Depletion of intracellular glutathione mediates zinc-induced cell death in rat primary astrocytes

Experimental Brain Research

Volumn 143, Issue 2, 2002, Pages 257-263

  Ryu, Jae ^a   Shin, Chan ^a   Choi, Ji Woong ^a   Min, Hye ^a   Ryu, Jong ^b   Choi, Chang Rak ^c   Ko, Kwang ^a  

^a Seoul National University   (South Korea)

^b Kyung Hee University   (South Korea)

^c The Catholic University of Korea   (South Korea)

Author keywords

Astrocyte; Glutathione; Mitochondria; Reactive oxygen species; Zn2+

Indexed keywords

ACETYLCYSTEINE; ASCORBIC ACID; GLUTATHIONE; LACTATE DEHYDROGENASE; REACTIVE OXYGEN METABOLITE; ZINC; ZINC ION;

ANIMAL CELL; ARTICLE; ASTROCYTE; CELL DAMAGE; CELL DEATH; CELL NUCLEUS; CONTROLLED STUDY; CYTOTOXICITY; ENZYME RELEASE; GLIOMA CELL; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPLETION; RAT;

ANIMALS; ASTROCYTES; CELL DEATH; CELLS, CULTURED; GLIOMA; GLUTATHIONE; MEMBRANE POTENTIALS; MITOCHONDRIA; PREFRONTAL CORTEX; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; TUMOR CELLS, CULTURED; ZINC;

EID: 0036192499     PISSN: 00144819     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00221-001-0991-7     Document Type: Article

References (51)

1. Replenishment of glutathione levels improves mucosal function in experimental acute colitis
2. The antioxidant action of N-aectylcysteine: Its reaction with hydrogen peroxide, hydroxyl radical, superoxide and hypochlorous acid
3. 2+ from brain tissue during activity
4. Excitation-transcription coupling mediated by zinc influx through voltage-dependent calcium channels
5. Regulation of caspase activation and apoptosis by cellular zinc fluxes and zinc deprivation: A review
6. Induction of nitric oxide synthesis lowers intracellular glutathione in microglia of primary glial cultures
7. Zinc and brain injury
8. Zinc neurotoxicity in cortical cell culture
9. Protection by a manganese porphyrin of endogenous peroxynitrite-induced death of glial cells via inhibition of mitochondrial transmembrane potential decrease
10. Lovastatin-induced proliferation inhibition and apoptosis in C6 glial cells
11. Inhibition of free radical production or free radical scavenging protects from the excitotoxic cell death mediated by glutamate in cultures of cerebellar granule neurons
12. N-Acetylcysteine: Pharmacological considerations and experimental and clinical applications
13. i
14. Neurobiology of zinc and zinc-containing neurons
15. A quinoline fluorescence method for visualizing and assaying the histochemically reactive zinc (bouton zinc) in the brain
16. Loss of zinc staining from hippocampal mossy fibers during kainic acid induced seizures: A histofluorescence study
17. 2+-induced neurotoxicity in rat primary cortical cultures: Involvement of L-type calcium channels
18. Uptake and intracellular distribution of labile and total Zn(II) in C6 rat glioma cells investigated with fluorescent and atomic absorption
19. 2+: An endogenous modulator of ligand- and voltage-gated ion channels
20. Stimulation-induced uptake and release of zinc in hippocampal slices
21. Generation of reactive oxygen species, release of L-glutamate and activation of caspases are required for oxygen-induced apoptosis of embryonic hippocampal neurons in culture
22. Synergistic depletion of astrocytic glutathione by glucose deprivation and peroxynitrite: Correlation with mitochondrial dysfunction and subsequent cell death
23. 2+ entry produces oxidative neuronal necrosis in cortical cell cultures
24. Zinc-induced cortical neuronal death with features of apoptosis and necrosis: Mediation by free radicals
25. Zinc toxicity on cultured cortical neurons: Involvement of N-methyl-D-aspartate receptors
26. Potentiated necrosis of cultured cortical neurons by neurotrophins
27. Staurosporine-induced neuronal apoptosis
28. The role of zinc in selective neuronal death after transient global cerebral ischemia
29. Histochemically reactive zinc in plaques of the Swedish mutant beta-amyloid precursor protein transgenic mice
30. Neuronal and glial apoptosis after traumatic spinal cord injury
31. Apoptosis is induced by beta-amyloid in cultured central nervous system neurons
32. Characterization of zinc-induced neuronal death in primary cultures of rat cerebellar granule cells
33. The mechanism of the insulin-like effects of ionic zinc
34. Mitochondrial impairment as an early event in the process of apoptosis induced by glutathione depletion in neuronal cells: Relevance to Parkinson's disease
35. gp120-induced neurotoxicity in hippocampal pyramidal neuron cultures: Protective action of TGF-beta1
36. Hepatic glutathione reductase
37. Induction and activation by zinc of NADPH oxidase in cultured cortical neurons and astrocytes
38. Mediation by membrane protein kinase C of zinc-induced oxidative neuronal injury in mouse cortical cultures
39. 2+ homeostasis
40. 2+-permeable AMPA/kainate channels triggers prolonged mitochondrial superoxide production
41. + and inhibition of glycolysis
42. Augmentation of endotoxin hepatotoxicity by zinc
43. Modulation of inhibitory and excitatory amino acid receptor ion channels by zinc
44. Inhibition of glutathione peroxidase by cadmium and other metal ions
45. Effects of zinc on rat hepatoma HTC cells and primary cultured rat hepatocytes
46. Histochemically-reactive zinc in amyloid plaques, angiopathy, and degenerating neurons of Alzheimer's diseased brains
47. Zinc toxicity and induction of the 72 kD heat shock protein in primary astrocyte culture
48. + alpha beta TCRloCD3ει thymocytes by zinc
49. Possible role of zinc in the selective degeneration of dentate hilar neurons after cerebral ischemia in the adult rat
50. 2+: A novel ionic mediator of neural injury in brain disease
51. 2+ permeable AMPA/kainate channels and triggers selective neural injury