메뉴 건너뛰기




Volumn 86, Issue 2, 1996, Pages 136-142

Alterations of the p15, p16, and p18 genes in osteosarcoma

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CHROMOSOMAL LOCALIZATION; CHROMOSOME 15P; CHROMOSOME 16P; CHROMOSOME 18P; CHROMOSOME 9P; CHROMOSOME ANALYSIS; ENZYME ACTIVITY; GENE DELETION; GENE SEQUENCE; GENETIC ANALYSIS; GENETIC POLYMORPHISM; HUMAN; HUMAN CELL; HUMAN TISSUE; MISSENSE MUTATION; NORMAL HUMAN; OSTEOSARCOMA; POLYACRYLAMIDE GEL ELECTROPHORESIS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; TUMOR SUPPRESSOR GENE;

EID: 0029918497     PISSN: 01654608     EISSN: None     Source Type: Journal    
DOI: 10.1016/0165-4608(95)00216-2     Document Type: Article
Times cited : (103)

References (57)
  • 6
    • 0028236238 scopus 로고
    • p53: Tumor suppression through control of the cell cycle
    • Kern SE (1994): p53: Tumor suppression through control of the cell cycle. Gastroenterology 106:1708-1711.
    • (1994) Gastroenterology , vol.106 , pp. 1708-1711
    • Kern, S.E.1
  • 7
    • 0028009849 scopus 로고
    • The cell cycle and the retinoblastoma protein family
    • Ewen ME (1994): The cell cycle and the retinoblastoma protein family. Cancer Metastasis Rev 13:45-66.
    • (1994) Cancer Metastasis Rev , vol.13 , pp. 45-66
    • Ewen, M.E.1
  • 8
    • 0027768579 scopus 로고
    • Breaking the cycle
    • Hunter T (1993): Breaking the cycle. Cell 75:839-841.
    • (1993) Cell , vol.75 , pp. 839-841
    • Hunter, T.1
  • 10
    • 0027496935 scopus 로고
    • The p21 Cdk-interacting protein Cip1 is a potent inhibitor of Gl cyclin-dependent kinases
    • Harper JW, Adami GR, Wei N, Keyomarsi K, Elledge SJ (1993): The p21 Cdk-interacting protein Cip1 is a potent inhibitor of Gl cyclin-dependent kinases. Cell 75:805-816.
    • (1993) Cell , vol.75 , pp. 805-816
    • Harper, J.W.1    Adami, G.R.2    Wei, N.3    Keyomarsi, K.4    Elledge, S.J.5
  • 12
    • 0027141559 scopus 로고
    • Use of a sensitive and efficient subtraction hybridization protocol for the identification of genes differentially regulated during the induction of differentiation in human melanoma cells
    • Jiang H, Fisher PB (1993): Use of a sensitive and efficient subtraction hybridization protocol for the identification of genes differentially regulated during the induction of differentiation in human melanoma cells. Mol Cell Differ 1:285-299.
    • (1993) Mol Cell Differ , vol.1 , pp. 285-299
    • Jiang, H.1    Fisher, P.B.2
  • 13
    • 0028342664 scopus 로고
    • Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screen
    • Noda A, Ning Y, Venable SF, Pereira-Smith OM, Smith JR (1994): Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screen. Exp Cell Res 211:90-98.
    • (1994) Exp Cell Res , vol.211 , pp. 90-98
    • Noda, A.1    Ning, Y.2    Venable, S.F.3    Pereira-Smith, O.M.4    Smith, J.R.5
  • 14
    • 0027731971 scopus 로고
    • Inhibition of CDK2 activity in vivo by an associated 20K regulatory subunit
    • Gu Y, Turck CW, Morgan DO (1993): Inhibition of CDK2 activity in vivo by an associated 20K regulatory subunit. Nature 366:707-710.
    • (1993) Nature , vol.366 , pp. 707-710
    • Gu, Y.1    Turck, C.W.2    Morgan, D.O.3
  • 15
    • 0028179669 scopus 로고
    • p27Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest
    • Polyak K, Kato JY, Solomon MJ, Sherr CJ, Massague J, Roberts JM, Koff A (1994): p27Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest. Genes Dev 8:9-22.
