-
2
-
-
0030026129
-
Mammalian RAFT1 kinase domain provides rapamycin-sensitive TOR function in yeast
-
Alarcon, C. M., Cardenas, M. E. & Heitman, J. (1996). Mammalian RAFT1 kinase domain provides rapamycin-sensitive TOR function in yeast. Genes Dev 10, 279-288.
-
(1996)
Genes Dev
, vol.10
, pp. 279-288
-
-
Alarcon, C.M.1
Cardenas, M.E.2
Heitman, J.3
-
3
-
-
0029872079
-
Organization of the biosynthetic gene cluster for rapamycin in Streptomyces hygroscopicus: Analysis of the enzymatic domains in the modular polyketide synthase
-
Aparicio, J. F., Molnár, I., Schwecke, T., König, A., Haydock, S. F., Khaw, L. E., Staunton, J. & Leadlay, P. F. (1996). Organization of the biosynthetic gene cluster for rapamycin in Streptomyces hygroscopicus: analysis of the enzymatic domains in the modular polyketide synthase. Gene 169, 9-16.
-
(1996)
Gene
, vol.169
, pp. 9-16
-
-
Aparicio, J.F.1
Molnár, I.2
Schwecke, T.3
König, A.4
Haydock, S.F.5
Khaw, L.E.6
Staunton, J.7
Leadlay, P.F.8
-
4
-
-
0018101547
-
Rapamycin (AY-22,989), a new antifungal antibiotic. III. In vitro and in vivo evaluation
-
Baker, H., Sidorowicz, A., Sehgal, S. N. & Venzina, C. (1978). Rapamycin (AY-22,989), a new antifungal antibiotic. III. In vitro and in vivo evaluation. J Antibiot 31, 539-545.
-
(1978)
J Antibiot
, vol.31
, pp. 539-545
-
-
Baker, H.1
Sidorowicz, A.2
Sehgal, S.N.3
Venzina, C.4
-
5
-
-
0030021524
-
TOR controls translation initiation and early G1 progression in yeast
-
Barbet N. C., Schneider, U., Helliwell, S. B., Stansfield, I., Tuite, M. F. & Hall, M. N. (1996). TOR controls translation initiation and early G1 progression in yeast. Mol Biol Cell 7, 25-42.
-
(1996)
Mol Biol Cell
, vol.7
, pp. 25-42
-
-
Barbet N, C.1
Schneider, U.2
Helliwell, S.B.3
Stansfield, I.4
Tuite, M.F.5
Hall, M.N.6
-
6
-
-
0027323876
-
Identification of the immunophilins capable of mediating inhibition of signal transduction by cyclosporin A and FK506: Roles of calcineurin binding and cellular location
-
Bram, R. J., Hung, D. T., Martin, P. K., Schreiber, S. L. & Crabtree, G. R. (1993). Identification of the immunophilins capable of mediating inhibition of signal transduction by cyclosporin A and FK506: roles of calcineurin binding and cellular location. Mol Cell Biol 13, 4760-4769.
-
(1993)
Mol Cell Biol
, vol.13
, pp. 4760-4769
-
-
Bram, R.J.1
Hung, D.T.2
Martin, P.K.3
Schreiber, S.L.4
Crabtree, G.R.5
-
7
-
-
0028307855
-
Calcineurin is essential in cyclosporin A- and FK506-sensitive yeast strains
-
Breuder, T., Hemenway, C. S., Movva, N. R., Cardenas, M. E. & Heitman, J. (1994). Calcineurin is essential in cyclosporin A-and FK506-sensitive yeast strains. Proc Natl Acad Sci USA 91, 5372-5376.
-
(1994)
Proc Natl Acad Sci USA
, vol.91
, pp. 5372-5376
-
-
Breuder, T.1
Hemenway, C.S.2
Movva, N.R.3
Cardenas, M.E.4
Heitman, J.5
-
8
-
-
0028360374
-
A mammalian protein targeted by G1-arresting rapamycin-receptor complex
-
Brown, E. J., Albers, M. W., Shin, T. B., Ichikawa, K., Keith, C. T., Lane, W. S. & Schreiber, S. L. (1994). A mammalian protein targeted by G1-arresting rapamycin-receptor complex. Nature 369, 756-759.
