane, J.R.3
  • 96
    • 0035799341 scopus 로고    scopus 로고
    • Inflammation and thrombosis: The clot thickens
    • Libby, P. & Simon, D. I. Inflammation and thrombosis: the clot thickens. Circulation 103, 1718-1720 (2001).
    • (2001) Circulation , vol.103 , pp. 1718-1720
    • Libby, P.1    Simon, D.I.2
  • 97
    • 0035817627 scopus 로고    scopus 로고
    • Activated platelets mediate inflammatory signaling by regulated interleukin 1β synthesis
    • Lindemann, S. et al. Activated platelets mediate inflammatory signaling by regulated interleukin 1β synthesis. J. Cell. Biol. 154, 485-490 (2001).
    • (2001) J. Cell. Biol. , vol.154 , pp. 485-490
    • Lindemann, S.1
  • 98
    • 0030956673 scopus 로고    scopus 로고
    • Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men
    • Ridker, P. M., Cushman, M., Stampfer, M. J., Tracy, R. P. & Hennekens, C. H. Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men. N. Engl. J. Med. 336, 973-979 (1997).
    • (1997) N. Engl. J. Med. , vol.336 , pp. 973-979
    • Ridker, P.M.1    Cushman, M.2    Stampfer, M.J.3    Tracy, R.P.4    Hennekens, C.H.5
  • 99
    • 0035885045 scopus 로고    scopus 로고
    • Effect of clopidogrel added to aspirin before percutaneous coronary intervention on the risk associated with C-reactive protein
    • Chew, D. P. et al. Effect of clopidogrel added to aspirin before percutaneous coronary intervention on the risk associated with C-reactive protein. Am. J. Cardiol. 88, 672-674 (2001).
    • (2001) Am. J. Cardiol. , vol.88 , pp. 672-674
    • Chew, D.P.1
  • 100
    • 0036645047 scopus 로고    scopus 로고
    • Need to test the arterial inflammation hypothesis
    • Bhatt, D. L. & Topol, E. J. Need to test the arterial inflammation hypothesis. Circulation 106, 136-140 (2002).
    • (2002) Circulation , vol.106 , pp. 136-140
    • Bhatt, D.L.1    Topol, E.J.2
  • 101
    • 0030985937 scopus 로고    scopus 로고
    • Induction of cytokine expression in leukocytes by binding of thrombin- stimulated platelets
    • Neumann, F. J. et al. Induction of cytokine expression in leukocytes by binding of thrombin- stimulated platelets. Circulation 95, 2387-2394 (1997).
    • (1997) Circulation , vol.95 , pp. 2387-2394
    • Neumann, F.J.1
  • 102
    • 0006870550 scopus 로고    scopus 로고
    • Platelet activation in patients after an acute coronary syndrome: Results from the TIMI-12 trial
    • Thrombolysis in Myocardial Infarction
    • Ault, K. A. et al. Platelet activation in patients after an acute coronary syndrome: results from the TIMI-12 trial. Thrombolysis in Myocardial Infarction. J. Am. Coll. Cardiol. 33, 634-639 (1999).
    • (1999) J. Am. Coll. Cardiol. , vol.33 , pp. 634-639
    • Ault, K.A.1
  • 103
    • 0031955060 scopus 로고    scopus 로고
    • Increased platelet reactivity and circulating monocyte-platelet aggregates in patients with stable coronary artery disease
    • Furman, M. I. et al. Increased platelet reactivity and circulating monocyte-platelet aggregates in patients with stable coronary artery disease. J. Am. Coll. Cardiol. 31, 352-358 (1998).
    • (1998) J. Am. Coll. Cardiol. , vol.31 , pp. 352-358
    • Furman, M.I.1
  • 104
    • 0030783397 scopus 로고    scopus 로고
    • Reduction of monocyte-platelet interaction and monocyte activation in patients receiving antiplatelet therapy after coronary stent implantation
    • May, A. E. et al. Reduction of monocyte-platelet interaction and monocyte activation in patients receiving antiplatelet therapy after coronary stent implantation. Eur. Heart. J. 18, 1913-1920 (1997).
    • (1997) Eur. Heart. J. , vol.18 , pp. 1913-1920
    • May, A.E.1
  • 105
    • 0029090129 scopus 로고
    • Adjunctive selectin blockade successfully reduces infarct size beyond thrombolysis in the electrolytic canine coronary artery model
    • Silver, M. J. et al. Adjunctive selectin blockade successfully reduces infarct size beyond thrombolysis in the electrolytic canine coronary artery model. Circulation 92, 492-499 (1995).
    • (1995) Circulation , vol.92 , pp. 492-499
    • Silver, M.J.1
  • 106
    • 0036306595 scopus 로고    scopus 로고
    • Recombinant soluble P-selectin glycoprotein ligand-Ig (rPSGL-Ig) attenuates infarct size and myeloperoxidase activity in a canine model of ischemia-reperfusion
    • Wang, K. et al. Recombinant soluble P-selectin glycoprotein ligand-Ig (rPSGL-Ig) attenuates infarct size and myeloperoxidase activity in a canine model of ischemia-reperfusion. Thromb. Haemost. 88, 149-154 (2002).
