Mitogen-activated protein kinase activation is not necessary for, but antagonizes, 3T3-L1 adipocytic differentiation

Molecular and Cellular Biology

Volumn 17, Issue 10, 1997, Pages 6068-6075

  Font De Mora, Jaime ^a   Porras, Almudena ^a   Ahn, Natalie ^b   Santos, Eugenio ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b UNIVERSITY OF COLORADO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; ENZYME INHIBITOR; INSULIN; MITOGEN ACTIVATED PROTEIN KINASE; RAS PROTEIN; TUMOR NECROSIS FACTOR ALPHA;

ADIPOCYTE; ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CELL STRAIN 3T3; CONTROLLED STUDY; ENZYME ACTIVATION; LIPID VESICLE; MOUSE; NONHUMAN; NORTHERN BLOTTING; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROADIPOCYTE; SIGNAL TRANSDUCTION;

ANIMALIA;

EID: 0001632060     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.17.10.6068     Document Type: Article

References (57)

1. Ailhaud, G. 1982. Adipose cell differentiation in culture. Mol. Cell. Biochem. 49:17-31.
2. Alessi, D. R., A. Cuenda, P. Cohen, D. T. Dudley, and A. R. Saltiel. 1995. PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo. J. Biol. Chem. 270:27489-27491.
3. Benito, M., A. Porras, A. R. Nebreda, and E. Santos. 1991. Differentiation of 3T3-L1 fibroblasts to adipocytes by transfection of ras oncogenes. Science 253:565-568.;
4. Bernstein, L. R., D. K. Ferris, N. H. Colburn, and M. E. Sobel. 1994. A family of mitogen-activated protein kinase-related proteins interacts in vivo with activator protein-1 transcription factor. J. Biol. Chem. 269:9401-9404.
5. Bunone, G., P. A. Briand, R. J. Miksicek, and D. Picard. 1996. Activation of the unliganded estrogen receptor by EGF involves the MAP kinase pathway and direct phosphorylation. EMBO J. 15:2174-2183.
6. Chou, S. Y., V. Baichwal, and J. E. Ferrell, Jr. 1992. Inhibition of c-Jun DNA binding by mitogen-activated protein kinase. Mol. Biol. Cell 3:1117-1130.
7. Chuang, C. F., and S. Y. Ng. 1994. Functional divergence of the MAP kinase pathway. ERK1 and ERK2 activate specific transcription factors. FEBS Lett. 346:229-234.
8. Coso, O., M. Chiariello, J.-C. Yu, H. Teramoto, P. Crespo, N. Xu, T. Miki, and J. S. Gutkind. 1995. The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK signaling pathway. Cell 81:1137-1146.
9. Cowley, S., H. Paterson, P. Kemp, and C. J. Marshall. 1994. Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells. Cell 77:841-852.
10. Crespo, P., N. Xu, W. F. Simonds, and J. S. Gutkind. 1994. Ras-dependent activation of MAP kinase pathway mediated by G-protein beta gamma subunits. Nature 369:418-420.
11. Davis, R. J. 1995. Transcriptional regulation by MAP kinases. Mol. Reprod. Dev. 42:459-467.
12. Dudley, D. T., L. Pang, S. J. Decker, A. J. Bridges, and A. R. Saltiel. 1995. A synthetic inhibitor of the mitogen-activated protein kinase cascade. Proc. Natl. Acad. Sci. USA 92:7686-7689.
13. Flier, J. S. 1995. The adipocyte: storage depot or node on the energy information superhighway? Cell 80:15-18.
14. Franke, T. F., D. R. Kaplan, and L. C. Cantley. 1997. PI3K downstream AKTion blocks apoptosis. Cell 88:435-437.
15. Gallego, C., S. K. Gupta, L. E. Heasley, N. X. Quian, and G. L. Johnson. 1992. Mitogen-activated protein kinase activation resulting from selective oncogene expression in NIH 3T3 and rat 1a cells. Proc. Natl. Acad. Sci. USA 89:7355-7359.
16. Genot, E., S. Cleverley, S. Henning, and D. Cantrell. 1996. Multiple p21ras effector pathways regulate nuclear factor of activated T cells. EMBO J. 15:3923-3933.
17. Gille, H., A. D. Sharrocks, and P. Shaw. 1992. Phosphorylation of transcription factor p62TCF by MAP kinase stimulates ternary complex formation at c-fos promoter. Nature 358:414-417.
18. Gonzalez, F. A., D. L. Raden, and R. J. Davies. 1991. Identification of substrate recognition determinants for human ERK1 and ERK2 protein kinases. J. Biol. Chem. 266:22159-22163.
19. Graves, R. A., E. Tontonoz, and B. M. Spiegelman. 1992. Analysis of a tissue-specific enhancer: ARF6 regulates adipogenic gene expression. Mol. Cell. Biol. 12:1202-1208.
