Recent developments in MHC-class-I-mediated antigen presentation

Current Opinion in Immunology

Volumn 16, Issue 1, 2004, Pages 82-89

  Lehner, Paul J ^a   Cresswell, Peter ^b  

^a ADDENBROOKE S HOSPITAL   (United Kingdom)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; RIBOSOME PROTEIN; UBIQUITIN PROTEIN LIGASE; VIRUS PROTEIN;

ANTIGEN EXPRESSION; ANTIGEN PRESENTATION; ANTIGEN PRESENTING CELL; ANTIGEN RECOGNITION; CELL ORGANELLE; CYTOSOL; DENDRITIC CELL; ENDOPLASMIC RETICULUM; HUMAN; MAJOR HISTOCOMPATIBILITY COMPLEX; NONHUMAN; PHAGOCYTOSIS; PHAGOSOME; PROTEIN FAMILY; PROTEIN LOCALIZATION; PROTEIN TRANSPORT; REVIEW; T LYMPHOCYTE ACTIVATION;

EID: 1042290493     PISSN: 09527915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.coi.2003.11.012     Document Type: Review

References (58)

1. Schubert U., Anton L.C., Gibbs J., Norbury C.C., Yewdell J.W., Bennink J.R. Rapid degradation of a large fraction of newly synthesized proteins by proteasomes. Nature. 404:2000;770-774.
2. Reits E.A., Vos J.C., Gromme M., Neefjes J. The major substrates for TAP in vivo are derived from newly synthesized proteins. Nature. 404:2000;774-778.
3. Reits E.A., Griekspoor A., Neijssen J., Groothuis T., Jalink K., van Veelen P., Janssen H., Calafat J., Drijfhout J.W., Neefjes J. Peptide diffusion, protection and degradation in nuclear and cytoplasmic compartments before antigen presentation by MHC class I. Immunity. 18:2003;97-108.
4. Khan S., de Giuli R., Schmidtke G., Bruns M., Buchmeier M., van den Broek M., Groettrup M. Cutting edge: neosynthesis is required for the presentation of a T cell epitope from a long-lived viral protein. J. Immunol. 167:2001;4801-4804.
5. Blake N., Haigh T., Shaka'a G., Croom-Carter D., Rickinson A. The importance of exogenous antigen in priming the human CD8+ T cell response: lessons from the EBV nuclear antigen EBNA1. J. Immunol. 165:2000;7078-7087.
6. Levitskaya J., Coram M., Levitsky V., Imreh S., Steigerwald-Mullen P.M., Klein G., Kurilla M.G., Masucci M.G. Inhibition of antigen processing by the internal repeat region of the Epstein-Barr virus nuclear antigen-1. Nature. 375:1995;685-688.
7. Yin Y., Manoury B., Fahraeus R. Self-inhibition of synthesis and antigen presentation by Epstein-Barr virus-encoded EBNA1. Science. 301:2003;1371-1374.
8. Shastri N., Schwab S., Serwold T. Producing nature's gene-chips: the generation of peptides for display by MHC class I molecules. Annu. Rev. Immunol. 20:2002;463-493.
9. Schwab S.R., Li K.C., Kang C., Shastri N. Constitutive display of cryptic translation products by MHC class I molecules. Science. 301:2003;1367-1371 This paper provides in vivo evidence that the noncoding regions of mRNA and peptides encoded by non-methionine initiator codons are sources of antigenic peptides.
10. Princiotta M.F., Finzi D., Qian S.B., Gibbs J., Schuchmann S., Buttgereit F., Bennink J.R., Yewdell J.W. Quantitating protein synthesis, degradation, and endogenous antigen processing. Immunity. 18:2003;343-354 A comprehensive study on the dynamics of protein turnover and the efficiency of generating MHC class I assembled peptides.
11. Villanueva M.S., Fischer P., Feen K., Pamer E.G. Efficiency of MHC class I antigen processing: a quantitative analysis. Immunity. 1:1994;479-489.
12. York I.A., Mo A.X., Lemerise K., Zeng W., Shen Y., Abraham C.R., Saric T., Goldberg A.L., Rock K.L. The cytosolic endopeptidase, thimet oligopeptidase, destroys antigenic peptides and limits the extent of MHC class I antigen presentation. Immunity. 18:2003;429-440.
13. Kleijmeer M., Ramm G., Schuurhuis D., Griffith J., Rescigno M., Ricciardi-Castagnoli P., Rudensky A.Y., Ossendorp F., Melief C.J., Stoorvogel W.et al. Reorganization of multivesicular bodies regulates MHC class II antigen presentation by dendritic cells. J. Cell. Biol. 155:2001;53-63.
14. Chow A., Toomre D., Garrett W., Mellman I. Dendritic cell maturation triggers retrograde MHC class II transport from lysosomes to the plasma membrane. Nature. 418:2002;988-994.
15. Boes M., Cerny J., Massol R., Op den Brouw M., Kirchhausen T., Chen J., Ploegh H.L. T-cell engagement of dendritic cells rapidly rearranges MHC class II transport. Nature. 418:2002;983-988.