-
(1994)
Nature
, vol.369
, pp. 756-759
-
-
Brown, E.J.1
Albers, M.W.2
Shin, T.B.3
Ichikawa, K.4
Keith, C.T.5
Lane, W.S.6
Schreiber, S.L.7
-
9
-
-
0030881836
-
Phosphorylation of the translational repressor PHAS-I by the mammalian target of rapamycin
-
Brunn, G. J., Hudson, C. C., Sekulic, A., Williams, J. M., Hosoi, H., Houghton, P. J., Lawrence, J. C., Jr & Abraham, R. T. (1997). Phosphorylation of the translational repressor PHAS-I by the mammalian target of rapamycin. Science 277, 99-101.
-
(1997)
Science
, vol.277
, pp. 99-101
-
-
Brunn, G.J.1
Hudson, C.C.2
Sekulic, A.3
Williams, J.M.4
Hosoi, H.5
Houghton, P.J.6
Lawrence J.C., Jr.7
Abraham, R.T.8
-
10
-
-
0027382875
-
Dominant missense mutations in a novel yeast protein related to mammalian phosphatidylinositol 3-kinase and VPS34 abrogate rapamycin cytotoxicity
-
Cafferkey, R., Young, P. R., McLaughlin, M. M. & 7 other authors (1993). Dominant missense mutations in a novel yeast protein related to mammalian phosphatidylinositol 3-kinase and VPS34 abrogate rapamycin cytotoxicity. Mol Cell Biol 13, 6012-6023.
-
(1993)
Mol Cell Biol
, vol.13
, pp. 6012-6023
-
-
Cafferkey, R.1
Young, P.R.2
McLaughlin, M.M.3
-
11
-
-
0028597938
-
Immunophilins interact with calcineurin in the absence of exogenous immunosuppressive ligands
-
Cardenas, M. E., Hemenway, C., Muir, R. S., Ye, R., Florentino, D. & Heitman, J. (1994). Immunophilins interact with calcineurin in the absence of exogenous immunosuppressive ligands. EMBO J 13, 5944-5957.
-
(1994)
EMBO J
, vol.13
, pp. 5944-5957
-
-
Cardenas, M.E.1
Hemenway, C.2
Muir, R.S.3
Ye, R.4
Florentino, D.5
Heitman, J.6
-
12
-
-
0029559927
-
Molecular mechanisms of immunosuppression by cyclosporin, FK506, and rapamycin
-
Cardenas, M. E., Zhu, D. & Heitman, J. (1995a). Molecular mechanisms of immunosuppression by cyclosporin, FK506, and rapamycin. Curr Opin Nephrol Hypertens 4, 472-477.
-
(1995)
Curr Opin Nephrol Hypertens
, vol.4
, pp. 472-477
-
-
Cardenas, M.E.1
Zhu, D.2
Heitman, J.3
-
13
-
-
0028998848
-
Targets of immunophilin-immunosuppressant complexes are distinct highly conserved regions of calcineurin A
-
Cardenas, M. E., Muir, R. S., Breuder, T. & Heitman, J. (1995b). Targets of immunophilin-immunosuppressant complexes are distinct highly conserved regions of calcineurin A. EMBO J 14, 2772-2783.
-
(1995)
EMBO J
, vol.14
, pp. 2772-2783
-
-
Cardenas, M.E.1
Muir, R.S.2
Breuder, T.3
Heitman, J.4
-
15
-
-
0028598672
-
RAPT1, a mammalian homolog of yeast Tor, interacts with the FKBP12/rapamycin complex
-
Chiu, M. I., Katz, H. & Berlin, V. (1994). RAPT1, a mammalian homolog of yeast Tor, interacts with the FKBP12/rapamycin complex. Proc Natl Acad Sci USA 91, 12574-12578.
-
(1994)
Proc Natl Acad Sci USA
, vol.91
, pp. 12574-12578
-
-
Chiu, M.I.1
Katz, H.2
Berlin, V.3
-
16
-
-
0029808294
-
Nutrients, via the Tor proteins, stimulate the association of Tap42 with type 2A phosphatases
-
di Como, C. J. & Arndt, K. T. (1996). Nutrients, via the Tor proteins, stimulate the association of Tap42 with type 2A phosphatases. Genes Dev 10, 1904-1916.
-
(1996)
Genes Dev
, vol.10
, pp. 1904-1916
-
-
Di Como, C.J.1
Arndt, K.T.2
-
17
-
-
0025081416
-
An unusually large multifunctional polypeptide in the erythromycin producing polyketide synthase of Saccharopolyspora erythraea
-
Cortes, J., Haydock, S. H., Roberts, G. A., Bevitt, D. J. & Leadlay, P. F. (1990). An unusually large multifunctional polypeptide in the erythromycin producing polyketide synthase of Saccharopolyspora erythraea. Nature 348, 176-178.