20. Green, H., and O. Kehinde. 1976. Spontaneous heritable changes leading to increased adipose conversion in 3T3 cells. Cell 7:105-113.
21. Gupta, S., and R. J. Davis. 1994. MAP kinase binds to the NH2-terminal activation domain of c-Myc. FEBS Lett. 353:281-285.
22. He, J. H., S. Lakhani, K. Zu, J. Vila, P. Dent, P. W. Sturgill, and M. J. Weber. 1993. Dual phosphorylation and autophosphorylation in mitogen-activated protein (MAP) kinase activation. Biochem. J. 296:25-31.
23. Hotamisligil, G. S., P. Peraldi, A. Budavari, R. Ellis, M. F. White, and B. M. Spiegelman. 1996. IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha and obesity-induced insulin resistance. Science 271:665-668.
24. Hu, E., J. B. Kim, S. Sarraf, and B. M. Spiegelman. 1996. Inhibition of adipogenesis through MAP kinase-mediated phosphorylation of PPARγ. Science 274:2100-2103.
25. Lazar, D. F., R. J. Wiese, M. J. Brady, C. C. Mastrick, S. B. Waters, K. Yamaguchi, J. E. Pessin, P. Cuatrecasas, and A. R. Saltiel. 1995. Mitogen-activated protein kinase kinase inhibition does not block the stimulation of glucose utilization by insulin. J. Biol. Chem. 270:20801-20807.
26. Livingstone, C., G. Patel, and N. Jones. 1995. ATF-2 contains a phosphorylation-dependent transcriptional activation domain. EMBO J. 14:1785-1797.
27. MacDougald, O. A., and M. D. Lane. 1995. Transcriptional regulation of gene expression during adipocyte differentiation. Annu. Rev. Biochem. 64: 345-373.
28. Magun, R., B. M. Burgering, P. J. Coffer, D. Pardasani, Y. Lin, J. Chabot, and A. Sorisky. 1996. Expression of a constitutively activated form of protein kinase B (c-Akt) in 3T3-L1 preadipose cells causes spontaneous differentiation. Endocrinology 137:3590-3593.
29. Mansour, S. J., W. T. Matten, A. S. Hermann, J. M. Candia, S. Rong, F. Fukosawa, G. F. Vande Woude, and N. G. Ahn. 1994. Transformation of mammalian cells by constitutively active MAP kinase kinase. Science 265: 966-970.
30. Novikoff, A., P. M. Novikoff, O. M. Rosen, and C. S. Rubin. 1980. Organelle relationships in cultured 3T3-L1 preadipocytes. J. Cell Biol. 87:180-196.
31. Okazaki, K., and N. Sagata. 1995. The Mos/MAP kinase pathway stabilizes c-Fos by phosphorylation and augments its transforming activity in NIH 3T3 cells. EMBO J. 14:5048-5059.
32. Pang, L., T. Sawada, S. J. Decker, and A. R. Saltiel. 1995. Inhibition of MAP kinase kinase blocks the differentiation of PC-12 cells induced by nerve growth factor. J. Biol. Chem. 70:13585-13588.
33. Pearse, A. G. E. 1968. Histochemistry, 3rd ed. Little Brown, Boston, Mass.
34. Porras, A., A. R. Nebreda, M. Benito, and E. Santos. 1992. Activation of Ras by insulin in 3T3-L1 cells does not involve GTPase-activating protein phosphorylation. J. Biol. Chem. 2678:21124-21131.
35. Porras, A., K. Muszynski, U. R. Rapp, and E. Santos. 1994. Dissociation between activation of Raf-1 kinase and the 42-kDa mitogen-activated protein kinase/90-kDa S6 kinase (MAPK/RSK) cascade in the insulin/Ras pathway of adipocytic differentiation of 3T3-L1 cells. J. Biol. Chem. 269:12741-12748.
36. Porras, A., and E. Santos. 1996. The insulin/Ras pathway of adipocytic differentiation of 3T3-L1 cells: dissociation between Raf-1 kinase and the MAPK/RSK cascade. Int. J. Obes. Related. Metab. Disord. 20:S43-S51.
37. Reed, B. C., and M. D. Lane. 1980. Insulin receptor synthesis and turnover in differentiating 3T3-L1 preadipocytes. Proc. Natl. Acad. Sci. USA 77:285-289.
38. Reif, K., I. Gout, M. D. Waterfield, and D. A. Cantrell. 1993. Divergent regulation of phosphatidylinositol 3-kinase p85 alpha and p85 beta isoforms upon T cell activation. J. Biol. Chem. 268:10780-10788.
39. Roberts, T. M. 1992. Cell biology. A signal chain of events. Nature 360:534-535.
40. Rosen, O. M., C. J. Smith, C. Fung, and C. S. Rubin. 1978. Development of hormone receptors and hormone responsiveness in vitro. Effect of prolonged insulin treatment on hexose uptake in 3T3-L1 adipocytes. J. Biol. Chem. 253:7579-7583.
