Isolation of a single carboxyl-carboxylate proton binding site in the pore of a cyclic nucleotide-gated channel

Journal of General Physiology

Volumn 114, Issue 1, 1999, Pages 71-83

  Morrill, James A ^a   MacKinnon, Roderick ^b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b ROCKEFELLER UNIVERSITY   (United States)

Author keywords

Ion channel permeation proton block; Ligand gated ion channels patch clamp; Xenopus oocyte expression

Indexed keywords

CARBOXYLIC ACID DERIVATIVE; CYCLIC NUCLEOTIDE; ION CHANNEL;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; BINDING SITE; CELL ISOLATION; CHANNEL GATING; HEART MUSCLE CELL; MOLECULAR CLONING; NONHUMAN; PATCH CLAMP; PROTEIN EXPRESSION; PROTON TRANSPORT; XENOPUS;

ANIMALS; BINDING SITES; CARBOXYLIC ACIDS; CATFISHES; DIMERIZATION; ELECTRIC CONDUCTIVITY; GLUTAMATES; HYBRIDIZATION, GENETIC; HYDROGEN-ION CONCENTRATION; ION CHANNEL GATING; ION CHANNELS; MUTATION; NUCLEOTIDES, CYCLIC; OOCYTES; PATCH-CLAMP TECHNIQUES; PERMEABILITY; PROTEIN ISOFORMS; PROTONS; XENOPUS LAEVIS;

EID: 0033032511     PISSN: 00221295     EISSN: None     Source Type: Journal    
DOI: 10.1085/jgp.114.1.71     Document Type: Article

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