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Volumn 10, Issue 5, 2004, Pages 523-530

Molecular therapy intervention prospects in prostate cancer

Author keywords

Apoptosis; Genes; Molecular therapy; Par 4; Prostate cancer

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; ANTISENSE OLIGONUCLEOTIDE; APOPTOSIS INDUCING FACTOR; CALCIUM ION; CASPASE 8; DOXORUBICIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LEPTOMYCIN B; NIFEDIPINE; PACLITAXEL; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROSTATE APOPTOSIS RESPONSE 4 PROTEIN; PROTEIN BCL 2; PROTEIN BCL XL; PROTEIN KINASE B; PROTEIN P53; PROTEINASE ACTIVATED RECEPTOR 4; STAUROSPORINE; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; UNCLASSIFIED DRUG; VASCULOTROPIN; VINCRISTINE; WORTMANNIN;

EID: 1042280304     PISSN: 13816128     EISSN: None     Source Type: Journal    
DOI: 10.2174/1381612043453234     Document Type: Review
Times cited : (17)

References (95)
  • 1
    • 0035096839 scopus 로고    scopus 로고
    • Cancer - Emerging breakthrough drugs
    • Sawyer, TK. Cancer - emerging breakthrough drugs. Biotechniques 2001; 30(3), 626-632.
    • (2001) Biotechniques , vol.30 , Issue.3 , pp. 626-632
    • Sawyer, T.K.1
  • 2
    • 0029873670 scopus 로고    scopus 로고
    • Role of programmed (apoptotic) cell death during the progression and therapy for prostate cancer
    • Denmeade SR, Lin XS, Isaacs JT. Role of programmed (apoptotic) cell death during the progression and therapy for prostate cancer. Prostate 1996; 28:251-265.
    • (1996) Prostate , vol.28 , pp. 251-265
    • Denmeade, S.R.1    Lin, X.S.2    Isaacs, J.T.3
  • 5
    • 0035433420 scopus 로고    scopus 로고
    • Four deaths and a funeral: From caspases to alternative mechanisms
    • Leist M, Jaattela M. Four deaths and a funeral: from caspases to alternative mechanisms Nat Rev Mol Cell Biol 2001;2:589-598.
    • (2001) Nat. Rev. Mol. Cell Biol. , vol.2 , pp. 589-598
    • Leist, M.1    Jaattela, M.2
  • 6
    • 0032575750 scopus 로고    scopus 로고
    • Caspases: Enemies within
    • Thornberry NA, Lazebnik Y. Caspases: enemies within. Science 1998; 281: 1312-1316.
    • (1998) Science , vol.281 , pp. 1312-1316
    • Thornberry, N.A.1    Lazebnik, Y.2
  • 7
    • 0034641918 scopus 로고    scopus 로고
    • The biochemistry of apoplosis
    • Hengartner MO. The biochemistry of apoplosis. Nature 2000; 407: 770-776.
    • (2000) Nature , vol.407 , pp. 770-776
    • Hengartner, M.O.1
  • 9
    • 0026005818 scopus 로고
    • Programmed death of nonproliferating androgen-independent prostatic cancer cells
    • Martikainen P, Kyprianou N, Tucker R, Isaacs JT. Programmed death of nonproliferating androgen-independent prostatic cancer cells. Cancer Res 1991; 51: 4693-4700.
    • (1991) Cancer Res. , vol.51 , pp. 4693-4700
    • Martikainen, P.1    Kyprianou, N.2    Tucker, R.3    Isaacs, J.T.4
  • 12
    • 0034646601 scopus 로고    scopus 로고
    • Characterization of calcium release-activated apoptosis of LNCaP prostate cancer cells
    • Wertz IE, Dixit VM. Characterization of calcium release-activated apoptosis of LNCaP prostate cancer cells. J Biol Chem 2000; 275: 11470-11477.
    • (2000) J. Biol. Chem. , vol.275 , pp. 11470-11477
    • Wertz, I.E.1    Dixit, V.M.2
  • 13
    • 0028143317 scopus 로고
    • The role of calcium, pH, and cell proliferation in the programmed (apoptotic) death of androgen-independent prostatic cancer cells induced by thapsigargin
    • Furuya Y, Lundmo P, Short AD, Gill DL, Isaacs JT. The role of calcium, pH, and cell proliferation in the programmed (apoptotic) death of androgen-independent prostatic cancer cells induced by thapsigargin. Cancer Res 1994; 54: 6167-6175.
    • (1994) Cancer Res. , vol.54 , pp. 6167-6175
    • Furuya, Y.1    Lundmo, P.2    Short, A.D.3    Gill, D.L.4    Isaacs, J.T.5
  • 14
    • 0030690164 scopus 로고    scopus 로고
    • Mechanism and role of growth arrest in programmed (apoptotic) death of prostatic cancer cells induced by thapsigargin
    • Lin XS, Denmeade SR, Cisek L, Isaacs JT. Mechanism and role of growth arrest in programmed (apoptotic) death of prostatic cancer cells induced by thapsigargin. Prostate 1997; 33:201-207.
    • (1997) Prostate , vol.33 , pp. 201-207
    • Lin, X.S.1    Denmeade, S.R.2    Cisek, L.3    Isaacs, J.T.4
  • 15
    • 0028015669 scopus 로고
    • Commonality of the gene programs induced by effectors of apoptosis in androgen-dependent and -independent prostate cells
    • Sells SF, Wood DP Jr, Joshi-Barve SS, MuthukumarS, Jacob RJ, Crist SA, et al. Commonality of the gene programs induced by effectors of apoptosis in androgen-dependent and -independent prostate cells. Cell Growth Differ 1994; 5: 457-466.