16. MacAry P.A., Lindsay M., Scott M.A., Craig J.I., Luzio J.P., Lehner P.J. Mobilization of MHC class I molecules from late endosomes to the cell surface following activation of CD34-derived human Langerhans cells. Proc. Natl. Acad. Sci. USA. 98:2001;3982-3987.
17. Ackerman A.L., Cresswell P. Regulation of MHC class I transport in human dendritic cells and the dendritic-like cell line KG-1. J. Immunol. 170:2003;4178-4188 This paper describes the intracellular trafficking of MHC class I molecules in human DCs.
18. Delamarre L., Holcombe H., Mellman I. Presentation of exogenous antigens on major histocompatibility complex (MHC) class I and MHC class II molecules is differentially regulated during dendritic cell maturation. J. Exp. Med. 198:2003;111-122 This paper describes the intracellular trafficking of MHC class I molecules in murine DCs.
19. Garin J., Diez R., Kieffer S., Dermine J.F., Duclos S., Gagnon E., Sadoul R., Rondeau C., Desjardins M. The phagosome proteome: insight into phagosome functions. J. Cell Biol. 152:2001;165-180.
20. Gagnon E., Duclos S., Rondeau C., Chevet E., Cameron P.H., Steele-Mortimer O., Paiement J., Bergeron J.J., Desjardins M. Endoplasmic reticulum-mediated phagocytosis is a mechanism of entry into macrophages. Cell. 110:2002;119-131 This paper demonstrates recruitment of ER membrane to plasma membrane for formation of phagosomes.
21. Dick T., Bangia N., Peaper D., Cresswell P. Disulfide bond isomerization and the assembly of MHC class I-peptide complexes. Immunity. 16:2002;87-98.
22. Tsai B., Ye Y., Rapoport T.A. Retro-translocation of proteins from the endoplasmic reticulum into the cytosol. Nat. Rev. Mol. Cell. Biol. 3:2002;246-255.
23. ••].
24. ••].
25. ••] shows that phagosomes function as cross-presenting organelles, containing the apparatus required for retrograde translocation to the cytosol and all components of the peptide loading complex.
26. Serwold T., Gonzalez F., Kim J., Jacob R., Shastri N. ERAAP customizes peptides for MHC class I molecules in the endoplasmic reticulum. Nature. 419:2002;480-483.
27. Saric T., Chang S.C., Hattori A., York I.A., Markant S., Rock K.L., Tsujimoto M., Goldberg A.L. An IFN-gamma-induced aminopeptidase in the ER, ERAP1, trims precursors to MHC class I-presented peptides. Nat. Immunol. 3:2002;1169-1176.
28. Hengel H., Koopmann J.-O., Flohr T., Muranyi W., Goulmy E., Hammerling G.J., Koszinowski U.H. A viral ER-resident glycoprotein inactivates the MHC-encoded peptide transporter. Immunity. 6:1997;623-632.
29. Ahn K., Gruhler A., Galocha B., Jones T.R., Wiertz E.J.H.J., Ploegh H.L., Peterson P.A., Yang Y., Fruh K. The ER-luminal domain of the HCMV glycoprotein US6 inhibits peptide translocation by TAP. Immunity. 6:1997;613-621.
30. Lehner P.J., Karttunen J.T., Wilkinson G.W.G., Cresswell P. The human cytomegalovirus US6 glycoprotein inhibits the transporter associated with antigen processing-dependent peptide translocation. Proc. Natl. Acad. Sci. USA. 94:1997;6904-6909.
31. Kyritsis C., Gorbulev S., Hutschenreiter S., Pawlitschko K., Abele R., Tampe R. Molecular mechanism and structural aspects of transporter associated with antigen processing inhibition by the cytomegalovirus protein US6. J. Biol. Chem. 276:2001;48031-48039.
32. Coscoy L., Ganem D. Kaposi's sarcoma-associated herpesvirus encodes two proteins that block cell surface display of MHC class I chains by enhancing their endocytosis. Proc. Natl. Acad. Sci. USA. 97:2000;8051-8056.
33. Stevenson P.G., Efstathiou S., Doherty P.C., Lehner P.J. Inhibition of MHC class I-restricted antigen presentation by gamma 2-herpesviruses. Proc. Natl. Acad. Sci. USA. 97:2000;8455-8460.
34. Ishido S., Wang C., Lee B.S., Cohen G.B., Jung J.U. Downregulation of major histocompatibility complex class I molecules by Kaposi's sarcoma-associated herpesvirus K3 and K5 proteins. J. Virol. 74:2000;5300-5309.
