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Volumn 3, Issue 4-5, 2003, Pages 263-269

Modeling depression with transgenic mice: The neurotrophin hypothesis revisited

Author keywords

Animal model; Antidepressant; BDNF; Brain derived neurotrophic factor; cAMP response element binding protein; CREB; Depression; Knockout; Mice; Mutant; Neurotrophin; Stress; Transgenic; Tyrosine receptor kinase B (TrkB)

Indexed keywords

ANTIDEPRESSANT AGENT; BRAIN DERIVED NEUROTROPHIC FACTOR; BRAIN DERIVED NEUROTROPHIC FACTOR RECEPTOR; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; MONOAMINE OXIDASE INHIBITOR; NEUROTROPHIN; SEROTONIN UPTAKE INHIBITOR;

EID: 0344442811     PISSN: 15662772     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1566-2772(03)00088-4     Document Type: Review
Times cited : (3)

References (75)
  • 1
    • 0017108978 scopus 로고
    • Neuroendocrine regulation in depression. I. Limbic system-adrenocortical dysfunction
    • Carroll B.J. Curtis G.C. Mendels J. Neuroendocrine regulation in depression. I. Limbic system-adrenocortical dysfunction Arch Gen Psychiatry 33 1976 1039-1044
    • (1976) Arch. Gen. Psychiatry , vol.33 , pp. 1039-1044
    • Carroll, B.J.1    Curtis, G.C.2    Mendels, J.3
  • 2
    • 0023680751 scopus 로고
    • Clinical and biochemical manifestations of depression. Relation to the neurobiology of stress (1)
    • Gold P.W. Goodwin F.K. Chrousos G.P. Clinical and biochemical manifestations of depression. Relation to the neurobiology of stress (1) N Engl J Med 319 1988 348-353
    • (1988) N .Eng. J. Med. , vol.319 , pp. 348-353
    • Gold, P.W.1    Goodwin, F.K.2    Chrousos, G.P.3
  • 3
    • 0001571136 scopus 로고
    • The role of corticotropin-releasing factor in the pathophysiology of affective and anxiety disorders: Laboratory and clinical studies
    • 296-308
    • Owens M.J. Nemeroff C.B. The role of corticotropin-releasing factor in the pathophysiology of affective and anxiety disorders: laboratory and clinical studies Ciba Found Symp 172 296-308 1993 216-308
    • (1993) Ciba Found. Symp. , vol.172 , pp. 216-308
    • Owens, M.J.1    Nemeroff, C.B.2
  • 4
    • 0029926722 scopus 로고    scopus 로고
    • Antidepressants and hypothalamic-pituitary-adrenocortical regulation
    • Holsboer F. Barden N. Antidepressants and hypothalamic-pituitary-adrenocortical regulation Endocr Rev 17 1996 187-205
    • (1996) Endocr. Rev. , vol.17 , pp. 187-205
    • Holsboer, F.1    Barden, N.2
  • 5
    • 0030229916 scopus 로고    scopus 로고
    • The corticotropin-releasing factor (CRF) hypothesis of depression: New findings and new directions
    • Nemeroff C.B. The corticotropin-releasing factor (CRF) hypothesis of depression: new findings and new directions Mol Psychiatry 1 1996 336-342
    • (1996) Mol. Psychiatry , vol.1 , pp. 336-342
    • Nemeroff, C.B.1
  • 6
    • 0036828946 scopus 로고    scopus 로고
    • Stress, metaplasticity, and antidepressants
    • Garcia R. Stress, metaplasticity, and antidepressants Curr Mol Med 2 2002 629-638
    • (2002) Curr. Mol. Med. , vol.2 , pp. 629-638
    • Garcia, R.1
  • 7
    • 0036272279 scopus 로고    scopus 로고
    • Antidepressants and neuroplasticity
    • C D.S. Duman R.S. Antidepressants and neuroplasticity Bipolar Disord 4 2002 183-194
    • (2002) Bipolar. Disord. , vol.4 , pp. 183-194
    • Duman, R.S.1
  • 9
    • 0033079596 scopus 로고    scopus 로고
    • Neurotrophins and depression
    • Altar C.A. Neurotrophins and depression Trends Pharmacol Sci 20 1999 59-61
    • (1999) Trends Pharmacol. Sci. , vol.20 , pp. 59-61
    • Altar, C.A.1
  • 11
    • 0033797445 scopus 로고    scopus 로고
    • The corticosteroid receptor hypothesis of depression
    • Holsboer F. The corticosteroid receptor hypothesis of depression Neuropsychopharmacology 23 2000 477-501
