Synthesis, activity, and molecular modeling of a new series of tricyclic pyridazinones as selective aldose reductase inhibitors

Journal of Medicinal Chemistry

Volumn 39, Issue 22, 1996, Pages 4396-4405

  Costantino, Luca ^a   Rastelli, Giulio ^a   Vescovini, Katia ^a   Cignarella, Giorgio ^b   Vianello, Paola ^b   Del Corso, Antonella ^c   Cappiello, Mario ^c   Mura, Umberto ^d   Barlocco, Daniela ^a  

^a Dipto di Scienze Farmaceutiche   (Italy)

^b Istituto Chim Farmaceutico E Tossicologico   (Italy)

^c Dipto di Fisiologia e Biochimica   (Italy)

^d UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ALDEHYDE REDUCTASE; ALDOSE REDUCTASE INHIBITOR; GLUTATHIONE REDUCTASE; IDITOL DEHYDROGENASE; OXIDOREDUCTASE; PYRIDAZINONE DERIVATIVE; QUERCETIN; SORBINIL; TOLRESTAT;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG SPECIFICITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; MOLECULAR DYNAMICS; MOLECULAR MODEL; NONHUMAN;

ALDEHYDE REDUCTASE; ANIMALS; CATTLE; GLUTATHIONE REDUCTASE; L-IDITOL 2-DEHYDROGENASE; MODELS, MOLECULAR; MOLECULAR CONFORMATION; PROTEIN CONFORMATION; PYRIDAZINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0029911124     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm960124f     Document Type: Article

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