Reduction of c-Src activity by substituted 5,7-diphenyl-pyrrolo[2,3-d]- pyrimidines induces osteoclast apoptosis in vivo and in vitro. Involvement of ERK1/2 pathway

Bone

Volumn 34, Issue 1, 2004, Pages 65-79

  Recchia, Irene ^a   Rucci, Nadia ^a   Funari, Alessia ^a   Migliaccio, Silvia ^a   Taranta, Anna ^b   Longo, Maurizio ^c   Kneissel, Michaela ^d   Šuša, Mira ^d   Fabbro, Doriano ^d   Teti, Anna ^a  

^a UNIVERSITY OF L'AQUILA   (Italy)

^b LABORATORIO DI PATOLOGIA VASCOLARE   (Italy)

^c SAPIENZA UNIVERSITY OF ROME   (Italy)

^d NOVARTIS PHARMA AG   (Switzerland)

Author keywords

Apoptosis; Bone resorption; c Src; MAPK; Osteoclast

Indexed keywords

ACTIN; ALENDRONIC ACID; CALCITRIOL; CASPASE 3; CASPASE 8; CASPASE 9; CGP 76030; CGP 77675; CYCLIN DEPENDENT KINASE INHIBITOR; FAS ANTIGEN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BCL XL; PROTEIN P21; PROTEIN P53; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE KINASE INHIBITOR; PYRIMIDINE DERIVATIVE; STRESS ACTIVATED PROTEIN KINASE; SYNAPTOPHYSIN; UNCLASSIFIED DRUG;

ACTIN FILAMENT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL ADHESION; CELL COUNT; CELL DEATH; CELL FUNCTION; CELL MATURATION; CELL NUCLEUS; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; DRUG POTENCY; DRUG SELECTIVITY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; ENZYME REGULATION; FEMALE; HYPERCALCEMIA; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NEWBORN; NONHUMAN; OSTEOCLAST; OSTEOLYSIS; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT;

EID: 0942289886     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bone.2003.06.004     Document Type: Article

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