    • (2000) Neuropsychopharmacology , vol.23 , pp. 477-501
    • Holsboer, F.1
  • 12
    • 0035153486 scopus 로고    scopus 로고
    • Stress, hypercortisolism and corticosteroid receptors in depression: Implications for therapy
    • Holsboer F. Stress, hypercortisolism and corticosteroid receptors in depression: implications for therapy J Affect Disord 62 2001 77-91
    • (2001) J. Affect. Disord. , vol.62 , pp. 77-91
    • Holsboer, F.1
  • 13
    • 0031308699 scopus 로고    scopus 로고
    • Historical perspective on CMS model
    • Porsolt R.D. Historical perspective on CMS model Psychopharmacology (Berl) 134 363-364 1997 367-371
    • (1997) Psychopharmacology (Berl) , vol.134 , Issue.363-364 , pp. 367-371
    • Porsolt, R.D.1
  • 14
    • 0033988574 scopus 로고    scopus 로고
    • Animal models of depression: Utility for transgenic research
    • Porsolt R.D. Animal models of depression: utility for transgenic research Rev Neurosci 11 2000 53-58
    • (2000) Rev. Neurosci. , vol.11 , pp. 53-58
    • Porsolt, R.D.1
  • 15
    • 0036328118 scopus 로고    scopus 로고
    • The validity of animal models of predisposition to depression
    • Willner P. Mitchell P.J. The validity of animal models of predisposition to depression Behav Pharmacol 13 2002 169-188
    • (2002) Behav. Pharmacol. , vol.13 , pp. 169-188
    • Willner, P.1    Mitchell, P.J.2
  • 16
    • 0026586536 scopus 로고
    • Regulation of neurotrophin mRNA expression in the rat brain by glucocorticoids
    • Barbany G. Persson H. Regulation of neurotrophin mRNA expression in the rat brain by glucocorticoids Eur J Neurosci 4 1992 396-403
    • (1992) Eur. J. Neurosci. , vol.4 , pp. 396-403
    • Barbany, G.1    Persson, H.2
  • 17
    • 0028815653 scopus 로고
    • Regulation of BDNF and trkB mRNA in rat brain by chronic electroconvulsive seizure and antidepressant drug treatments
    • Nibuya M. Morinobu S. Duman R.S. Regulation of BDNF and trkB mRNA in rat brain by chronic electroconvulsive seizure and antidepressant drug treatments J Neurosci 15 1995 7539-7547
    • (1995) J. Neurosci. , vol.15 , pp. 7539-7547
    • Nibuya, M.1    Morinobu, S.2    Duman, R.S.3
  • 18
    • 0029119707 scopus 로고
    • Stress increases brain-derived neurotropic factor messenger ribonucleic acid in the hypothalamus and pituitary
    • Smith M.A. Makino S. Kim S.Y. Kvetnansky R. Stress increases brain-derived neurotropic factor messenger ribonucleic acid in the hypothalamus and pituitary Endocrinology 136 1995 3743-3750
    • (1995) Endocrinology , vol.136 , pp. 3743-3750
    • Smith, M.A.1    Makino, S.2    Kim, S.Y.3    Kvetnansky, R.4
  • 19
    • 0029050864 scopus 로고
    • Stress and antidepressants differentially regulate neurotrophin 3 mRNA expression in the locus coeruleus
    • Smith M.A. Makino S. Altemus M. et al. Stress and antidepressants differentially regulate neurotrophin 3 mRNA expression in the locus coeruleus Proc Natl Acad Sci USA 92 1995 8788-8792
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 8788-8792
    • Smith, M.A.1    Makino, S.2    Altemus, M.3
  • 20
    • 0030920788 scopus 로고    scopus 로고
    • Immobilization stress reduced the expression of neurotrophins and their receptors in the rat brain
    • Ueyama T. Kawai Y. Nemoto K. et al. Immobilization stress reduced the expression of neurotrophins and their receptors in the rat brain Neurosci Res 28 1997 103-110
    • (1997) Neurosci. Res. , vol.28 , pp. 103-110
    • Ueyama, T.1    Kawai, Y.2    Nemoto, K.3
  • 21
    • 0030956924 scopus 로고    scopus 로고
    • Corticosterone regulates expression of BDNF and trkB but not NT-3 and trkC mRNA in the rat hippocampus
    • Schaaf M.J. Hoetelmans R.W. de Kloet E.R. Vreugdenhil E. Corticosterone regulates expression of BDNF and trkB but not NT-3 and trkC mRNA in the rat hippocampus J Neurosci Res 48 1997 334-341