-
(1990)
Nature
, vol.348
, pp. 176-178
-
-
Cortes, J.1
Haydock, S.H.2
Roberts, G.A.3
Bevitt, D.J.4
Leadlay, P.F.5
-
18
-
-
0033043180
-
Rapamycin antifungal action is mediated via conserved complexes with FKBP12 and TOR kinase homologs in Cryptococcus neoformans
-
Cruz, M. C., Cavallo, L. M., Görlach, J., M., Cox, G., Perfect, J. R., Cardenas, M. E. & Heitman, J. (1999). Rapamycin antifungal action is mediated via conserved complexes with FKBP12 and TOR kinase homologs in Cryptococcus neoformans. Mol Cell Biol 19, 4101-4112.
-
(1999)
Mol Cell Biol
, vol.19
, pp. 4101-4112
-
-
Cruz, M.C.1
Cavallo, L.M.2
Görlach, J.3
Cox, G.4
Perfect, J.R.5
Cardenas, M.E.6
Heitman, J.7
-
19
-
-
0026415106
-
Modular organization of genes required for complex polyketide biosynthesis
-
Donadio, S., Staver, M. J., McAlpine, J. B., Swanson, S. J. & Katz, L. (1991). Modular organization of genes required for complex polyketide biosynthesis. Science 252, 675-679.
-
(1991)
Science
, vol.252
, pp. 675-679
-
-
Donadio, S.1
Staver, M.J.2
McAlpine, J.B.3
Swanson, S.J.4
Katz, L.5
-
20
-
-
0028568052
-
The Saccharomyces cerevisiae FKS1 (ETG1) gene encodes an integral membrane protein which is a subunit of 1,3-β-D-glucan synthase
-
Douglas, C. M., Foor, F., Marrinan, J. A. & 11 other authors (1994). The Saccharomyces cerevisiae FKS1 (ETG1) gene encodes an integral membrane protein which is a subunit of 1,3-β-D-glucan synthase. Proc Natl Acad Sci USA 91, 12907-12911.
-
(1994)
Proc Natl Acad Sci USA
, vol.91
, pp. 12907-12911
-
-
Douglas, C.M.1
Foor, F.2
Marrinan, J.A.3
-
21
-
-
0029965775
-
Antascomicins A, B, C, D and E. Novel FKBP12 binding compounds from a Micromonospora strain
-
Fehr, T., Sanglier, J. J., Schuler, W., Gschwind, L., Ponelle, M., Schilling, W. & Wioland, C. (1996). Antascomicins A, B, C, D and E. Novel FKBP12 binding compounds from a Micromonospora strain. J Antibiot 49, 230-233.
-
(1996)
J Antibiot
, vol.49
, pp. 230-233
-
-
Fehr, T.1
Sanglier, J.J.2
Schuler, W.3
Gschwind, L.4
Ponelle, M.5
Schilling, W.6
Wioland, C.7
-
22
-
-
0024406857
-
A novel genetic system to detect protein-protein interactions
-
Fields, S. & Song, O.-K. (1989). A novel genetic system to detect protein-protein interactions. Nature 340, 245-246.
-
(1989)
Nature
, vol.340
, pp. 245-246
-
-
Fields, S.1
Song, O.-K.2
-
23
-
-
0026619467
-
Calcineurin mediates inhibition by FK506 and cyclosporin of recovery from α-factor arrest in yeast
-
Foor, F., Parent, S. A., Morin, N., Dahl, A. M., Ramadan, N., Chrebet, G., Bostian, K. A. & Nielsen, J. B. (1992). Calcineurin mediates inhibition by FK506 and cyclosporin of recovery from α-factor arrest in yeast. Nature 360, 682-684.
-
(1992)
Nature
, vol.360
, pp. 682-684
-
-
Foor, F.1
Parent, S.A.2
Morin, N.3
Dahl, A.M.4
Ramadan, N.5
Chrebet, G.6
Bostian, K.A.7
Nielsen, J.B.8
-
24
-
-
0023708531
-
FR-900520 and FR-900523, novel immunosuppressants isolated from a Streptomyces. I. Taxonomy of the producing strain
-
Hatanaka, H., Iwami, M., Kino, T., Goto, T. & Okuhara, M. (1988a). FR-900520 and FR-900523, novel immunosuppressants isolated from a Streptomyces. I. Taxonomy of the producing strain. J Antibiot 41, 1586-1591.
