Substitution of a Single Residue in Stichodactyla helianthus Peptide, ShK-Dap22, Reveals a Novel Pharmacological Profile

Biochemistry

Volumn 42, Issue 46, 2003, Pages 13698-13707

  Middleton, Richard E ^a   Sanchez, Manuel ^a   Linde, Ana Rosa ^a,b   Bugianesi, Randal M ^a   Dai, Ge ^a   Felix, John P ^a   Koprak, Sam L ^a   Staruch, Mary Jo ^a   Bruguera, Marc ^a   Cox, Rachael ^a   Ghosh, Amrita ^a   Hwang, Jeremy ^a   Jones, Simmonette ^a   Kohler, Martin ^a   Slaughter, Robert S ^a   McManus, Owen B ^a   Kaczorowski, Gregory J ^a   Garcia, Maria L ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

^b INSTITUTO OSWALDO CRUZ   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

PHARMACOLOGY;

BIOASSAY; BRAIN; IMMUNOLOGY; ORGANIC ACIDS; SUBSTITUTION REACTIONS; TISSUE;

BIOCHEMISTRY;

IMMUNOSUPPRESSIVE AGENT; POTASSIUM CHANNEL; STICHODACTYLA HELIANTHUS LYSINE 22 DIAMINOPROPIONIC ACID; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING ASSAY; CONTROLLED STUDY; DRUG EFFICACY; DRUG POTENCY; EMBRYO; FEMALE; FIBROBLAST; HUMAN; HUMAN CELL; HUMAN TISSUE; KIDNEY; LYMPHOCYTE ACTIVATION; NONHUMAN; PRIORITY JOURNAL; SEA ANEMONE; STICHODACTYLA HELIANTHUS; VOLTAGE CLAMP; WILD TYPE; XENOPUS;

AMINO ACID SUBSTITUTION; ANIMALS; BRAIN; CELL LINE; CHO CELLS; CNIDARIAN VENOMS; CRICETINAE; HUMANS; INHIBITORY CONCENTRATION 50; MEMBRANE POTENTIALS; OOCYTES; PEPTIDES; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHANNELS; RADIOLIGAND ASSAY; SEA ANEMONES; STRUCTURE-ACTIVITY RELATIONSHIP; T-LYMPHOCYTES; XENOPUS;

ACTINIARIA; ANEMONE; ANIMALIA; HELIANTHUS; STICHODACTYLA; STICHODACTYLA HELIANTHUS;

EID: 0345254907     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi035209e     Document Type: Article

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