Lack of association between UCP2 gene polymorphisms and obesity phenotype in Italian Caucasians

Journal of Endocrinological Investigation

Volumn 26, Issue 10, 2003, Pages 985-990

  Maestrini, S ^a   Podesta F ^a,b   Di Blasio, A M ^a   Savia, G ^a   Brunani, A ^a   Tagliaferri, A ^a   Mencarelli, M ^a   Chiodini, I ^c   Liuzzi, Antonio ^a  

^a ISTITUTO AUXOLOGICO ITALIANO   (Italy)

^b UNIVERSITY OF MILAN   (Italy)

^c San Giuseppe Hospital   (Italy)

Author keywords

Diabetes; Genotype; Obesity; Polymorphism; Uncoupling protein2 (UCP2)

Indexed keywords

ALANINE; CHOLESTEROL; GLUCOSE; GLYCOSYLATED HEMOGLOBIN; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; IMMUNOREACTIVE INSULIN; INSULIN; LEPTIN; ORAL ANTIDIABETIC AGENT; THYROID HORMONE; THYROTROPIN; THYROXINE; TRIACYLGLYCEROL; UNCOUPLING PROTEIN 2; VALINE;

3' UNTRANSLATED REGION; ADIPOSE TISSUE; ADULT; ALLELE; AMINO ACID SUBSTITUTION; ANTHROPOMETRIC PARAMETERS; ARTICLE; BODY FAT; BODY MASS; BODY WEIGHT; CALORIC INTAKE; CAUCASIAN; CODON; DIABETES MELLITUS; DIET THERAPY; ENERGY EXPENDITURE; ETHNIC GROUP; EXON; FEMALE; GENE DELETION; GENE INSERTION; GENE STRUCTURE; GENETIC ASSOCIATION; GENETIC CODE; GENETIC POLYMORPHISM; GENETIC VARIABILITY; GENOTYPE; HEAT; HIP; HUMAN; INSULIN SENSITIVITY; ITALY; LEAN BODY WEIGHT; MAJOR CLINICAL STUDY; MALE; MEASUREMENT; METABOLIC PARAMETERS; MORBID OBESITY; OBESITY; PATHOGENESIS; PHENOTYPE; RESPIRATION CONTROL; REST; THERMOGENESIS;

EID: 0346368465     PISSN: 03914097     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF03348196     Document Type: Article

References (31)

