Efficient calf thymus DNA condensation upon binding with novel bile acid polyamine amides

Bioconjugate Chemistry

Volumn 13, Issue 3, 2002, Pages 481-490

  Geall, Andrew J ^a   Al Hadithi, Dima ^a   Blagbrough, Ian S ^a  

^a University of Bath   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMIDES; BINDING ENERGY; CONDENSATION; FLUORESCENCE QUENCHING; GENE THERAPY; GENE TRANSFER; LIGHT SCATTERING; LIPOSOMES; MICELLES; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PH; POSITIVE IONS; SELF ASSEMBLY;

ACYLATIONS; BILE ACID; CALF THYMUS; CHOLIC ACIDS; DNA CONDENSATION; LITHOCHOLIC ACIDS; PHYSIOLOGICAL PH; POLYAMINES; POLYAMMONIUM; TETRAAMINES;

DNA;

HELIOTHIS ZEA VIRUS 1;

BILE ACID; CALF THYMUS DNA; DNA; DRUG DERIVATIVE; ETHIDIUM; NORSPERMINE; POLYAMINE; POLYLYSINE; SPERMINE;

ANIMAL; ARTICLE; BINDING SITE; CATTLE; CHEMISTRY; GENE THERAPY; METABOLISM; SPECTROFLUOROMETRY;

ANIMALS; BILE ACIDS AND SALTS; BINDING SITES; CATTLE; DNA; ETHIDIUM; GENE THERAPY; POLYAMINES; POLYLYSINE; SPECTROMETRY, FLUORESCENCE; SPERMINE;

EID: 0036000122     PISSN: 10431802     EISSN: None     Source Type: Journal    
DOI: 10.1021/bc000093+     Document Type: Article

References (107)

