The insulin-like growth factor system

Experimental Diabesity Research

Volumn 4, Issue 4, 2003, Pages 205-212

  Le Roith, Derek ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

Binding proteins; Insulin like growth factors; Receptors; Signaling pathways

Indexed keywords

BINDING PROTEIN; CONNECTIVE TISSUE GROWTH FACTOR; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; GROWTH FACTOR RECEPTOR BOUND PROTEIN 2; GROWTH HORMONE; INSULIN RECEPTOR; LIGAND; SOMATOMEDIN; SOMATOMEDIN B; SOMATOMEDIN B RECEPTOR; SOMATOMEDIN C; SOMATOSTATIN DERIVATIVE;

BINDING AFFINITY; CARCINOGENESIS; CELL GROWTH; CELL SURVIVAL; DIABETES MELLITUS; DIABETIC NEPHROPATHY; EMBRYO DEVELOPMENT; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; GROWTH REGULATION; HUMAN; HUMAN CELL; INSULIN RESISTANCE; MALNUTRITION; POSTNATAL DEVELOPMENT; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; REVIEW; SIGNAL TRANSDUCTION;

EID: 0345767517     PISSN: 15438600     EISSN: None     Source Type: Journal    
DOI: 10.1155/edr.2003.205     Document Type: Review

References (82)

1. Backer, J. M., Myers, M. G., Jr., Shoelson, S. E., Chin, D. J., Sun, X. J., Miralpeix, M., Hu, P., Margolis, B., Skolnik, E. Y., Schlessinger, J., et al. (1992) Phosphatidylinositol 3′-kinase is activated by association with IRS-1 during insulin stimulation. EMBO J, 11, 3469-3479.
2. Bai, H., Pollman, M. J., Inishi, Y., and Gibbons, G. H. (1999) Regulation of vascular smooth muscle cell apoptosis. Modulation of bad by a phosphatidylinositol 3-kinase-dependent pathway. Circ. Res., 85,229-237.
3. Baker, J., Liu, J. P., Robertson, E. J., and Efstratiadis, A. (1993) Role of insulin-like growth factors in embryonic and postnatal growth. Cell, 75, 73-82.
4. Baxter, R. C. (2000) The IGF binding proteins. Am. J. Physiol. Endocrinol. Metab., 278, E967-E976.
5. Beitner-Johnson, D., Blakesley, V. A., Shen-Orr, Z., Jimenez, M., Stannard, B., Wang, L. M., Pierce, J., and Le Roith, D. (1996) The proto-oncogene product c-Crk associates with insulin receptor substrate-1 and 4PS. Modulation by insulin growth factor-I (IGF) and enhanced IGF-I signaling. J. Biol. Chem., 271, 9287-9290.
6. Bichell, D. P., Kikuchi, K., and Rotwein, P. (1992) Growth hormone rapidly activates insulin-like growth factor I gene transcription in vivo. Mol. Endocrinol., 6, 1899-1908.
7. Blenis, J. (1993) Signal transduction via the MAP kinases: Proceed at your own RSK. Proc. Natl. Acad. Sci. U. S. A., 90, 5889-5892.
8. Brink, M., Chrast, J., Price, S. R., Mitch, W. E., and Delafontaine, P. (1999) Angiotensin II stimulates gene expression of cardiac insulin-like growth factor I and its receptor through effects on blood pressure and food intake. Hypertension, 34, 1053-1059.
9. Butler, M., McKay, R. A., Popoff, I. J., Gaarde, W. A., Witchell, D., Murray, S. F., Dean, N. M., Bhanot, S. and Monia, B. P. (2002) Specific inhibition of PTEN expression reverses hyperglycemia in diabetic mice. Diabetes, 51, 1028-1034.
10. Butt, A. J., Firth, S. M., King, M. A., and Baxter, R. C. (2000) Insulin-like growth factor-binding protein-3 modulates expression of Bax and Bcl-2 and potentiates p53-independent radiation-induced apoptosis in human breast cancer cells. J. Biol. Chem., 275, 39174-39181.