    • (2002) Thromb. Haemost. , vol.88 , pp. 149-154
    • Wang, K.1
  • 107
    • 0034887991 scopus 로고    scopus 로고
    • Prevention of intimal hyperplasia with recombinant soluble P-selectin glycoprotein ligand-immunoglobulin in the porcine coronary artery balloon injury model
    • Wang, K. et al. Prevention of intimal hyperplasia with recombinant soluble P-selectin glycoprotein ligand-immunoglobulin in the porcine coronary artery balloon injury model. J. Am. Coll. Cardiol. 38, 577-582 (2001).
    • (2001) J. Am. Coll. Cardiol. , vol.38 , pp. 577-582
    • Wang, K.1
  • 108
    • 0032539794 scopus 로고    scopus 로고
    • Increased levels of soluble P-selectin in hypercholesterolemic patients
    • Davi, G. et al. Increased levels of soluble P-selectin in hypercholesterolemic patients. Circulation 97, 953-957 (1998).
    • (1998) Circulation , vol.97 , pp. 953-957
    • Davi, G.1
  • 109
    • 0000210136 scopus 로고    scopus 로고
    • Complementary, additive benefit of clopidogrel and lipid-lowering therapy in patients with atherosclerosis
    • Bhatt, D. L. et al. Complementary, additive benefit of clopidogrel and lipid-lowering therapy in patients with atherosclerosis. J. Amer. Coll. Cardiol. 35 (Suppl. A), 326 (2000).
    • (2000) J. Amer. Coll. Cardiol. , vol.35 , Issue.SUPPL. A , pp. 326
    • Bhatt, D.L.1
  • 110
    • 0032484987 scopus 로고    scopus 로고
    • CD40 ligand on activated platelets triggers an inflammatory reaction of endothelial cells
    • Henn, V. et al. CD40 ligand on activated platelets triggers an inflammatory reaction of endothelial cells. Nature 391, 591-594 (1998).
    • (1998) Nature , vol.391 , pp. 591-594
    • Henn, V.1
  • 111
    • 0034691087 scopus 로고    scopus 로고
    • Atherosclerosis: The emerging role of inflammation and the CD40-CD40 ligand system
    • Phipps, R. P. Atherosclerosis: the emerging role of inflammation and the CD40-CD40 ligand system. Proc. Natl Acad. Sci. USA 97, 6930-6932 (2000).
    • (2000) Proc. Natl Acad. Sci. USA , vol.97 , pp. 6930-6932
    • Phipps, R.P.1
  • 112
    • 0033871084 scopus 로고    scopus 로고
    • CD40 ligation induces tissue factor expression in human vascular smooth muscle cells
    • Schonbeck, U. et al. CD40 ligation induces tissue factor expression in human vascular smooth muscle cells. Am. J. Pathol. 156, 7-14 (2000).
    • (2000) Am. J. Pathol. , vol.156 , pp. 7-14
    • Schonbeck, U.1
  • 113
    • 0031764991 scopus 로고    scopus 로고
    • Activated platelets induce tissue factor expression on human umbilical vein endothelial cells by ligation of CD40
    • Slupsky, J. R. et al. Activated platelets induce tissue factor expression on human umbilical vein endothelial cells by ligation of CD40. Thromb. Haemost. 80, 1008-1014 (1998).
    • (1998) Thromb. Haemost. , vol.80 , pp. 1008-1014
    • Slupsky, J.R.1
  • 114
    • 0344850187 scopus 로고    scopus 로고
    • Enhanced levels of soluble and membrane-bound CD40 ligand in patients with unstable angina: Possible reflection of T lymphocyte and platelet involvement in the pathogenesis of acute coronary syndromes
    • Aukrust, P. et al. Enhanced levels of soluble and membrane-bound CD40 ligand in patients with unstable angina: possible reflection of T lymphocyte and platelet involvement in the pathogenesis of acute coronary syndromes. Circulation 100, 614-620 (1999).
    • (1999) Circulation , vol.100 , pp. 614-620
    • Aukrust, P.1
  • 116
    • 0037143597 scopus 로고    scopus 로고
    • Platelet-derived CD40L: The switch-hitting player of cardiovascular disease
    • Andre, P., Nannizzi-Alaimo, L., Prasad, S. K. & Phillips, D. R. Platelet-derived CD40L: the switch-hitting player of cardiovascular disease. Circulation 106, 896-899 (2002).
    • (2002) Circulation , vol.106 , pp. 896-899
    • Andre, P.1    Nannizzi-Alaimo, L.2    Prasad, S.K.3    Phillips, D.R.4
  • 117
    • 0035824895 scopus 로고    scopus 로고
    • CD40 signaling and plaque instability
    • Schonbeck, U. & Libby, P. CD40 signaling and plaque instability. Circ. Res. 89, 1092-1103 (2001).