-
(1988)
J Antibiot
, vol.41
, pp. 1586-1591
-
-
Hatanaka, H.1
Iwami, M.2
Kino, T.3
Goto, T.4
Okuhara, M.5
-
25
-
-
0023691846
-
FR-900520 and FR-900523, novel immunosuppressants isolated from a Streptomyces. II. Fermentation, isolation and physico-chemical and biological characteristics
-
Hatanaka, H., Kino, T., Miyata, S., Inamura, N., Kuroda, A., Goto, T., Tanaka, H. & Okuhara. M. (1988b). FR-900520 and FR-900523, novel immunosuppressants isolated from a Streptomyces. II. Fermentation, isolation and physico-chemical and biological characteristics. J Antibiot 41, 1592-1601.
-
(1988)
J Antibiot
, vol.41
, pp. 1592-1601
-
-
Hatanaka, H.1
Kino, T.2
Miyata, S.3
Inamura, N.4
Kuroda, A.5
Goto, T.6
Tanaka, H.7
Okuhara, M.8
-
26
-
-
0025776523
-
Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast
-
Heitman, J., Movva, N. R. & Hall, M. N. (1991a). Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast. Science 253, 905-909.
-
(1991)
Science
, vol.253
, pp. 905-909
-
-
Heitman, J.1
Movva, N.R.2
Hall, M.N.3
-
27
-
-
0026012156
-
FK506-binding protein proline rotamase is a target for the immunosuppressive agent FK506 in Saccharomyces cerevisiae
-
Heitman, J., Movva, N. R., Hiestand, P. C. & Hall, M. N. (1991b). FK506-binding protein proline rotamase is a target for the immunosuppressive agent FK506 in Saccharomyces cerevisiae. Proc Natl Acad Sci USA 88, 1948-1952.
-
(1991)
Proc Natl Acad Sci USA
, vol.88
, pp. 1948-1952
-
-
Heitman, J.1
Movva, N.R.2
Hiestand, P.C.3
Hall, M.N.4
-
28
-
-
0026857926
-
Proline isomerases at the crossroads of protein folding, signal transduction, and immunosuppression
-
Heitman, J., Movva, N. R. & Hall, M. N. (1992). Proline isomerases at the crossroads of protein folding, signal transduction, and immunosuppression. New Biol 4, 448-460.
-
(1992)
New Biol
, vol.4
, pp. 448-460
-
-
Heitman, J.1
Movva, N.R.2
Hall, M.N.3
-
29
-
-
0028137771
-
TORI and TOR2 are structurally and functionally similar but not identical phosphatidylinositol kinase homologues in yeast
-
Helliwell, S. B., Wagner, P., Kunz, J., Deuter-Reinhard, M., Henriquez, R. & Hall, M. N. (1994). TORI and TOR2 are structurally and functionally similar but not identical phosphatidylinositol kinase homologues in yeast. Mol Biol Cell 5, 105-118.
-
(1994)
Mol Biol Cell
, vol.5
, pp. 105-118
-
-
Helliwell, S.B.1
Wagner, P.2
Kunz, J.3
Deuter-Reinhard, M.4
Henriquez, R.5
Hall, M.N.6
-
31
-
-
0028234434
-
The antimicrobial activities of cyclosporine, FK506, and rapamycin
-
High, K. P. (1994). The antimicrobial activities of cyclosporine, FK506, and rapamycin. Transplantation 57, 1689-1700.
-
(1994)
Transplantation
, vol.57
, pp. 1689-1700
-
-
High, K.P.1
-
32
-
-
0030455820
-
Genomic libraries and a host strain designed for highly efficient two-hybrid selection in yeast
-
James, P., Halladay, J. & Craig, E. A. (1996). Genomic libraries and a host strain designed for highly efficient two-hybrid selection in yeast. Genetics 144, 1425-1436.
-
(1996)
Genetics
, vol.144
, pp. 1425-1436
-
-
James, P.1
Halladay, J.2
Craig, E.A.3
-
33
-
-
0001436716
-
Manipulation of modular polyketide synthase
-
Katz, L. (1997). Manipulation of modular polyketide synthase. Chem Rev 97, 2557-2575.