41. Rubin, C. S., A. Hirsch, C. Fung, and O. M. Rosen. 1978. Development of hormone receptors and hormonal responsiveness in vitro. Insulin receptors and insulin sensitivity in the preadipocyte and adipocyte forms of 3T3-L1 cells. J. Biol. Chem. 253:7570-7578.
42. Sale, E. M., P. G. P. Atkinson, and G. J. Sale. 1995. Requirement of MAP kinase for differentiation of fibroblasts to adipocytes, for insulin activation of p90 S6 kinase and for insulin or serum stimulation of DNA synthesis. EMBO J. 14:674-684.
43. Smith, P., L. S. Wise, R. Berkowitz, C. Wan, and C. S. Rubin. 1988. Insulin-like growth factor-I is an essential regulator of the differentiation of 3T3-L1 adipocytes. J. Biol. Chem. 263:9402-9408.
44. Stephens, J. M., and P. H. Pekala. 1991. Transcriptional repression of the GLUT4 and C/EBP genes in 3T3-L1 adipocytes by tumor necrosis factor-alpha. J. Biol. Chem. 266:21839-21845.
45. Stephens, J. M., and P. H. Pekala. 1992. Transcriptional repression of the C/EBP-alpha and GLUT4 genes in 3T3-L1 adipocytes by tumor necrosis factor-alpha. Regulation is coordinate and independent of protein synthesis. J. Biol. Chem. 267:13580-13584.
46. Szalkowski, D., S. White-Carrington, J. Berger, and B. Zhang. 1995. Antidiabetic thiazolidincdiones block the inhibitory effect of tumor necrosis factor-α on differentiation, insulin-stimulated glucose uptake, and gene expression in 3T3-L1 cells. Endocrinology 136:1474-1481.
47. Taylor, G. A., M. J. Thompson, W. S. Lai, and P. J. Blackshear. 1995. Phosphorylation of tristetraprolin, a potential zinc finger transcription factor, by mitogen stimulation in intact cells and by mitogen-activated protein kinase in vitro. J. Biol. Chem. 270:13341-13347.
48. Tomiyama, K., H. Nakata, H. Sasa, S. Arimura, E. Nishio, and Y. Watanabe. 1995. Wortmannin, a specific phosphatidylinositol 3-kinase inhibitor inhibits adipocytic differentiation of 3T3 L1 cells. Biochem. Biophys. Res. Commun. 212:263-269.
49. Tontonoz, P., E. Hu, R. A. Graves, A. I. Budavari, and B. M. Spiegelman. 1994. mPPAR gamma 2: tissue-specific regulator of an adipocyte enhancer. Genes Dev. 8:1224-1234.
50. Tontonoz, P., E. Hu, and B. M. Spiegelman. 1994. Stimulation of adipogenesis in fibroblasts by PPARgamma2, a lipid-activated transcription factor. Cell 79:1147-1156.
51. Troppmair, J., J. T. Bruder, H. Munoz, P. A. Lloyd, J. Kyriakis, P. Banerjee, J. Avruch, and U. R. Rapp. 1994. Mitogen-activated protein kinase/extracellular signal-regulated protein kinase activation by oncogenes, serum, and 12-O-tetradecanoylphorbol-13-acetate requires Raf and is necessary for transformation. J. Biol. Chem. 269:7030-7035.
52. Valverde, A. M., T. Teruel, M. Lorenzo, and M. Benito. 1996. Involvement of Raf-1 kinase and protein kinase C ζ in IGF-I-induced brown adipocyte mitogenic signaling cascades: inhibition by cAMP. Endocrinology 137:3832-3841.
53. Whitmarsh, A. J., P. Shore, A. D. Sharrocks, and R. J. Davis. 1995. Integration of MAP kinase signal transduction pathways at the serum response element. Science 269:403-407.
54. Williams, N. G., H. Paradis, S. Agarwal, D. L. Charest, S. L. Pelech, and T. M. Roberts. 1993. Rat-1 and p21v-ras cooperate in the activation of mitogen-activated protein kinase. Proc. Natl. Acad. Sci. USA 90:5772-5776.
55. Winston, B. W., C. A. Lange-Carter, A. M. Gardner, G. L. Johnson, and D. W. H. Riches. 1995. Tumor necrosis factor alpha rapidly activates the mitogen-activated protein kinase (MAPK) cascade in a MAPK kinase kinase-dependent, c-Raf-1-independent fashion in mouse macrophages. Proc. Natl. Acad. Sci. USA 92:1614-1618.
56. Wood, K., and T. M. Roberts. 1993. Oncogenes and protein kinases in neuronal growth-factor action. Biochem. Biophys. Acta 1155:133-150.
57. Wood, K. W., C. Sarnecki, R. M. Roberts, and J. Blenis. 1992. Ras mediates nerve growth factor receptor modulation of three signal-transducing protein kinases: MAP kinase, Raf-1, and RSK. Cell 68:1041-1050.