    • (2001) Circ. Res. , vol.89 , pp. 1092-1103
    • Schonbeck, U.1    Libby, P.2
  • 118
    • 0035544019 scopus 로고    scopus 로고
    • Ligation of CD40 on vascular smooth muscle cells mediates loss of interstitial collagen via matrix metalloproteinase activity
    • Horton, D. B., Libby, P. & Schonbeck, U. Ligation of CD40 on vascular smooth muscle cells mediates loss of interstitial collagen via matrix metalloproteinase activity. Ann. NY Acad. Sci. 947, 329-336 (2001).
    • (2001) Ann. NY Acad. Sci. , vol.947 , pp. 329-336
    • Horton, D.B.1    Libby, P.2    Schonbeck, U.3
  • 119
    • 0037143657 scopus 로고    scopus 로고
    • CD40 ligand inhibits endothelial cell migration by increasing production of endothelial reactive oxygen species
    • Urbich, C., Dernbach, E., Aicher, A., Zeiher, A. M. & Dimmeler, S. CD40 ligand inhibits endothelial cell migration by increasing production of endothelial reactive oxygen species. Circulation 106, 981-986 (2002).
    • (2002) Circulation , vol.106 , pp. 981-986
    • Urbich, C.1    Dernbach, E.2    Aicher, A.3    Zeiher, A.M.4    Dimmeler, S.5
  • 120
    • 0034691108 scopus 로고    scopus 로고
    • Inhibition of CD40 signaling limits evolution of established atherosclerosis in mice
    • Schonbeck, U., Sukhova, G. K., Shimizu, K., Mach, F. & Libby, P. Inhibition of CD40 signaling limits evolution of established atherosclerosis in mice. Proc. Natl Acad. Sci. USA 97, 7458-7463 (2000).
    • (2000) Proc. Natl Acad. Sci. USA , vol.97 , pp. 7458-7463
    • Schonbeck, U.1    Sukhova, G.K.2    Shimizu, K.3    Mach, F.4    Libby, P.5
  • 121
    • 0035853027 scopus 로고    scopus 로고
    • Ticlopidine pretreatment before coronary stenting is associated with sustained decrease in adverse cardiac events: Data from the evaluation of platelet IIb/IIIa inhibitor for stenting (EPISTENT) trial
    • Steinhubl, S. R., Ellis, S. G., Wolski, K., Lincoff, A. M. & Topol, E. J. Ticlopidine pretreatment before coronary stenting is associated with sustained decrease in adverse cardiac events: data from the evaluation of platelet IIb/IIIa inhibitor for stenting (EPISTENT) trial. Circulation 103, 1403-1409 (2001).
    • (2001) Circulation , vol.103 , pp. 1403-1409
    • Steinhubl, S.R.1    Ellis, S.G.2    Wolski, K.3    Lincoff, A.M.4    Topol, E.J.5
  • 122
    • 0037087142 scopus 로고    scopus 로고
    • Clopidogrel inhibits platelet adhesion and platelet-dependent mitogenesis in vascular smooth muscle cells
    • Hermann, A., Weber, A. A. & Schror, K. Clopidogrel inhibits platelet adhesion and platelet-dependent mitogenesis in vascular smooth muscle cells. Thromb. Res. 105, 173-175 (2002).
    • (2002) Thromb. Res. , vol.105 , pp. 173-175
    • Hermann, A.1    Weber, A.A.2    Schror, K.3
  • 123
    • 0035075438 scopus 로고    scopus 로고
    • Platelet CD40 ligand (CD40L)-subcellular localization, regulation of expression, and inhibition by clopidogrel
    • Hermann, A., Rauch, B. H., Braun, M., Schror, K. & Weber, A. A. Platelet CD40 ligand (CD40L)-subcellular localization, regulation of expression, and inhibition by clopidogrel. Platelets 12, 74-82 (2001).
    • (2001) Platelets , vol.12 , pp. 74-82
    • Hermann, A.1    Rauch, B.H.2    Braun, M.3    Schror, K.4    Weber, A.A.5
  • 124
    • 0035799376 scopus 로고    scopus 로고
    • RANTES deposition by platelets triggers monocyte arrest on inflamed and atherosclerotic endothelium
    • von Hundelshausen, P. et al. RANTES deposition by platelets triggers monocyte arrest on inflamed and atherosclerotic endothelium. Circulation 103, 1772-1777 (2001).
    • (2001) Circulation , vol.103 , pp. 1772-1777
    • von Hundelshausen, P.1
  • 125
    • 0037126048 scopus 로고    scopus 로고
    • Deposition of platelet RANTES triggering monocyte recruitment requires P-selectin and is involved in neointima formation after arterial injury
    • Schober, A. et al. Deposition of platelet RANTES triggering monocyte recruitment requires P-selectin and is involved in neointima formation after arterial injury. Circulation 106, 1523-1529 (2002).