11. Cheatham, B., and Kahn, C. R. (1995) Insulin action and the insulin signaling network. Endocr. Rev., 16, 117-142.
12. Clemmons, D. R. (2001) Use of mutagenesis to probe IGF-binding protein structure/function relationships. Endocr. Rev., 22, 800-817.
13. Crews, C. M., and Erikson, R. L. (1993) Extracellular signals and reversible protein phosphorylation: What to Mek of it all. Cell, 74, 215-217.
14. Dalle, S., Imamura, T., Rose, D. W., Worrall, D. S., Ugi, S., Hupfeld, C. J., and Olefsky, J. M. (2002) Insulin induces heterologous desensitization of G-protein-coupled receptor and insulin-like growth factor I signaling by downregulating beta-arrestin- 1. Mol. Cell Biol., 22, 6272-6285.
15. Dalle, S., Ricketts, W., Imamura, T., Vollenweider, P., and Olefsky, J. M. (2001) Insulin and insulin-like growth factor I receptors utilize different G protein signaling components. J. Biol. Chem., 276, 15688-15695.
16. Daughaday, W. H., Emanuele, M. A., Brooks, M. H., Barbato, A. L., Kapadia, M., and Rotwein, P. (1988) Synthesis and secretion of insulin-like growth factor II by a leiomyosarcoma with associated hypoglycemia. N. Engl. J. Med., 319, 1434-1440.
17. Dupont, J., Karas, M., and Le Roith, D. (2000) The potentiation of estrogen on insulin-like growth factor I action in MCF-7 human breast cancer cells includes cell cycle components. J. Biol. Chem., 275, 35893-35901.
18. Ernst, M., and Rodan, G. A. (1991) Estradiol regulation of insulin-like growth factor-I expression in osteoblastic cells: Evidence for transcriptional control. Mol. Endocrinol., 5, 1081-1089.
19. Fantin, V. R., Sparling, J. D., Slot, J. W., Keller, S. R., Lienhard, G. E., and Lavan, B. E. (1998) Characterization of insulin receptor substrate 4 in human embryonic kidney 293 cells. J. Biol. Chem., 273, 10726-10732.
20. Federici, M., Porzio, O., Zucaro, L., Fusco, A., Borboni, P., Lauro, D., and Sesti, G. (1997a) Distribution of insulin/insulin-like growth factor-I hybrid receptors in human tissues. Mol. Cell Endocrinol., 129, 121-126.
21. Federici, M., Porzio, O., Zucaro, L., Giovannone, B., Borboni, P., Marini, M. A., Lauro, D., and Sesti, G. (1997b) Increased abundance of insulin/IGF-I hybrid receptors in adipose tissue from NIDDM patients. Mol. Cell Endocrinol., 135, 41-47.
22. Florini, J. R., Ewton, D. Z., and Coolican, S. A. (1996) Growth hormone and the insulin-like growth factor system in myogenesis. Endocr. Rev., 17, 481-517.
23. Flyvbjerg, A. (2000) Putative pathophysiological role of growth factors and cytokines in experimental diabetic kidney disease. Diabetologia, 43, 1205-1223.
24. Formisano, P., Najjar, S. M., Gross, C. N., Philippe, N., Oriente, F., Kern-Buell, C. L., Accili, D., and Gorden, P. (1995) Receptor-mediated internalization of insulin. Potential role of pp120/HA4, a substrate of the insulin receptor kinase. J. Biol. Chem., 270, 24073-24077.
25. Frasca, F., Pandini, G., Scalia, P., Sciacca, L., Mineo, R., Costantino, A., Goldfine, I. D., Belfiore, A., and Vigneri, R. (1999) Insulin receptor isoform A, a newly recognized, high-affinity insulin-like growth factor II receptor in fetal and cancer cells. Mol. Cell Biol., 19, 3278-3288.
26. Hermanto, U., Zong, C. S., Li, W., and Wang, L. H. (2002) RACK1, an insulin-like growth factor I (IGF-I) receptor-interacting protein, modulates IGF-I-dependent integrin signaling and promotes cell spreading and contact with extracellular matrix. Mol. Cell Biol., 22, 2345-2365.
