Relationships between structure and high-throughput screening permeability of peptide derivatives and related compounds with artificial membranes: Application to prediction of Caco-2 cell permeability

Bioorganic and Medicinal Chemistry

Volumn 12, Issue 1, 2004, Pages 257-264

  Ano, Rieko ^a   Kimura, Yukitaka ^a   Shima, Motohiro ^a   Matsuno, Ryuichi ^a   Ueno, Tamio ^a   Akamatsu, Miki ^a  

^a KYOTO UNIVERSITY   (Japan)

Author keywords

Artificial membrane; Caco 2; Dipeptide derivatives; Indole compounds; PAMPA; Structure permeability relationships

Indexed keywords

3 INDOLECARBOXYLIC ACID; ACETYL DEXTRO TRYPTOPHYLVALINAMIDE; ACETYLTRYPTOPHANAMIDE; ACETYLTRYPTOPHYLVALINAMIDE; ACETYLTYROSYLLEUCINAMIDE; ACETYLTYROSYLPHENYLALANINAMIDE; CYCLO(TRYPTOPHYLGLYCINE); CYCLO(TRYPTOPHYLTRYPTOPHAN); CYCLO(TRYPTOPHYLTYROSINE); GLYCYLTRYPTOPHANAMIDE; INDOLE DERIVATIVE; INDOLEACETAMIDE; INDOLEACETIC ACID; INDOLEPROPIONIC ACID; PEPTIDE DERIVATIVE; PHENYLALANYLTRYPTOPHANAMIDE; TERT BUTYLOXYCARBONYLTRYPTOPHAN; TRYPTAMINE; TRYPTOPHANAMIDE; TRYPTOPHOL; TRYPTOPHYLALANYLVALINAMIDE; UNCLASSIFIED DRUG;

ARTICLE; ARTIFICIAL MEMBRANE; CELL MEMBRANE PERMEABILITY; CELL STRAIN CACO 2; CONTROLLED STUDY; DRUG ABSORPTION; DRUG PENETRATION; DRUG SCREENING; HUMAN; HUMAN CELL; HYDROGEN BOND; HYDROPHOBICITY; INTESTINE EPITHELIUM CELL; LIPID MEMBRANE; MOLECULE; PH; PHYSICAL CHEMISTRY; PREDICTION; QUANTITATIVE ANALYSIS; QUANTITATIVE STRUCTURE ACTIVITY RELATION;

EID: 0347301796     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2003.10.002     Document Type: Article

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