Elimination of the BKCa channel's high-affinity CA2+ sensitivity

Journal of General Physiology

Volumn 120, Issue 2, 2002, Pages 173-189

  Bao, Lin ^a,b   Rapin, Anne M ^a,b   Holmstrand, Ericka C ^a,b   Cox, Daniel H ^a,b  

^a TUFTS MEDICAL CENTER   (United States)

^b TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Bowl; Ca2+; Ca2+ binding; mSlo; Potassium channel; Slo

Indexed keywords

CALCIUM ION; POTASSIUM CHANNEL; POTASSIUM ION; CALCIUM; CALCIUM ACTIVATED POTASSIUM CHANNEL; LARGE CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL; MAGNESIUM;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; BINDING SITE; CALCIUM BINDING; CONTROLLED STUDY; ENERGY TRANSFER; HYDROPHOBICITY; NONHUMAN; POTASSIUM CONDUCTANCE; SITE DIRECTED MUTAGENESIS; ANIMAL; BINDING COMPETITION; BIOLOGICAL MODEL; DRUG EFFECT; GENETICS; METABOLISM; MUTATION; OOCYTE; PHYSIOLOGY; XENOPUS LAEVIS;

ANIMAL; BINDING SITES; BINDING, COMPETITIVE; CALCIUM; MAGNESIUM; MODELS, BIOLOGICAL; MUTATION; OOCYTES; POTASSIUM CHANNELS, CALCIUM-ACTIVATED; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; XENOPUS LAEVIS; ANIMALS; LARGE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS;

EID: 0036023399     PISSN: 00221295     EISSN: None     Source Type: Journal    
DOI: 10.1085/jgp.20028627     Document Type: Article

References (50)

1. Calcium-activated potassium channels expressed from cloned complementay DNAs
2. Properties of single calcium-activated potassium channels in cultured rat muscle
3. 2+ buffers
4. Ca2+-binding activity of a COOH-terminal fragment of the Drosophila BK channel involved in Ca2+-dependent activation
5. Enzymes that bind nucleotides
6. Contribution of potential EF hand motifs to the calcium-dependent gating of a mouse brain large conductance, calcium-sensitive K(+) channel
7. mSlo, a complex mouse gene encoding "maxi" calcium-activated potassium channels
8. Role of the β1 subunit in large-conductance Ca(2+)-activated K(+) channel gating energetics. Mechanisms of enhanced Ca(2+) sensitivity
9. Allosteric gating of a large conductance Ca-activated K+ channel
10. Allosteric linkage between voltage and Ca(2+)-dependent activation of BK-type mslo1 K(+) channels
11. + channels
12. + (hslo) channel from smooth muscle
13. Role of the S4 segment in a voltage-dependent calcium-sensitive potassium (hSlo) channel
14. Coordination chemistry of alkali and alkali-earth cations with macrocyclic ligands
15. The charybdotoxin receptor of a Shaker K+ channel: Peptide and channel residues mediating molecular recognition
16. Allosteric effects of Mg2+ on the gating of Ca2+-activated K+ channels from mammalian skeletal muscle
17. Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches
18. Revealing the architecture of a K+ channel pore through mutant cycles with a peptide inhibitor
19. Allosteric voltage gating of potassium channels II. Mslo channel gating charge movement in the absence of Ca(2+)
20. Allosteric voltage gating of potassium channels I. Mslo ionic currents in the absence of Ca(2+)
21. Structure of the RCK domain from the E. coli K+ channel and demonstration of its presence in the human BK channel
22. Varieties of calcium-activated potassium channels
23. Crystal structure of the A domain from the alpha subunit of integrin CR3 (CD11b/CD18)
24. Calcium-activated potassium channels: Regulation by calcium
25. A calcium switch for the functional coupling between alpha (hslo) and beta subunits (KV,Ca beta) of maxi K channels
26. The gating of single calcium-dependent potassium channels is described by an activation/blockade mechanism
27. Gating kinetics of Ca2+-activated K+ channels from rat muscle incorporated into planar lipid bilayers. Evidence for two voltage-dependent Ca2+ binding reactions
28. Gating and conductance properties of BK channels are modulated by the S9-S10 tail domain of the alpha subunit. A study of mSlo1 and mSlo3 wild-type and chimeric channels
29. A strongly interacting pair of residues on the contact surface of charybdotoxin and a Shaker K+ channel
30. Physiological roles and properties of potassium channels in arterial smooth muscle
31. Spatial localization of the K+ channel selectivity filter by mutant cycle-based structure analysis
32. Presynaptic calcium signals and transmitter release are modulated by calcium-activated potassium channels
33. Functional colocalization of calcium and calcium-gated potassium channels in control of transmitter release
34. Investigating single-channel gating mechanisms through analysis of two-dimensional dwell-time distributions
35. Voltage and Ca2+ activation of single large-conductance Ca2+-activated K+ channels described by a two-tiered allosteric gating mechanism
36. Energetics of protein-protein interactions: Analysis of the barnase-barstar interface by single mutations and double mutant cycles
37. A novel calcium-sensing domain in the BK channel
38. Slo3, a novel pH-sensitive K+ channel from mammalian spermatocytes
39. Transplantable sites confer calcium sensitivity to BK channels
40. Structure of the gating domain of a Ca2+-activated K+ channel complexed with Ca2+/calmodulin
41. Tetraethylammonium block of Slowpoke calcium-activated potassium channels expressed in Xenopus oocytes: Evidence for tetrameric channel formation
42. Intracellular Mg(2+) enhances the function of BK-type Ca(2+)-activated K(+) channels
43. Voltage-controlled gating in a large conductance Ca2+-sensitive K+channel (hslo)
44. Electrostatic distance geometry in a K+ channel vestibule
45. Complex voltage-dependent behavior of single unliganded calcium-sensitive potassium channels
46. Molecular mechanism for ligand discrimination of cyclic nucleotide-gated channels
47. Calcium sensitivity of BK-type KCa channels determined by a separable domain
48. A helical region in the C terminus of small-conductance Ca2+-activated K+ channels controls assembly with apo-calmodulin
49. Mechanism of calcium gating in small-conductance calcium-activated potassium channels
50. Allosteric regulation of BK channel gating by Ca(2+) and Mg(2+) through a nonselective, low affinity divalent cation site