GPCR-mediated transactivation of RTKs in the CNS: Mechanisms and consequences

Trends in Neurosciences

Volumn 27, Issue 1, 2004, Pages 48-53

  Shah, Bukhtiar H ^a   Catt, Kevin J ^a  

^a EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DOPAMINE; EPIDERMAL GROWTH FACTOR; FIBROBLAST GROWTH FACTOR; G PROTEIN COUPLED RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; NEUROTROPHIN; PHOSPHOTRANSFERASE; PLATELET DERIVED GROWTH FACTOR; PROTEIN TYROSINE KINASE; TROPOMYOSIN;

ANIMAL; CELL PROLIFERATION; CELL REGENERATION; CELL SURVIVAL; CENTRAL NERVOUS SYSTEM; HUMAN; MOLECULAR DYNAMICS; MOLECULAR INTERACTION; NERVE CELL DIFFERENTIATION; NERVOUS SYSTEM DEVELOPMENT; NONHUMAN; PHYSIOLOGY; PRIORITY JOURNAL; PROTEIN FUNCTION; REVIEW; SIGNAL TRANSDUCTION; SYNAPTIC TRANSMISSION; TRANSACTIVATION;

EID: 0346156094     PISSN: 01662236     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tins.2003.11.003     Document Type: Review

References (66)