    • (1994) Genes Dev , vol.8 , pp. 9-22
    • Polyak, K.1    Kato, J.Y.2    Solomon, M.J.3    Sherr, C.J.4    Massague, J.5    Roberts, J.M.6    Koff, A.7
  • 16
    • 0028176483 scopus 로고
    • Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals
    • Polyak K, Lee MH, Erdjument-Bromage H, Koff A, Roberts JM, Tempst P, Massague J (1994): Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals. Cell 78:59-66.
    • (1994) Cell , vol.78 , pp. 59-66
    • Polyak, K.1    Lee, M.H.2    Erdjument-Bromage, H.3    Koff, A.4    Roberts, J.M.5    Tempst, P.6    Massague, J.7
  • 17
    • 0028363519 scopus 로고
    • p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, related to p21
    • Toyoshima H, Hunter T (1994): p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, related to p21. Cell 78:67-74.
    • (1994) Cell , vol.78 , pp. 67-74
    • Toyoshima, H.1    Hunter, T.2
  • 19
    • 0028988159 scopus 로고
    • p57KIP2, a structurally distinct member of the p21CIP1 Cdk-inhibitor family, is a candidate tumor suppressor gene
    • Matsuoka S, Edward M, Bai C, Parker S, Zhang P, Baldini A, Harper JW, Elledge SJ (1995): p57KIP2, a structurally distinct member of the p21CIP1 Cdk-inhibitor family, is a candidate tumor suppressor gene. Genes Dev 9:650-662.
    • (1995) Genes Dev , vol.9 , pp. 650-662
    • Matsuoka, S.1    Edward, M.2    Bai, C.3    Parker, S.4    Zhang, P.5    Baldini, A.6    Harper, J.W.7    Elledge, S.J.8
  • 20
    • 0028168242 scopus 로고
    • p15INK4B is a potential effector of TGF-beta-induced cell cycle arrest
    • Hannon GJ, Beach D (1994): p15INK4B is a potential effector of TGF-beta-induced cell cycle arrest. Nature 371:257-261.
    • (1994) Nature , vol.371 , pp. 257-261
    • Hannon, G.J.1    Beach, D.2
  • 21
    • 0028582034 scopus 로고
    • Growth suppression by p18, a p16INK4/MTSq- and p14INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function
    • Guan KL, Jenkins CW, Li Y, Nichols MA, Wu X, O'Keefe CL, Matera AG, Xiong Y (1994): Growth suppression by p18, a p16INK4/MTSq- and p14INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function. Genes Dev 8:2939-2952.
    • (1994) Genes Dev , vol.8 , pp. 2939-2952
    • Guan, K.L.1    Jenkins, C.W.2    Li, Y.3    Nichols, M.A.4    Wu, X.5    O'Keefe, C.L.6    Matera, A.G.7    Xiong, Y.8
  • 22
    • 0027769876 scopus 로고
    • A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4
    • Serrano M, Hannon GJ, Beach D (1993): A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4. Nature 366:704-707.
    • (1993) Nature , vol.366 , pp. 704-707
    • Serrano, M.1    Hannon, G.J.2    Beach, D.3
  • 23
    • 0028918388 scopus 로고
    • Novel INK4 proteins, p19 and p18, are specific inhibitors of the cyclin D-dependent kinases CDK4 and CDK6
    • Hirai H, Roussel MF, Kato J, Ashmun RA, Sherr CJ (1995): Novel INK4 proteins, p19 and p18, are specific inhibitors of the cyclin D-dependent kinases CDK4 and CDK6. Mol Cell Biol 15:2672-2681.
    • (1995) Mol Cell Biol , vol.15 , pp. 2672-2681
    • Hirai, H.1    Roussel, M.F.2    Kato, J.3    Ashmun, R.A.4    Sherr, C.J.5
  • 24
    • 0028911830 scopus 로고
    • Identification of human and mouse p19, a novel CDK4 and CDK6 inhibitor with homology to p16ink4
    • Ka Ming Chan F, Zhang J, Cheng L, Shapiro DN, Winoto A (1995): Identification of human and mouse p19, a novel CDK4 and CDK6 inhibitor with homology to p16ink4. Mol Cell Biol 15:2682-2688.