    • (2002) Circulation , vol.106 , pp. 1523-1529
    • Schober, A.1
  • 126
    • 0033580603 scopus 로고    scopus 로고
    • Platelet microparticles promote platelet interaction with subendothelial matrix in a glycoprotein IIb/IIIa-dependent mechanism
    • Merten, M., Pakala, R., Thiagarajan, P. & Benedict, C. R. Platelet microparticles promote platelet interaction with subendothelial matrix in a glycoprotein IIb/IIIa-dependent mechanism. Circulation 99, 2577-2582 (1999).
    • (1999) Circulation , vol.99 , pp. 2577-2582
    • Merten, M.1    Pakala, R.2    Thiagarajan, P.3    Benedict, C.R.4
  • 127
    • 0034651686 scopus 로고    scopus 로고
    • Leukocyte-leukocyte interactions mediated by platelet microparticles under flow
    • Forlow, S. B., McEver, R. P. & Nollert, M. U. Leukocyte-leukocyte interactions mediated by platelet microparticles under flow. Blood 95, 1317-1323 (2000).
    • (2000) Blood , vol.95 , pp. 1317-1323
    • Forlow, S.B.1    McEver, R.P.2    Nollert, M.U.3
  • 128
    • 0342369575 scopus 로고    scopus 로고
    • Effect of ticlopidine on platelet-derived microparticles in patients with connective tissue diseases
    • Kagawa, H., Nomura, S., Nagahama, M., Ozaki, Y. & Fukuhara, S. Effect of ticlopidine on platelet-derived microparticles in patients with connective tissue diseases. Haemostasis 29, 255-261 (1999).
    • (1999) Haemostasis , vol.29 , pp. 255-261
    • Kagawa, H.1    Nomura, S.2    Nagahama, M.3    Ozaki, Y.4    Fukuhara, S.5
  • 129
    • 0036714323 scopus 로고    scopus 로고
    • Inhibition of ADP-induced P-selectin expression and platelet-leukocyte conjugate formation by clopidogrel and the P2Y12 receptor antagonist AR- C69931MX but not aspirin
    • Storey, R. F., Judge, H. M., Wilcox, R. G. & Heptinstall, S. Inhibition of ADP-induced P-selectin expression and platelet-leukocyte conjugate formation by clopidogrel and the P2Y12 receptor antagonist AR- C69931MX but not aspirin. Thromb. Haemost. 88, 488-494 (2002).
    • (2002) Thromb. Haemost. , vol.88 , pp. 488-494
    • Storey, R.F.1    Judge, H.M.2    Wilcox, R.G.3    Heptinstall, S.4
  • 130
    • 0034954596 scopus 로고    scopus 로고
    • The P2Y12 receptor as a therapeutic target in cardiovascular disease
    • Storey, F. The P2Y12 receptor as a therapeutic target in cardiovascular disease. Platelets 12, 197-209 (2001).
    • (2001) Platelets , vol.12 , pp. 197-209
    • Storey, F.1
  • 131
    • 0035164358 scopus 로고    scopus 로고
    • The ATP-gated P2X1 ion channel acts as a positive regulator of platelet responses to collagen
    • Oury, C. et al. The ATP-gated P2X1 ion channel acts as a positive regulator of platelet responses to collagen. Thromb. Haemost. 86, 1264-1271 (2001).
    • (2001) Thromb. Haemost. , vol.86 , pp. 1264-1271
    • Oury, C.1
  • 132
    • 0030756508 scopus 로고    scopus 로고
    • Defective platelet activation in G α(q)-deficient mice
    • Offermanns, S., Toombs, C. F., Hu, Y. H. & Simon, M.I. Defective platelet activation in G α(q)-deficient mice. Nature 389, 183-186 (1997).
    • (1997) Nature , vol.389 , pp. 183-186
    • Offermanns, S.1    Toombs, C.F.2    Hu, Y.H.3    Simon, M.I.4
  • 133
    • 0034665782 scopus 로고    scopus 로고
    • ADP induces partial platelet aggregation without shape change and potentiates collagen-induced aggregation in the absence of Gαq
    • Ohlmann, P. et al. ADP induces partial platelet aggregation without shape change and potentiates collagen-induced aggregation in the absence of Gαq. Blood 96, 2134-2139 (2000).
    • (2000) Blood , vol.96 , pp. 2134-2139
    • Ohlmann, P.1
  • 134
    • 0035164364 scopus 로고    scopus 로고
    • The P2Y1 receptor antagonist adenosine-2′,5′-diphosphate non- selectively antagonizes the platelet P2X1 ion channel
    • Toth-Zsamboki, E., Oury, C., Tytgat, J., Vermylen, J. & Hoylaerts, M. F. The P2Y1 receptor antagonist adenosine-2′,5′-diphosphate non- selectively antagonizes the platelet P2X1 ion channel. Thromb. Haemost. 86, 1338-1339 (2001).
    • (2001) Thromb. Haemost. , vol.86 , pp. 1338-1339
    • Toth-Zsamboki, E.1    Oury, C.2    Tytgat, J.3    Vermylen, J.4    Hoylaerts, M.F.5
  • 135
    • 0035843178 scopus 로고    scopus 로고
    • Identification of the platelet ADP receptor targeted by antithrombotic drugs
    • Hollopeter, G. et al. Identification of the platelet ADP receptor targeted by antithrombotic drugs. Nature 409, 202-207 (2001).
