Self-inhibition of synthesis and antigen presentation by Epstein-Barr virus-encoded EBNA1

Science

Volumn 301, Issue 5638, 2003, Pages 1371-1374

  Yin, Yili ^a   Manoury, Bénédicte ^a   Fåhraeus, Robin ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; ANTIGENS; BIODEGRADATION; PROTEINS; RNA; VIRUSES;

CYTOTOXICITY;

IMMUNOLOGY;

MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; PROTEASOME;

RNA; VIRUS;

ANIMAL CELL; ANTIGEN PRESENTATION; ARTICLE; CELL KILLING; CHIMERA; CYTOTOXIC T LYMPHOCYTE; EPSTEIN BARR VIRUS; GENETIC CODE; MOLECULAR RECOGNITION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; RNA TRANSLATION; TANDEM REPEAT; VIRUS EXPRESSION; VIRUS INHIBITION;

AMINO ACID MOTIFS; ANTIGEN PRESENTATION; CYSTEINE ENDOPEPTIDASES; EIF-2 KINASE; EPSTEIN-BARR VIRUS NUCLEAR ANTIGENS; HERPESVIRUS 4, HUMAN; HISTOCOMPATIBILITY ANTIGENS CLASS I; HUMANS; MULTIENZYME COMPLEXES; PEPTIDES; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN BIOSYNTHESIS; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT FUSION PROTEINS; REPETITIVE SEQUENCES, AMINO ACID; RNA, MESSENGER; T-LYMPHOCYTES, CYTOTOXIC; TRANSCRIPTION, GENETIC; TRANSFECTION; TUMOR CELLS, CULTURED; VIRUS LATENCY;

ANIMALIA; HUMAN HERPESVIRUS 4;

EID: 0041971307     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1088902     Document Type: Article

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25. Supported by the Cancer Research UK (CRUK). R.F. is a CRUK Senior Fellow. We thank C. Stephen for help with the initial work on the effect of GAr on its own translation and for cloning the EBNA1wt and EBΔGA constructs into the pCDNA3 vector. Both EBNA1wt and EBΔGA cDNA were a kind gift from N. Blake and A. Rickinson.