    • (1995) Mol Cell Biol , vol.15 , pp. 2682-2688
    • Ka Ming Chan, F.1    Zhang, J.2    Cheng, L.3    Shapiro, D.N.4    Winoto, A.5
  • 27
    • 0028275733 scopus 로고
    • Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers
    • Nobori T, Miura K, Wu DJ, Lois A, Takabayashi K, Carson DA (1994): Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers. Nature 368:753-756.
    • (1994) Nature , vol.368 , pp. 753-756
    • Nobori, T.1    Miura, K.2    Wu, D.J.3    Lois, A.4    Takabayashi, K.5    Carson, D.A.6
  • 34
    • 0028138707 scopus 로고
    • Higher frequency of alterations in the p16/cdkn2 gene in squamous cell carcinoma cell lines than in primary tumors of the head and neck
    • Zhang SY, Klienszanto AJP, Sauter ER, Shafarenko M (1994): Higher frequency of alterations in the p16/cdkn2 gene in squamous cell carcinoma cell lines than in primary tumors of the head and neck. Cancer Res 54:5050-5053.
    • (1994) Cancer Res , vol.54 , pp. 5050-5053
    • Zhang, S.Y.1    Klienszanto, A.J.P.2    Sauter, E.R.3    Shafarenko, M.4
  • 35
    • 0027938776 scopus 로고
    • INK4B) display frequent homozygous deletions in primary cells from T- but not B-cell lineage acute lymphoblastic leukemias
    • INK4B) display frequent homozygous deletions in primary cells from T- but not B-cell lineage acute lymphoblastic leukemias. Blood 84:4038-4044.
    • (1994) Blood , vol.84 , pp. 4038-4044
    • Hebert, J.1    Cayuela, J.M.2    Berkeley, J.3    Francois, S.4
  • 36
    • 0029002249 scopus 로고
    • Homozygous deletions of the p15 (MTS2) and p16 (CDKN2/MTS1) genes in adult T-cell leukemia
    • Hatta Y, Hirama T, Miller CW, Yamada Y, Tomonaga M, Koeffler HP (1995): Homozygous deletions of the p15 (MTS2) and p16 (CDKN2/MTS1) genes in adult T-cell leukemia. Blood 85:2699-2704.
    • (1995) Blood , vol.85 , pp. 2699-2704
    • Hatta, Y.1    Hirama, T.2    Miller, C.W.3    Yamada, Y.4    Tomonaga, M.5    Koeffler, H.P.6
  • 38
    • 0028652269 scopus 로고
    • CDKN2 (p16/MTS1) gene deletion or CDK4 amplification occurs in the majority of glioblastomas
    • Schmidt EE, Ichimura K, Reifenberger G, Collins VP (1994): CDKN2 (p16/MTS1) gene deletion or CDK4 amplification occurs in the majority of glioblastomas. Cancer Res 54:6321-6324.
    • (1994) Cancer Res , vol.54 , pp. 6321-6324
    • Schmidt, E.E.1    Ichimura, K.2    Reifenberger, G.3    Collins, V.P.4
  • 39
    • 0028338514 scopus 로고
    • Frequent somatic mutation of the mts1/cdk4i (multiple tumor suppressor cyclin-dependent kinase 4 inhibitor) gene in esophageal squamous cell carcinoma
    • Mori T, Miura K, Aoki T, Nishihira T, Mori S, Nakamura Y (1994): Frequent somatic mutation of the mts1/cdk4i (multiple tumor suppressor cyclin-dependent kinase 4 inhibitor) gene in esophageal squamous cell carcinoma. Cancer Res 54:3396-3397.
    • (1994) Cancer Res , vol.54 , pp. 3396-3397
    • Mori, T.1    Miura, K.2    Aoki, T.3    Nishihira, T.4    Mori, S.5    Nakamura, Y.6
  • 40
    • 0028024945 scopus 로고
    • Somatic mutations of the MTS (multiple tumor suppressor) 1/CDK41 (cyclin-dependent kinase-4 inhibitor) gene in human primary non-small cell lung carcinomas
    • Hayashi N, Sugimoto Y, Tsuchiya E, Ogawa M, Nakamura Y (1994): Somatic mutations of the MTS (multiple tumor suppressor) 1/CDK41 (cyclin-dependent kinase-4 inhibitor) gene in human primary non-small cell lung carcinomas. Biochem Biophys Res Commun 202:1426-1430.