    • (1994) Cell Growth Differ. , vol.5 , pp. 457-466
    • Sells, S.F.1    Wood Jr., D.P.2    Joshi-Barve, S.S.3    Muthukumar, S.4    Jacob, R.J.5    Crist, S.A.6
  • 16
    • 0018830636 scopus 로고
    • Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation
    • Wyllie AH. Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation. Nature 1980; 284:555-556.
    • (1980) Nature , vol.284 , pp. 555-556
    • Wyllie, A.H.1
  • 18
    • 0028206341 scopus 로고
    • BH1 and BH2 domains of Bcl-2 are required for inhibition of apoptosis and heterodimerization with Bax
    • Yin XM, Oltvai ZN, Korsmeyer SJ. BH1 and BH2 domains of Bcl-2 are required for inhibition of apoptosis and heterodimerization with Bax. Nature 1994; 369: 321-323.
    • (1994) Nature , vol.369 , pp. 321-323
    • Yin, X.M.1    Oltvai, Z.N.2    Korsmeyer, S.J.3
  • 19
    • 0029032660 scopus 로고
    • Structure-function analysis of Bcl-2 protein. Identification of conserved domains important for homodimerization with Bcl-2 and heterodimerization with Bax
    • Hanada M, Aime-Sempe C, Sato T, Reed JC. Structure-function analysis of Bcl-2 protein. Identification of conserved domains important for homodimerization with Bcl-2 and heterodimerization with Bax. J Biol Chem 1995; 270: 11962-11969.
    • (1995) J. Biol. Chem. , vol.270 , pp. 11962-11969
    • Hanada, M.1    Aime-Sempe, C.2    Sato, T.3    Reed, J.C.4
  • 20
    • 0028809209 scopus 로고
    • Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death
    • 1995
    • Yang E, Zha J, Jockel J, Boise LH, Thompson CB, Korsmeyer SJ. (1995) Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death. Cell 1995; 80:285-291.
    • (1995) Cell , vol.80 , pp. 285-291
    • Yang, E.1    Zha, J.2    Jockel, J.3    Boise, L.H.4    Thompson, C.B.5    Korsmeyer, S.J.6
  • 21
    • 0030861571 scopus 로고    scopus 로고
    • Bcl-2 and Bax function independently to regulate cell death
    • 1997
    • Knudson CM, Korsmeyer SJ. (1997) Bcl-2 and Bax function independently to regulate cell death. Nat Genet 1997; 16: 358-363.
    • (1997) Nat. Genet. , vol.16 , pp. 358-363
    • Knudson, C.M.1    Korsmeyer, S.J.2
  • 22
    • 0023812417 scopus 로고
    • Oncogenic potential of bcl-2 demonstrated by gene transfer
    • 1988
    • Reed JC, Cuddy M, Slabiak T, Croce CM, Nowell PC. (1988) Oncogenic potential of bcl-2 demonstrated by gene transfer. Nature 1988;336:259-261.
    • (1988) Nature , vol.336 , pp. 259-261
    • Reed, J.C.1    Cuddy, M.2    Slabiak, T.3    Croce, C.M.4    Nowell, P.C.5
  • 23
    • 0034326272 scopus 로고    scopus 로고
    • Bcl-xL in prostate cancer cells: Effects of overexpression and down-regulation on chemosensitivity
    • Lebedeva I, Rando R, Ojwang J, Cossum P, Stein CA. Bcl-xL in prostate cancer cells: effects of overexpression and down-regulation on chemosensitivity. Cancer Res 2000; 60: 6052-6060.
    • (2000) Cancer Res. , vol.60 , pp. 6052-6060
    • Lebedeva, I.1    Rando, R.2    Ojwang, J.3    Cossum, P.4    Stein, C.A.5
  • 24
    • 0027362667 scopus 로고
    • Investigation of the subcellular distribution of the bcl-2 oncoprotein: Residence in the nuclear envelope, endoplasmic reticulum, and outer mitochondrial membranes
    • Krajewski S, Tanaka S, Takayama S, Schibler MJ, Fenton W, Reed JC. Investigation of the subcellular distribution of the bcl-2 oncoprotein: residence in the nuclear envelope, endoplasmic reticulum, and outer mitochondrial membranes. Cancer Res 1993; 53:4701-4714.
    • (1993) Cancer Res. , vol.53 , pp. 4701-4714
    • Krajewski, S.1    Tanaka, S.2    Takayama, S.3    Schibler, M.J.4    Fenton, W.5    Reed, J.C.6
  • 26
    • 0030843575 scopus 로고    scopus 로고
    • Overexpression of Bcl-X(L) inhibits Ara-C-induced mitochondrial loss of cytochrome c and other perturbations that activate the molecular cascade of apoptosis
    • Kim CN, Wang X, Huang Y, Ibrado AM, Liu L, Fang G, et al. Overexpression of Bcl-X(L) inhibits Ara-C-induced mitochondrial loss of cytochrome c and other perturbations that activate the molecular cascade of apoptosis. Cancer Res 1997; 57: 3115-3120.
    • (1997) Cancer Res. , vol.57 , pp. 3115-3120
    • Kim, C.N.1    Wang, X.2    Huang, Y.3    Ibrado, A.M.4    Liu, L.5    Fang, G.6
  • 27
    • 0031037897 scopus 로고    scopus 로고
    • The release of cytochrome c from mitochondria: A primary site for Bcl-2 regulation of apoptosis
    • Kluck RM, Bossy-Wetzel E, Green DR, Newmeyer DD. The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis. Science 1997; 275: 1132-1136.
