Kaposi's sarcoma-associated herpesvirus K3 utilizes the ubiquitin-proteasome system in routing class I major histocompatibility complexes to late endocytic compartments

Journal of Virology

Volumn 76, Issue 11, 2002, Pages 5522-5531

  Lorenzo, Mayra E ^a   Jung, Jae U ^a   Ploegh, Hidde L ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ASPARTIC PROTEINASE INHIBITOR; BETA 2 MICROGLOBULIN; CYSTEINE PROTEINASE; CYSTEINE PROTEINASE INHIBITOR; HOMEODOMAIN PROTEIN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; PEPTIDE; PROTEASOME; PROTEASOME INHIBITOR; UBIQUITIN;

AMINO TERMINAL SEQUENCE; ARTICLE; CELL MEMBRANE; DOWN REGULATION; ENDOCYTOSIS; ENDOSOME; GENE K3; GENE K5; HUMAN HERPESVIRUS 8; INTERNALIZATION; LYSOSOME; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN STRUCTURE; VIRUS GENE;

CYSTEINE ENDOPEPTIDASES; ENDOCYTOSIS; HERPESVIRUS 8, HUMAN; HISTOCOMPATIBILITY ANTIGENS CLASS I; HUMANS; LIGASES; MULTIENZYME COMPLEXES; PROTEASOME ENDOPEPTIDASE COMPLEX; SUBCELLULAR FRACTIONS; TUMOR CELLS, CULTURED; UBIQUITIN; UBIQUITIN-PROTEIN LIGASES; VIRAL PROTEINS;

EID: 0036091854     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.76.11.5522-5531.2002     Document Type: Article

References (51)

1. The PHD finger: Implications for chromatin-mediated transcriptional regulation
2. Mammalian tumor susceptibility gene 101 (TSG101) and the yeast homologue, Vps23p, both function in late endosomal trafficking
3. Covalent modification of the active site threonine of proteasomal beta subunits and the Escherichia coli homolog HslV by a new class of inhibitors
4. MHC class I ubiquitination by a viral PHD/LAP finger protein
5. Ubiquitin and the control of protein fate in the secretory and endocytic pathways
6. Solution structure of the PHD domain from the KAP-1 corepressor: Structural determinants for PHD, RING and LIM zinc-binding domains
7. Kaposi's sarcoma-associated herpesvirus encodes two proteins that block cell surface display of MHC class I chains by enhancing their endocytosis
8. A viral protein that selectively downregulates ICAM-1 and B7-2 and modulates T cell costimulation
9. A novel class of herpesvirus-encoded membrane-bound E3 ubiquitin ligases regulates endocytosis of proteins involved in immune recognition
10. Cathepsin S controls the trafficking and maturation of MHC class Il molecules in dendritic cells
11. Multiple roles for Rsp5p-dependent ubiquitination at the internalization step of endocytosis
12. Membrane transport: Ubiquitylation in endosomal sorting
13. Cbl-b-dependent coordinated degradation of the epidermal growth factor receptor signaling complex
14. Human cytomegalovirus US2 endoplasmic reticulum-lumenal domain dictates association with major histocompatibility complex class I in a locusspecific manner
15. Epoxide electrophiles as activity-dependent cysteine protease profiling and discovery tools
16. The ubiquitin system
17. A new ticket for entry into budding vesicles - Ubiquitin
18. Protein regulation by monoubiquitin
19. Ubiquitination of a yeast plasma membrane receptor signals its ligand-stimulated endocytosis
20. The alpha chain of the T cell antigen receptor is degraded in the cytosol
21. Inhibition of natural killer cell-mediated cytotoxicity by Kaposi's sarcoma-associated herpesvirus K5 protein
22. Downregulation of major histocompatibility complex class I molecules by Kaposi's sarcoma-associated herpesvirus K3 and K5 proteins
23. Degradation of the Met tyrosine kinase receptor by the ubiquitinproteasome pathway
24. RING finger proteins: Mediators of ubiquitin ligase activity
25. Ubiquitin-dependent sorting into the multivesicular body pathway requires the function of a conserved endosomal protein sorting complex, ESCRT-I
26. Viral immune evasion strategies and the underlying cell biology
27. Uptake of the ATPbinding cassette (ABC) transporter Ste6 into the yeast vacuole is blocked in the doa4 mutant
28. Multiple endocytic trafficking pathways of MHC class I molecules induced by a herpesvirus protein
29. Rapid deubiquitination of nucleosomal histones in human tumor cells caused by proteasome inhibitors and stress response inducers: Effects on replication transcription, translation, and the cellular stress response
30. A single 13-kilobase divergent locus in the Kaposi sarcomaassociated herpesvirus (human herpesvirus 8) genome contains nine open reading frames that are homologous to or related to cellular proteins
31. Use of a monoclonal antibody (W6/32) in structural studies of HLA-A,B,C antigens
32. Resistance is futile. Assimilation of cellular machinery by HIV-1
33. Ubiquitin enters the new millennium
34. One-dimensional isoelectric focusing of proteins in slab gels
35. Sorting of proteins into multivesicular bodies: Ubiquitin-dependent and -independent targeting
36. Involvement of the ubiquitin/proteasome system in sorting of the interleukin 2 receptor beta chain to late endocytic compartments
37. Two species of lysosomal organelles in cultured human fibroblasts
38. p53 accumulation, defective cell proliferation, and early embryonic lethality in mice lacking tsg101
39. The leukemia-associated-protein (LAP) domain, a cysteine-rich motif, is present in a wide range of proteins, including MLL, AF10, and MLLT6 proteins
40. Biogenesis of the yeast vacuole (lysosome). The precursor forms of the soluble hydrolase carboxypeptidase yscS are associated with the vacuolar membrane
41. Monoclonal antibodies raised against denatured HLA-B locus heavy chains permit biochemical characterization of certain HLA-C locus products
42. Inhibition of MHC class I-restricted antigen presentation by gamma 2-herpesviruses
43. The cytosolic tail of class I MHC heavy chain is required for its dislocation by the human cytomegalovirus US2 and US11 gene products
44. A role for ubiquitin ligase recruitment in retrovirus release
45. The Doa4 deubiquitinating enzyme is required for ubiquitin homeostasis in yeast
46. Viral subversion of the immune system
47. Dislocation of type I membrane proteins from the ER to the cytosol is sensitive to changes in redox potential
48. Endocytosis and degradation of the growth hormone receptor are proteasome-dependent
49. Preparation of microsomal membranes for cotranslational protein translocation
50. Molecular mechanisms underlying endocytosis and sorting of ErbB receptor tyrosine kinases
51. Yeast epsins contain an essential N-terminal ENTH domain, bind clathrin and are required for endocytosis