Potassium Channels: Symmetric, Selective, and Sensitive

Angewandte Chemie - International Edition

Volumn 42, Issue 46, 2003, Pages 5671-5675

  Trauner, Dirk ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Ion channels; Membranes; Neurobiology; Protein structures; Structure elucidation

Indexed keywords

CELL MEMBRANES; CRYSTAL STRUCTURE; X RAY ANALYSIS;

ION CHANNELS;

POTASSIUM;

CARBONYL DERIVATIVE; KCSA PROTEIN; MEMBRANE PROTEIN; PEPTIDE; POTASSIUM ION; UNCLASSIFIED DRUG; WATER;

CELL MEMBRANE; CHANNEL GATING; CRYSTAL STRUCTURE; CRYSTALLIZATION; ION CHANNEL; NEUROBIOLOGY; NONHUMAN; POTASSIUM CHANNEL; PROKARYOTE; PROTEIN STRUCTURE; REVIEW; STRUCTURE ANALYSIS; X RAY ANALYSIS;

ANIMALS; ION CHANNEL GATING; MODELS, MOLECULAR; POTASSIUM CHANNELS; PROTEIN STRUCTURE, QUATERNARY; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

EID: 0348134918     PISSN: 14337851     EISSN: None     Source Type: Journal    
DOI: 10.1002/anie.200301724     Document Type: Review

References (19)

1. a) B. Hille, Ion Channels of Excitable Membranes, 3rd ed., Sinauer, Sunderland, 2001;
2. b) F. M. Ashcroft, Ion Channels and Disease, Academic, San Diego, 2000;
3. c) C. A. Hübner, T. J. Jentsch, Hum. Mol. Genet. 2002, 11, 2435;
4. d) G. Yellen, Nature 2002, 419, 35.
5. M. L. Garcia, Y. D. Gao, O. B. McManus, G. J. Kaczorowski, Toxicon 2001, 39, 739.
6. R. MacKinnon, S. L. Cohen, A. Kuo, A. Lee, B. T. Chait, Science 1998, 280, 106.
7. Y. X. Jiang, V. Ruta, J. Y. Chen, A. Lee, R. MacKinnon, Nature 2003, 423, 42.
8. D. A. Doyle, J. M. Cabral, R. A. Pfuetzner, A. L. Kuo, J. M. Gulbis, S. L. Cohen, B. T. Chait, R. MacKinnon, Science 1998, 280, 69.
9. Y. F. Zhou, J. H. Morais-Cabral, A. Kaufman, R. MacKinnon, Nature 2001, 414, 43.
10. a) Y. X. Jiang, A. Lee, J. Y. Chen, M. Cadene, B. T. Chait, R. MacKinnon, Nature 2002, 417, 515;
11. b) Y. X. Jiang, A. Lee, J. Y. Chen, M. Cadene, B. T. Chait, R. MacKinnon, Nature 2002, 417, 523.
12. a) Y. X. Jiang, A. Lee, J. Y. Chen, V. Ruta, M. Cadene, B. T. Chait, R. MacKinnon, Nature 2003, 423, 33;
13. b) Y. X. Jiang, V. Ruta, J. Y. Chen, A. Lee, R. MacKinnon, Nature 2003, 423, 42.
14. a) B. E. Cohen, M. Grabe, L. Y. Jan, Neuron 2003, 39, 395;
15. b) C. Miller, Nat. Struct. Biol. 2003, 10, 422.
16. D. M. Papazian, T. L. Schwarz, B. L. Tempel, Y. N. Jan, L. Y. Jan, Science 1987, 237, 749.
17. A. L. Kuo, J. M. Gulbis, J. F. Antcliff, T. Rahman, E. D. Lowe, J. Zimmer, J. Cuthbertson, F. M. Ashcroft, T. Ezaki, D. A. Doyle, Science 2003, 300, 1922.
18. J. M. Gulbis, M. Zhou, S. Mann, R. MacKinnon, Science 2000, 289, 123.
19. S. N. Gradl, J. P. Felix, E. Y. Isacoff, M. L. Garcia, D. Trauner, J. Am. Chem. Soc. 2003, 125, 12668.