    • (1997) Science , vol.275 , pp. 1132-1136
    • Kluck, R.M.1    Bossy-Wetzel, E.2    Green, D.R.3    Newmeyer, D.D.4
  • 28
    • 0031036872 scopus 로고    scopus 로고
    • Prevention of apoptosis by Bcl-2: Release of cytochrome c from mitochondria blocked
    • Yang J, Liu X, Bhalla K, Kim CN, Ibrado AM, Cai J, et al. Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked. Science 1997; 275: 1129-1132.
    • (1997) Science , vol.275 , pp. 1129-1132
    • Yang, J.1    Liu, X.2    Bhalla, K.3    Kim, C.N.4    Ibrado, A.M.5    Cai, J.6
  • 29
    • 0342978014 scopus 로고    scopus 로고
    • Cell-specific induction of apoptosis by microinjection of cytochrome c. Bcl-xL has activity independent of cytochrome c release
    • Li F, Srinivasan A, Wang Y, Armstrong RC, Tomaselli KJ, Fritz LC. Cell-specific induction of apoptosis by microinjection of cytochrome c. Bcl-xL has activity independent of cytochrome c release. J Biol Chem 1997; 272: 30299-30305.
    • (1997) J. Biol. Chem. , vol.272 , pp. 30299-30305
    • Li, F.1    Srinivasan, A.2    Wang, Y.3    Armstrong, R.C.4    Tomaselli, K.J.5    Fritz, L.C.6
  • 30
    • 0029792981 scopus 로고    scopus 로고
    • Overexpression of Bcl-2 or Bcl-xL inhibits Ara-C-induced CPP32/Yama protease activity and apoptosis of human acute myelogenous leukemia HL-60 cells
    • Ibrado AM, Huang Y, Fang G, Liu L, Bhalla K. Overexpression of Bcl-2 or Bcl-xL inhibits Ara-C-induced CPP32/Yama protease activity and apoptosis of human acute myelogenous leukemia HL-60 cells. Cancer Res 1996; 56: 4743-4748.
    • (1996) Cancer Res. , vol.56 , pp. 4743-4748
    • Ibrado, A.M.1    Huang, Y.2    Fang, G.3    Liu, L.4    Bhalla, K.5
  • 31
    • 0032851963 scopus 로고    scopus 로고
    • Implications of cell death regulation in the pathogenesis and treatment of prostate cancer
    • Bruckheimer EM, Gjertsen BT, McDonnell TJ. Implications of cell death regulation in the pathogenesis and treatment of prostate cancer. Semin Oncol 1999; 26: 382-398.
    • (1999) Semin. Oncol. , vol.26 , pp. 382-398
    • Bruckheimer, E.M.1    Gjertsen, B.T.2    McDonnell, T.J.3
  • 32
    • 0031012825 scopus 로고    scopus 로고
    • Expression of bcl-2 oncoprotein and p53 protein accumulation in bone marrow metastases of androgen independent prostate cancer
    • McDonnell TJ, Navone NM, Troncoso P, Pisters LL, Conti C, von Eschenbach AC, et al. Expression of bcl-2 oncoprotein and p53 protein accumulation in bone marrow metastases of androgen independent prostate cancer. J Urol 1997; 157: 569-574.
    • (1997) J. Urol. , vol.157 , pp. 569-574
    • McDonnell, T.J.1    Navone, N.M.2    Troncoso, P.3    Pisters, L.L.4    Conti, C.5    von Eschenbach, A.C.6
  • 33
    • 0029077281 scopus 로고
    • Overexpression of bcl-2 protects prostate cancer cells from apoptosis in vitro and confers resistance to androgen depletion in vivo
    • Raffo AJ, Perlman H, Chen MW, Day ML, Streitman JS, Buttyan R. Overexpression of bcl-2 protects prostate cancer cells from apoptosis in vitro and confers resistance to androgen depletion in vivo. Cancer Res 1995; 55: 4438-4445.
    • (1995) Cancer Res. , vol.55 , pp. 4438-4445
    • Raffo, A.J.1    Perlman, H.2    Chen, M.W.3    Day, M.L.4    Streitman, J.S.5    Buttyan, R.6
  • 35
    • 0035901954 scopus 로고    scopus 로고
    • Bcl-2 oncoprotein protects the human prostatic carcinoma cell line PC3 from TRAIL-mediated apoptosis
    • Rokhlin OW, Guseva N, Tagiyev A, Knudson CM, Cohen MB. Bcl-2 oncoprotein protects the human prostatic carcinoma cell line PC3 from TRAIL-mediated apoptosis. Oncogene 2001; 20: 2836-2843.
    • (2001) Oncogene , vol.20 , pp. 2836-2843
    • Rokhlin, O.W.1    Guseva, N.2    Tagiyev, A.3    Knudson, C.M.4    Cohen, M.B.5
  • 36
    • 0033981234 scopus 로고    scopus 로고
    • Heterogeneous apoptotic responses of prostate cancer cell lines identify an association between sensitivity to staurosporine-induced apoptosis, expression of Bcl-2 family members, and caspase activation
    • Marcelli M, Marani M, Li X, Sturgis L, Haidacher SJ, Trial JA, et al. Heterogeneous apoptotic responses of prostate cancer cell lines identify an association between sensitivity to staurosporine-induced apoptosis, expression of Bcl-2 family members, and caspase activation. Prostate 2000; 42: 260-273.