27. Hofbauer, L. C., Rafferzeder, M., Janssen, O. E., and Gartner, R. (1995) Insulin-like growth factor I messenger ribonucleic acid expression in porcine thyroid follicles is regulated by thyrotropin and iodine. Eur. J. Endocrinol., 132, 605-610.
28. Jones, J. I., and Clemmons, D. R. (1995) Insulin-like growth factors and their binding proteins: Biological actions. Endocr. Rev., 16, 3-34.
29. Jones, J. I., Gockerman, A., Busby, W. H., Jr., Wright, G., and Clemmons, D. R. (1993) Insulin-like growth factor binding protein 1 stimulates cell migration and binds to the alpha 5 beta 1 integrin by means of its Arg-Gly-Asp sequence. Proc. Natl. Acad. Sci. U. S. A., 90, 10553-10557.
30. Kato, H., Faria, T. N., Stannard, B., Roberts, C. T., Jr., and Le Roith, D. (1993) Role of tyrosine kinase activity in signal transduction by the insulin-like growth factor-I (IGF-I) receptor. Characterization of kinase-deficient IGF-I receptors and the action of an IGF-I-mimetic antibody (alpha IR-3). J. Biol. Chem., 268, 2655-2661.
31. Kaytor, E. N., Zhu, J. L., Pao, C. I., and Phillips, L. S. (2001) Insulin-responsive nuclear proteins facilitate Sp1 interactions with the insulin-like growth factor-I gene. J. Biol. Chem., 276, 36896-36901.
32. Kiely, P. A., Sant, A., and O'Connor, R. (2002) RACK1 is an insulin-like growth factor 1 (IGF-1) receptor-interacting protein that can regulate IGF-1-mediated Akt activation and protection from cell death. J. Biol. Chem., 277, 22581-22589.
33. Kim, B., and Feldman, E. L. (2002) Insulin-like growth factor I prevents mannitol-induced degradation of focal adhesion kinase and Akt. J. Biol. Chem., 277, 27393-27400.
34. Lalou, C., Lassarre, C., and Binoux, M. (1996) A proteolytic fragment of insulin-like growth factor (IGF) binding protein-3 that fails to bind IGFs inhibits the mitogenic effects of IGF-I and insulin. Endocrinology, 137, 3206-3212.
35. Lamothe, B., Bucchini, D., Jami, J., and Joshi, R. L. (1996) Reexamining interaction of the SH2 domains of SYP and GAP with insulin and IGF-1 receptors in the two-hybrid system. Gene, 182, 77-80.
36. Landau, D., Chin, E., Bondy, C., Domene, H., Roberts, C. T., Jr., Gronbaek, H., Flyvbjerg, A., and Le Roith, D. (1995) Expression of insulin-like growth factor binding proteins in the rat kidney: Effects of long-term diabetes. Endocrinology, 136, 1835-1842.
37. Lavan, B. E., and Lienhard, G. E. (1993) The insulin-elicited 60-kDa phosphotyrosine protein in rat adipocytes is associated with phosphatidylinositol 3-kinase. J. Biol. Chem., 268, 5921-5928.
38. Lee, C. H., Li, W., Nishimura, R., Zhou, M., Batzer, A. G., Myers, M. G., Jr., White, M. F., Schlessinger, J., and Skolnik, E. Y. (1993) Nck associates with the SH2 domain-docking protein IRS-1 in insulin-stimulated cells. Proc. Natl. Acad. Sci. U. S. A., 90, 11713-11717.
39. Le Roith, D., Bondy, C., Yakar, S., Liu, J. L., and Butler, A. (2001) The somatomedin hypothesis: 2001. Endocr. Rev., 22, 53-74.
40. Le Roith, D., Werner, H., Beitner-Johnson, D., and Roberts, C. T., Jr. (1995) Molecular and cellular aspects of the insulin-like growth factor I receptor. Endocrine Rev., 16, 143-163.