-
(1997)
Chem Rev
, vol.97
, pp. 2557-2575
-
-
Katz, L.1
-
34
-
-
2642591970
-
Mutational biosynthesis of novel rapamycins by a strain of Streptomyces hygroscopicus NRRL 5491 disrupted in rapL, encoding a putative lysine cyclodeaminase
-
Khaw, L. E., Böhm, G. A., Metcalfe, S., Staunton, J. & Leadlay, P. F. (1998). Mutational biosynthesis of novel rapamycins by a strain of Streptomyces hygroscopicus NRRL 5491 disrupted in rapL, encoding a putative lysine cyclodeaminase. J Bacteriol 180, 809-814.
-
(1998)
J Bacteriol
, vol.180
, pp. 809-814
-
-
Khaw, L.E.1
Böhm, G.A.2
Metcalfe, S.3
Staunton, J.4
Leadlay, P.F.5
-
35
-
-
0023261356
-
FK-506, a novel immunosuppressant isolated from a Streptomyces. II. Immunosuppressive effect of FK-506 in vitro
-
Kino, T., Hatanaka, H., Miyata, S. & 8 other authors (1987). FK-506, a novel immunosuppressant isolated from a Streptomyces. II. Immunosuppressive effect of FK-506 in vitro. J Antibiot 40, 1256-1265.
-
(1987)
J Antibiot
, vol.40
, pp. 1256-1265
-
-
Kino, T.1
Hatanaka, H.2
Miyata, S.3
-
37
-
-
0025893168
-
Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes
-
Liu, J., Farmer, J. D., Lane, W. S., Friedman, J., Weissman, I. & Schreiber, S. L. (1991). Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes. Cell 66, 807-815.
-
(1991)
Cell
, vol.66
, pp. 807-815
-
-
Liu, J.1
Farmer, J.D.2
Lane, W.S.3
Friedman, J.4
Weissman, I.5
Schreiber, S.L.6
-
38
-
-
0030898921
-
Gene disruption and replacement in the rapamycin-producing Streptomyces hygroscopicus strain ATCC 29253
-
Lomovskaya, N., Fonstein, L., Ruan, X., Stassi, D., Katz, L. & Hutchinson, C. R. (1997). Gene disruption and replacement in the rapamycin-producing Streptomyces hygroscopicus strain ATCC 29253. Microbiology 143, 875-883.
-
(1997)
Microbiology
, vol.143
, pp. 875-883
-
-
Lomovskaya, N.1
Fonstein, L.2
Ruan, X.3
Stassi, D.4
Katz, L.5
Hutchinson, C.R.6
-
39
-
-
0028825698
-
TOR mutations confer rapamycin resistance by preventing interaction with FKBP12-rapamycin
-
Lorenz, M. C. & Heitman, J. (1995). TOR mutations confer rapamycin resistance by preventing interaction with FKBP12-rapamycin. J Biol Chem 270, 27531-27537.
-
(1995)
J Biol Chem
, vol.270
, pp. 27531-27537
-
-
Lorenz, M.C.1
Heitman, J.2
-
40
-
-
0029329592
-
Structure-activity studies of rapamycin analogs: Evidence that the C-7 methoxy group is part of the effector domain and positioned at the FKBP12-FRAP interface
-
Luengo, J. I., Yamashita, D. S., Dunnington, D. & 18 other authors (1995). Structure-activity studies of rapamycin analogs: evidence that the C-7 methoxy group is part of the effector domain and positioned at the FKBP12-FRAP interface. Chem Biol 2, 471-481.
-
(1995)
Chem Biol
, vol.2
, pp. 471-481
-
-
Luengo, J.I.1
Yamashita, D.S.2
Dunnington, D.3
-
41
-
-
0022504494
-
The effects of cyclosporine on Toxoplasma gondii in vivo and in vitro
-
McCabe, R. E., Luft, B. J. & Remington, J. S. (1986). The effects of cyclosporine on Toxoplasma gondii in vivo and in vitro. Transplantation 41, 611-615.
-
(1986)
Transplantation
, vol.41
, pp. 611-615
-
-
McCabe, R.E.1
Luft, B.J.2
Remington, J.S.3
-
42
-
-
0029883934
-
Organisation of the biosynthetic gene cluster for rapamycin in Streptomyces hygroscopicus : Analysis of genes flanking the polyketide synthase
-
Molnár, I., Aparicio, J. F., Haydock, S. F., Khaw, L. E., Schwecke, T., König, A., Staunton, J. & Leadlay, P. F. (1996). Organisation of the biosynthetic gene cluster for rapamycin in Streptomyces hygroscopicus : analysis of genes flanking the polyketide synthase. Gene 169, 1-7.