    • (2001) Nature , vol.409 , pp. 202-207
    • Hollopeter, G.1
  • 136
    • 0032826036 scopus 로고    scopus 로고
    • Decreased platelet aggregation, increased bleeding time and resistance to thromboembolism in P2Y1-deficient mice
    • Fabre, J. E. et al. Decreased platelet aggregation, increased bleeding time and resistance to thromboembolism in P2Y1-deficient mice. Nature Med. 5, 1199-202 (1999).
    • (1999) Nature Med. , vol.5 , pp. 1199-1202
    • Fabre, J.E.1
  • 137
    • 0342723744 scopus 로고    scopus 로고
    • Defective platelet aggregation and increased resistance to thrombosis in purinergic P2Y(1) receptor-null mice
    • Leon, C. et al. Defective platelet aggregation and increased resistance to thrombosis in purinergic P2Y(1) receptor-null mice. J. Clin. Invest. 104, 1731-1737 (1999).
    • (1999) J. Clin. Invest. , vol.104 , pp. 1731-1737
    • Leon, C.1
  • 138
    • 0036121597 scopus 로고    scopus 로고
    • Role of ADP receptor P2Y(12) in platelet adhesion and thrombus formation in flowing blood
    • Remijn, J. A. et al. Role of ADP receptor P2Y(12) in platelet adhesion and thrombus formation in flowing blood. Arterioscler. Thromb. Vasc. Biol. 22, 686-691 (2002).
    • (2002) Arterioscler. Thromb. Vasc. Biol. , vol.22 , pp. 686-691
    • Remijn, J.A.1
  • 139
    • 0037188563 scopus 로고    scopus 로고
    • Functional significance of adenosine 5′-diphosphate receptor (P2Y(12)) in platelet activation initiated by binding of von Willebrand factor to platelet GP Ibα induced by conditions of high shear rate
    • Goto, S., Tamura, N., Eto, K., Ikeda, Y. & Handa, S. Functional significance of adenosine 5′-diphosphate receptor (P2Y(12)) in platelet activation initiated by binding of von Willebrand factor to platelet GP Ibα induced by conditions of high shear rate. Circulation 105, 2531-2536 (2002).
    • (2002) Circulation , vol.105 , pp. 2531-2536
    • Goto, S.1    Tamura, N.2    Eto, K.3    Ikeda, Y.4    Handa, S.5
  • 140
    • 0035760304 scopus 로고    scopus 로고
    • Blockade of adenosine diphosphate receptors P2Y(12) and P2Y(1) is required to inhibit platelet aggregation in whole blood under flow
    • Turner, N. A., Moake, J. L. & McIntire, L. V. Blockade of adenosine diphosphate receptors P2Y(12) and P2Y(1) is required to inhibit platelet aggregation in whole blood under flow. Blood 98, 3340-3345 (2001).
    • (2001) Blood , vol.98 , pp. 3340-3345
    • Turner, N.A.1    Moake, J.L.2    McIntire, L.V.3
  • 141
    • 0035464192 scopus 로고    scopus 로고
    • Resistance to thromboembolism in PI3Kγ-deficient mice
    • Hirsch, E. et al. Resistance to thromboembolism in PI3Kγ-deficient mice. FASEB J 15, 2019-2021 (2001).
    • (2001) FASEB J. , vol.15 , pp. 2019-2021
    • Hirsch, E.1
  • 142
    • 0035843161 scopus 로고    scopus 로고
    • Cardiovascular biology. Small cells, big issues
    • Brass, S. Cardiovascular biology. Small cells, big issues. Nature 409, 145-147 (2001).
    • (2001) Nature , vol.409 , pp. 145-147
    • Brass, S.1
  • 143
    • 0345540629 scopus 로고    scopus 로고
    • Targeted disruption of cd39/ATP diphosphohydrolase results in disordered hemostasis and thromboregulation
    • Enjyoji, K. et al. Targeted disruption of cd39/ATP diphosphohydrolase results in disordered hemostasis and thromboregulation. Nature Med. 5, 1010-1017 (1999).
    • (1999) Nature Med. , vol.5 , pp. 1010-1017
    • Enjyoji, K.1
  • 144
    • 0036072088 scopus 로고    scopus 로고
    • Reversal of thrombin-induced deactivation of CD39/ATPDase in endothelial cells by HMG-CoA reductase inhibition: Effects on Rho- GTPase and adenosine nucleotide metabolism
    • Kaneider, N. C. et al. Reversal of thrombin-induced deactivation of CD39/ATPDase in endothelial cells by HMG-CoA reductase inhibition: effects on Rho- GTPase and adenosine nucleotide metabolism. Arterioscler. Thromb. Vasc. Biol. 22, 894-900 (2002).
