Synthesis, Biochemical Properties and Molecular Modelling Studies of Organometallic Specific Estrogen Receptor Modulators (SERMs), the Ferrocifens and Hydroxyferrocifens: Evidence for an Antiproliferative Effect of Hydroxyferrocifens on both Hormone-Dependent and Hormone-Independent Breast Cancer Cell Lines

Chemistry - A European Journal

Volumn 9, Issue 21, 2003, Pages 5223-5236

  Top, Siden ^a   Vessières, Anne ^a   Leclercq, Guy ^b   Quivy, Jacques ^b   Tang, J ^a   Vaissermann, J ^c   Huché, Michel ^a   Jaouen, Gérard ^a  

^a CNRS   (France)

^b JULES BORDET INSTITUTE   (Belgium)

^c SORBONNE UNIVERSITÉ   (France)

Author keywords

Antitumor agents; Bio organometallic chemistry; Breast cancer; Iron; Tamoxifen

Indexed keywords

ETHYLENE; HORMONES; IRON COMPOUNDS; ISOMERS; KETONES; METABOLISM; SYNTHESIS (CHEMICAL); TOXIC MATERIALS;

MOLECULAR MODELLING;

ORGANOMETALLICS;

1 [4 (2 DIMETHYLAMINETHOXY)PHENYL] 1 (4 HYDROXYPHENYL) 2 FERROCENYL 1 BUTENE; 1 [4 (2 DIMETHYLAMINETHOXY)PHENYL] 1 (4 HYDROXYPHENYL) 2 FERROCENYLETHENE; 1 [4 (4 BROMOPENTOXY)PHENYL] 1 (4 HYDROXYPHENYL) 2 FERROCENYLBUT 1 ENE; 1 [4 (4 BROMOPENTOXY)PHENYL] 1 PHENYL 2 FERROCENYLBUT 1 ENE; 1 [4 (4 CHLOROCTOXY) 1 PHENYL] 2 FERROCENYLBUT 1 ENE; 1 [4 (4 CHLOROCTOXY)PHENYL] 1 (4 HYDROXYPHENYL) 2 FERROCENYLBUT 1 ENE; 1 [4 (4 DIMETHYLAMINOCTOXY)PHENYL] 1 (4 HYDROXYPHENYL) 2 FERROCENYLBUT 1 ENE; 1 [4 (4 DIMETHYLAMINOCTOXY)PHENYL] 1 PHENYL 2 FERROCENYLBUT 1 ENE; 1 [4 (4 DIMETHYLAMINOPENTOXY)PHENYL] 1 (4 HYDROXYPHENYL) 2 FERROCENYLBUT 1 ENE; 1 [4 (4 DIMETHYLAMINOPENTOXY)PHENYL] 1 PHENYL 2 FERROCENYLBUT 1 ENE; 1,1 BIS(4 HYDROXYPHENYL) 2 FERROCENYLETHENE; 1,1 BIS(4 METHOXYPHENYL) 2 FERROCENYLETHENE; [4 (4 BROMOPENTOXY)PHENYL](4 HYDROXYPHENYL)KETONE; [4 (4 CHLOROOCTOXY)PHENYL](4 HYDROXYPHENYL)KETONE; [4 (4 CHLOROOCTOXY)PHENYL](PHENYL)KETONE; ANTIESTROGEN; CHLOROFORM; DIMETHYL SULFOXIDE; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; ETHYL FERROCENYLACETATE; FERROCENE DERIVATIVE; HYDROXYTAMOXIFEN; KETONE DERIVATIVE; SELECTIVE ESTROGEN RECEPTOR MODULATOR; TAMOXIFEN; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BINDING AFFINITY; BREAST ADENOCARCINOMA; BREAST CANCER; CANCER CELL; CELL LINE; CELL PROLIFERATION; CELL STRAIN MCF 7; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG EFFECT; DRUG SYNTHESIS; HORMONE DEPENDENCE; HUMAN; HUMAN CELL; ISOMER; ISOMERISM; LIPOPHILICITY; MOLECULAR MODEL; X RAY;

ANIMALS; ANTINEOPLASTIC AGENTS, HORMONAL; BREAST NEOPLASMS; CELL LINE, TUMOR; CRYSTALLOGRAPHY, X-RAY; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; FEMALE; FERROUS COMPOUNDS; HUMANS; MODELS, MOLECULAR; NEOPLASMS, HORMONE-DEPENDENT; RADIOLIGAND ASSAY; RECEPTORS, ESTROGEN; SELECTIVE ESTROGEN RECEPTOR MODULATORS; SHEEP; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TAMOXIFEN; UTERUS;

EID: 0344876663     PISSN: 09476539     EISSN: None     Source Type: Journal    
DOI: 10.1002/chem.200305024     Document Type: Article

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