41. Lin, F. T., Daaka, Y., and Lefkowitz, R. J. (1998) Beta-arrestins regulate mitogenic signaling and clathrin-mediated endocytosis of the insulin-like growth factor I receptor. J. Biol. Chem., 273, 31640-31643.
42. Liu, J. L., and Le Roith, D. (1999) Insulin-like growth factor I is essential for postnatal growth in response to growth hormone. Endocrinology, 140, 5178-5184.
43. Liu, J. P., Baker, J., Perkins, A. S., Robertson, E. J., and Efstratiadis, A. (1993) Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r). Cell, 75, 59-72.
44. Lowenstein, E. J., Daly, R. J., Batzer, A. G., Li, W., Margolis, B., Lammers, R., Ullrich, A., Skolnik, E. Y., Bar-Sagi, D., and Schlessinger, J. (1992) The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling. Cell, 70, 431-442.
45. Luttrell, L. M., van Biesen, T., Hawes, B. E., Koch, W. J., Touhara, K., and Lefkowitz, R. J. (1995) G beta gamma subunits mediate mitogen-activated protein kinase activation by the tyrosine kinase insulin-like growth factor 1 receptor. J. Biol. Chem., 270, 16495-16498.
46. Maile, L. A., and Clemmons, D. R. (2002) Regulation of insulin-like growth factor I receptor dephosphorylation by SHPS-1 and the tyrosine phosphatase SHP-2. J. Biol. Chem., 277, 8955-8960.
47. Maile, L. A., Gill, Z. P., Perks, C. M., and Holly, J. M. (1999) The role of cell surface attachment and proteolysis in the insulin-like growth factor (IGF)-independent effects of IGF-binding protein-3 on apoptosis in breast epithelial cells. Endocrinology, 140, 4040-4045.
48. Mulroney, S. E., Lumpkin, M. D., Roberts, C. T., Jr., Le Roith, D., and Haramati, A. (1992) Effect of a growth hormone-releasing factor antagonist on compensatory renal growth, insulin-like growth factor-I (IGF-I), and IGF-I receptor gene expression after unilateral nephrectomy in immature rats. Endocrinology, 130, 2697-2702.
49. Murphy, L. J., and Friesen, H. G. (1988) Differential effects of estrogen and growth hormone on uterine and hepatic insulin-like growth factor I gene expression in the ovariectomized hypophysectomized rat. Endocrinology, 122, 325-332.
50. Najjar, S. M., Blakesley, V. A., Li Calzi, S., Kato, H., Le Roith, D., and Choice, C. V. (1997) Differential phosphorylation of pp120 by insulin and insulin-like growth factor-1 receptors: Role for the C-terminal domain of the beta-subunit. Biochemistry, 36, 6827-6834.
51. Pandini, G., Frasca, F., Mineo, R., Sciacca, L., Vigneri, R., and Belfiore, A. (2002) Insulin/insulin-like growth factor I hybrid receptors have different biological characteristics depending on the insulin receptor isoform involved. J. Biol. Chem., 277, 39684-39695.
52. Patti, M. E., Sun, X. J., Bruening, J. C., Araki, E., Lipes, M. A., White, M. F., and Kahn, C. R. (1995) 4PS/insulin receptor substrate (IRS)-2 is the alternative substrate of the insulin receptor in IRS-1-deficient mice. J. Biol. Chem., 270, 24670-24673.
53. Pelicci, G., Lanfrancone, L., Grignani, F., McGlade, J., Cavallo, F., Forni, G., Nicoletti, I., Pawson, T., and Pelicci, P. G. (1992) A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction. Cell, 70, 93-104.
54. Pennisi, P. A., Barr, V., Nunez, N. P., Stannard, B., and Le Roith, D. (2002) Reduced expression of insulin-like growth factor I receptors in MCF-7 breast cancer cells leads to a more metastatic phenotype. Cancer Res., 62, 6529-6537.