    • (1997) J. Neurosci. Res. , vol.48 , pp. 334-341
    • Schaaf, M.J.1    Hoetelmans, R.W.2    de Kloet, E.R.3    Vreugdenhil, E.4
  • 22
  • 23
    • 0035826517 scopus 로고    scopus 로고
    • Physical activity-antidepressant treatment combination: Impact on brain-derived neurotrophic factor and behavior in an animal model
    • Russo-Neustadt A. Ha T. Ramirez R. Kesslak J.P. Physical activity-antidepressant treatment combination: impact on brain-derived neurotrophic factor and behavior in an animal model Behav Brain Res 120 2001 87-95
    • (2001) Behav. Brain Res. , vol.120 , pp. 87-95
    • Russo-Neustadt, A.1    Ha, T.2    Ramirez, R.3    Kesslak, J.P.4
  • 24
    • 0027191974 scopus 로고
    • Glucocorticoids depress activity-dependent expression of BDNF mRNA in hippocampal neurones
    • Cosi C. Spoerri P.E. Comelli M.C. Guidolin D. Skaper S.D. Glucocorticoids depress activity-dependent expression of BDNF mRNA in hippocampal neurones Neuroreport 4 1993 527-530
    • (1993) Neuroreport. , vol.4 , pp. 527-530
    • Cosi, C.1    Spoerri, P.E.2    Comelli, M.C.3    Guidolin, D.4    Skaper, S.D.5
  • 25
    • 0036298493 scopus 로고    scopus 로고
    • Downregulation of BDNF mRNA in the hippocampal dentate gyrus after re-exposure to cues previously associated with footshock
    • Rasmusson A.M. Shi L. Duman R. Downregulation of BDNF mRNA in the hippocampal dentate gyrus after re-exposure to cues previously associated with footshock Neuropsychopharmacology 27 2002 133 142
    • (2002) Neuropsychopharmacology , vol.27 , pp. 133-142
    • Rasmusson, A.M.1    Shi, L.2    Duman, R.3
  • 26
    • 0034720257 scopus 로고    scopus 로고
    • Mapping the differences in the brain concentration of brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) in an animal model of depression
    • Angelucci F. Aloe L. Vasquez P.J. Mathe A.A. Mapping the differences in the brain concentration of brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) in an animal model of depression Neuroreport 11 2000 1369-1373
    • (2000) Neuroreport. , vol.11 , pp. 1369-1373
    • Angelucci, F.1    Aloe, L.2    Vasquez, P.J.3    Mathe, A.A.4
  • 27
    • 0032576396 scopus 로고    scopus 로고
    • Increased temporal cortex CREB concentrations and antidepressant treatment in major depression
    • Dowlatshahi D. MacQueen G.M. Wang J.F. Young L.T. Increased temporal cortex CREB concentrations and antidepressant treatment in major depression Lancet 352 1998 1754-1755
    • (1998) Lancet , vol.352 , pp. 1754-1755
    • Dowlatshahi, D.1    MacQueen, G.M.2    Wang, J.F.3    Young, L.T.4
  • 28
    • 0035881828 scopus 로고    scopus 로고
    • Increased hippocampal BDNF immunoreactivity in subjects treated with antidepressant medication
    • Chen B. Dowlatshahi D. MacQueen G.M. Wang J.F. Young L.T. Increased hippocampal BDNF immunoreactivity in subjects treated with antidepressant medication Biol Psychiatry 50 2001 260-265
    • (2001) Biol. Psychiatry , vol.50 , pp. 260-265
    • Chen, B.1    Dowlatshahi, D.2    MacQueen, G.M.3    Wang, J.F.4    Young, L.T.5
  • 29
    • 0036202956 scopus 로고    scopus 로고
    • Decreased serum brain-derived neurotrophic factor levels in major depressed patients
    • Karege F. Perret G. Bondolfi G. et al. Decreased serum brain-derived neurotrophic factor levels in major depressed patients Psychiatry Res 109 2002 143-148
    • (2002) Psychiatry Res. , vol.109 , pp. 143-148
    • Karege, F.1    Perret, G.2    Bondolfi, G.3
  • 30
    • 0030788275 scopus 로고    scopus 로고
    • Anterograde transport of endogenous brain-derived neurotrophic factor in hippocampal mossy fibers
    • Smith M.A. Zhang L.X. Lyons W.E. Mamounas L.A. Anterograde transport of endogenous brain-derived neurotrophic factor in hippocampal mossy fibers Neuroreport 8 1997 1829-1834