    • (2002) Arterioscler. Thromb. Vasc. Biol. , vol.22 , pp. 894-900
    • Kaneider, N.C.1
  • 145
    • 0036121594 scopus 로고    scopus 로고
    • Elucidation of the thromboregulatory role of CD39/ectoapyrase in the ischemic brain
    • Pinsky, D. J. et al. Elucidation of the thromboregulatory role of CD39/ectoapyrase in the ischemic brain. J. Clin. Invest. 109, 1031-1040 (2002).
    • (2002) J. Clin. Invest. , vol.109 , pp. 1031-1040
    • Pinsky, D.J.1
  • 146
    • 0033712603 scopus 로고    scopus 로고
    • Antiplatelet agents in stroke prevention combination therapy: Present and future
    • Weksler, B. B. Antiplatelet agents in stroke prevention. combination therapy: present and future. Cerebrovasc. Dis. 10, 41-48 (2000).
    • (2000) Cerebrovasc. Dis. , vol.10 , pp. 41-48
    • Weksler, B.B.1
  • 147
    • 0036287538 scopus 로고    scopus 로고
    • Thrombin receptor antagonists; recent advances in PAR-1 antagonist development
    • Anderluh, M. & Dolenc, M. S. Thrombin receptor antagonists; recent advances in PAR-1 antagonist development. Curr. Med. Chem. 9, 1229-1250 (2002).
    • (2002) Curr. Med. Chem. , vol.9 , pp. 1229-1250
    • Anderluh, M.1    Dolenc, M.S.2
  • 148
    • 0035817872 scopus 로고    scopus 로고
    • Cardiovascular biology. Platelets and proteases
    • Brass, S. Cardiovascular biology. Platelets and proteases. Nature 413, 26-27 (2001).
    • (2001) Nature , vol.413 , pp. 26-27
    • Brass, S.1
  • 149
    • 0037092952 scopus 로고    scopus 로고
    • Protease-activated receptors 1 and 4 do not stimulate G(i) signaling pathways in the absence of secreted ADP and cause human platelet aggregation independently of G(i) signaling
    • Kim, S. et al. Protease-activated receptors 1 and 4 do not stimulate G(i) signaling pathways in the absence of secreted ADP and cause human platelet aggregation independently of G(i) signaling. Blood 99, 3629-3636 (2002).
    • (2002) Blood , vol.99 , pp. 3629-3636
    • Kim, S.1
  • 150
    • 0035817822 scopus 로고    scopus 로고
    • Role of thrombin signaling in platelets in haemostasis and thrombosis
    • Sambrano, G. R., Weiss, E. J., Zheng, Y. W., Huang, W. & Coughlin, S. R. Role of thrombin signaling in platelets in haemostasis and thrombosis. Nature 413, 74-78 (2001).
    • (2001) Nature , vol.413 , pp. 74-78
    • Sambrano, G.R.1    Weiss, E.J.2    Zheng, Y.W.3    Huang, W.4    Coughlin, S.R.5
  • 151
    • 0033559805 scopus 로고    scopus 로고
    • Protease-activated receptors 1 and 4 mediate activation of human platelets by thrombin
    • Kahn, M. L., Nakanishi-Matsui, M., Shapiro, M. J., Ishihara, H. & Coughlin, S. R. Protease-activated receptors 1 and 4 mediate activation of human platelets by thrombin. J. Clin. Invest. 103, 879-887 (1999).
    • (1999) J. Clin. Invest. , vol.103 , pp. 879-887
    • Kahn, M.L.1    Nakanishi-Matsui, M.2    Shapiro, M.J.3    Ishihara, H.4    Coughlin, S.R.5
  • 152
    • 0036285450 scopus 로고    scopus 로고
    • Selective inhibition of protease-activated receptor 4-dependent platelet activation by YD-3
    • Wu, C. C. et al. Selective inhibition of protease-activated receptor 4-dependent platelet activation by YD-3. Thromb. Haemost. 87, 1026-1033 (2002).
    • (2002) Thromb. Haemost. , vol.87 , pp. 1026-1033
    • Wu, C.C.1
  • 153
    • 0036797715 scopus 로고    scopus 로고
    • Attacked from within, blood thins
    • Bahou, W. F. Attacked from within, blood thins. Nature Med. 8, 1082-1083 (2002)
    • (2002) Nature Med. , vol.8 , pp. 1082-1083
    • Bahou, W.F.1
  • 154
    • 0036797590 scopus 로고    scopus 로고
    • Pepducin-based intervention of thrombin-receptor signaling and systemic platelet activation
    • Covic, L., Misra, M., Badar, J., Singh, C. & Kuliopulos, A. Pepducin-based intervention of thrombin-receptor signaling and systemic platelet activation. Nature Med. 8, 1161-1165 (2002).
    • (2002) Nature Med. , vol.8 , pp. 1161-1165
    • Covic, L.1    Misra, M.2    Badar, J.3    Singh, C.4    Kuliopulos, A.5
  • 155
    • 0037154270 scopus 로고    scopus 로고
    • Activation and inhibition of G protein-coupled receptors by cell-penetrating membrane-tethered peptides
    • Covic, L., Gresser, A. L., Talavera, J., Swift, S. & Kuliopulos, A. Activation and inhibition of G protein-coupled receptors by cell-penetrating membrane-tethered peptides. Proc. Natl Acad. Sci. USA 99, 643-648 (2002).