1. Pierce K.L., et al. Seven-transmembrane receptors. Nat. Rev. Mol. Cell Biol. 3:2002;639-650.
2. Brodie C. Protein kinase C-ε plays a role in neurite outgrowth in response to epidermal growth factor and nerve growth factor in PC12 cells. Cell Growth Differ. 10:1999;183-191.
3. Bozon B., et al. MAPK, CREB and zif268 are all required for the consolidation of recognition memory. Philos. Trans. R. Soc. Lond. B Biol. Sci. 358:2003;805-814.
4. Cohen-Cory S. The developing synapse: construction and modulation of synaptic structures and circuits. Science. 298:2002;770-776.
5. Huang Y., et al. CAKβ/Pyk2 kinase is a signaling link for induction of long-term potentiation in CA1 hippocampus. Neuron. 29:2001;485-496.
6. Knap L.T., Klam E. Role of reactive oxygen species in hippocampal long-term potentiation: contributory or inhibitory? J. Neurosci. Res. 70:2002;1-7.
7. Menard C., et al. An essential role for a MEK-C/EBP pathway during growth factor-regulated cortical neurogenesis. Neuron. 36:2002;597-610.
8. Minichiello L., et al. Mechanism of TrkB-mediated hippocampal long-term potentiation. Neuron. 36:2002;121-137.
9. Waschek J.A. Multiple actions of pituitary adenylyl cyclase activating peptide in nervous system development and regeneration. Dev. Neurosci. 24:2002;14-23.
10. Yang F., et al. PI-3 kinase and IP3 are both necessary and sufficient to mediate NT3-induced synaptic potentiation. Nat. Neurosci. 4:2001;19-28.
11. Lowes V.L., et al. Integration of signals from receptor tyrosine kinases and G protein-coupled receptors. Neurosignals. 11:2002;5-19.
12. Bergmann A., et al. Regulation of cell number by MAPK-dependent control of apoptosis: a mechanism for trophic survival signaling. Dev. Cell. 2:2002;159-170.
13. Xiang Y., et al. Nerve growth cone guidance mediated by G protein-coupled receptors. Nat. Neurosci. 5:2002;843-848.
14. Luttrell L.M. Activation and targeting of mitogen-activated protein kinases by G-protein-coupled receptors. Can. J. Physiol. Pharmacol. 80:2002;375-382.
15. Lutrell L.M., Lefkowitz R.J. The role of β-arrestins in the termination and transduction of G-protein-coupled receptor signals. J. Cell Sci. 115:2002;455-465.
16. Seal D.F., Courtneidge S.A. The ADAMs family of metalloproteases: multidomain proteins with multiple functions. Genes Dev. 17:2003;7-30.
17. Kaczmarek L., et al. Matrix metalloproteinases in the adult brain physiology: a link between c-Fos, AP-1 and remodeling of neuronal connections? EMBO J. 21:2002;6643-6648.
18. Rosenberg G.A. Matrix metalloproteases in neuroinflammation. Glia. 39:2002;279-291.
19. Prenzel N., et al. EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF. Nature. 402:1999;884-888.
20. Cussac D., et al. α2B-adrenergic receptor activates MAPK via a pathway involving arachidonic acid metabolism, matrix metalloproteases, and epidermal growth factor receptor transactivation. J. Biol. Chem. 277:2002;19882-19888.
21. Pierce K.L., et al. Epidermal growth factor (EGF) receptor-dependent ERK activation by G protein-coupled receptors. A co-culture system for identifying intermediates upstream and downstream of heparin-binding EGF shedding. J. Biol. Chem. 276:2001;23155-23160.
22. Jorissen R.N., et al. Epidermal growth factor receptor: mechanisms of activation and signaling. Exp. Cell Res. 284:2003;31-53.
23. Yamada M. The neurotrophic action and signalling of epidermal growth factor. Prog. Neurobiol. 51:1997;19-37.
24. Bounanno A., Fischbach G.D. Neuregulin and ErbB receptor signaling pathways in the nervous system. Curr. Opin. Neurobiol. 11:2001;287-296.
25. Yin G., et al. Angiotensin II signaling pathways mediated by tyrosine kinases. Int. J. Biochem. Cell Biol. 35:2003;780-783.
26. Shah B.H., Catt K.J. Calcium-independent activation of extracellularly re6gulated kinases 1 and 2 in hepatic C9 cells: roles of PKCδ, Src/proline-rich tyrosine kinase 2, and epidermal growth factor receptor transactivation. Mol. Pharmacol. 61:2002;343-351.
27. Thomas W., et al. Adenoviral-directed expression of the type 1A angiotensin receptor promotes cardiomyocyte hypertrophy via transactivation of the epidermal growth factor receptor. Circ. Res. 90:2002;135-142.
28. Asakura M., et al. Cardiac hypertrophy is inhibited by antagonism of ADAM12 processing of HB-EGF: metallproteinase inhibitors as a new therapy. Nat. Med. 8:2002;35-40.
29. Zwick E., et al. Critical role of calcium-dependent epidermal growth factor receptor transactivation in PC12 cell membrane depolarization and bradykinin signaling. J. Biol. Chem. 272:1997;24767-24770.
30. Schlessinger J. Cell signaling by receptor tyrosine kinases. Cell. 103:2000;211-225.
31. Vaudry D., et al. Signaling pathways for PC12 cell differentiation: making the right connections. Science. 296:2002;1648-1649.
32. Piiper A., et al. Cyclic AMP induces transactivation of the receptors for epidermal growth factor and nerve growth factor, thereby modulating activation of MAP kinase, Akt, and neurite outgrowth in PC12 cells. J. Biol. Chem. 277:2002;43623-43630.
33. Yan Y., et al. The metalloprotease Kuzbanian (ADAM10) mediates the transactivation of EGF receptor by G protein-coupled receptors. J. Cell Biol. 158:2002;221-226.
34. Du Y., Dreyfus C.F. Oligodendrocytes as providers of growth factors. J. Neurosci. Res. 68:2002;647-654.