    • (1997) Neuroreport. , vol.8 , pp. 1829-1834
    • Smith, M.A.1    Zhang, L.X.2    Lyons, W.E.3    Mamounas, L.A.4
  • 31
    • 0029992189 scopus 로고    scopus 로고
    • Chronic antidepressant administration increases the expression of cAMP response element binding protein (CREB) in rat hippocampus
    • Nibuya M. Nestler E.J. Duman R.S. Chronic antidepressant administration increases the expression of cAMP response element binding protein (CREB) in rat hippocampus J Neurosci 16 1996 2365-2372
    • (1996) J. Neurosci. , vol.16 , pp. 2365-2372
    • Nibuya, M.1    Nestler, E.J.2    Duman, R.S.3
  • 32
    • 0034213455 scopus 로고    scopus 로고
    • cAMP response element-mediated gene transcription is upregulated by chronic antidepressant treatment
    • Thome J. Sakai N. Shin K. et al. cAMP response element-mediated gene transcription is upregulated by chronic antidepressant treatment J Neurosci 20 2000 4030-4036
    • (2000) J. Neurosci. , vol.20 , pp. 4030-4036
    • Thome, J.1    Sakai, N.2    Shin, K.3
  • 33
    • 0036196495 scopus 로고    scopus 로고
    • Altered regulation of CREB by chronic antidepressant administration in the brain of transgenic mice with impaired glucocorticoid receptor function
    • Blom J.M. Tascedda F. Carra S. et al. Altered regulation of CREB by chronic antidepressant administration in the brain of transgenic mice with impaired glucocorticoid receptor function Neuropsychopharmacology 26 2002 605-614
    • (2002) Neuropsychopharmacology , vol.26 , pp. 605-614
    • Blom, J.M.1    Tascedda, F.2    Carra, S.3
  • 34
    • 0031685366 scopus 로고    scopus 로고
    • Molecular and cellular actions of chronic electroconvulsive seizures
    • Duman R.S. Vaidya V.A. Molecular and cellular actions of chronic electroconvulsive seizures J ECT 14 1998 181-193
    • (1998) J. ECT , vol.14 , pp. 181-193
    • Duman, R.S.1    Vaidya, V.A.2
  • 35
    • 0032104158 scopus 로고    scopus 로고
    • Repeated electroconvulsive shock extends the duration of enhanced gene expression for BDNF in rat brain compared with a single administration
    • Zetterstrom T.S. Pei Q. Grahame-Smith D.G. Repeated electroconvulsive shock extends the duration of enhanced gene expression for BDNF in rat brain compared with a single administration Brain Res Mol Brain Res 57 1998 106-110
    • (1998) Brain Res. Mol. Brain Res. , vol.57 , pp. 106-110
    • Zetterstrom, T.S.1    Pei, Q.2    Grahame-Smith, D.G.3
  • 36
    • 0037218768 scopus 로고    scopus 로고
    • Activation of the TrkB neurotrophin receptor is induced by antidepressant drugs and is required for antidepressant-induced behavioral effects
    • Saarelainen T. Hendolin P. Lucas G. et al. Activation of the TrkB neurotrophin receptor is induced by antidepressant drugs and is required for antidepressant-induced behavioral effects J Neurosci 23 2003 349-357
    • (2003) J. Neurosci. , vol.23 , pp. 349-357
    • Saarelainen, T.1    Hendolin, P.2    Lucas, G.3
  • 37
    • 0033821342 scopus 로고    scopus 로고
    • Antidepressant drug exposure is associated with mRNA levels of tyrosine receptor kinase B in major depressive disorder
    • Bayer T.A. Schramm M. Feldmann N. Knable M.B. Falkai P. Antidepressant drug exposure is associated with mRNA levels of tyrosine receptor kinase B in major depressive disorder Prog Neuropsychopharmacol Biol Psychiatry 24 2000 881-888
    • (2000) Prog. Neuropsychopharmacol Biol. Psychiatry , vol.24 , pp. 881-888
    • Bayer, T.A.1    Schramm, M.2    Feldmann, N.3    Knable, M.B.4    Falkai, P.5
  • 38
  • 41
    • 0024403530 scopus 로고
    • Strain-specific effects of antidepressants on escape deficits induced by inescapable shock