    • (2000) Prostate , vol.42 , pp. 260-273
    • Marcelli, M.1    Marani, M.2    Li, X.3    Sturgis, L.4    Haidacher, S.J.5    Trial, J.A.6
  • 37
    • 0035866339 scopus 로고    scopus 로고
    • Overexpression of BCL-X(L) underlies the molecular basis for resistance to staurosporine-induced apoptosis in PC-3 cells
    • Li X, Marani M, Mannucci R, Kinsey B, Andriani F, Nicoletti I, et al. Overexpression of BCL-X(L) underlies the molecular basis for resistance to staurosporine-induced apoptosis in PC-3 cells. Cancer Res 2001; 61: 1699- 1706.
    • (2001) Cancer Res. , vol.61 , pp. 1699-1706
    • Li, X.1    Marani, M.2    Mannucci, R.3    Kinsey, B.4    Andriani, F.5    Nicoletti, I.6
  • 38
    • 0034719680 scopus 로고    scopus 로고
    • The transcription factor NF-kappaB: Control of oncogenesis and cancer therapy resistance
    • Mayo MW, Baldwin AS. The transcription factor NF-kappaB: control of oncogenesis and cancer therapy resistance. Biochim Biophys Acta 2000; 1470: M55-M62.
    • (2000) Biochim. Biophys Acta , vol.1470
    • Mayo, M.W.1    Baldwin, A.S.2
  • 39
    • 0035849720 scopus 로고    scopus 로고
    • Blockade of NF-kappa B activity in human prostate cancer cells is associated with suppression of angiogenesis, invasion, and metastasis
    • Huang S, Pettaway CA, Uehara H, Bucana CD, Fidler IJ. Blockade of NF-kappa B activity in human prostate cancer cells is associated with suppression of angiogenesis, invasion, and metastasis. Oncogene 2001; 20: 4188-4197.
    • (2001) Oncogene , vol.20 , pp. 4188-4197
    • Huang, S.1    Pettaway, C.A.2    Uehara, H.3    Bucana, C.D.4    Fidler, I.J.5
  • 40
    • 0033517999 scopus 로고    scopus 로고
    • Constitutive activation of IkappaB kinase alpha and NF-kappaB in prostate cancer cells is inhibited by ibuprofen
    • Palayoor ST, Yournell MY, Calderwood SK, Coleman CN. Constitutive activation of IkappaB kinase alpha and NF-kappaB in prostate cancer cells is inhibited by ibuprofen. Oncogene 1999; 18: 7389-7394.
    • (1999) Oncogene , vol.18 , pp. 7389-7394
    • Palayoor, S.T.1    Yournell, M.Y.2    Calderwood, S.K.3    Coleman, C.N.4
  • 41
    • 0030610472 scopus 로고    scopus 로고
    • Activation of NF-kappaB by antineoplastic agents. Role of protein kinase C
    • Das KC, White CW. Activation of NF-kappaB by antineoplastic agents. Role of protein kinase C. J Biol Chem 1997; 272:14914-14920.
    • (1997) J. Biol. Chem. , vol.272 , pp. 14914-14920
    • Das, K.C.1    White, C.W.2
  • 42
    • 0032881288 scopus 로고    scopus 로고
    • AKT/PKB and other D3 phosphoinositide-regulated kinases: Kinase activation by phosphoinositide-dependent phosphorylation
    • Chan TO, Rittenhouse SE, Tsichlis PN. AKT/PKB and other D3 phosphoinositide-regulated kinases: kinase activation by phosphoinositide-dependent phosphorylation. Annu Rev Biochem 1999;68:965-1014.
    • (1999) Annu. Rev. Biochem. , vol.68 , pp. 965-1014
    • Chan, T.O.1    Rittenhouse, S.E.2    Tsichlis, P.N.3
  • 43
    • 0033517244 scopus 로고    scopus 로고
    • Akt is more than just a Bad kinase
    • Khwaja A. Akt is more than just a Bad kinase. Nature 1999; 401:33-34.
    • (1999) Nature , vol.401 , pp. 33-34
    • Khwaja, A.1
  • 44
    • 0035912833 scopus 로고    scopus 로고
    • Akt suppresses androgen-induced apoptosis by phosphorylating and inhibiting androgen receptor
    • Lin HK, Yeh S, Kang HY, Chang C. Akt suppresses androgen-induced apoptosis by phosphorylating and inhibiting androgen receptor. Proc Natl Acad Sci USA 2001; 98: 7200-7205.
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 7200-7205
    • Lin, H.K.1    Yeh, S.2    Kang, H.Y.3    Chang, C.4
  • 45
    • 0035914394 scopus 로고    scopus 로고
    • Pro-survival function of Akt/protein kinase B in prostate cancer cells. Relationship with TRAIL resistance
    • Thakkar H, Chen X, Tyan F, Gim S, Robinson H, Lee C, et al. Pro-survival function of Akt/protein kinase B in prostate cancer cells. Relationship with TRAIL resistance. J Biol Chem 2001; 276: 38361-38369.
    • (2001) J. Biol. Chem. , vol.276 , pp. 38361-38369
    • Thakkar, H.1    Chen, X.2    Tyan, F.3    Gim, S.4    Robinson, H.5    Lee, C.6
  • 46
    • 0034749615 scopus 로고    scopus 로고
    • Role of P13K signaling in survival and progression of LNCaP prostate cancer cells to the androgen refractory state
    • Murillo H, Huang H, Schmidt LJ, Smith DJ, Tindall DJ. Role of P13K signaling in survival and progression of LNCaP prostate cancer cells to the androgen refractory state. Endocrinology 2001; 142: 4795-4805.