1. Borecki IB, Blangero J, Rice T, Perusse L, Bouchard C, Rao DC. Evidence for at least two major loci influencing human fatness. Am J Hum Genet 1998, 63: 831-8.
2. Montague CT, Sadaf Farooqi I, Whitehead JP, et al. Congenital leptin deficiency is associated with severe early onset obesity in humans. Nature 1997, 387: 903-8.
3. Strobel A, Issad T, Camoin L, Ozata M, Strosberg AD. A leptin missense mutation associated with hypogonadism and morbid obesity. Nat Genet 1998, 18: 213-5.
4. Clement K, Vaisse C, Laholou N, et al. A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction. Nature 1998, 392: 398-401.
5. Wisse BE, Schwartz MW. Role of melacortins in control of obesity. Lancet 2001, 358: 857-9.
6. Jequier E. Does a thermogenic defect play a role in the pathogenesis of human obesity? Clin Physiol 2002, 3: 1-7.
7. Nicholls DG, Locke RM. Thermogenic mechanism in brown fat. Physiol Rev 1984, 64: 1-64.
8. Lean M, James WP, Jennings G, Trayhurn P. Brown adipose tissue uncoupling protein content in human infants, children and adults. Clin Sci (Oxf) 1986, 71: 291-7.
9. Millet L, Vidal H, Andreelli F, et al. Increased uncoupling 2 and 3 mRNA expression during fasting in obese and lean humans. J Clin Invest 1997, 100: 2665-70.
10. Weigle DS, Selfridge LE, Schwartz MW, et al. Elevated free fatty acids induce uncoupling protein 3 expression in muscle: A potential explanation for the effect of fasting. Diabetes 1998, 47: 289-302.
11. Carkin J, Mull E, Miao W, et al. Regulation of the thyroid member of the uncoupling protein family, UCP3, by cold and thyroid hormone. Biochem Biophys Res Commun 1997, 240: 222-7.
12. Gong DW, He Y, Karas M, Reitman M. Uncoupling protein 3 is a mediator of thermogenesis regulated by thyroid hormone beta 3-adrenergic agonist and leptin. J Biol Chem 1997, 272: 24129-32.
13. Pedersen O, Dalgaard LT. Uncoupling proteins: Functional characteristics and role in the pathogenesis of obesity and Type II diabetes. Diabetologia 2001, 44: 946-65.
14. Urhammer SA, Dalgaard LT, Sorensen TIA, et al. Mutational analysis of the coding region of the uncoupling protein 2 gene in obese NIDDM patients: Impact of a common amino acid polymorphism on juvenile and maturity onset forms of obesity and insulin resistance. Diabetologia 1997, 40: 1227-30.
15. Otabe S, Clement K, Rich N, et al. Mutation screening of the human UCP 2 gene in normoglycemic and NIDDM morbidly obese patients. Diabetes 1998, 47: 840-2.
16. Walder K, Norman RA, Hanson RL, et al. Association between uncoupling protein polymorphisms (UCP2-UCP3) and energy metabolism/obesity in Pima Indians. Hum Mol Genet 1998, 7: 1431-5.
17. Cassell PG, Neverova M, Jammohamed S, et al. An uncoupling protein 2 gene variant is associated with a raised body mass index but not Type II diabetes. Diabetologia 1999, 42: 688-92.
18. Wadden TA, Bartlet S, Letizia KA, Foster GD, Stunkard AJ. Relationship of dieting history to resting metabolic rate, body composition, eating behavior, and subsequent weight loss. Am J Clin Nutr 1992, 56: 203S-8S.
19. Katz A, Nambi SS, Mather K, et al. Quantitative insulin sensitivity check index: A simple accurate method for assessing insulin sensitivity in humans. J Clin Endocrinol Metab 2000, 85: 2402-10.
20. Kubota T, Mori H, Tamori Y. Molecular screening of uncoupling protein 2 gene in patients with noninsulin-dependent diabetes mellitus or obesity. J Clin Endocrinol Metab 1998, 83: 2800-4.
21. Klannemark M, Orho M, Groop L. No relationship between identified variants in the uncoupling protein 2 gene and energy expenditure. Eur J Endocrinol 1998, 139: 217-23.
22. Tu N, Chen H, Winnikes U, et al. Structural organization and mutational analysis of the human uncoupling protein-2 (hUCP2)gene. Life Sci 1999, 64: PL41-50.
23. Yanovski JA, Diament AL, Sovik KN, Nguyen TT, Li H, Sebring NG, Warden C. Associations between uncoupling protein 2, body composition, and resting energy expenditure in lean and obese African American, white, and Asian children. Am J Clin Nutr 2000, 71: 1405-12.
24. Astrup A, Toubro S, Dalgaard LT, et al. Impact of the V/V 55 polymorphism of the uncoupling protein 2 gene on 24-h energy expediture and substrate oxidation. Int J Obes Relat Metab Disord 1999, 23: 1030-4.
25. Dalgaard LT, Sorensen TIA, Andersen T, Hansen T, Pedersen O. An untranslated insertion variant in the uncoupling protein 2 gene is not related to body mass index and changes in body weight during a 26-year follow-up in Danish Caucasian men. Diabetologia 1999, 42: 1413-6.
26. Van Rossum CTM, Hoebee B, Seidell JC, et al. Genetic factors as predictors of weight gain in young adult Dutch men and women. Int J Obes Relat Metab Disord 2002, 26: 517-28.
27. Langin D. Diabetes, insulin secretion, and the pancreatic beta-cell mitochondrion. N Engl J Med 2001, 345: 1772-4.
28. Chan CB, De Leo D, Joseph JW, et al. Increased uncoupling protein-2 levels in β-cells are associated with impaired glucose-stimulated insulin secretion. Diabetes 2001, 50: 1302-10.
29. Saleh MC, Wheeler MB, Chan CB. Uncoupling protein-2: Evidence for its function as a metabolic regulator. Diabetologia 2002, 45: 174-87.
30. Esterbauer H, Schneiter C, Oberkofler H, et al. A common polymorphism in the promoter of UCP2 is associated with decreased risk of obesity in middle-aged humans. Nat Gen 2001, 28: 178-83.
31. Krempler F, Esterbauer H, Weitgasser R, et al. A functional polymorphism in the promoter of UCP2 enhances obesity risk but reduces type-2 diabetes risk in obese middle-aged humans. Diabetes 2002, 51: 3331-5.