Rational Design of an Indolebutanoic Acid Derivative as a Novel Aldose Reductase Inhibitor Based on Docking and 3D QSAR Studies of Phenethylamine Derivatives

Journal of Medicinal Chemistry

Volumn 46, Issue 26, 2003, Pages 5619-5627

  Sun, Won Suck ^a   Park, Yoon Sun ^a   Yoo, Jakyung ^b   Park, Ki Duk ^a   Kim, Sung Han ^a   Kim, Jung Han ^a   Park, Hyun Ju ^b  

^a Yonsei University   (South Korea)

^b Sungkyunkwan University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

4 OXO 4 (4 HYDROXYINDOLE)BUTANOIC ACID; ALDEHYDE REDUCTASE; ALDOSE REDUCTASE INHIBITOR; BUTYRIC ACID DERIVATIVE; INDOLEBUTANOIC ACID DERIVATIVE; N 2 METHYLBUTANOYLTYRAMINE; PHENETHYLAMINE DERIVATIVE; TOLRESTAT; UNCLASSIFIED DRUG; YUA 001;

ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; DRUG BINDING SITE; DRUG DESIGN; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HYDROGEN BOND; HYDROPHOBICITY; IC 50; KIDNEY; NONHUMAN; QUANTITATIVE STRUCTURE ACTIVITY RELATION; SWINE;

ALDEHYDE REDUCTASE; ANIMALS; BUTYRIC ACIDS; ENZYME INHIBITORS; INDOLES; KIDNEY; MODELS, MOLECULAR; PHENETHYLAMINES; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; SWINE;

EID: 0347627163     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0205346     Document Type: Article

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