Low frequency of p16/CDKN2 gene mutations in esophageal carcinomas

International Journal of Cancer

Volumn 66, Issue 3, 1996, Pages 301-304

  Esteve, Asunción ^a,b   Martel Planche, Ghyslaine ^a   Sylla, Bakary S ^a   Hollstein, Monica ^c   Hainaut, Pierre ^a   Montesano, Ruggero ^a  

^a INTERNATIONAL AGENCY FOR RESEARCH ON CANCER   (France)

^b HOSPITAL CLÍNIC   (Spain)

^c GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE; PROTEIN P16;

ADENOCARCINOMA; ARTICLE; CDKN2 GENE; CLINICAL ARTICLE; ESOPHAGUS CARCINOMA; GENE MUTATION; HUMAN; HUMAN TISSUE; PRIORITY JOURNAL; SQUAMOUS CELL CARCINOMA; TUMOR SUPPRESSOR GENE;

ADENOCARCINOMA; BASE SEQUENCE; CARCINOMA, SQUAMOUS CELL; CARRIER PROTEINS; CYCLIN-DEPENDENT KINASE INHIBITOR P16; DNA MUTATIONAL ANALYSIS; DNA PRIMERS; ESOPHAGEAL NEOPLASMS; EXONS; FRANCE; GENES, TUMOR SUPPRESSOR; HUMANS; INCIDENCE; ITALY; MOLECULAR SEQUENCE DATA; POINT MUTATION; POLYMERASE CHAIN REACTION; SEQUENCE DELETION;

EID: 0029938115     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0215(19960503)66:3<301::AID-IJC5>3.0.CO;2-2     Document Type: Article

References (23)