55. Perks, C. M., Bowen, S., Gill, Z. P., Newcomb, P. V., and Holly, J. M. (1999a) Differential IGF-independent effects of insulin-like growth factor binding proteins (1-6) on apoptosis of breast epithelial cells. J. Cell Biochem., 75, 652-664.
56. Perks, C. M., Newcomb, P. V., Norman, M. R., and Holly, J. M. (1999b) Effect of insulin-like growth factor binding protein-1 on integrin signaling and the induction of apoptosis in human breast cancer cells. J. Mol. Endocrinol., 22, 141-150.
57. Pugazhenthi, S., Boras, T., O'Connor, D., Meintzer, M. K., Heidenreich, K. A., and Reusch, J. E. (1999) Insulin-like growth factor I-mediated activation of the transcription factor cAMP response element-binding protein in PC12 cells. Involvement of p38 mitogen-activated protein kinase-mediated pathway. J. Biol. Chem., 274, 2829-2837.
58. Rajaram, S., Baylink, D. J., and Mohan, S. (1997) Insulin-like growth factor-binding proteins in serum and other biological fluids: Regulation and functions. Endocr. Rev., 18, 801-831.
59. Ravichandran, L. V., Chen, H., Li, Y., and Quon, M. J. (2001) Phosphorylation of PTP1B at Ser(50) by Akt impairs its ability to dephosphorylate the insulin receptor. Mol. Endocrinol., 15, 1768-1780.
60. Raz, I., Rubinger, D., Popovtzer, M., Gronbaek, H., Weiss, O., and Flyvbjerg, A. (1998) Octreotide prevents the early increase in renal insulin-like growth factor binding protein 1 in streptozotocin diabetic rats. Diabetes, 47, 924-930.
61. Rotem-Yehudar, R., Galperin, E., and Horowitz, M. (2001) Association of insulin-like growth factor 1 receptor with ehd1 and snap29. J. Biol. Chem., 276, 33054-33060.
62. Rui, L., Aguirre, V., Kim, J. K., Shulman, G. I., Lee, A., Corbould, A., Dunaif, A., and White, M. F. (2001) Insulin/IGF-1 and TNF-alpha stimulate phosphorylation of IRS-1 at inhibitory Ser307 via distinct pathways. J. Clin. Invest., 107, 181-189.
63. Sasaoka, T., Ishiki, M., Sawa, T., Ishihara, H., Takata, Y., Imamura, T., Usui, I., Olefsky, J. M., and Kobayashi, M. (1996) Comparison of the insulin and insulin-like growth factor 1 mitogenic intracellular signaling pathways. Endocrinology, 137, 4427-4434.
64. Schedlich, L. J., Le Page, S. L., Firth, S. M., Briggs, L. J., Jans, D. A., and Baxter, R. C. (2000) Nuclear import of insulin-like growth factor-binding protein-3 and -5 is mediated by the importin beta subunit. J. Biol. Chem., 275, 23462-23470.
65. Schedlich, L. J., Young, T. F., Firth, S. M., and Baxter, R. C. (1998) Insulin-like growth factor-binding protein (IGFBP)-3 and IGFBP-5 share a common nuclear transport pathway in T47D human breast carcinoma cells. J. Biol. Chem., 273, 18347-18352.
66. Sciacca, L., Costantino, A., Pandini, G., Mineo, R., Frasca, F., Scalia, P., Sbraccia, P., Goldfine, I. D., Vigneri, R., and Belfiore, A. (1999) Insulin receptor activation by IGF-II in breast cancers: Evidence for a new autocrine/paracrine mechanism. Oncogene, 18, 2471-2479.
67. Skolnik, E. Y., Lee, C. H., Batzer, A., Vicentini, L. M., Zhou, M., Daly, R., Myers, M. J., Jr., Backer, J. M., Ullrich, A., White, M. F., et al. (1993) The SH2/SH3 domain-containing protein GRB2 interacts with tyrosine-phosphorylated IRS1 and Shc: Implications for insulin control of ras signalling. EMBO J., 12, 1929-1936.