35. Haque M., Ueda K., Nakano K., Hirata Y., Parravicini C., Corbellino M., Yamanishi K. Major histocompatibility complex class I molecules are down-regulated at the cell surface by the K5 protein encoded by Kaposi's sarcoma- associated herpesvirus/human herpesvirus-8. J. Gen. Virol. 82:2001;1175-1180.
36. Coscoy L., Ganem D. A viral protein that selectively downregulates ICAM-1 and B7-2 and modulates T cell costimulation. J. Clin. Invest. 107:2001;1599-1606.
37. Guerin J.L., Gelfi J., Boullier S., Delverdier M., Bellanger F.A., Bertagnoli S., Drexler I., Sutter G., Messud-Petit F. Myxoma virus leukemia-associated protein is responsible for major histocompatibility complex class I and Fas-CD95 down-regulation and defines scrapins, a new group of surface cellular receptor abductor proteins. J. Virol. 76:2002;2912-2923.
38. Fruh K., Bartee E., Gouveia K., Mansouri M. Immune evasion by a novel family of viral PHD/LAP-finger proteins of gamma-2 herpesviruses and poxviruses. Virus Res. 88:2002;55-69.
39. •] show the ubiquitination of MHC class I molecules by viral E3 ligases.
40. Sanchez D.J., Coscoy L., Ganem D. Functional organization of MIR2, a novel viral regulator of selective endocytosis. J. Biol. Chem. 277:2002;6124-6130.
41. Scheel H., Hofmann K. No evidence for PHD fingers as ubiquitin ligases. Trends Cell. Biol. 13:2003;285-287.
42. Aravind L., Iyer L.M., Koonin E.V. Scores of RINGS but no PHDs in ubiquitin signaling. Cell Cycle. 2:2003;123-126.
43. •].
44. •].
45. Ishido S., Choi J.K., Lee B.S., Wang C., DeMaria M., Johnson R.P., Cohen G.B., Jung J.U. Inhibition of natural killer cell-mediated cytotoxicity by Kaposi's sarcoma-associated herpesvirus K5 protein. Immunity. 13:2000;365-374.
46. Lybarger L., Wang X., Harris M.R., Virgin H.W. 4th, Hansen T.H. Virus subversion of the MHC class I peptide-loading complex. Immunity. 18:2003;121-130.
47. Miley M.J., Truscott S.M., Yu Y.Y., Gilfillan S., Fremont D.H., Hansen T.H., Lybarger L. Biochemical features of the MHC-related protein 1 consistent with an immunological function. J. Immunol. 170:2003;6090-6098.
48. Stevenson P.G., May J.S., Smith X.G., Marques S., Adler H., Koszinowski U.H., Simas J.P., Efstathiou S. K3-mediated evasion of CD8(+) T cells aids amplification of a latent gamma-herpesvirus. Nat. Immunol. 3:2002;733-740 MK3-deficient MHV68 demonstrates a critical role for MK3 in establishment of latent viral infection.
49. Lorenzo M.E., Jung J.U., Ploegh H.L. Kaposi's sarcoma-associated herpesvirus K3 utilizes the ubiquitin-proteasome system in routing class major histocompatibility complexes to late endocytic compartments. J. Virol. 76:2002;5522-5531.
50. Coscoy L., Ganem D. PHD domains and E3 ubiquitin ligases: viruses make the connection. Trends Cell. Biol. 13:2003;7-12.
51. Pickart C.M. Ubiquitin enters the new millennium. Mol. Cell. 8:2001;499-504.
52. Katzmann D.J., Odorizzi G., Emr S.D. Receptor downregulation and multivesicular-body sorting. Nat. Rev. Mol. Cell. Biol. 3:2002;893-905.
53. von Schwedler U.K., Stuchell M., Muller B., Ward D.M., Chung H.Y., Morita E., Wang H.E., Davis T., He G.P., Cimbora D.M.et al. The protein network of HIV budding. Cell. 114:2003;701-713.
54. Garrus J.E., von Schwedler U.K., Pornillos O.W., Morham S.G., Zavitz K.H., Wang H.E., Wettstein D.A., Stray K.M., Cote M., Rich R.L.et al. Tsg101 and the vacuolar protein sorting pathway are essential for hiv-1 budding. Cell. 107:2001;55-65.
55. Mansouri M., Bartee E., Gouveia K., Hovey Nerenberg B.T., Barrett J., Thomas L., Thomas G., McFadden G., Fruh K. The PHD/LAP-domain protein M153R of myxomavirus is a ubiquitin ligase that induces the rapid internalization and lysosomal destruction of CD4. J. Virol. 77:2003;1427-1440.
56. Holzerlandt R., Orengo C., Kellam P., Alba M.M. Identification of new herpesvirus gene homologs in the human genome. Genome Res. 12:2002;1739-1748.
57. Jenner R.G., Boshoff C. The molecular pathology of Kaposi's sarcoma-associated herpesvirus. Biochim. Biophys. Acta. 1602:2002;1-22.
58. Goto E., Ishido S., Sato Y., Ohgimoto S., Ohgimoto K., Nagano-Fujii M., Hotta H. c-MIR, a human E3 ubiquitin ligase, is a functional homolog of herpesvirus proteins MIR1 and MIR2 and has similar activity. J. Biol. Chem. 278:2003;14657-14668.