Use of Caco-2 cells and LC/MS/MS to screen a peptide combinatorial library for permeable structures

International Journal of Pharmaceutics

Volumn 177, Issue 1, 1999, Pages 103-115

  Stevenson, Cynthia L ^a   Augustijns, Patrick F ^a   Hendren, R Wayne ^a  

^a GLAXOSMITHKLINE   (United States)

Author keywords

Caco 2 cell monolayers; Combinatorial peptide libraries; LC MS MS; Oral absorption

Indexed keywords

DIPEPTIDE; PEPTIDE; PEPTIDE LIBRARY; SYNTHETIC PEPTIDE; TRIPEPTIDE;

ARTICLE; CELL STRAIN CACO 2; CONTROLLED STUDY; DRUG ABSORPTION; DRUG PENETRATION; HUMAN; HUMAN CELL; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; ORAL DRUG ADMINISTRATION; PEPTIDE SYNTHESIS; PRIORITY JOURNAL; SCREENING;

ADMINISTRATION, ORAL; ADMINISTRATION, TOPICAL; BIOLOGICAL AVAILABILITY; CACO-2 CELLS; EPITHELIUM; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HUMANS; PEPTIDES;

EID: 0032903489     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(98)00331-7     Document Type: Article

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