    • (2002) Proc. Natl Acad. Sci. USA , vol.99 , pp. 643-648
    • Covic, L.1    Gresser, A.L.2    Talavera, J.3    Swift, S.4    Kuliopulos, A.5
  • 156
    • 0037012483 scopus 로고    scopus 로고
    • Effect of leptin on arterial thrombosis following vascular injury in mice
    • Bodary, P. F., Westrick, R. J., Wickenheiser, K. J., Shen, Y. & Eitzman, D. T. Effect of leptin on arterial thrombosis following vascular injury in mice. JAMA 287, 1706-1709 (2002).
    • (2002) JAMA , vol.287 , pp. 1706-1709
    • Bodary, P.F.1    Westrick, R.J.2    Wickenheiser, K.J.3    Shen, Y.4    Eitzman, D.T.5
  • 157
    • 0035179087 scopus 로고    scopus 로고
    • Leptin-dependent platelet aggregation and arterial thrombosis suggests a mechanism for atherothrombotic disease in obesity
    • Konstantinides, S., Schafer, K, Koschnick, S. & Loskutoff, D. J. Leptin-dependent platelet aggregation and arterial thrombosis suggests a mechanism for atherothrombotic disease in obesity. J. Clin. Invest. 108, 1533-1540 (2001).
    • (2001) J. Clin. Invest. , vol.108 , pp. 1533-1540
    • Konstantinides, S.1    Schafer, K.2    Koschnick, S.3    Loskutoff, D.J.4
  • 158
    • 0035684130 scopus 로고    scopus 로고
    • The prothrombotic effects of leptin possible implications for the risk of cardiovascular disease in obesity
    • discussion 141-142
    • Konstantinides, S., Schafer, K. & Loskutoff, D. J. The prothrombotic effects of leptin possible implications for the risk of cardiovascular disease in obesity. Ann. NY Acad. Sci. 947, 134-141: discussion 141-142 (2001).
    • (2001) Ann. NY Acad. Sci. , vol.947 , pp. 134-141
    • Konstantinides, S.1    Schafer, K.2    Loskutoff, D.J.3
  • 159
    • 0032971218 scopus 로고    scopus 로고
    • Leptin promotes aggregation of human platelets via the long form of its receptor
    • Nakata, M., Yada, T., Soejima, N. & Maruyama, I. Leptin promotes aggregation of human platelets via the long form of its receptor. Diabetes 48, 426-429 (1999).
    • (1999) Diabetes , vol.48 , pp. 426-429
    • Nakata, M.1    Yada, T.2    Soejima, N.3    Maruyama, I.4
  • 160
    • 0037097589 scopus 로고    scopus 로고
    • Arp2/3 complex is required for actin polymerization during platelet shape change
    • Li, Z., Kim, E. S. & Bearer, E. L. Arp2/3 complex is required for actin polymerization during platelet shape change. Blood 99, 4466-4474 (2002)
    • (2002) Blood , vol.99 , pp. 4466-4474
    • Li, Z.1    Kim, E.S.2    Bearer, E.L.3
  • 161
    • 0034877518 scopus 로고    scopus 로고
    • Production and characterization of saratin, an inhibitor of von Willebrand factor dependent platelet adhesion to collagen
    • Barnes, C. S. et al. Production and characterization of saratin, an inhibitor of von Willebrand factor dependent platelet adhesion to collagen. Semin. Thromb. Hemost. 27, 337-348 (2001).
    • (2001) Semin. Thromb. Hemost. , vol.27 , pp. 337-348
    • Barnes, C.S.1
  • 162
    • 0033793186 scopus 로고    scopus 로고
    • Anti-human von willebrand factor monoclonal antibody AJvW-2 prevents thrombus deposition and neointima formation after balloon injury in guinea pigs
    • Kageyama, S., Yamamoto, H. & Yoshimoto, R. Anti-human von willebrand factor monoclonal antibody AJvW-2 prevents thrombus deposition and neointima formation after balloon injury in guinea pigs. Arterioscler. Thromb. Vasc. Biol. 20, 2303-2308 (2000).
    • (2000) Arterioscler. Thromb. Vasc. Biol. , vol.20 , pp. 2303-2308
    • Kageyama, S.1    Yamamoto, H.2    Yoshimoto, R.3
  • 163
    • 0034101943 scopus 로고    scopus 로고
    • Antithrombotic effect of platelet glycoprotein Ib-blocking monoclonal antibody Fab fragments in nonhuman primates
    • Cauwenberghs, N. et al. Antithrombotic effect of platelet glycoprotein Ib-blocking monoclonal antibody Fab fragments in nonhuman primates. Arterioscler. Thromb. Vasc. Biol. 20, 1347-1353 (2000).