    • Shanks N. Anisman H. Strain-specific effects of antidepressants on escape deficits induced by inescapable shock Psychopharmacology (Berl) 99 1989 122-128
    • (1989) Psychopharmacology (Berl) , vol.99 , pp. 122-128
    • Shanks, N.1    Anisman, H.2
  • 42
    • 0026570070 scopus 로고
    • Animal behavioural studies in the evaluation of antidepressant drugs
    • Thiebot M.H. Martin P. Puech A.J. Animal behavioural studies in the evaluation of antidepressant drugs Br J Psychiatry Suppl 1992 44-50
    • (1992) Br. J. Psychiatry Suppl. , pp. 44-50
    • Thiebot, M.H.1    Martin, P.2    Puech, A.J.3
  • 44
    • 0037092425 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor produces antidepressant effects in behavioral models of depression
    • Shirayama Y. Chen A.C. Nakagawa S. Russell D.S. Duman R.S. Brain-derived neurotrophic factor produces antidepressant effects in behavioral models of depression J Neurosci 22 2002 3251-3261
    • (2002) J. Neurosci. , vol.22 , pp. 3251-3261
    • Shirayama, Y.1    Chen, A.C.2    Nakagawa, S.3    Russell, D.S.4    Duman, R.S.5
  • 45
    • 0017618768 scopus 로고
    • Depression: A new animal model sensitive to antidepressant treatments
    • Porsolt R.D. Le Pichon M. Jalfre M. Depression: a new animal model sensitive to antidepressant treatments Nature 266 1977 730-732
    • (1977) Nature , vol.266 , pp. 730-732
    • Porsolt, R.D.1    Le Pichon, M.2    Jalfre, M.3
  • 46
    • 0034820849 scopus 로고    scopus 로고
    • Mice with targeted mutations of glucocorticoid and mineralocorticoid receptors: Models for depression and anxiety?
    • Gass P. Reichardt H.M. Strekalova T. Henn F. Tronche F. Mice with targeted mutations of glucocorticoid and mineralocorticoid receptors: models for depression and anxiety? Physiol Behav 73 2001 811-825
    • (2001) Physiol. Behav. , vol.73 , pp. 811-825
    • Gass, P.1    Reichardt, H.M.2    Strekalova, T.3    Henn, F.4    Tronche, F.5
  • 47
    • 0032516040 scopus 로고    scopus 로고
    • Impaired fetal T cell development and perinatal lethality in mice lacking the cAMP response element binding protein
    • Rudolph D. Tafuri A. Gass P. et al. Impaired fetal T cell development and perinatal lethality in mice lacking the cAMP response element binding protein Proc Natl Acad Sci USA 95 1998 4481-4486
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 4481-4486
    • Rudolph, D.1    Tafuri, A.2    Gass, P.3
  • 48
    • 0028238472 scopus 로고
    • Targeted mutation of the CREB gene: Compensation within the CREB/ATF family of transcription factors
    • Hummler E. Cole T.J. Blendy J.A. et al. Targeted mutation of the CREB gene: compensation within the CREB/ATF family of transcription factors Proc Natl Acad Sci USA 91 1994 5647-5651
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 5647-5651
    • Hummler, E.1    Cole, T.J.2    Blendy, J.A.3
  • 49
    • 0029980672 scopus 로고    scopus 로고
    • Targeting of the CREB gene leads to up-regulation of a novel CREB mRNA isoform
    • Blendy J.A. Kaestner K.H. Schmid W. Gass P. Schutz G. Targeting of the CREB gene leads to up-regulation of a novel CREB mRNA isoform EMBO J 15 1996 1098-1106
    • (1996) EMBO J. , vol.15 , pp. 1098-1106
    • Blendy, J.A.1    Kaestner, K.H.2    Schmid, W.3    Gass, P.4    Schutz, G.5
  • 50
    • 0032448684 scopus 로고    scopus 로고
    • Deficits in memory tasks of mice with CREB mutations depend on gene dosage
    • Gass P. Wolfer D.P. Balschun D. et al. Deficits in memory tasks of mice with CREB mutations depend on gene dosage Learn Mem 5 1998 274-288
    • (1998) Learn Mem. , vol.5 , pp. 274-288
    • Gass, P.1    Wolfer, D.P.2    Balschun, D.3
  • 51
    • 0036193291 scopus 로고    scopus 로고
    • Behavioral analysis of CREB alphadelta mutation on a B6/129 F1 hybrid background
