Examination of the role of the acidic hydrogen in imparting selectivity of 7-(aminosulfonyl)-1,2,3,4-tetrahydroisoquinoline (SK and F 29661) toward inhibition of phenylethanolamine N-methyltransferase vs the α2-adrenoceptor

Journal of Medicinal Chemistry

Volumn 40, Issue 25, 1997, Pages 3997-4005

  Grunewald, Gary L ^a   Dahanukar, Vilas H ^a   Caldwell, Timothy M ^a   Criscione, Kevin R ^a  

^a UNIVERSITY OF KANSAS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,2,3,4 TETRAHYDRO 7 ISOQUINOLINESULFONAMIDE; 7 ((N (METHYLSULFONYL)AMINO)METHYL) 1,2,3,4 TETRAHYDROISOQUINOLINE; ALPHA 2 ADRENERGIC RECEPTOR; ENZYME INHIBITOR; UNCLASSIFIED DRUG;

ADRENERGIC RECEPTOR BLOCKING; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; DRUG CONFORMATION; ELECTRON TRANSPORT; ENZYME INHIBITION; HYDROGEN BOND; MALE; NONHUMAN; PH MEASUREMENT; RAT; RECEPTOR AFFINITY; RECEPTOR BINDING;

ANIMALS; CLONIDINE; ENZYME INHIBITORS; ISOQUINOLINES; MALE; PHENYLETHANOLAMINE N-METHYLTRANSFERASE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ADRENERGIC, ALPHA-2; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0031443518     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm960235e     Document Type: Article

References (36)

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