Comparison of the insulin and insulin-like growth factor 1 mitogenic intracellular signaling pathways

Endocrinology

Volumn 137, Issue 10, 1996, Pages 4427-4434

  Sasaoka, Toshiyasu ^a   Ishiki, Manabu ^b   Sawa, Tasuku ^b   Ishihara, Hajime ^b   Takata, Yasumitsu ^b   Imamura, Takeshi ^b   Usui, Isao ^b   Olefsky, Jerrold M ^b   Kobayashi, Masashi ^b  

^a UNIVERSITY OF TOYAMA   (Japan)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

BROXURIDINE; INSULIN; INSULIN RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN P21; SOMATOMEDIN C; SOMATOMEDIN C RECEPTOR;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; DNA SYNTHESIS; DNA SYNTHESIS INHIBITION; ELECTROPHORETIC MOBILITY; IMMUNOBLOTTING; IMMUNOPRECIPITATION; MITOGENESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION;

EID: 0029747283     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/endo.137.10.8828504     Document Type: Article

References (48)

1. Ullrich A, Bell JR, Chen EY, Herrera R, Petruzzelli LM, Dull TJ, Gray A, Coussens L, Liao Y-C, Tsubokawa M, Mason A, Seeburg PH, Grunfeld C, Rosen OM, Ramachandran J 1985 Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes. Nature 313:756-761
2. Ullrich A, Gray A, Tam AW, Yang-Feng T, Tsubokawa M, Collins C, Henzel W, Bon TL, Kathuria S, Chen E, Jacobs S, Francke U, Ramachandran J, Fujita-Yamaguchi Y 1986 Insulin-like growth factor I receptor primary structure: comparison with insulin receptor suggests structural determinants that define functional specificity. EMBO J 5:2503-2512
3. Jones JI, Clemmons DR 1995 Insulin-like growth factors and their binding proteins: biological actions. Endocr Rev 16:3-34
4. Shemer J, Adamo M, Wilson GL, Heffez D, Zick Y, LeRoith D 1987 Insulin and insulin-like growth factor-I stimulate a common endogenous phosphoprotein substrate (pp185) in intact neuroblastoma cells. J Biol Chem 262:15476-15482
5. Myers MG, Sun XJ, Cheatham B, Jachna BR, Glasheen EM, Backer JM, White MF 1993 IRS-1 is a common element in insulin and insulin-like growth factor-I signaling to the phosphatidylinositol 3′-kinase. Endocrinology 132:1421-1430
6. Sun XJ, Rothenberg P, Kahn CR, Backer JM, Araki E, Wilden PA, Cahill DA, Goldstein BJ, White MF 1991 Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein. Nature 352:73-77
7. Myers MG, Backer JM, Sun XJ, Shoelson S, Hu P, Schlessinger J, Yoakim M, Schaffhausen B, White MF 1992 IRS-1 activates phosphatidylinositol 3′-kinase by associating with src homology 2 domains of p85. Proc Natl Acad Sci USA 89:10350-10354
8. Sun XJ, Crimmins DL, Myers MG, Miralpeix M, White MF 1993 Pleiotropic insulin signals are engaged by multisite phosphorylation of IRS-1. Mol Cell Biol 13:7418-7428
9. Tobe K, Matuoka K, Tamemoto H, Ueki K, Kaburagi Y, Asai S, Noguchi T, Matsuda M, Tanaka S, Hattori S, Fukui Y, Akanuma Y, Yazaki Y, Takenawa T, Kadowaki T 1993 Insulin stimulates association of insulin receptor substrate-1 with the protein abundant src homology/growth factor receptor-bound protein 2. J Biol Chem 268:11167-11171
10. Skolnik EY, Lee C-H, Batzer A, Vicentini LM, Zhou M, Daly R, Myers MJ, Backer JM, Ullrich A, White MF, Schlessinger J 1993 The SH2/SH3 domain-containing protein GRB2 interacts with tyrosine-phosphorylated IRS-1 and Shc: implications for insulin control of ras signaling. EMBO J 12:1929-1936
11. Kuhne MR, Pawson T, Lienhard GE, Feng G-S 1993 The insulin receptor substrate 1 associates with the SH2-containing phosphotyrosine phosphatase Syp. J Biol Chem 268:11479-11481