68. Soni, P., Lakkis, M., Poy, M. N., Fernstrom, M. A., and Najjar, S. M. (2000) The differential effects of pp120 (Ceacam 1) on the mitogenic action of insulin and insulin-like growth factor 1 are regulated by the nonconserved tyrosine 1316 in the insulin receptor. Mol. Cell Biol., 20, 3896-3905.
69. Stewart, C. E., and Rotwein, P. (1996) Growth, differentiation, and survival: Multiple physiological functions for insulin-like growth factors. Physiol. Rev., 76, 1005-1026.
70. Sun, X. J., Goldberg, J. L., Qiao, L. Y., and Mitchell, J. J. (1999) Insulin-induced insulin receptor substrate-1 degradation is mediated by the proteasome degradation pathway. Diabetes, 48, 1359-1364.
71. Sun, X. J., Pons, S., Asano, T., Myers, M. G., Jr., Glasheen, E., and White, M. F. (1996) The Fyn tyrosine kinase binds Irs-1 and forms a distinct signaling complex during insulin stimulation. J. Biol. Chem., 271, 10583-10587.
72. Ullrich, A., Bell, J. R., Chen, E. Y., Herrera, R., Petruzzelli, L. M., Dull, T. J., Gray, A., Coussens, L., Liao, Y. C., Tsubokawa, M., et al. (1985) Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes. Nature, 313, 756-761.
73. Ullrich, A., Gray, A., Tam, A. W., Yang-Feng, T., Tsubokawa, M., Collins, C., Henzel, W., Le Bon, T., Kathuria, S., Chen, E., et al. (1986) Insulin-like growth factor I receptor primary structure: Comparison with insulin receptor suggests structural determinants that define functional specificity. EMBO J., 5, 2503-2512.
74. Wang, J., Zhou, J., Powell-Braxton, L., and Bondy, C. (1999) Effects of Igf1 gene delection on postnatal growth patterns. Endocrinology, 140, 3391-3394.
75. Werner, H., Shen-orr, Z., Stannard, B., Burguera, B., Roberts, C. T., Jr., and Le Roith, D. (1990) Experimental diabetes increases insulinlike growth factor I and II receptor concentration and gene expression in kidney. Diabetes, 39, 1490-1497.
76. White, M. F. (1994) The IRS-1 signaling system. Curr. Opin. Genet. Dev., 4, 47-54.
77. Winnay, J. N., Bruning, J. C., Burks, D. J., and Kahn, C. R. (2000) Gab-1-mediated IGF-1 signaling in IRS-1-deficient 3T3 fibroblasts. J. Biol. Chem., 275, 10545-10550.
78. Xiao, S., Rose, D. W., Sasaoka, T., Maegawa, H., Burke, T. R., Jr., Roller, P. P., Shoelson, S. E., and Olefsky, J. M. (1994) Syp (SH-PTP2) is a positive mediator of growth factor-stimulated mitogenic signal transduction. J. Biol. Chem., 269, 21244-21248.
79. Yakar, S., Liu, J. L., Stannard, B., Butler, A., Accili, D., Sauer, B., and Le Roith, D. (1999) Normal growth and development in the absence of hepatic insulin-like growth factor I. Proc. Natl. Acad. Sci. U. S. A., 96, 7324-7329.
80. Yakar, S., Rosen, C. J., Beamer, W. G., Ackert-Bicknell, C. L., Wu, Y., Liu, J. L., Ooi, G. T., Setser, J., Frystyk, J., Boisclair, Y. R., and Le Roith, D. (2002) Circulating levels of IGF-1 directly regulate bone growth and density. J. Clin. Invest., 110, 771-781.
81. Zhang, J., Chrysis, D., and Underwood, L. E. (1998) Reduction of hepatic insulin-like growth factor I (IGF-I) messenger ribonucleic acid (mRNA) during fasting is associated with diminished splicing of IGF-I pre-mRNA and decreased stability of cytoplasmic IGF-I mRNA. Endocrinology, 139, 4523-4530.
82. Zapf, J. (1995) Physiological role of the insulin-like growth factor binding proteins. Eur. J. Endocrinol., 132, 645-654.