Pharmacological actions of the antidepressant venlafaxine beyond aminergic receptors

International Journal of Neuropsychopharmacology

Volumn 2, Issue 1, 1999, Pages 1-8

  Rossby, S Paul ^a,c   Manier, D Hal ^a   Liang, Shan ^a   Nalepa, Irena ^b   Sulser, Fridolin ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b INSTITUTE OF PHARMACOLOGY   (Poland)

^c VANDERBILT UNIVERSITY   (United States)

Author keywords

Competitive PCR, CREB mRNA; CREB phosphorylation; DHA binding sites; Nonlinear regression analysis; PKA activity; Venlafaxine

Indexed keywords

EID: 0002314272     PISSN: 14611457     EISSN: None     Source Type: Journal    
DOI: 10.1017/S1461145799001273     Document Type: Article

References (29)

1. Bolden-Watson C, Richelson E (1993). Blockade by newly developed antidepressants of biogenic amine uptake into rat brain synaptosomes. Life Sciences 52, 1023-1029.
2. Chomczynski P (1993). A reagent for the single-step simultaneous isolation of RNA, DNA, and protein from cell and tissue samples. BioTechniques 15, 532-537.
3. Clerc GE, Ruimy P, Verdeau PJ (1996). A double-blind comparison of venlafaxine and fluoxetine in patients hospitalized for major depression and melancholia. International Clinical Psychopharmacology 9, 139-143.
4. 2+ in fibroblast cells. FEBS Letters 391, 131-133.
5. Eiring A, Sulser F (1997). An increased synaptic availability of norepinephrine is not essential for antidepressant induced increases in hippocampal GR mRNA. Journal of Neural Transmission 104, 1255-1258.
6. Gillespie DD, Manier DH, Sulser F (1989). Characterization of the 5-HT sensitive dihydroalprenolol binding sites with low affinity for isoproterenol. Neuropsychopharmacology 2, 265-271.
7. Gonzalez GA, Montminy MR (1989). Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133. Cell 59, 675-680.
8. Guelfi JD, White AC, Hackett J, Guichoux JV (1995). Effectiveness of venlafaxine in hospitalized patients with major depression and melancholia. Journal of Clinical Psychiatry 56, 450-458.
9. Lefkowitz RJ (1993). G Protein-coupled receptor kinases. Cell 74, 409-412.
10. Lowry DH, Rosebrough NJ, Farr AL, Randall RJ (1951). Protein measurement with the Folin phenol reagent. Journal of Biological Chemistry 193, 265-275.
11. Manier DH, Gillespie DD, Sulser F (1989). Dual aminergic regulation of central beta adrenoceptors: effect of atypical antidepressants and 5-hydroxytryptophan. Neuropsychopharmacology 2 (2), 89-95.
12. Meyer TE, Habener JF (1993). Cyclic adenosine 3′,5′-monophosphate response element binding protein (CREB) and related transcriptional-activating deoxyribonucleic acid-binding proteins. Endocrine Reviews 14, 269-290.
13. Moyer JA, Muth EA, Haskins JT, Lappe RW, Sigg EB (1984). In vivo antidepressant profiles of the novel bicyclic compounds Wy-45030 and Wy-45881. Society for Neuroscience 10, 26.
14. Muller FU, Boknik P, Horst A, Knapp J, Linck B, Schmitz W, Vahlensieck U, Walter A (1995). In vivo isoproterenol treatment leads to downregulation of the mRNA encoding the cAMP response element binding protein in rat heart. Biochemical and Biophysical Research Communications 215, 1043-1049.
15. Munson RJ, Rodbard D (1980). A versatile computerized approach for characterization of ligand-binding systems. Analytical Biochemistry 107, 20-239.
16. Muth EA, Haskins JT, Moyer JA, Husbands GEM, Nielsen ST, Sigg EB (1986). Antidepressant biochemical profile of the mood tricyclic compound Wy-45030, an ethyl cyclo hexanol derivative. Biochemical Pharmacology 35, 4493-4497.
17. Muth EA, Moyer JA, Haskins JT, Andree TH, Husbands GE (1991). Biochemical, neuropathophysiological and behavioral effects of Wy-45233 and other identified metabolites of the antidepressant venlafaxine. Drug Developmental Research 23, 191-199.
18. Nalepa I, Manier DH, Gillespie DG, Rossby SP, Schmidt DE, Sulser F (1998). Lack of beta adrenoceptor desensitization in brain following the dual noradrenaline and serotonin reuptake inhibitor venlafaxine. European Journal of Neuropsychopharmacology 8, 227-232.
19. Nestler EJ, Terwilliger RZ, Duman RS (1989). Chronic antidepressant administration alters the subcellular distribution of cyclic AMP-dependent protein kinase in rat frontal cortex. Journal of Neurochemistry 53, 1644-1647.
20. Nibuya M, Nestler EJ, Duman RS (1996). Chronic antidepressant administration increases the expression of cAMP response element binding protein (CREB) in rat hippocampus. Journal of Neuroscience 16, 2365-2372.
21. Pariante CM, Pearce BD, Pisell TL, Owens MJ, Miller AH (1997). Steroid-independent translocation of the glucocorticoid receptor by the antidepressant desipramine. Molecular Pharmacology 52, 571-581.
22. Pepin MC, Govindan MV, Barden N (1992). Increased glucocorticoid receptor gene promoter activity after antidepressant treatment. Molecular Pharmacology 41, 1016-1022.
23. Rossby SP, Nalepa I, Huang M, Burt A, Perrin C, Schmidt DE, Sulser F (1995). Norepinephrine-independent regulation of GRII mRNA in vivo by a tricyclic antidepressant. Brain Research 687, 79-82.
24. Rudolph RL, Fabre L, Feighner J, Rickels K (1998). A randomized, placebo-controlled, dose-response trial of venlafaxine hydrochloride in the treatment of major depression. Journal of Clinical Psychiatry, 59, 116-123.
25. Ruppert S, Cole TJ, Boshart M, Schmid E, Schulz G (1992). Multiple mRNA isoforms of the transcriptional activator protein CREB: generation by alternative splicing and specific expression in primary spermatocytes. EMBO Journal 11, 1503-1512.
26. Waeber G, Meyer TE, LeSieur M, Hermann H, Gerard N, Habener JF (1991). Developmental stage-specific expression of the cyclic AMP response element binding protein CREB during spermatogenesis involves alternative exon splicing. Molecular Endocrinology 5, 1418-1430.
27. Wuarin J, Schibler U (1990). Expression of the liver-enriched transcriptional activator protein DBP follows a stringent circadian rhythm. Cell 63, 1257-1266.
28. Wurtman RJ, Axelrod J, Kelly DE (1968). The Pineal. New York, London: Academic Press.
29. Yamamoto KK, Gonzales GA, Biggs II, WH, Montminy MR (1988). Phosphorylation induced binding and transcriptional efficacy of nuclear factor CREB. Nature 334, 494-498.