    • (2001) Endocrinology , vol.142 , pp. 4795-4805
    • Murillo, H.1    Huang, H.2    Schmidt, L.J.3    Smith, D.J.4    Tindall, D.J.5
  • 47
    • 17144436629 scopus 로고    scopus 로고
    • Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers
    • Steck PA, Pershouse MA, Jasser SA, Yung WK, Lin H, Ligon AH, et al. Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers. Nat Genet 1997; 15: 356-362.
    • (1997) Nat. Genet. , vol.15 , pp. 356-362
    • Steck, P.A.1    Pershouse, M.A.2    Jasser, S.A.3    Yung, W.K.4    Lin, H.5    Ligon, A.H.6
  • 48
    • 0033152165 scopus 로고    scopus 로고
    • Regulation of Akt/PKB activity, cellular growth, and apoptosis in prostate carcinoma cells by MMAC/ PTEN
    • Davies MA, Koul D, Dhesi H, Berman R, McDonnell TJ, McConkey D, et al. Regulation of Akt/PKB activity, cellular growth, and apoptosis in prostate carcinoma cells by MMAC/ PTEN. Cancer Res 1999; 59: 2551-2556.
    • (1999) Cancer Res. , vol.59 , pp. 2551-2556
    • Davies, M.A.1    Koul, D.2    Dhesi, H.3    Berman, R.4    McDonnell, T.J.5    McConkey, D.6
  • 49
    • 0032574718 scopus 로고    scopus 로고
    • Inactivation of the tumor suppressor PTEN/MMAC1 in advanced human prostate cancer through loss of expression
    • Whang YE, Wu X, Suzuki H, Reiter RE, Tran C, Vessella RL, et al. Inactivation of the tumor suppressor PTEN/MMAC1 in advanced human prostate cancer through loss of expression. Proc Natl Acad Sci USA 1998; 95: 5246-5250.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 5246-5250
    • Whang, Y.E.1    Wu, X.2    Suzuki, H.3    Reiter, R.E.4    Tran, C.5    Vessella, R.L.6
  • 50
    • 0029875164 scopus 로고    scopus 로고
    • Suppression of the malignant phenotype of human prostate cancer cell line PPC-1 by introduction of normal fragments of human chromosome 10
    • Murakami YS, Albertsen H, Brothman AR, Leach RJ, White RL. Suppression of the malignant phenotype of human prostate cancer cell line PPC-1 by introduction of normal fragments of human chromosome 10. Cancer Res 1996; 56: 2157-2160.
    • (1996) Cancer Res. , vol.56 , pp. 2157-2160
    • Murakami, Y.S.1    Albertsen, H.2    Brothman, A.R.3    Leach, R.J.4    White, R.L.5
  • 51
    • 0035920131 scopus 로고    scopus 로고
    • The PTEN tumor suppressor protein inhibits tumor necrosis factor-induced nuclear factor kappa B activity
    • Gustin JA, Maehama T, Dixon JE, Donner DB. The PTEN tumor suppressor protein inhibits tumor necrosis factor-induced nuclear factor kappa B activity. J Biol Chem 2001; 276:27740-27744.
    • (2001) J. Biol. Chem. , vol.276 , pp. 27740-27744
    • Gustin, J.A.1    Maehama, T.2    Dixon, J.E.3    Donner, D.B.4
  • 52
    • 0037930504 scopus 로고    scopus 로고
    • The relation of p53 protein nuclear accumulation and angiogenesis in human prostatic carcinoma
    • Sep
    • Yu EY, Yu E, Meyer GE, Brawer MK. The relation of p53 protein nuclear accumulation and angiogenesis in human prostatic carcinoma. Prostate Cancer Prostatic Dis 1997 Sep; 1 (1):39-44.
    • (1997) Prostate Cancer Prostatic Dis. , vol.1 , Issue.1 , pp. 39-44
    • Yu, E.Y.1    Yu, E.2    Meyer, G.E.3    Brawer, M.K.4
  • 54
    • 0037369108 scopus 로고    scopus 로고
    • Leptomycin B stabilizes and activates p53 in primary prostatic epithelia] cells and induces apoptosis in the LNCaP cell line
    • Lecane PS, Kiviharju TM, Sellers RG, Peehl DM. Leptomycin B stabilizes and activates p53 in primary prostatic epithelia] cells and induces apoptosis in the LNCaP cell line. Prostate 2003; 54(4): 258-67.
    • (2003) Prostate , vol.54 , Issue.4 , pp. 258-267
    • Lecane, P.S.1    Kiviharju, T.M.2    Sellers, R.G.3    Peehl, D.M.4
  • 55
    • 0032988573 scopus 로고    scopus 로고
    • Synthesis of procaspases-3 and -7 during apoptosis in prostate cancer cells
    • Bowen C, Voeller HJ, Kikly K, Gelmann EP. Synthesis of procaspases-3 and -7 during apoptosis in prostate cancer cells. Cell Death Differ 1999; 6: 394-401.