1. New chemistry of naturally occurring polyamines
2. Polyamines
3. Methods for selective modification of spermidine and its homologues
4. Gene transfer with synthetic cationic amphiphiles: Prospects for gene therapy
5. Polyamines as targets for therapeutic intervention
6. Polyamines and polyamine amides as potent selective receptor probes, novel therapeutic lead compounds, and synthetic vectors in gene therapy
7. Cationic facial amphiphiles: A promising class of transfection agents
8. Chemistry and cellular aspects of cationic facial amphiphiles
9. Nucleic acid interactions. V. Effects of cyclobuxine
10. Nucleic acid interactions. VI. Effects of steroidal diamines
11. Nucleic acid-small molecule interactions. VII. Further characterization of deoxyribonucleic acid-diamino steroid complexes
12. Variation of the supercoils in closed circular DNA by binding of antibiotics and drugs: Evidence for molecular models involving intercalation
13. Poisonous substance of toads
14. Toad poisons. (XI). Constitution of bufotalin
15. Steroids and related natural-products. 104. Synthesis of Bufalitoxin and Bufotoxin. 36. Bufadienolides
16. Molecular umbrellas
17. Design and synthesis of molecular umbrellas
18. Novel cationic amphiphiles as delivery agents for antisense oligonucleotides
19. Squalamine - An aminosterol antibiotic from the shark
20. Synthesis of squalamine. A steroidal antibiotic from the shark
21. Stereoselective synthesis of squalamine dessulfate
22. Rapid construction of a squalamine mimic
23. Spermine and thermine conjugates of cholic acid condense DNA, but lithocholic acid polyamine conjugates do so more efficiently
24. a studies and condensation of calf thymus DNA
25. Homologation of polyamines in the rapid synthesis of lipospermine conjugates and related lipoplexes
26. Practical synthesis of unsymmetrical polyamine amides
27. Homologation of polyamines in the synthesis of lipo-spermine conjugates and related lipoplexes
28. a studies and condensation of calf thymus DNA
29. DNA condensation by bile acid conjugates of thermine and spermine
30. DNA condensation by cholesterol polyamine carbamates
31. The regiochemical distribution of positive charges along cholesterol polyamine carbamates plays significant roles in modulating DNA binding affinity and lipofection
32. The interaction of spermine and pentamines with DNA
33. Structural specificity of polyamines in left-handed Z-DNA formation: Immunological and spectroscopic studies
34. n insert
35. Interactions between acyclic and cyclic peralkylammonium compounds and DNA. 33
36. DNA aggregation induced by polyamines and cobalthexamine
37. Ionic and structural specificity effects of natural and synthetic polyamines on the aggregation and resolubilization of single-, double-, and triplestranded DNA
38. Condensation of DNA by multivalent cations - Considerations on mechanism
39. DNA condensation
40. DNA condensation by multivalent cations
41. Efficient gene transfer into mammalian primary endocrine cells with lipopolyamine-coated DNA
42. Novel polyaminolipids enhance the cellular uptake of oligonucleotides
43. Detailed analysis of structures and formulations of cationic lipids for efficient gene transfer to the lung
44. Efficient gene transfer into mammalian cells with cholesteryl-spermidine
45. Transfection of myoblasts in primary culture with isomeric cationic cholesterol derivatives
46. Synthesis, activity, and structure-activity relationship studies of novel cationic lipids for DNA transfer
47. Gene transfer with lipospermines and polyethylenimines
48. Cellular uptake of cationic lipid/DNA complexes by cultured myoblasts and myotubes
49. Transfer of genes to humans. Early lessons and obstacles to success
50. Nonviral strategies for gene therapy
51. Gene geniuses
52. Cationic lipid-based gene delivery systems: Pharmaceutical perspectives
53. Gene therapy - Promises, problems and prospects
54. Structural effects in novel steroidal polyamine-DNA binding
55. Synthesis and DNA binding properties of C3-, C12-, and C24-substituted amino-steroids derived from bile acids
56. Hydrophobic vs Coulombic interactions in the binding of steroidal polyamines to DNA
57. Nomenclature for synthetic gene delivery systems
58. Potential antitumor agents. 28. Deoxyribonucleic acid polyintercalating agents
59. Mode of formation and structural features of DNA-cationic liposome complexes used for transfection
60. Nuclear magnetic resonance spectroscopy of bile acids. Development of two-dimensional NMR methods for the elucidation of proton resonance assignments for five common hydroxylated bile acids, and their parent bile acid, 5β-cholanoic acid
61. 1-spermine probed by LD, CD, normal absorption, and molecular modelling compared with those of spermidine and spermine
62. 1-spermine with poly[d(G-C).d(G-C)] and poly[d(A-T).d(A-T)]
63. Multiple DNA-binding modes of anthracene-9-carbonyl-N1 spermine
64. Asymmetric intercalation of N1-(acridin-9-ylcarbonyl)spermine at homopurine sites of duplex DNA
65. Electrostatics and biological systems
66. The binding of spermine and magnesium to DNA
67. Existence of an extended series of antitumor compounds which bind to deoxyribonucleic acid by nonintercalative means
68. The effect of structural changes in a polyamine backbone on its DNA-binding properties
69. Synthesis and DNA-binding properties of polyamine analogues
70. Survey of the DNA binding properties of natural and synthetic polyamino compounds
71. Differential effects of spermine and its analogues on the structures of polynucleotides complexed with ethidium bromide
72. Boron-containing polyamines as DNA targeting agents for neutron capture therapy of brain tumors: Synthesis and biological evaluation
73. Visualization of drug-nucleic acid interactions at atomic resolution
74. 6
75. A constant radius of curvature model for the organization of DNA in toroidal condensates
76. Double-stranded DNA organization in bacteriophage heads: An alternative toriod-based model
77. Molecular flexibility of extended and compacted polynucleosomes - A steady-state fluorescence polarization study
78. Effects of variation in the structure of spermine on the association with DNA and the induction of DNA conformational changes
79. Counterion-induced condensation of deoxyribonucleic acid. A light-scattering study
80. The molecular theory of polyelectrolyte solutions with applications to the electrostatic properties of polynucleotides
81. 2 duplex: Calorimetric and spectroscopic studies
82. The interaction of nucleic acids with diamines
83. Diaminoalkanes with an odd number of carbon atoms induce compaction of a single double-stranded DNA chain
84. Interaction of polynucleotides with natural and model membranes
85. Liposomes as agents of DNA transfer
86. New structures in complex formation between DNA and cationic liposomes visualized by freeze-fracture electron microscopy
87. Formation of novel hydrophobic complexes between cationic lipids and plasmid DNA
88. Lipid/DNA complexes as an intermediate in the preparation of particles for gene transfer: An alternative to cationic liposome/DNA aggregates
89. Compact form of DNA induced by spermidine
90. DNA condensation with polyamines I. Spectroscopic studies
91. DNA condensation with polyamines II. Electron microscopic studies
92. High-resolution atomic-force microscopy of DNA: The pitch of the double helix
93. DNA condensation for gene therapy as monitored by atomic force microscopy
94. The observation of the local ordering characteristics of spermidine-condensed DNA: Atomic force microscopy and polarizing microscopy studies
95. High-yield preparation of oligomeric C-type DNA toroids and their characterization by cryoelectron microscopy
96. Salt nucleic acid interactions
97. Large electrostatic differences in the binding thermodynamics of a cationic peptide to oligomeric and polymeric DNA
98. Analysis of effects of salts and uncharged solutes on protein and nucleic acid equilibria and processes: A practical guide to recognizing and interpreting polyelectrolyte effects. Hofmeister effects, and osmotic effects of salts
99. The importance of Coulombic end effects: Experimental characterization of the effects of oligonucleotide flanking charges on the strength and salt dependence of oligocation (L8+) binding to single-stranded DNA oligomers
100. Molecular mechanics of the formation of cholic acid micelles
101. Enhancing the "stickiness" of bile acids to cross-linked polymers: A bioconjugate approach to the design of bile acid sequestrants
102. Cheno-, urso- and deoxycholic acid spermine conjugates: Relative binding affinities for calf thymus DNA
103. DNA bending by small, mobile multivalent cations
104. Nucleation of DNA condensation by static loops: Formation of DNA toroids with reduced dimensions