Evidence for at least two major loci influencing human fatness

American Journal of Human Genetics

Volumn 63, Issue 3, 1998, Pages 831-838

  Borecki, Ingrid B ^a   Blangero, John ^b   Rice, Treva ^a   Pérusse, Louis ^c   Bouchard, Claude ^c   Rao, D C ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b SOUTHWEST FOUNDATION FOR BIOMEDICAL RESEARCH   (United States)

^c UNIVERSITÉ LAVAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ADOLESCENT; ADULT; ARTICLE; BODY MASS; BODY WEIGHT; CHILD; FEMALE; GENE LOCUS; HUMAN; MALE; OBESITY; PEDIGREE; PHENOTYPE; PLEIOTROPY; PRIORITY JOURNAL;

EID: 0032231716     PISSN: 00029297     EISSN: None     Source Type: Journal    
DOI: 10.1086/302006     Document Type: Article

References (29)

1. Akaike H (1974) A new look at the statistical model identification. IEEE Trans Automat Control 19:716-723
2. Blangero J, Konigsberg LW (1991) Multivariate segregation analysis using the mixed model. Genet Epidemiol 8:299-316
3. Blangero J, MacCluer JW, Kammerer CM, Mott GE, Dyer TD, McGill HC Jr (1990) Genetic analysis of apolipoprotein A-I in two dietary environments. Am J Hum Genet 47:414-428
4. Borecki IB, Bonney GE, Rice T, Bouchard C, Rao DC (1993) Influence of genotype-dependent effects of covariates on the outcome of segregation analysis of the body mass index. Am J Hum Genet 53:676-687
5. Borecki IB, Higgins M, Schreiner PJ, Arnett DK, Mayer-Davis E, Hunt SC, Province MA (1998) Evidence for multiple determinants of the body mass index: the National Heart, Lung, and Blood Institute Family Heart Study. Obes Res 6: 107-114
6. Borecki IB, Rice T, Bouchard C, Rao DC (1991) Commingling analysis of generalized body mass and composition measures: the Québec Family Study. Int J Obes 15:763-773
7. Borecki IB, Rice T, Pérusse L, Bouchard C, Rao DC (1995) Major gene influence on the propensity to store fat in trunk versus extremity depots: evidence from the Quebec Family Study. Obes Res 3:1-8
8. Bouchard C, Pérusse L (1988) Heredity and body fat. Ann Rev Nutr 8:259-277
9. Bouchard C, Rice T, Lemieux S, Despres JP, Perusse L, Rao DC (1996) Major gene for abdominal visceral fat area in the Quebec Family Study. Int J Obes Relat Metab Disord 20:420-427
10. Chagnon YC, Perusse L, Bouchard C (1998) The human obesity gene map: the 1997 update. Obes Res 6:76-92
11. Comuzzie AG, Blangero J, Mahaney MC, Mitchell BD, Hixson JE, Samollow PM, Stern MP, et al (1995) Major gene with sex-specific effects influences fat mass in Mexican-Americans. Genet Epidemiol 12:475-488
12. Comuzzie AG, Hixson JE, Almasy L, Mitchell BD, Mahaney MC, Dyer TD, Stern MP, et al (1997) A major quantitative trait locus determining serum leptin levels and fat mass is located on human chromosome 2. Nat Genet 15:273-276
13. Garrison RJ, Higgins MW, Kannel WB (1996) Obesity and coronary heart disease. Curr Opin Lipidol 7:199-202
14. Hasstedt SJ (1989) Pedigree Analysis Package, v3.0. Department of Human Genetics, University of Utah, Salt Lake City
15. Hasstedt SJ, Hoffman M, Leppert MF, Elbein SC (1997) Recessive inheritance of obesity in familial non-insulin-dependent diabetes mellitus, and lack of linkage to nine candidate genes. Am J Hum Genet 61:668-677
16. Hasstedt SJ, Ramirez ME, Kuida H, Williams RR (1989) Recessive inheritance of a relative fat pattern. Am J Hum Genet 45:917-925
17. Lecomte E, Herbeth B, Nicaud V, Rakotovao R, Artur Y, Tiret L (1997) Segregation analysis of fat mass and fat-free mass with age-and sex-dependent effects: the Stanislas Family Study. Genet Epidemiol 14:51-62
18. Moll PP, Burns TL, Lauer RM (1991) The genetic and environmental sources of body mass index variability: the Muscatine ponderosity family study. Am J Hum Genet 49: 1243-1255
19. Norman RA, Thompson DB, Foroud T, Garvey WT, Bennett PH, Bogardus C, Ravussin E, et al (1997) Genomewide search for genes influencing percent body fat in Pima Indians: suggestive linkage at chromosome 11q21-q22. Am J Hum Genet 60:166-173
20. Pérusse L, Rice T, Bouchard C, Vogler GP, Rao DC (1989) Cardiovascular risk factors in a French-Canadian population: resolution of genetic and familial environmental effects on blood pressure by using extensive information on environmental correlates. Am J Hum Genet 45:240-251
21. Popkin BM, Paeratakul S, Zhai F, Ge K (1995) A review of dietary and environmental correlates of obesity with emphasis on developing countries. Obes Res 3 Suppl 2: 145S-153S
22. Price RA (1992) Increases in prevalence and extent of obesity in post-World War II birth cohorts: implications for genetic analyses. Behav Genet 22:746
23. Price RA, Ness R, Laskarzewski P (1990) Common major gene inheritance of extreme overweight. Hum Biol 62:747-765
24. Province MA, Arnqvist P, Keller J, Higgins M, Rao DC (1990) Strong evidence for a major gene for obesity in the large, unselected, total Community Health Study of Tecumseh. Am J Hum Genet Suppl 47:A143
25. Rice T, Borecki IB, Bouchard C, Rao DC (1993a) Segregation analysis of body mass index in an unselected French-Canadian sample: the Québec Family Study. Obes Res 1: 288-294
26. _ (1993b) Segregation analysis of fat mass and other body composition measures derived from underwater weighing. Am J Hum Genet 52:967-973
27. Rice T, Bouchard C, Perusse L, Rao DC (1995) Familial clustering of multiple measures of adiposity and fat distribution in the Quebec Family Study: a trivariate analysis of percent body fat, body mass index, and trunk-to-extremity skinfold ratio. Int J Obes Relat Metab Disord 19:902-908
28. Rice T, Despres JP, Daw EW, Gagnon J, Borecki IB, Perusse L, Leon AS, et al (1997a) Familial resemblance for abdominal visceral fat: the HERITAGE family study. Int J Obes Relat Metab Disord 21:1024-1031
29. Rice T, Despres JP, Perusse L, Gagnon J, Leon AS, Skinner JS, Wilmore JH, et al (1997b) Segregation analysis of abdominal visceral fat: the HERITAGE Family Study. Obes Res 5: 417-424