    • Graves L. Dalvi A. Lucki I. Blendy J.A. Abel T. Behavioral analysis of CREB alphadelta mutation on a B6/129 F1 hybrid background Hippocampus 12 2002 18-26
    • (2002) Hippocampus , vol.12 , pp. 18-26
    • Graves, L.1    Dalvi, A.2    Lucki, I.3    Blendy, J.A.4    Abel, T.5
  • 52
    • 0037092432 scopus 로고    scopus 로고
    • cAMP response element-binding protein is essential for the upregulation of brain-derived neurotrophic factor transcription, but not the behavioral or endocrine responses to antidepressant drugs
    • Conti A.C. Cryan J.F. Dalvi A. Lucki I. Blendy J.A. cAMP response element-binding protein is essential for the upregulation of brain-derived neurotrophic factor transcription, but not the behavioral or endocrine responses to antidepressant drugs J Neurosci 22 2002 3262-3268
    • (2002) J. Neurosci. , vol.22 , pp. 3262-3268
    • Conti, A.C.1    Cryan, J.F.2    Dalvi, A.3    Lucki, I.4    Blendy, J.A.5
  • 53
    • 0037115028 scopus 로고    scopus 로고
    • Inhibition of cAMP response element-binding protein or dynorphin in the nucleus accumbens produces an antidepressant-like effect
    • Newton S.S. Thome J. Wallace T.L. et al. Inhibition of cAMP response element-binding protein or dynorphin in the nucleus accumbens produces an antidepressant-like effect J Neurosci 22 2002 10883-10890
    • (2002) J. Neurosci. , vol.22 , pp. 10883-10890
    • Newton, S.S.1    Thome, J.2    Wallace, T.L.3
  • 54
    • 0344411758 scopus 로고    scopus 로고
    • Dissociation between morphine physical dependence and motivational responses and increased anxiety-like behavior in CREB deficient mice
    • (submitted)
    • Valverde O, Mantamadiotis T, Torrecilla M, et al. Dissociation between morphine physical dependence and motivational responses and increased anxiety-like behavior in CREB deficient mice. Neuropsychopharmacology 2003 (submitted).
    • (2003) Neuropsychopharmacology
    • Valverde, O.1    Mantamadiotis, T.2    Torrecilla, M.3
  • 55
    • 0033944685 scopus 로고    scopus 로고
    • Synaptic plasticity in the basolateral amygdala in transgenic mice expressing dominant-negative cAMP response element-binding protein (CREB) in forebrain
    • Rammes G. Steckler T. Kresse A. et al. Synaptic plasticity in the basolateral amygdala in transgenic mice expressing dominant-negative cAMP response element-binding protein (CREB) in forebrain Eur J Neurosci 12 2000 2534-2546
    • (2000) Eur. J. Neurosci. , vol.12 , pp. 2534-2546
    • Rammes, G.1    Steckler, T.2    Kresse, A.3
  • 56
    • 0029017970 scopus 로고
    • Neuronal deficits, not involving motor neurons, in mice lacking BDNF and/or NT4
    • Conover J.C. Erickson J.T. Katz D.M. et al. Neuronal deficits, not involving motor neurons, in mice lacking BDNF and/or NT4 Nature 375 1995 235-238
    • (1995) Nature , vol.375 , pp. 235-238
    • Conover, J.C.1    Erickson, J.T.2    Katz, D.M.3
  • 57
    • 0034801530 scopus 로고    scopus 로고
    • Performance of heterozygous brain-derived neurotrophic factor knockout mice on behavioral analogues of anxiety, nociception, and depression
    • MacQueen G.M. Ramakrishnan K. Croll S.D. et al. Performance of heterozygous brain-derived neurotrophic factor knockout mice on behavioral analogues of anxiety, nociception, and depression Behav Neurosci 115 2001 1145-1153
    • (2001) Behav. Neurosci. , vol.115 , pp. 1145-1153
    • MacQueen, G.M.1    Ramakrishnan, K.2    Croll, S.D.3
  • 58
    • 0344411757 scopus 로고    scopus 로고
    • Mice with reduced BDNF expression show regular brain monoamine levels and unaltered emotional behavior
    • (in press)
    • Chourbaji S, Hellweg R, Brandis D. Mice with reduced BDNF expression show regular brain monoamine levels and unaltered emotional behaviorMol Brain Res 2003 (in press).
    • (2003) Mol. Brain Res.
