Long-Term Treatment with Insulin Induces Apoptosis in Brown Adipocytes: Role of Oxidative Stress

Endocrinology

Volumn 144, Issue 12, 2003, Pages 5390-5401

  Porras, Almudena ^a,c   Zuluaga, Susana ^a   Valladares, Amparo ^a   Álvarez, Alberto M ^b,d   Herrera, Blanca ^a   Fabregat, Isabel ^a   Benito, Manuel ^a  

^a UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

^b Instituto de Bioquimica   (Spain)

^c UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

^d INSTITUTO DE SALUD CARLOS III   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

A 4034; ANTIOXIDANT; ASCORBIC ACID; BENZYLOXYCARBONYLVALYLALANYLASPARTYL FLUOROMETHYL KETONE; CASPASE 3; CASPASE 8; CASPASE 9; CYTOCHROME C; GLUTATHIONE; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BID; PROTEIN P70; RAPAMYCIN; REACTIVE OXYGEN METABOLITE; RECOMBINANT HUMAN INSULIN; S6 KINASE; SUPEROXIDE DISMUTASE;

ANIMAL CELL; APOPTOSIS; ARTICLE; BROWN ADIPOSE TISSUE; CONTROLLED STUDY; CYTOKINE RELEASE; ENZYME ACTIVATION; ENZYME ACTIVITY; FETUS; LONG TERM CARE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN DEGRADATION; RAT;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ADIPOCYTES; ADIPOSE TISSUE, BROWN; ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; ANTIOXIDANTS; APOPTOSIS; CASPASE 3; CASPASE 8; CASPASE 9; CASPASES; CELLS, CULTURED; CULTURE MEDIA, CONDITIONED; ENZYME INHIBITORS; HYPOGLYCEMIC AGENTS; INSULIN; OXIDATIVE STRESS; RATS; SIROLIMUS;

EID: 0344394259     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/en.2003-0622     Document Type: Article

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