Effect of ring size or an additional heteroatom on the potency and selectivity of bicyclic benzylamine-type inhibitors of phenylethanolamine N- methyltransferase

Journal of Medicinal Chemistry

Volumn 39, Issue 18, 1996, Pages 3539-3546

  Grunewald, Gary L ^a   Dahanukar, Vilas H ^a   Ching, Piao ^a,b   Criscione, Kevin R ^a  

^a UNIVERSITY OF KANSAS   (United States)

^b UNIVERSITY OF KANSAS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA 2 ADRENERGIC RECEPTOR; BENZYLAMINE DERIVATIVE; BICYCLO COMPOUND; CLONIDINE; PHENTOLAMINE; PHENYLETHANOLAMINE N METHYLTRANSFERASE; RADIOLIGAND; TRANSFERASE INHIBITOR;

ANIMAL TISSUE; ARTICLE; CALCULATION; COMPETITIVE INHIBITION; DRUG ACTIVITY; DRUG CONFORMATION; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; ENZYME INHIBITION; ENZYME PURIFICATION; MALE; MOLECULAR MODEL; NONHUMAN; RAT; STEREOCHEMISTRY;

ANIMALS; BENZYLAMINES; ENZYME INHIBITORS; MALE; PHENYLETHANOLAMINE N-METHYLTRANSFERASE; RATS; RATS, SPRAGUE-DAWLEY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0029795609     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm9508292     Document Type: Article

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