    • (1999) Cell Death Differ. , vol.6 , pp. 394-401
    • Bowen, C.1    Voeller, H.J.2    Kikly, K.3    Gelmann, E.P.4
  • 56
    • 0035477544 scopus 로고    scopus 로고
    • Par-4 drives trafficking and activation of Fas and Fas1 to induce prostate cancer cell apoptosis and tumor regression
    • Chakraborty M, Qiu SG, Vasudevan KM, Rangnekar VM. Par-4 drives trafficking and activation of Fas and Fas1 to induce prostate cancer cell apoptosis and tumor regression. Cancer Res 2001; 61: 7255-7263.
    • (2001) Cancer Res. , vol.61 , pp. 7255-7263
    • Chakraborty, M.1    Qiu, S.G.2    Vasudevan, K.M.3    Rangnekar, V.M.4
  • 58
    • 0037328539 scopus 로고    scopus 로고
    • Apoptosis by Par-4 in cancer and neurodegenerative diseases
    • 283
    • El-Guendy N, Rangnekar VM. Apoptosis by Par-4 in cancer and neurodegenerative diseases. Exp Cell Res 2003; 1; 283(1): 51-66.
    • (2003) Exp. Cell Res. , vol.1 , Issue.1 , pp. 51-66
    • El-Guendy, N.1    Rangnekar, V.M.2
  • 59
    • 0028206341 scopus 로고
    • BH1 and BH2 domains of Bcl-2 are required for inhibition of apoptosis and heterodimerization with Bax
    • Yin XM, Oltavi ZN, Korsmeyer SJ. BH1 and BH2 domains of Bcl-2 are required for inhibition of apoptosis and heterodimerization with Bax. Nature 1994; 369 (6478), 321-323.
    • (1994) Nature , vol.369 , Issue.6478 , pp. 321-323
    • Yin, X.M.1    Oltavi, Z.N.2    Korsmeyer, S.J.3
  • 60
    • 0023786047 scopus 로고
    • Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells
    • Vaux DL, Cory S, Adams JM. Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells. Nature 1988; 335 (6189), 440-442.
    • (1988) Nature , vol.335 , Issue.6189 , pp. 440-442
    • Vaux, D.L.1    Cory, S.2    Adams, J.M.3
  • 61
    • 0030572696 scopus 로고    scopus 로고
    • The product of par-4, a gene induced during apoptosis, interacts selectively with the atypical isoforms of protein kinase C
    • Diaz-Meco MT, Municio MM, Frutos S, Sanchez P, Lozano J, Sanz L, et al. The product of par-4, a gene induced during apoptosis, interacts selectively with the atypical isoforms of protein kinase C. Cell 1996; 86(5), 777-786.
    • (1996) Cell , vol.86 , Issue.5 , pp. 777-786
    • Diaz-Meco, M.T.1    Municio, M.M.2    Frutos, S.3    Sanchez, P.4    Lozano, J.5    Sanz, L.6
  • 62
    • 0033518129 scopus 로고    scopus 로고
    • Interaction partners of Dlk/ZIP kinase: Co-expression of Dlk/ZIP kinase and Par-4 results in cytoplasmic retention and apoptosis
    • Page G, Kogel D, Rangnekar V, Scheidtmann KH. Interaction partners of Dlk/ZIP kinase: co-expression of Dlk/ZIP kinase and Par-4 results in cytoplasmic retention and apoptosis. Oncogene 1999; 18(51), 7265-7273.
    • (1999) Oncogene , vol.18 , Issue.51 , pp. 7265-7273
    • Page, G.1    Kogel, D.2    Rangnekar, V.3    Scheidtmann, K.H.4
  • 63
    • 0037005888 scopus 로고    scopus 로고
    • p62 forms a ternary complex with PKCzeta and PAR-4 and antagonizes PAR-4-induced PKCzeta inhibition
    • Chang S, Kim JH, Shin J. p62 forms a ternary complex with PKCzeta and PAR-4 and antagonizes PAR-4-induced PKCzeta inhibition. FEBS Lett 2002; 510(1-2), 57-61.
    • (2002) FEBS Lett. , vol.510 , Issue.1-2 , pp. 57-61
    • Chang, S.1    Kim, J.H.2    Shin, J.3
  • 64
    • 10544225383 scopus 로고    scopus 로고
    • A novel repressor, par-4, modulates transcription and growth suppression functions of the Wilms' tumor suppressor WT1
    • Johnstone RW, See RH, Sells SF, Wang J, Muthukkumar S, Englert C, et al. A novel repressor, par-4, modulates transcription and growth suppression functions of the Wilms' tumor suppressor WT1. Mol Cell Biol 1996; 16(12), 6945-6956.
    • (1996) Mol. Cell Biol. , vol.16 , Issue.12 , pp. 6945-6956
    • Johnstone, R.W.1    See, R.H.2    Sells, S.F.3    Wang, J.4    Muthukkumar, S.5    Englert, C.6
  • 66
    • 0033604464 scopus 로고    scopus 로고
    • Negative regulation of Par-4 by oncogenic Ras is essential for cellular transformation
    • Qiu SG, Krishnan S, El-Guendy N, Rangnekar VM. Negative regulation of Par-4 by oncogenic Ras is essential for cellular transformation. Oncogene 1999; 18(50) 7115-7123.
    • (1999) Oncogene , vol.18 , Issue.50 , pp. 7115-7123
    • Qiu, S.G.1    Krishnan, S.2    El-Guendy, N.3    Rangnekar, V.M.4
  • 67
    • 0033570912 scopus 로고    scopus 로고
    • The downregulation of the pro-apoptotic protein Par-4 is critical for Ras-induced survival and tumor progression
    • Barradas M, Monjas A, Diaz-Meco MT, Serrano M, Moscat J. The downregulation of the pro-apoptotic protein Par-4 is critical for Ras-induced survival and tumor progression. EMBO J 1999; 18(22), 6362-6369.
