Reduced expression of insulin-like growth factor I receptors in MCF-7 breast cancer cells leads to a more metastatic phenotype

Cancer Research

Volumn 62, Issue 22, 2002, Pages 6529-6537

  Pennisi, Patricia A ^a   Barr, Valarie ^a   Nunez, Nomeli P ^a,b   Stannard, Bethel ^a   Le Roith, Derek ^a,b  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATENIN; PROTEIN CDC42; PROTEIN P120; RAC1 PROTEIN; RHO FACTOR; SOMATOMEDIN C RECEPTOR; UVOMORULIN;

ARTICLE; BREAST CANCER; BREAST METASTASIS; CELL AGGREGATION; CELL MIGRATION; CELL MOTILITY; CELL STRAIN MCF 7; COMPLEX FORMATION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; METASTASIS POTENTIAL; PHENOTYPE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN FUNCTION; PROTEIN STABILITY; RISK FACTOR;

BREAST NEOPLASMS; CDC42 GTP-BINDING PROTEIN; CELL ADHESION; CELL AGGREGATION; CELL MOVEMENT; DNA, ANTISENSE; HUMANS; NEOPLASM METASTASIS; RAC1 GTP-BINDING PROTEIN; RECEPTOR, IGF TYPE 1; RHOA GTP-BINDING PROTEIN; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 0037112511     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (54)

