Design, synthesis, and biological evaluation of C9- and C2-substituted pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidines as new A2A and A3 adenosine receptors antagonists

Journal of Medicinal Chemistry

Volumn 46, Issue 7, 2003, Pages 1229-1241

  Baraldi, Pier Giovanni ^a   Fruttarolo, Francesca ^a   Tabrizi, Mojgan Aghazadeh ^a   Preti, Delia ^a   Romagnoli, Romeo ^a   El Kashef, Hussein ^b   Moorman, Allan ^c   Varani, Katia ^a   Gessi, Stefania ^a   Merighi, Stefania ^a   Borea, Pier Andrea ^a  

^a UNIVERSITY OF FERRARA   (Italy)

^b Assiut University   (Egypt)

^c King Pharmaceuticals   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5 AMINO 2 (2 FURYL) 7 (2 PHENYLETHYL)PYRAZOLO[4,3 E][1,2,4]TRIAZOLO[1,5 C]PYRIMIDINE; 5 AMINO 7 (2 PHENYLETHYL) 2 (2 ETHOXYPHENYL)PYRAZOLO[4,3 E] 1,2,4 TRIAZOLO[1,5 C]PYRIMIDINE; 5 AMINO 8 METHYL 9 METHYLSULFANYL 2 (2 FURYL) PYRAZOLO[4,3 E] 1,2,4 TRIAZOLO[1,5 C]PYRIMIDINE; ADENOSINE A2A RECEPTOR ANTAGONIST; ADENOSINE A3 RECEPTOR ANTAGONIST; LEAD; PHENYL GROUP; PYRAZOLO[4,3 E] 1,2,4 TRIAZOLO[1,5 C]PYRIMIDINE; PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL STRUCTURE; MANNICH REACTION; RECEPTOR AFFINITY; RECEPTOR BINDING; SOLUBILITY; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ANIMALS; BINDING, COMPETITIVE; CRICETINAE; DRUG DESIGN; HUMANS; MOLECULAR CONFORMATION; PYRAZOLES; PYRIMIDINES; RADIOLIGAND ASSAY; RECEPTOR, ADENOSINE A2A; RECEPTOR, ADENOSINE A3; RECEPTORS, PURINERGIC P1; SOLUBILITY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0345269287     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm021023m     Document Type: Article

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