    • (1999) EMBO J. , vol.18 , Issue.22 , pp. 6362-6369
    • Barradas, M.1    Monjas, A.2    Diaz-Meco, M.T.3    Serrano, M.4    Moscat, J.5
  • 68
    • 0033538336 scopus 로고    scopus 로고
    • Inactivation of the inhibitory kappaB protein kinase /nuclear factor kappaB pathway by Par-4 expression potentiates tumor necrosis factor alpha-induced apoptosis
    • Diaz-Meco MT, Lallena MJ, Monjas A, Frutos S, Moscat J. Inactivation of the inhibitory kappaB protein kinase /nuclear factor kappaB pathway by Par-4 expression potentiates tumor necrosis factor alpha-induced apoptosis. J Biol Chem 1999; 274(28), 19606-19612
    • (1999) J. Biol. Chem. , vol.274 , Issue.28 , pp. 19606-19612
    • Diaz-Meco, M.T.1    Lallena, M.J.2    Monjas, A.3    Frutos, S.4    Moscat, J.5
  • 69
    • 0031564954 scopus 로고    scopus 로고
    • p73 is a simian [correction of human] p53-related protein that can induce apoptosis
    • Jost CA, Marin MC, Kaelin WG Jr. p73 is a simian [correction of human] p53-related protein that can induce apoptosis. Nature 1997; 389:191-194.
    • (1997) Nature , vol.389 , pp. 191-194
    • Jost, C.A.1    Marin, M.C.2    Kaelin Jr., W.G.3
  • 70
    • 0030792007 scopus 로고    scopus 로고
    • Positioning atypical protein kinase C isoforms in the UV-induced apoptotic signaling cascade
    • Berra E, Municia MM, Sanz L, Frutos S, Diaz-Meco MT, Moscat J. Positioning atypical protein kinase C isoforms in the UV-induced apoptotic signaling cascade. Mol Cell Biol 1997; 17(8), 4346-4354.
    • (1997) Mol. Cell Biol. , vol.17 , Issue.8 , pp. 4346-4354
    • Berra, E.1    Municia, M.M.2    Sanz, L.3    Frutos, S.4    Diaz-Meco, M.T.5    Moscat, J.6
  • 72
    • 0033595892 scopus 로고    scopus 로고
    • The Rel/NF-kappa B signal transduction pathway: Introduction
    • Gilmore TD. The Rel/NF-kappa B signal transduction pathway: introduction. Oncogene 1999; 18(49), 6842-6844.
    • (1999) Oncogene , vol.18 , Issue.49 , pp. 6842-6844
    • Gilmore, T.D.1
  • 73
    • 0030271387 scopus 로고    scopus 로고
    • NF-kappa B: Ten years after
    • Baeuerle PA and Baltimore D. NF-kappa B: ten years after Cell 1996; 87(1), 13-20.
    • (1996) Cell , vol.87 , Issue.1 , pp. 13-20
    • Baeuerle, P.A.1    Baltimore, D.2
  • 74
    • 0033596124 scopus 로고    scopus 로고
    • Aberrant rel/nfkb genes and activity in human cancer
    • Rayet B, Gelinas C. Aberrant rel/nfkb genes and activity in human cancer. Oncogene 1999; 18(49), 6938-6947.
    • (1999) Oncogene , vol.18 , Issue.49 , pp. 6938-6947
    • Rayet, B.1    Gelinas, C.2
  • 75
    • 0030979773 scopus 로고    scopus 로고
    • Double identity for proteins of the Bcl-2 family
    • Reed JC. Double identity for proteins of the Bcl-2 family. Nature 1997; 387(6635), 773-776.
    • (1997) Nature , vol.387 , Issue.6635 , pp. 773-776
    • Reed, J.C.1
  • 76
    • 0037204952 scopus 로고    scopus 로고
    • The Fas signaling pathway: More than a paradigm
    • Wajant H. The Fas signaling pathway: more than a paradigm. Science 2002; 296(5573), 1635-1636.
    • (2002) Science , vol.296 , Issue.5573 , pp. 1635-1636
    • Wajant, H.1
  • 77
    • 0037381871 scopus 로고    scopus 로고
    • Par-4 for molecular therapy of prostate cancer
    • Butler J, Rangnekar VM. Par-4 for molecular therapy of prostate cancer. Current Drug Targets 2003; 4(3): 223-30.
    • (2003) Current Drug Targets , vol.4 , Issue.3 , pp. 223-230
    • Butler, J.1    Rangnekar, V.M.2
  • 78
    • 0031158978 scopus 로고    scopus 로고
    • Current challenges of gene therapy for prostate cancer
    • discussion 856-861
    • Harrison GS, Glode LM. Current challenges of gene therapy for prostate cancer. Oncology 1997; 11(6), 845-856; discussion 856-861.
    • (1997) Oncology , vol.11 , Issue.6 , pp. 845-856
    • Harrison, G.S.1    Glode, L.M.2
  • 79
    • 0029945161 scopus 로고    scopus 로고
    • Molecular analysis of T lymphocyte-directed gene therapy for adenosine deaminase deficiency: Long-term expression in vivo of genes introduced with a retroviral vector
    • Mullen CA, Snitzer K, Culver KW, Morgan RA, Anderson WF, Blaese RM. Molecular analysis of T lymphocyte-directed gene therapy for adenosine deaminase deficiency: long-term expression in vivo of genes introduced with a retroviral vector. Hum Gene Ther 1996; 7(9), 1123-1129.