12. Lee C-H, Li W, Nishimura R, Zhou M, Batzer AG, Myers MG, White MF, Schlessinger J, Skolnik EY 1993 Nck associates with the SH2 domain-docking protein IRS-1 in insulin-stimulated cells. Proc Natl Acad Sci USA 90:11713-11717
13. Pelicci G, Lanfrancone L, Grignani F, McGlade J, Cavallo F, Forni G, Nicoletti I, Grignani F, Pawson T, Pelicci PG 1992 A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction. Cell 70:93-104
14. Pronk GJ, McGlade J, Pelicci G, Pawson T, Bos JL 1993 Insulin-induced phosphorylation of the 46- and 52-kDa Shc proteins. J Biol Chem 268:5748-5753
15. Sasaoka T, Rose DW, Jhun BH, Saltiel AR, Draznin B, Olefsky JM 1994 Evidence for a functional role of Shc proteins in mitogenic signaling induced by insulin, insulin-like growth factor-1, and epidermal growth factor. J Biol Chem 269:13689-13694
16. Mastick CC, Kato H, Roberts CT, LeRoith D, Saltiel AR 1994 Insulin and insulin-like growth factor-I receptors similarly stimulate deoxyribonucleic acid synthesis despite differences in cellular protein tyrosine phosphorylation. Endocrinology 135:214-222
17. Satoh T, Nakafuku M, Kaziro Y 1992 Function of ras as a molecular switch in signal transduction. J Biol Chem 267:24149-24152
18. Jhun BH, Meinkoth JL, Leitner JW, Draznin B, Olefsky JM 1994 Insulin and insulin-like growth factor-I signal transduction requires p21ras. J Biol Chem 269:5699-5704
19. Blenis J 1993 Signal transduction via the MAP kinases: proceed at your own RSK. Proc Natl Acad Sci USA 90:5889-5892
20. Cobb MH, Goldsmith EJ 1995 How MAP kinases are regulated. J Biol Chem 270:14843-14846
21. Sasaoka T, Draznin B, Leitner JW, Langlois WJ, Olefsky JM 1994 Shc is the predominant signaling molecule coupling insulin receptors to activation of guanine nucleotide releasing factor and p21ras-GTP formation. J Biol Chem 269:10734-10738
22. Giorgetti S, Pelicci PG, Pelicci G, Obberghen EV 1994 Involvement of src-homology/collagen (SHC) proteins in signaling through the insulin receptor and the insulin-like-growth-factor-I-reeeptor. Eur J Biochem 223:195-202
23. McClain DA, Maegawa H, Lee J, Dull TJ, Ullrich A, Olefsky JM 1987 A mutant insulin receptor with defective tyrosine kinase displays no biologic activity and does not undergo endocytosis. J Biol Chem 262:14663-14671
24. Maegawa H, Olefsky JM, Thies S, Boyd D, Ullrich A, McClain DA 1988 Insulin receptors with defective tyrosine kinase inhibit normal receptor function at the level of substrate phosphorylation. J Biol Chem 263:12629-12637
25. Ravichandran KS, Lorenz U, Shoelson SE, Burakoff SJ 1995 Interaction of Shc with Grb2 regulates association of Grb2 with mSOS. Mol Cell Biol 15:593-600
26. Rose DW, Saltiel AR, Majumdar M, Decker SJ, Olefsky JM 1994 Insulin receptor substrate 1 is required for insulin-mediated mitogenic signal transduction. Proc Natl Acad Sci USA 91:797-801
27. Gustafson TA, He W, Craparo A, Schaub CD, O'Neill TJ 1995 Phosphotyrosine-dependent interaction of SHC and insulin receptor substrate 1 with the NPEY motif of the insulin receptor via a novel non-SH2 domain. Mol Cell Biol 15:2500-2508
28. Craparo A, O'Neill TJ, Gustafson TA 1995 Non-SH2 domains within insulin receptor substrate-1 and SHC mediate their phosphotyrosine-dependent interaction with the NPEY motif of the insulin-like growth factor I receptor. J Biol Chem 270:15639-15643
29. Beitner-Johnson D, Blakesley VA, Shen-Orr Z, Jimenez M, Stannard B, Wang L-M, Pierce J, LeRoith D 1996 The proto-oncogene product c-Crk associates with insulin receptor substrate-1 and 4PS. J Biol Chem 271:9287-9290