-
(1996)
Gene
, vol.169
, pp. 1-7
-
-
Molnár, I.1
Aparicio, J.F.2
Haydock, S.F.3
Khaw, L.E.4
Schwecke, T.5
König, A.6
Staunton, J.7
Leadlay, P.F.8
-
43
-
-
0027479079
-
The α-mating type locus of Cryptococcus neoformans contains a peptide pheromone gene
-
Moore, T. D. E. & Edman, J. C. (1993). The α-mating type locus of Cryptococcus neoformans contains a peptide pheromone gene. Mol Cell Biol 13, 1962-1970.
-
(1993)
Mol Cell Biol
, vol.13
, pp. 1962-1970
-
-
Moore, T.D.E.1
Edman, J.C.2
-
44
-
-
0026503793
-
Identity of immunosuppressant FR-900520 with ascomycin
-
Morisaki, M. & Arai, T. (1992). Identity of immunosuppressant FR-900520 with ascomycin. J Antibiot 45, 126-128.
-
(1992)
J Antibiot
, vol.45
, pp. 126-128
-
-
Morisaki, M.1
Arai, T.2
-
45
-
-
0029831399
-
Characterization of methyltransferase and hydroxylase genes involved in the biosynthesis of the immunosuppressants FK506 and FK520
-
Motamedi, H., Shafiee, A., Cai, S.-J., Streicher, S. L., Arison, B. H. & Miller, R. R. (1996). Characterization of methyltransferase and hydroxylase genes involved in the biosynthesis of the immunosuppressants FK506 and FK520. J Bacteriol 178, 5243-5248.
-
(1996)
J Bacteriol
, vol.178
, pp. 5243-5248
-
-
Motamedi, H.1
Shafiee, A.2
Cai, S.-J.3
Streicher, S.L.4
Arison, B.H.5
Miller, R.R.6
-
46
-
-
0031043482
-
Structural organization of a multifunctional polyketide synthase involved in the biosynthesis of the macrolide immunosuppressant FK506
-
Motamedi, H., Cai, S.-J., Shafiee, A. & Elliston, K. O. (1997). Structural organization of a multifunctional polyketide synthase involved in the biosynthesis of the macrolide immunosuppressant FK506. Eur J Biochem 244, 74-79.
-
(1997)
Eur J Biochem
, vol.244
, pp. 74-79
-
-
Motamedi, H.1
Cai, S.-J.2
Shafiee, A.3
Elliston, K.O.4
-
47
-
-
0025873287
-
Biosynthesis of the immunosuppressant immunomycin: The enzymology of pipecolate incorporation
-
Nielsen, J. B., Hsu, M.-J., Byrne, K. M. & Kaplan, L. (1991). Biosynthesis of the immunosuppressant immunomycin: the enzymology of pipecolate incorporation. Biochemistry 30, 5789-5796.
-
(1991)
Biochemistry
, vol.30
, pp. 5789-5796
-
-
Nielsen, J.B.1
Hsu, M.-J.2
Byrne, K.M.3
Kaplan, L.4
-
48
-
-
0029111959
-
Generation of novel rapamycin structures by microbial manipulations
-
Nishida, H., Sakakibara, T., Aoki, F. & 9 other authors (1995). Generation of novel rapamycin structures by microbial manipulations. J Antibiot 48, 657-666.
-
(1995)
J Antibiot
, vol.48
, pp. 657-666
-
-
Nishida, H.1
Sakakibara, T.2
Aoki, F.3
-
49
-
-
0031008864
-
Calcineurin is required for virulence of Cryptococcus neoformans
-
Odom, A., Muir, S., Lim, E., Toffaletti, D. L., Perfect, J. & Heitman, J. (1997a). Calcineurin is required for virulence of Cryptococcus neoformans. EMBO J 16, 2576-2589.