1. Ullrich, A., Gray, A., Tam, A. W., Yang-Feng, T., Tsubokawa, M., Collins, Henzel, W., Le Bon, T., Kathuria, S., Chen, E., et al. Insulin-like growth factor I receptor primary structure: Comparison with insulin receptor suggests structural determinants that define functional specificity. EMBO J., 5: 2503-2512, 1986
2. Pollak, M. Insulin-like growth factor physiology and cancer risk. Eur. J. Cancer, 36: 1224-1228, 2000
3. Ellis, M. J., Singer, C., Homby, A., Rasmussen, A., and Cullen, K. J. Insulin-like growth factor mediated stromal-epithelial interactions in human breast cancer. Breast Cancer Res. Treat., 31: 249-261, 1994
4. Wu, Y., Yakar, S., Zhao, L., Hennighausen, L., and LeRoith. D. Circulating insulin-like growth factor-I levels regulate colon cancer growth and metastasis. Cancer Res., 62: 1030-1035, 2002
5. Lee, A. V., and Yee, D. Insulin-like growth factors and breast cancer. Biomed. Pharmacother., 49: 415-421, 1995
6. Neuenschwander. S., Roberts. C. T., Jr., and LeRoith, D. Growth inhibition of MCF-7 breast cancer cells by stable expression of an insulin-like growth factor I receptor antisense ribonucleic acid. Endocrinology, 136: 4298-4303, 1995
7. Papa, V., Gliozzo, B., Clark, G. M., McGuire. W. L., Moore, D., Fujita-Yamaguchi, Y., Vigneri R., Goldfine, I. D., and Pezzino, V. Insulin-like growth factor-I receptors are overexpressed and predict a low risk in human breast cancer. Cancer Res., 53: 3736-3740, 1993
8. Guvakova, M. A., and Surmacz, E. Overexpressed IGF-I receptors reduce estrogen growth requirements, enhance survival, and promote E-cadherin-mediated cell-cell adhesion in human breast cancer cells. Exp. Cell Res., 231: 149-162, 1997
9. Gumbiner, B. M. Regulation of cadherin adhesive activity. J. Cell Biol., 148: 399-404, 2000
10. Peri, A. K., Wilgenbus. P., Dahl. U., Semb, H., and Christofori. G. A causal role for E-cadherin in the transition from adenoma to carcinoma. Nature (Lond.), 392: 190-193, 1998
11. Shapiro, L., Fannon. A. M., Kwong, P. D., Thompson, A., Lehmann, M. S., Grubel, G., Legrand, J. F., Als-Nielsen. J., Colman, D. R., and Hendrickson, W. A. Structural basis of cell-cell adhesion by cadherins. Nature (Lond.), 374: 327-337, 1995
12. Adams, C. L., and Nelson, W. J. Cytomechanics of cadherin-mediated cell-cell adhesion. Curr. Opin. Cell Biol., 10: 572-577, 1998
13. Nieset, J. E., Redfield, A. R., Jin. F., Knudsen, K. A., Johnson, K. R., and Wheelock, M J. Characterization of the interactions of α-catenin with α-actinin and β-catenin/aplakoglobin. J Cell Sci., 110: 1013-1022, 1997
14. Willert, K., and Nusse, R. β-catenin: A key mediator of Wnt signaling. Curr. Opin. Genet. Dev., 8: 95-102, 1998
15. Hecht, A., and Kemler. R. Curbing the nuclear activities of β-catenin. Control over Wnt target gene expression. EMBO Rep., 1: 24-28, 2000
16. Rubinfeld, B., Albert, I., Porfiri. E., Fiol. C., Munemitsu. S., and Polakis, P. Binding of GSK3β to the APC-β-catenin complex and regulation of complex assembly. Science (Wash. DC). 272: 1023-1026, 1996
17. Korinek, V., Barker, N., Morin, P. J., van Wichen, D., de Weger, R., Kinzler. K. W., Vogelstein. B., and Clevers. H. Constitutive transcriptional activation by a β-catenin-Tcf complex in APC-/-colon carcinoma. Science (Wash. DC), 275: 1784-1787, 1997
18. Novak, A., Hsu, S. C., Leung-Hagesteijn, C., Radeva, G., Papkoff. J., Montesano, R., Roskelley, C., Grosschedl, R., and Dedhar, S. Cell adhesion and the integrin-linked kinase regulate the LEF-I and β-catenin signaling pathways. Proc. Natl. Acad. Sci. USA, 95: 4374-4379, 1998
19. Reynolds, A. B., Daniel, J. M., Mo, Y. Y., Wu. J., and Zhang, Z. The novel catenin p 120cas binds classical cadherins and induces an unusual morphological phenotype in NIH3T3 fibroblasts. Exp. Cell Res., 225: 328-337, 1996
20. Chen, H., Paradies, N. E., Fedor-Chaiken. M., and Brackenbury, R. E-cadherin mediates adhesion and suppresses cell motility via distinct mechanisms. J. Cell Sci., 110: 345-356, 1997
21. Hall, A. Rho GTPases and the actin cytoskeleton. Science (Wash. DC), 279: 509-514, 1998
22. Fukata, M., Nakagawa, M., Kuroda, S., and Kaibuchi, K. Cell adhesion and Rho small GTPases. J. Cell Sci., 112: 4491-4500, 1999
23. Takai, Y., Sasaki, T., and Matozaki. T. Small GTP-binding proteins. Physiol. Rev., 81: 153-208, 2001
24. Noren, N. K., Liu, B. P., Burridge, K., and Kreft, B. p120 catenin regulates the actin cytoskeleton via Rho family GTPases. J. Cell Biol., 150: 567-580, 2000
25. Dupont, J., Karas. M., and LeRoith, D. The potentiation of estrogen on insulin-like growth factor I action in MCF-7 human breast cancer cells includes cell cycle components. J. Biol. Chem., 275. 35893-35901, 2000
26. 1 integrin by means of its Arg-Gly-Asp sequence. Proc. Natl. Acad. Sci. USA, 90: 10553-10557, 1993
27. Haft, C. R., Klausner, R. D., and Taylor, S. I. Involvement of dileucine motifs in the internalization and degradation of the insulin receptor. J. Biol. Chem., 269: 26286-26294, 1994
28. Haft, C. R., de la Luz Sierra, M., Barr, V. A., Haft, D. H., and Taylor. S. I. Identification of a family of sorting nexin molecules and characterization of their association with receptors. Mol. Cell. Biol., 18: 7278-7287, 1998