30. Tamemoto H, Kadowaki T, Tobe K, Yagi T, Sakura H, Hayakawa T, Terauchi Y, Ueki K, Kaburagi Y, Satoh S, Sekihara H, Yoshioka S, Horikoshi H, Furuta Y, Ikawa Y, Kasuga M, Yazaki Y, Aizawa S 1994 Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1. Nature 372:182-186
31. Araki E, Lipes MA, Patti M-E, Bruning JC, Haag III B, Johnson RS, Kahn CR 1994 Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene. Nature 372:186-190
32. Tobe K, Tamemoto H, Yamauchi T, Aizawa S, Yazaki Y, Kadowaki T 1995 Identification of a 190-kDa protein as a novel substrate for the insulin receptor kinase functionally similar to insulin receptor substrate-1. J Biol Chem 270:5698-5701
33. Cherniack AD, Klarlund JK, Conway BR, Czech MP 1995 Disassembly of son-of-sevenless proteins from Grb2 during p21ras desensitization by insulin. J Biol Chem 270:1485-1488
34. Waters SB, Yamauchi K, Pessin JE 1995 Insulin-stimulated disassociation of the SOS-Grb2 complex. Mol Cell Biol 15:2791-2799
35. Langlois WJ, Sasaoka T, Saltiel AR, Olefsky JM 1995 Negative feedback regulation and desensitization of insulin- and epidermal growth factor-stimulated p21ras activation. J Biol Chem 270:25320-25323
36. Sasaoka T, Langlois WJ, Leitner JW, Draznin B, Olefsky JM 1994 The signaling pathway coupling epidermal growth factor receptors to activation of p21ras. J Biol Chem 269:32621-32625
37. Benjamin CW, Jones DA 1994 Platelet-derived growth factor stimulates growth factor receptor binding protein-2 association with Shc in vascular smooth muscle cells. J Biol Chem 269:30911-30916
38. Clark EA, Brugge JS 1995 Integrins and signal transduction pathways: the road taken. Science 268:233-239
39. Vuori K, Ruoslahti E 1994 Association of insulin receptor substrate-1 with integrins. Science 266:1576-1578
40. Schlaepfer DD, Hanks SK, Hunter T, Geer P 1994 Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase. Nature 372:786-791
41. Pillay TS, Sasaoka T, Olefsky JM 1995 Insulin stimulates the tyrosine dephosphorylation of pp125 focal adhesion kinase. J Biol Chem 270:991-994
42. Knight JB, Yamauchi K, Pessin JE 1995 Divergent insulin and platelet-derived growth factor regulation of focal adhesion kinase (pp125FAK) tyrosine phosphorylation, and rearrangement of actin stress fibers. J Biol Chem 270:10199-10203
43. Xiao S, Rose DW, Sasaoka T, Maegawa H, Burke TR, Roller PP, Shoelson SE, Olefsky JM 1994 Syp (SH-PTP2) is a positive mediator of growth factor-stimulated mitogenic signal transduction. J Biol Chem 269:21244-21248
44. Milarski KL, Saltiel AR 1994 Expression of catalytically inactive Syp phosphatase in 3T3 cells blocks stimulation of mitogen-activated protein kinase by insulin. J Biol Chem 269:21239-21243
45. Yamauchi K, Milarski KL, Saltiel AR, Pessin JE 1995 Protein-tyrosine-phosphatase SHPTP2 is a required positive effector for insulin downstream signaling. Proc Natl Acad Sci USA 92:664-668
46. Noguchi T, Matozaki T, Horita K, Fujioka Y, Kasuga M 1994 Role of SH-PTP2, a protein-tyrosine phosphatase with src homology 2 domains, in insulin-stimulated ras activation. Mol Cell Biol 14:6674-6682
47. Yamauchi K, Ribon V, Saltiel AR, Pessin JE 1995 Identification of the major SHPTP2-binding protein that is tyrosine-phosphorylated in response to insulin. J Biol Chem 270:17716-17722
48. Langlois WJ, Sasaoka T, Yip CC, Olefsky JM 1995 Functional characterization of hybrid receptors composed of a truncated insulin receptor and wild type insulin-like growth factor 1 or insulin receptors. Endocrinology 136:1978-1986