    • Chourbaji, S.1    Hellweg, R.2    Brandis, D.3
  • 59
    • 0034792085 scopus 로고    scopus 로고
    • Conditional deletion of brain-derived neurotrophic factor in the postnatal brain leads to obesity and hyperactivity
    • Rios M. Fan G. Fekete C. et al. Conditional deletion of brain-derived neurotrophic factor in the postnatal brain leads to obesity and hyperactivity Mol Endocrinol 15 2001 1748-1757
    • (2001) Mol. Endocrinol. , vol.15 , pp. 1748-1757
    • Rios, M.1    Fan, G.2    Fekete, C.3
  • 60
    • 0242490254 scopus 로고    scopus 로고
    • Forebrain-specific trkB-receptor knockout mice: Behaviorally more hyperactive than depressive
    • (in press)
    • Zörner B, Wolfer DP, Brandis D. Forebrain-specific trkB-receptor knockout mice: behaviorally more hyperactive than depressive. Biol Psychiatry 2003 (in press).
    • (2003) Biol. Psychiatry
    • Zörner, B.1    Wolfer, D.P.2    Brandis, D.3
  • 61
    • 0030934390 scopus 로고    scopus 로고
    • Spatial memory in transgenic mice with impaired glucocorticoid receptor function
    • Rousse I. Beaulieu S. Rowe W. et al. Spatial memory in transgenic mice with impaired glucocorticoid receptor function Neuroreport 8 1997 841-845
    • (1997) Neuroreport. , vol.8 , pp. 841-845
    • Rousse, I.1    Beaulieu, S.2    Rowe, W.3
  • 62
    • 0031437277 scopus 로고    scopus 로고
    • Spatial learning deficits in mice with a targeted glucocorticoid receptor gene disruption
    • Oitzl M.S. de Kloet E.R. Joels M. Schmid W. Cole T.J. Spatial learning deficits in mice with a targeted glucocorticoid receptor gene disruption Eur J Neurosci 9 1997 2284-2296
    • (1997) Eur. J. Neurosci. , vol.9 , pp. 2284-2296
    • Oitzl, M.S.1    de Kloet, E.R.2    Joels, M.3    Schmid, W.4    Cole, T.J.5
  • 63
    • 0032495862 scopus 로고    scopus 로고
    • Enhanced morphine-induced behavioural effects and dopamine release in the nucleus accumbens in a transgenic mouse model of impaired glucocorticoid (type II) receptor function: Influence of long-term treatment with the antidepressant moclobemide
    • Sillaber I. Montkowski A. Landgraf R. et al. Enhanced morphine-induced behavioural effects and dopamine release in the nucleus accumbens in a transgenic mouse model of impaired glucocorticoid (type II) receptor function: influence of long-term treatment with the antidepressant moclobemide Neuroscience 85 1998 415-425
    • (1998) Neuroscience , vol.85 , pp. 415-425
    • Sillaber, I.1    Montkowski, A.2    Landgraf, R.3
  • 64
    • 0033592920 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor-deficient mice develop aggressiveness and hyperphagia in conjunction with brain serotonergic abnormalities
    • Lyons W.E. Mamounas L.A. Ricaurte G.A. et al. Brain-derived neurotrophic factor-deficient mice develop aggressiveness and hyperphagia in conjunction with brain serotonergic abnormalities Proc Natl Acad Sci USA 96 1999 15239-15244
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 15239-15244
    • Lyons, W.E.1    Mamounas, L.A.2    Ricaurte, G.A.3
  • 65
    • 0036457097 scopus 로고    scopus 로고
    • Forced swimming evokes a biphasic response in CREB phosphorylation in extrahypothalamic limbic and neocortical brain structures in the rat
    • Bilang-Bleuel A. Rech J. De Carli S. Holsboer F. Reul J.M. Forced swimming evokes a biphasic response in CREB phosphorylation in extrahypothalamic limbic and neocortical brain structures in the rat Eur J Neurosci 15 2002 1048-1060
    • (2002) Eur. J. Neurosci. , vol.15 , pp. 1048-1060
    • Bilang-Bleuel, A.1    Rech, J.2    De Carli, S.3    Holsboer, F.4    Reul, J.M.5
  • 66
    • 0037129941 scopus 로고    scopus 로고
    • Immobilization stress rapidly modulates BDNF mRNA expression in the hypothalamus of adult male rats