29. Sander, E. E., ten Klooster, J. P., van Delft, S., van der Kammen, R. A., and Collard, J. G. Rac downregulates Rho activity: Reciprocal balance between both GTPases determines cellular morphology and migratory behavior. J. Cell Biol., 147: 1009-1022, 1999
30. Evers, E. E., Zondag, G. C., Mallm, A., Price, L. S., ten Klooster, J. P., van der Kammen. R. A., and Collard, J. G. Rho family proteins in cell adhesion and cell migration. Eur. J. Cancer, 36: 1269-1274, 2000
31. Bae, S. N., Arand, G., Azzam, H., Pavasant, P., Torri, J., Frandsen, T. L., and Thompson, E. W. Molecular and cellular analysis of basement membrane invasion by human breast cancer cells in Matrigel-based in vitro assays. Breast Cancer Res. Treat., 24: 241-255, 1993
32. v integrins. Oncogene, 19: 1915-1923, 2000
33. 4 integrin promotes carcinoma invasion. Cell, 91: 949-960, 1997
34. Birchmeier, W., and Behrens, J. Cadherin expression in carcinomas: Role in the formation of cell junctions and the prevention of invasiveness. Biochim. Biophys. Acta, 1198: 11-26, 1994
35. Doerr. M. E., and Jones, J. I. The roles of integrins and extracellular matrix proteins in the insulin-like growth factor I-stimulated chemotaxis of human breast cancer cells. J. Biol. Chem., 271: 2443-2447. 1996
36. Beavon, I. R. The E-cadherin-catenin complex in turnout metastasis: Structure, function and regulation. Eur. J. Cancer, 36: 1607-1620, 2000
37. Terranova, V. P., Hujanen, E. S., Loeb, D. M., Martin, G. R., Thomburg, L., and Glushko, V. Use of a reconstituted basement membrane to measure cell invasiveness and select for highly invasive tumor cells. Proc. Natl. Acad. Sci. USA, 83: 465-469, 1986
38. Howe, A., Aplin, A. E., Alahari, S. K., and Juliano, R. L. Integrin signaling and cell growth control. Curr. Opin. Cell Biol., 10: 220-231, 1998
39. 3 integrin in IGF-I signaling. J. Cell Sci., 114: 1417-1425, 2001
40. Andre. F., Rigot, V., Thimonier, J., Montixi, C., Parat. F., Pommier, G., Marvaldi, J., and Luis, J. Integrins and E-cadherin cooperate with IGF-I to induce migration of epithelial colonic cells. Int. J. Cancer, 83: 497-505, 1999
41. Gumbiner, B. M. Cell adhesion: The molecular basis of tissue architecture and morphogenesis. Cell, 84: 345-357, 1996
42. Rasbridge, S. A., Gillett, C. E., Sampson, S. A., Walsh, F. S., and Millis. R. R. Epithelial (E-) and placental (P-) cadherin cell adhesion molecule expression in breast carcinoma. J. Pathol., 169: 245-250, 1993
43. Inoue, M., Ogawa, H., Miyata, M., Shiozaki. H., and Tanizawa, O. Expression of E-cadherin in normal, benign, and malignant tissues of female genital organs. Am. J. Clin. Pathol., 98: 76-80, 1992
44. Berx. G., Cleton-Jansen, A. M., Strumane, K., de Leeuw, W. J., Nollet, F., van Roy, F., and Cornelisse, C. E-cadherin is inactivated in a majority of invasive human lobular breast cancers by truncation mutations throughout its extracellular domain. Oncogene, 13: 1919-1925, 1996
45. Matsuyoshi, N., Hamaguchi, M., Taniguchi, S., Nagafuchi, A., Tsukita, S., and Takeichi, M. Cadherin-mediated cell-cell adhesion is perturbed by v-src tyrosine phosphorylation in metastatic fibroblasts. J. Cell Biol., 118: 703-714, 1992
46. Kaibuchi, K., Kuroda, S., Fukata, M., and Nakagawa, M. Regulation of cadherin-mediated cell-cell adhesion by the Rho family GTPases. Curr. Opin. Cell Biol., 11: 591-596, 1999
47. Braga. V. M., Machesky, L. M., Hall, A., and Hotchin, N. A. The small GTPases Rho and Rac are required for the establishment of cadherin-dependent cell-cell contacts. J. Cell Biol., 137: 1421-1431, 1997
48. Aplin, A. E., Howe. A., Alahari, S. K., and Juliano, R. L. Signal transduction and signal modulation by cell adhesion receptors: The role of integrins, cadherins, immunoglobulin-cell adhesion molecules, and selectins. Pharmacol. Rev., 50: 197-263, 1998
49. Yap, A. S., Niessen, C. M., and Gumbiner, B. M., The juxtamembrane region of the cadherin cytoplasmic tail supports lateral clustering, adhesive strengthening, and interaction with p120ctn. J. Cell Biol., 141: 779-789, 1998
50. ctn acts as an inhibitory regulator of cadherin function in colon carcinoma cells. J. Cell Biol., 145: 551-562, 1999
51. Keely, P. J., Westwick. J. K., Whitehead, I. P., Der, C. J., and Parise, L. V. Cdc42 and Rac 1 induce integrin-mediated cell motility and invasiveness through PI(3)K. Nature (Lond.), 390: 632-636, 1997
52. Nobes, C. D., and Hall, A. Rho GTPases control polarity, protrusion, and adhesion during cell movement. J. Cell Biol., 144: 1235-1244, 1999
53. Kimura, K., Ito, M., Amano, M., Chihara, K., Fukata. Y., Nakafuku, M., Yamamori, B., Feng, J., Nakano, T., Okawa, K., Iwamatsu, A., and Kaibuchi, K. Regulation of myosin phosphatase by Rho and Rho-associated kinase (Rho-kinase). Science (Wash. DC), 273: 245-248, 1996
54. Behrens, J., Vakaet, L., Friis, R., Winterhager, E., Van Roy, F., Mareel, M. M., and Birchmeier, W. Loss of epithelial differentiation and gain of invasiveness correlates with tyrosine phosphorylation of the E-cadherin/β-catenin complex in cells transformed with a temperature-sensitive v-SRC gene. J. Cell Biol., 120: 757-766, 1993