-
(1997)
EMBO J
, vol.16
, pp. 2576-2589
-
-
Odom, A.1
Muir, S.2
Lim, E.3
Toffaletti, D.L.4
Perfect, J.5
Heitman, J.6
-
50
-
-
0031028176
-
The immunosuppressant FK506 and its nonimmunosuppressive analog L-685,818 are toxic to Cryptococcus neoformans by inhibition of a common target protein
-
Odom, A., Poeta, M. D., Perfect J. & Heitman, J. (1997b). The immunosuppressant FK506 and its nonimmunosuppressive analog L-685,818 are toxic to Cryptococcus neoformans by inhibition of a common target protein. Antimicrob Agents Chemother 41, 156-161.
-
(1997)
Antimicrob Agents Chemother
, vol.41
, pp. 156-161
-
-
Odom, A.1
Poeta, M.D.2
Perfect, J.3
Heitman, J.4
-
51
-
-
0026669831
-
FK-506-binding proteins from Streptomycetes producing immunosuppressive macrolactones of the FK-506 type
-
Pahl, A. & Keller, U. (1992). FK-506-binding proteins from Streptomycetes producing immunosuppressive macrolactones of the FK-506 type. J Bacteriol 174, 5888-5894.
-
(1992)
J Bacteriol
, vol.174
, pp. 5888-5894
-
-
Pahl, A.1
Keller, U.2
-
52
-
-
0027787589
-
Calcineurin-dependent growth of an FK506- and CsA-hypersensitive mutant of Saccharomyces cerevisiae
-
Parent S. A., Nielsen, J. B., Morin, N., Chrebet, G., Ramadan, N., Dahl, A. M., Hsu, M.-J., Bostian, K. A. & Poor, F. (1993). Calcineurin-dependent growth of an FK506- and CsA-hypersensitive mutant of Saccharomyces cerevisiae. J Gen Microbiol 139, 2973-2984.
-
(1993)
J Gen Microbiol
, vol.139
, pp. 2973-2984
-
-
Parent, S.A.1
Nielsen, J.B.2
Morin, N.3
Chrebet, G.4
Ramadan, N.5
Dahl, A.M.6
Hsu, M.-J.7
Bostian, K.A.8
Poor, F.9
-
53
-
-
0028239893
-
RAFT1 : A mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs
-
Sabatini, D. M., Erdjument-Bromage, H., Lui, M., Tempst, P. & Snyder, S. H. (1994). RAFT1 : a mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs. Cell 78, 35-43.
-
(1994)
Cell
, vol.78
, pp. 35-43
-
-
Sabatini, D.M.1
Erdjument-Bromage, H.2
Lui, M.3
Tempst, P.4
Snyder, S.H.5
-
54
-
-
0028950217
-
Isolation of a protein target of the FKBP12-rapamycin complex in mammalian cells
-
Sabers, C. J., Martin, M. M., Brunn, G. J., Williams, J. M., Dumont, F. J., Wiederrecht G. & Abraham, R. T. (1995). Isolation of a protein target of the FKBP12-rapamycin complex in mammalian cells. J Biol Chem 270, 815-822.
-
(1995)
J Biol Chem
, vol.270
, pp. 815-822
-
-
Sabers, C.J.1
Martin, M.M.2
Brunn, G.J.3
Williams, J.M.4
Dumont, F.J.5
Wiederrecht, G.6
Abraham, R.T.7
-
55
-
-
0028869649
-
Meridamycin: A novel nonimmunosuppressive FKBP12 ligand from Streptomyces hygroscopicus
-
Salituro, G. M., Zink, D. L., Dahl, A., Nielsen, J., Wu, E., Huang, L., Kastner, C. & Dumont F. J. (1995). Meridamycin: a novel nonimmunosuppressive FKBP12 ligand from Streptomyces hygroscopicus. Tetrahedron Lett 36, 997-1000.
-
(1995)
Tetrahedron Lett
, vol.36
, pp. 997-1000
-
-
Salituro, G.M.1
Zink, D.L.2
Dahl, A.3
Nielsen, J.4
Wu, E.5
Huang, L.6
Kastner, C.7
Dumont F, J.8
-
56
-
-
0026575932
-
The mechanism of action of cyclosporin A and FK506
-
Schreiber, S. L. & Crabtree, G. R. (1992). The mechanism of action of cyclosporin A and FK506. Immunol Today 13, 136-142.
-
(1992)
Immunol Today
, vol.13
, pp. 136-142
-
-
Schreiber, S.L.1
Crabtree, G.R.2
-
57
-
-
0029098323
-
The biosynthetic gene cluster for the polyketide immunosuppressant rapamycin
-
Schwecke, T., Aparicio, J. F., Molnár & 10 other authors (1995). The biosynthetic gene cluster for the polyketide immunosuppressant rapamycin. Proc Natl Acad Sci USA 92, 7839-7843.