    • Rage F. Givalois L. Marmigere F. Tapia-Arancibia L. Arancibia S. Immobilization stress rapidly modulates BDNF mRNA expression in the hypothalamus of adult male rats Neuroscience 112 2002 309-318
    • (2002) Neuroscience , vol.112 , pp. 309-318
    • Rage, F.1    Givalois, L.2    Marmigere, F.3    Tapia-Arancibia, L.4    Arancibia, S.5
  • 67
    • 0034893125 scopus 로고    scopus 로고
    • Learned helplessness in the rat: Improvements in validity and reliability
    • Vollmayr B. Henn F.A. Learned helplessness in the rat: improvements in validity and reliability Brain Res Brain Res Protoc 8 2001 1-7
    • (2001) Brain Res. Brain Res. Protoc. , vol.8 , pp. 1-7
    • Vollmayr, B.1    Henn, F.A.2
  • 68
    • 0035884949 scopus 로고    scopus 로고
    • Altered responsiveness to cocaine and increased immobility in the forced swim test associated with elevated cAMP response element-binding protein expression in nucleus accumbens
    • Pliakas A.M. Carlson R.R. Neve R.L. et al. Altered responsiveness to cocaine and increased immobility in the forced swim test associated with elevated cAMP response element-binding protein expression in nucleus accumbens J Neurosci 21 2001 7397-7403
    • (2001) J. Neurosci. , vol.21 , pp. 7397-7403
    • Pliakas, A.M.1    Carlson, R.R.2    Neve, R.L.3
  • 70
    • 0036169831 scopus 로고    scopus 로고
    • Noradrenergic antidepressants: Does chronic treatment increase or decrease nuclear CREB-P?
    • Manier D.H. Shelton R.C. Sulser F. Noradrenergic antidepressants: does chronic treatment increase or decrease nuclear CREB-P? J Neural Transm 109 2002 91-99
    • (2002) J. Neural. Transm. , vol.109 , pp. 91-99
    • Manier, D.H.1    Shelton, R.C.2    Sulser, F.3
  • 71
    • 0025000588 scopus 로고
    • Chronic antidepressant administration decreases the expression of tyrosine hydroxylase in the rat locus coeruleus
    • Nestler E.J. McMahon A. Sabban E.L. Tallman J.F. Duman R.S. Chronic antidepressant administration decreases the expression of tyrosine hydroxylase in the rat locus coeruleus Proc Natl Acad Sci USA 87 1990 7522-7526
    • (1990) Proc. Natl. Acad. Sci. USA , vol.87 , pp. 7522-7526
    • Nestler, E.J.1    McMahon, A.2    Sabban, E.L.3    Tallman, J.F.4    Duman, R.S.5
  • 72
    • 0027516202 scopus 로고
    • Regulation of beta 1-adrenergic receptor mRNA and ligand binding by antidepressant treatments and norepinephrine depletion in rat frontal cortex
    • Hosoda K. Duman R.S. Regulation of beta 1-adrenergic receptor mRNA and ligand binding by antidepressant treatments and norepinephrine depletion in rat frontal cortex J Neurochem 60 1993 1335-1343
    • (1993) J. Neurochem. , vol.60 , pp. 1335-1343
    • Hosoda, K.1    Duman, R.S.2
  • 73
    • 0033598708 scopus 로고    scopus 로고
    • Subplate neurons: A missing link among neurotrophins, activity, and ocular dominance plasticity?
    • McAllister A.K. Subplate neurons: a missing link among neurotrophins, activity, and ocular dominance plasticity? Proc Natl Acad Sci USA 96 1999 13600-13602
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 13600-13602
    • McAllister, A.K.1
  • 74
    • 0035234670 scopus 로고    scopus 로고
    • Neurotrophins as synaptic modulators
    • Poo M.M. Neurotrophins as synaptic modulators Nat Rev Neurosci 2 2001 24-32
    • (2001) Nat. Rev. Neurosci. , vol.2 , pp. 24-32
    • Poo, M.M.1
  • 75
    • 0038147541 scopus 로고    scopus 로고
    • Enhancing neuronal plasticity and cellular resilience to develop novel, improved therapeutics for difficult-to-treat depression
    • Manji H.K. Quiroz J.A. Sporn J. et al. Enhancing neuronal plasticity and cellular resilience to develop novel, improved therapeutics for difficult-to-treat depression Biol Psychiatry 53 2003 707-742
    • (2003) Biol. Psychiatry , vol.53 , pp. 707-742
    • Manji, H.K.1    Quiroz, J.A.2    Sporn, J.3


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