1. CAIRNS, P., MAO, L., MERLO, A., LEE, D.J., SCHWAB, D., EBY, Y., TOKINO, K., VAN DER RIET, P., BLAUGRUND, J.E. and SIDRANSKY, D., Rates of p16 (MTS1) mutations in primary tumors with 9p loss. Science, 265, 415-416 (1994).
2. CALDAS, C., HAHN, S.A., DA COSTA, L.T., REDSTON, M.S., SCHUTTE, M., SEYMOUR, A.B., WEINSTEIN, C.L., HRLBAN, R.H., YEO, C.J. and KERN, S.E., Frequent somatic mutations and homozygous deletions of the p16 (MTS1) gene in pancreatic adenocarcinoma. Nature (Genet.), 8, 27-32 (1994).
3. CHENG, J.Q., JHANWAR, S.C., KLEIN, W.M., BELL, D.W., LEE, W.C., ALTOMARE, D.A., NOBORI, T., OLOPADE, O.I., BUCKLER, A.J. and TESTA, J., p16 alterations and deletion mapping of 9p21-p22 in malignant mesothelioma. Cancer Res., 54, 5547-5551 (1994).
4. ESTEVE, A., LEHMAN, T., JIANG, W., WEINSTEIN, I.B., HARRIS, C.C., RUOL, A., PERACCHIA, A., MONTESANO, R. and HOLLSTEIN, M., Correlation of p53 mutations with epidermal growth factor receptor overexpression and absence of mdm2 amplification in human esophageal carcinomas. Mol Carcinogenesis. 8, 306-311 (1993).
5. HARTWELL, L.H. and KASTAN, M.B., Cell cycle control and cancer. Science, 266, 1821-1828 (1994).
6. IGAKI, H., SASAKI, H., KISHI, T., SAKAMOTO, H., TACHIMORI, Y., KATO, H., WATANABE. H., SUGIMURA, T. and TERADA, M., Highly frequent homozygous deletion of the p16 gene in esophageal cancer cell lines. Biochem. biophys. Res. Commun., 203, 1090-1095 (1994).
7. IGAKI, H., SASAKI, H., TACHLMORI, Y., KATO, H., WATANABE, H., KIMURA, T., HARADA, Y., SUGIMURA, T. and TERADA, M., Mutation frequency of the p16/CDKN2 gene in primary cancers in the upper digestive tract. Cancer Res., 55, 3421-3423 (1995).
8. JIANG, W., ZHANG, Y.J., KAHN, S.M., HOLLSTEIN, M.C., SANTELLA, R.M., Lu, S.H., HARRIS, C.C., MONTESANO, R. and WEINSTEIN, I.B., Altered expression of the cyclin D1 and retinoblastoma genes in human esophageal cancer. Proc nat. Acad. Sci. (Wash.), 90, 9026-9030 (1993).
9. KAMB, A., GRUIS, N.A., WEAVER-FELDHAUS, J., LIU, Q., HARSHMAN, K., TAVTIGIAN, S.V., STOCKERT, E., DAY, R.S., III. JOHNSON, B.E. and SKOLNICK, M.H., A cell cycle regulator potentially involved in genesis of many tumors types. Science, 264, 436-440 (1994)
10. LI, Y.-J., HOANG-XUAN, K., DELATTRE, J.-Y., POISSON, M., THOMAS, G. and HAMELIN, R., Frequent loss of heterozygosity on chromosome 9, and low incidence of mutations of cyclin-dependent kinase inhibitors p15 (MTS2) and p16 (MTS1) genes in gliomas. Oncogene, 11, 597-600 (1995).
11. MONTESANO, R., HOLLSTEIN, M. and HAINAUT, P., Genetic alterations in esophageal cancer and their relevance to etiology and pathogenesis: a review. (1996). (In press).
12. MORI, T., MIURA, K., AOKI, T., NISHIHIRA, T., MORI, S. and NAKAMLRA, Y., Frequent somatic mutation of the MTS1/CDK41 (multiple tumor suppressor/cyclin-dependent kinase 4 inhibitor) gene in oesophageal squamous cell carcinoma. Cancer Res., 54, 3396-3397 (1994).
13. NOBORI, T., MIURA, K., Wu, D.J., LOIS, A., TAKABAYASHI, K. and CARSON, D.A., Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers. Nature (Lond.), 368, 753-756 (1994)
14. OHTA, M., NAGAI, H., SHIMIZU, M., RASIO, D., BERD, D., MASTRANGELO, M., SINGH, A.D., SHIELDS, J.A., SHIELDS, C.L., CROCE, C.M. and HUEBNER, K., Rarity of somatic and germline mutations of the cyclin-dependent kinase 4 inhibitor gene, CDK41, in melanoma. Cancer Res., 54, 5269-5272 (1994).
15. INK4 mutations and altered expression in human tumors and cell lines. Cold Spring Harb. Symp. Quant. Biol, 59, 49-57 (1994).
16. SERRANO, M., HANNON, G.J. and BEACH, D.A., A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4. Nature (Lond.), 366, 704-707 (1993).
17. SPRUCK, C.H., III, GONZALES-ZULUETA, M., SHIBATA, A., SIMONEAU, A.R., LIN, M.F., GONZALES, F., TSAI, Y.C. and JONES, P.A., p16 gene in uncultured tumours. Nature (Lond.), 370, 183-184 (1994).
18. TARMIN, L., YIN, J., ZHOU, X., SUZUKI, H., JIANG, H.Y., RHYU, M.G., ABRAHAM. J.M., KRASNA, M.J., COTTRELL, J, and MELTZER, S.J., Frequent loss of heterozygosity on chromosome 9 in adenocarcinoma and squamous cell carcinoma of the esophagus. Cancer Res., 54, 6094-6096 (1994).
19. UEKI, K., RUBIO, M.P., RAMESH, V., CORREA, K.M., RUTTER, J.L., VON DEIMLING, A., BUCKLER, A.J., GUSELLA, J.F. and Louis, D.N., MTS1/CDKN2 gene mutations are rare in primary human astrocytomas with allelic loss of chromosome 9p. Hum. mol. Genet., 3, 1841-1845 (1994).
20. ink4) in human breast carcinomas. Cancer Res., 54, 5262-5264 (1994).
21. ink4B/MTS2 genes in biliary tract cancers. Cancer Res., 55, 2756-2760 (1995).
22. ZHANG, S.Y., KLEIN-SZANTO, A.J.P., SAUTER, E.R., SHAFARENKO, M., MITSUNAGA, S., NOBORI, T., CARSON, D.A., RIDGE, J.A. and GOODROW, T.L., Higher frequency of alterations in the p16/CDKN2 gene in squamous cell carcinoma cell lines than in primary tumors of the head and neck. Cancer Res., 54, 5050-5053 (1994).
23. ZHOU, X., TARMIN, L., YIN. J., JIANG, H.Y., SUZUKI, H., RHYU, M.G., ABRAHAM, J.M. and MELTZER, S.J., The MTS1 gene is frequently mutated in primary human esophageal tumors. Oncogene, 9, 3737-3741 (1994).