-
(1995)
Proc Natl Acad Sci USA
, vol.92
, pp. 7839-7843
-
-
Schwecke, T.1
Aparicio, J.F.2
-
58
-
-
0016713286
-
Rapamycin (AY-22,989), a new antifungal antibiotic. II. Fermentation, isolation and characterization
-
Sehgal, S. N., Baker, H. & Vezina, C. (1975). Rapamycin (AY-22,989), a new antifungal antibiotic. II. Fermentation, isolation and characterization. J Antibiot 28, 727-732.
-
(1975)
J Antibiot
, vol.28
, pp. 727-732
-
-
Sehgal, S.N.1
Baker, H.2
Vezina, C.3
-
59
-
-
0025978949
-
Getting started with yeast
-
Sherman, F. (1991). Getting started with yeast. Methods Enzymol 194, 3-21.
-
(1991)
Methods Enzymol
, vol.194
, pp. 3-21
-
-
Sherman, F.1
-
60
-
-
0018606537
-
Rapamycin (AY-22,989), a new antifungal antibiotic. IV. Mechanism of action
-
Singh, K., Sun, S. & Vezina, C (1979). Rapamycin (AY-22,989), a new antifungal antibiotic. IV. Mechanism of action. J Antibiot XXXII, 630-645.
-
(1979)
J Antibiot
, vol.32
, pp. 630-645
-
-
Singh, K.1
Sun, S.2
Vezina, C.3
-
61
-
-
0024844391
-
Sensitivity to cyclosporin A is mediated by cyclophilin in Neurospora crassa and Saccharomyces cerevisiae
-
Tropschug, M., Barthelmess, I. B. & Neupert W. (1989). Sensitivity to cyclosporin A is mediated by cyclophilin in Neurospora crassa and Saccharomyces cerevisiae. Nature 342, 953-955.
-
(1989)
Nature
, vol.342
, pp. 953-955
-
-
Tropschug, M.1
Barthelmess, I.B.2
Neupert, W.3
-
62
-
-
0016724057
-
Rapamycin (AY-22,989), a new antifungal antibiotic. I. Taxonomy of the producing Streptomycete and isolation of the active principle
-
Vezina, C., Kudelski, A. & Sehgal, S. N. (1975). Rapamycin (AY-22,989), a new antifungal antibiotic. I. Taxonomy of the producing Streptomycete and isolation of the active principle. J Antibiot 28, 721-726.
-
(1975)
J Antibiot
, vol.28
, pp. 721-726
-
-
Vezina, C.1
Kudelski, A.2
Sehgal, S.N.3
-
63
-
-
0030800386
-
Rapamycin specifically interferes with the developmental response of fission yeast to starvation
-
Weisman, R., Choder, M. & Koltin, Y. (1997). Rapamycin specifically interferes with the developmental response of fission yeast to starvation. J Bacteriol 179, 6325-6334.
-
(1997)
J Bacteriol
, vol.179
, pp. 6325-6334
-
-
Weisman, R.1
Choder, M.2
Koltin, Y.3
-
64
-
-
0031801642
-
Antifungal activities of rapamycin and its derivatives, prolylrapamycin, 32-desmethylrapamycin, and 32-desmethoxyrapamycin
-
Wong, G. K., Griffith, S., Kojima, I. & Demain, A. L. (1998). Antifungal activities of rapamycin and its derivatives, prolylrapamycin, 32-desmethylrapamycin, and 32-desmethoxyrapamycin. J Antibiot 51, 487-491.
-
(1998)
J Antibiot
, vol.51
, pp. 487-491
-
-
Wong, G.K.1
Griffith, S.2
Kojima, I.3
Demain, A.L.4
-
65
-
-
0029071264
-
TOR kinase domains are required for two distinct functions, only one of which is inhibited by rapamycin
-
Zheng, X.-F., Florentino, D., Chen, J., Crabtree, G. R. & Schreiber, S. L. (1995). TOR kinase domains are required for two distinct functions, only one of which is inhibited by rapamycin. Cell 82, 121-130.
-
(1995)
Cell
, vol.82
, pp. 121-130
-
-
Zheng, X.-F.1
Florentino, D.2
Chen, J.3
Crabtree, G.R.4
Schreiber, S.L.5
|