35. Prevot V., et al. Normal female sexual development requires neuregulin-erbB receptor signaling in hypothalamic astrocytes. J. Neurosci. 23:2003;230-239.
36. Shah B.H., et al. Dependence of gonadotropin-releasing hormone-induced neuronal MAPK signaling on epidermal growth factor receptor transactivation. J. Biol. Chem. 278:2003;2866-2875.
37. Shah B.H., et al. Roles of Src and EGF receptor transactivation in transient and sustained ERK1/2 responses to GnRH receptor activation. J. Biol. Chem. 278:2003;19118-19126.
38. Kornblum H., et al. Multiple trophic actions of heparin-binding epidermal growth factor (HB-EGF) in the central nervous system. Eur. J. Neurosci. 11:1999;3236-3246.
39. Jin K., et al. Cerebral neurogenesis is induced by intranasal administration of growth factors. Ann. Neurol. 53:2003;405-409.
40. Peavy R.D., et al. Metabotropic glutamate receptor 5-induced phosphorylation of extracellular signal-regulated kinase in astrocytes depends on transactivation of the epidermal growth factor receptors. J. Neurosci. 21:2001;9619-9628.
41. Dziedzic B., et al. Neuron-to-glia signaling is mediated by excitatory amino acid receptors regulates ErbB receptor function in astroglial cells of the neuroendocrine brain. J. Neurosci. 23:2003;915-926.
42. Yang S.N., et al. Activation of gonadotropin-releasing hormone receptor induces a long-term enhancement of excitatory postsynaptic currents mediated by ionotropic glutamate receptors in the rat hippocampus. Neurosci. Lett. 260:1999;33-36.
43. 2+ concentrations in rat hippocampus. Brain Res. 587:1992;102-108.
44. Heldin C.H., Westermark B. Mechanism of action and in vivo role of platelet-derived growth factor. Physiol. Rev. 79:1999;1283-1316.
45. Lei S., et al. Platelet-derived growth factor receptor-induced feed-forward inhibition of excitatory transmission between hippocampal pyramidal neurons. J. Biol. Chem. 274:1999;30617-30623.
46. Kotecha S.A., et al. A D2 class dopamine receptor transactivates a receptor tyrosine kinase to inhibit NMDA receptor transmission. Neuron. 35:2002;1111-1122.
47. Milenkovic I., et al. P2Y receptor-mediated stimulation of Muller glial cell DNA synthesis: dependence on EGF and PDGF receptor transactivation. Invest. Ophthalmol. Vis. Sci. 44:2003;1211-1220.
48. Cross M.J., Claesson-Welsh L. FGF and VEGF function in angiogenesis: signaling pathways, biological responses and therapeutic inhibition. Trends Pharmacol. Sci. 22:2001;201-207.
49. Ford-Perriss M., et al. Fibroblast growth factors in the developing central nervous system. Clin. Exp. Pharmacol. Physiol. 28:2001;493-503.
50. Williams E.-J., et al. The FGF receptor uses the endocannabinoid signaling system to couple to an axonal growth response. J. Cell Biol. 160:2003;481-486.
51. Law P.Y., et al. Molecular mechanisms and regulation of opioid receptor signaling. Annu. Rev. Pharmacol. Toxicol. 40:2000;389-430.
52. Sakaguchi M., et al. Effects of opioids on neuronal survival in culture of embryonic chick dorsal root ganglion neurons. Neurosci. Lett. 262:1999;17-20.
53. Belcheva M.M., et al. The fibroblast growth factor receptor is at the site of convergence between μ-opioid receptor and growth factor signaling pathways in rat C6 glioma cells. J. Pharmacol. Exp. Ther. 303:2002;909-918.
54. Dermitzaki E., et al. Opioids transiently prevent activation of apoptotic mechanisms following short periods of serum withdrawal. J. Neurochem. 74:2000;960-969.
55. Iglesias M., et al. μ-opioid receptor activation prevents apoptosis following serum withdrawal in differentiated SH-SY5Y cells and cortical neurons via phosphatidylinositol 3-kinase. Neuropharmacology. 44:2003;482-492.
56. Huang E.J., Reichardt L.F. TRK receptors: roles in neuronal signal transduction. Annu. Rev. Biochem. 72:2003;609-642.
57. Chao M.V. Neurotrophins and their receptors: a convergent point for many signaling pathways. Nat. Rev. Neurosci. 4:2003;299-309.
58. Vicario-Abejon C., et al. Role of neurotrophins in central synapse formation and stablization. Nat. Rev. Neurosci. 3:2002;965-974.
59. Lyons W.E., et al. Brain-derived neurotrophic factor-deficient mice develop aggressiveness and hyperphagia in conjunction with brain serotonergic abnormalities. Proc. Natl. Acad. Sci. U. S. A. 96:1999;15239-15244.
60. Rakhit S., et al. Nerve growth factor stimulation of p42/p44 mitogen-activated protein kinase in PC12 cells: role of Gi/o, G protein-coupled receptor kinase 2, β-arrestin 1, and endocytic processing. Mol. Pharmacol. 60:2001;63-70.
61. 2A receptor interactions with receptors for other neurotransmitters and neuromodulators. Eur. J. Pharmacol. 375:1999;101-113.
62. Lee F.S., Chao M.V. Activation of Trk neurotrophin receptors in the absence of neurotrophins. Proc. Natl. Acad. Sci. U. S. A. 98:2001;3555-3560.
63. Lee F.S., et al. Activation of Trk neurotrophin receptor signaling by pituitary adenylate cyclase-activating polypeptides. J. Biol. Chem. 277:2002;9096-9102.
64. Ledent C., et al. Aggressiveness, hypoalgesia and high blood pressure in mice lacking the adenosine A2a receptor. Nature. 388:1997;674-678.
65. 2+ spikes in cultured hippocampal networks through G-protein-coupled receptors. J. Neurosci. 23:2003;4156-4163.
66. Lu B. BDNF and activity-dependent synaptic modulation. Learn. Mem. 10:2003;86-98.