    • (1996) Hum. Gene Ther. , vol.7 , Issue.9 , pp. 1123-1129
    • Mullen, C.A.1    Snitzer, K.2    Culver, K.W.3    Morgan, R.A.4    Anderson, W.F.5    Blaese, R.M.6
  • 81
    • 0344188096 scopus 로고    scopus 로고
    • An adenovirus mutant that replicates selectively in p53-deficient human tumor cells
    • Bischoff JR, Kim DH, Williams A, Heise C, Horn S, Muna M, et al. An adenovirus mutant that replicates selectively in p53-deficient human tumor cells. Science 1996; 274(5286), 373-376.
    • (1996) Science , vol.274 , Issue.5286 , pp. 373-376
    • Bischoff, J.R.1    Kim, D.H.2    Williams, A.3    Heise, C.4    Horn, S.5    Muna, M.6
  • 82
    • 0033218746 scopus 로고    scopus 로고
    • Efficacy of a replication-competent adenovirus (ONYX-015) following intratumoral injection: Intratumoral spread and distribution effects
    • Heise CC, Williams A, Olesch J, Kirn DH. Efficacy of a replication-competent adenovirus (ONYX-015) following intratumoral injection: intratumoral spread and distribution effects. Cancer Gene Ther 1999; 6(6), 499-504.
    • (1999) Cancer Gene Ther. , vol.6 , Issue.6 , pp. 499-504
    • Heise, C.C.1    Williams, A.2    Olesch, J.3    Kirn, D.H.4
  • 83
    • 0029151404 scopus 로고
    • Adeno-associated virus vectors for gene therapy
    • Flotte TR, Carter BJ. Adeno-associated virus vectors for gene therapy. Gene Therapy 1995; 2(6), 357-362.
    • (1995) Gene Therapy , vol.2 , Issue.6 , pp. 357-362
    • Flotte, T.R.1    Carter, B.J.2
  • 84
    • 0031728883 scopus 로고    scopus 로고
    • Prospects for gene therapy in human prostate cancer
    • Ficazzola MA, Taneja SS. Prospects for gene therapy in human prostate cancer. Mol Med Today 1998; 4(11), 494-504.
    • (1998) Mol. Med. Today , vol.4 , Issue.11 , pp. 494-504
    • Ficazzola, M.A.1    Taneja, S.S.2
  • 86
    • 0031739086 scopus 로고    scopus 로고
    • Gene transfer: A review of methods and applications
    • Prince HM. Gene transfer: a review of methods and applications. Pathology 1998; 30(4), 335-347.
    • (1998) Pathology , vol.30 , Issue.4 , pp. 335-347
    • Prince, H.M.1
  • 88
    • 0028050467 scopus 로고
    • In vivo gene transfer into rabbit thyroid follicular cells by direct DNA injection
    • Sikes ML, O'Malley BW Jr, Finegold MJ, Ledley FD. In vivo gene transfer into rabbit thyroid follicular cells by direct DNA injection. Hum Gene Ther 1994; 5(7), 837-844.
    • (1994) Hum. Gene Ther. , vol.5 , Issue.7 , pp. 837-844
    • Sikes, M.L.1    O'Malley Jr., B.W.2    Finegold, M.J.3    Ledley, F.D.4
  • 91
  • 92
    • 0038128173 scopus 로고    scopus 로고
    • Application of in vivo electroporation to cancer gene therapy
    • Tamura T, Sakata T. Application of in vivo electroporation to cancer gene therapy. Curr Gene Ther 2003; 3(1): 59-64.
    • (2003) Curr. Gene Ther. , vol.3 , Issue.1 , pp. 59-64
    • Tamura, T.1    Sakata, T.2
  • 93
    • 0034777519 scopus 로고    scopus 로고
    • Ras signaling pathway proteins as therapeutic targets
    • Adjei AA. Ras signaling pathway proteins as therapeutic targets. Curr Pharm Design 2001; 7(16): 1581-94.
    • (2001) Curr. Pharm. Design. , vol.7 , Issue.16 , pp. 1581-1594
    • Adjei, A.A.1
  • 94
    • 0036025366 scopus 로고    scopus 로고
    • Inhibition of NF-kappaB and proteasome activity in tumors: Can we improve the therapeutic potential of topoisomerase I and topoisomerase II poisons
    • Ganapathi R, Vaziri SA, Tabata M, Takigawa N, Grabowski DR, Bukowski RM, et al. Inhibition of NF-kappaB and proteasome activity in tumors: can we improve the therapeutic potential of topoisomerase I and topoisomerase II poisons. Curr Pharm Design 2002; 8(22): 1945-58.
    • (2002) Curr. Pharm. Design. , vol.8 , Issue.22 , pp. 1945-1958
    • Ganapathi, R.1    Vaziri, S.A.2    Tabata, M.3    Takigawa, N.4    Grabowski, D.R.5    Bukowski, R.M.6
  • 95
    • 0036242415 scopus 로고    scopus 로고
    • Growth factors, cytokines and dendritic cell development
    • Vuckovic S, Clark GJ, Hart DN. Growth factors, cytokines and dendritic cell development. Curr Pharm Design 2002; 8(5): 405-18.
    • (2002) Curr. Pharm. Design. , vol.8 , Issue.5 , pp. 405-418
    • Vuckovic, S.1    Clark, G.J.2    Hart, D.N.3


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