    • (1994) Biochem Biophys Res Commun , vol.202 , pp. 1426-1430
    • Hayashi, N.1    Sugimoto, Y.2    Tsuchiya, E.3    Ogawa, M.4    Nakamura, Y.5
  • 44
    • 0024595101 scopus 로고
    • Detection of polymorphisms of human DNA by gel electrophoresis as single-strand conformation polymorphisms
    • Orita M, Iwahana H, Kanazawa H, Hayashi K, Sekiya T (1994): Detection of polymorphisms of human DNA by gel electrophoresis as single-strand conformation polymorphisms. Proc Natl Acad Sci USA 86:2766-2770.
    • (1994) Proc Natl Acad Sci USA , vol.86 , pp. 2766-2770
    • Orita, M.1    Iwahana, H.2    Kanazawa, H.3    Hayashi, K.4    Sekiya, T.5
  • 49
    • 0024368619 scopus 로고
    • Identification and characterization of a p53 gene mutation in a human osteosarcoma cell line
    • Romano JW, Ehrhart JC, Duthu A, Kim CM, Appella E, May P (1989): Identification and characterization of a p53 gene mutation in a human osteosarcoma cell line. Oncogene 4: 1483-1488.
    • (1989) Oncogene , vol.4 , pp. 1483-1488
    • Romano, J.W.1    Ehrhart, J.C.2    Duthu, A.3    Kim, C.M.4    Appella, E.5    May, P.6
  • 52
    • 0026595636 scopus 로고
    • Inactivation of p53 gene in human and murine osteosarcoma cells
    • Chandar N, Billig B, McMaster J, Novak J (1992): Inactivation of p53 gene in human and murine osteosarcoma cells. Br J Cancer 65:208-214.
    • (1992) Br J Cancer , vol.65 , pp. 208-214
    • Chandar, N.1    Billig, B.2    McMaster, J.3    Novak, J.4
  • 53
    • 0026740449 scopus 로고
    • Amplification of a gene encoding a p53-associated protein in human sarcomas
    • Oliner JD, Kinzler KW, Meltzer PS, George DL, Vogelstein B (1992): Amplification of a gene encoding a p53-associated protein in human sarcomas. Nature 358:80-83.
    • (1992) Nature , vol.358 , pp. 80-83
    • Oliner, J.D.1    Kinzler, K.W.2    Meltzer, P.S.3    George, D.L.4    Vogelstein, B.5
  • 54
    • 0023274236 scopus 로고
    • c-myc amplification and expression in newly established human osteosarcoma cell lines
    • Bogenmann E, Moghadam H, DeClerck YA, Mock A (1987): c-myc amplification and expression in newly established human osteosarcoma cell lines. Cancer Res 47:3808-3814.
    • (1987) Cancer Res , vol.47 , pp. 3808-3814
    • Bogenmann, E.1    Moghadam, H.2    DeClerck, Y.A.3    Mock, A.4
  • 55
    • 0024320941 scopus 로고
    • Antibodies detecting abnormalities of the retinoblastoma susceptibility gene product (pp110RB) in osteosarcomas and synovial sarcomas
    • Shew JY, Ling N, Yang XM, Fodstad O, Lee WH (1994): Antibodies detecting abnormalities of the retinoblastoma susceptibility gene product (pp110RB) in osteosarcomas and synovial sarcomas. Oncogene 4:205-214.
    • (1994) Oncogene , vol.4 , pp. 205-214
    • Shew, J.Y.1    Ling, N.2    Yang, X.M.3    Fodstad, O.4    Lee, W.H.5
  • 56
    • 0028172926 scopus 로고
    • Absence of p16(ink4) protein is restricted to the subset of lung cancer lines that retains wildtype RB
    • Otterson GA, Kratzke RA, Coxon A, Kim YW, Kaye FJ (1994): Absence of p16(ink4) protein is restricted to the subset of lung cancer lines that retains wildtype RB. Oncogene 9: 3375-3378.
    • (1994) Oncogene , vol.9 , pp. 3375-3378
    • Otterson, G.A.1    Kratzke, R.A.2    Coxon, A.3    Kim, Y.W.4    Kaye, F.J.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.