    • (2000) Arterioscler. Thromb. Vasc. Biol. , vol.20 , pp. 1347-1353
    • Cauwenberghs, N.1
  • 164
    • 0037037566 scopus 로고    scopus 로고
    • A critical role of platelet adhesion in the initiation of atherosclerotic lesion formation
    • Massberg, S. et al. A critical role of platelet adhesion in the initiation of atherosclerotic lesion formation. J. Exp. Med. 196, 887-896 (2002).
    • (2002) J. Exp. Med. , vol.196 , pp. 887-896
    • Massberg, S.1
  • 165
    • 0035126319 scopus 로고    scopus 로고
    • Deficiency or inhibition of Gas6 causes platelet dysfunction and protects mice against thrombosis
    • Angelillo-Scherrer, A. et al. Deficiency or inhibition of Gas6 causes platelet dysfunction and protects mice against thrombosis. Nature Med. 7, 215-221 (2001).
    • (2001) Nature Med. , vol.7 , pp. 215-221
    • Angelillo-Scherrer, A.1
  • 166
    • 0035960593 scopus 로고    scopus 로고
    • Single nucleotide polymorphisms in multiple novel thrombospondin genes may be associated with familial premature myocardial infarction
    • Topol, E. J. et al. Single nucleotide polymorphisms in multiple novel thrombospondin genes may be associated with familial premature myocardial infarction. Circulation 104, 2641-2644 (2001).
    • (2001) Circulation , vol.104 , pp. 2641-2644
    • Topol, E.J.1
  • 167
    • 0035937162 scopus 로고    scopus 로고
    • A model of platelet aggregation involving multiple interactions of thrombospondin-1, fibrinogen, and GPIIbIIIa receptor
    • Bonnefoy, A., Hantgan, R., Legrand, C. & Frojmovic, M. M. A model of platelet aggregation involving multiple interactions of thrombospondin-1, fibrinogen, and GPIIbIIIa receptor. J. Biol. Chem. 276, 5605-5612 (2001).
    • (2001) J. Biol. Chem. , vol.276 , pp. 5605-5612
    • Bonnefoy, A.1    Hantgan, R.2    Legrand, C.3    Frojmovic, M.M.4
  • 168
    • 0035852682 scopus 로고    scopus 로고
    • A thrombin receptor function for platelet glycoprotein Ib-IX unmasked by cleavage of glycoprotein V
    • Ramakrishnan, V. et al. A thrombin receptor function for platelet glycoprotein Ib-IX unmasked by cleavage of glycoprotein V. Proc. Natl Acad. Sci. USA 98, 1823-1828 (2001).
    • (2001) Proc. Natl Acad. Sci. USA , vol.98 , pp. 1823-1828
    • Ramakrishnan, V.1
  • 169
    • 0036141912 scopus 로고    scopus 로고
    • The influence of platelet collagen receptor polymorphisms in hemostasis and thrombotic disease
    • Kunicki, T. J. The influence of platelet collagen receptor polymorphisms in hemostasis and thrombotic disease. Arterioscler. Thromb. Vasc. Biol. 22, 14-20 (2002).
    • (2002) Arterioscler. Thromb. Vasc. Biol. , vol.22 , pp. 14-20
    • Kunicki, T.J.1
  • 170
    • 0030731403 scopus 로고    scopus 로고
    • Coronary artery disease and polymorphisms in a receptor mediating shear stress-dependent platelet activation
    • Murata, M. et al. Coronary artery disease and polymorphisms in a receptor mediating shear stress-dependent platelet activation. Circulation 96, 3281-3286 (1997).
    • (1997) Circulation , vol.96 , pp. 3281-3286
    • Murata, M.1
  • 171
    • 0035928604 scopus 로고    scopus 로고
    • Platelet glycoprotein Ibα HPA-2 Met/VNTR B haplotype as a genetic predictor of myocardial infarction and sudden cardiac death
    • Mikkelsson, J., Perola, M., Penttila, A. & Karhunen, P. J. Platelet glycoprotein Ibα HPA-2 Met/VNTR B haplotype as a genetic predictor of myocardial infarction and sudden cardiac death. Circulation 104, 876-880 (2001).
    • (2001) Circulation , vol.104 , pp. 876-880
    • Mikkelsson, J.1    Perola, M.2    Penttila, A.3    Karhunen, P.J.4
  • 172
    • 0037119003 scopus 로고    scopus 로고
    • Structures of glycoprotein Ibα and its complex with von Willebrand factor A1 domain
    • Huizinga, E. G. et al. Structures of glycoprotein Ibα and its complex with von Willebrand factor A1 domain. Science 297, 1176-1179 (2002).
    • (2002) Science , vol.297 , pp. 1176-1179
    • Huizinga, E.G.1
  • 173
    • 0037119606 scopus 로고    scopus 로고
    • Biomedicine. Contact - How platelets touch von Willebrand factor
    • Sadler, J. E. Biomedicine. Contact - how platelets touch von Willebrand factor. Science 297, 1128-1129 (2002).
    • (2002) Science , vol.297 , pp. 1128-1129
    • Sadler, J.E.1


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