Identifying the precursors of Hodgkin and Reed-Sternberg cells in Hodgkin's disease: Role of the germinal center in B-cell lymphomagenesis

Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology

Volumn 21, Issue 4 SUPPL., 1999, Pages

  Küppers, Ralf ^a,b  

^a UNIVERSITY OF COLOGNE   (Germany)

^b UNIVERSITY HOSPITAL OF COLOGNE   (Germany)

Author keywords

B cell; Germinal center; Hodgkin's disease; Lymphomagenesis; Somatic hypermutation

Indexed keywords

ANTIGEN BINDING; ANTIGEN SPECIFICITY; B CELL LYMPHOMA; B LYMPHOCYTE DIFFERENTIATION; CARCINOGENESIS; CELL MATURATION; CONFERENCE PAPER; GENE MUTATION; HODGKIN DISEASE; HUMAN; PRIORITY JOURNAL;

CELL DIFFERENTIATION; GENE REARRANGEMENT; GERMINAL CENTER; HODGKIN DISEASE; HUMANS; IMMUNOGLOBULIN HEAVY CHAINS; IMMUNOGLOBULIN VARIABLE REGION; LYMPHOMA, B-CELL; REED-STERNBERG CELLS;

PHRAGMITES;

EID: 0344242079     PISSN: 10779450     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (47)

1. Rajewsky K. Clonal selection and learning in the antibody system. Nature 1996;381:751-8.
2. Liu YI, Johnson GD, Gordon J, MacLennan IC. Germinal centres in T-cell-dependent antibody responses. Immunol Today 1992;13: 17-21.
3. Berek C, Berger A, Apel M. Maturation of the immune response in germinal centers. Cell 1991;67:1121-9.
4. Jacob J, Kelsoe G, Rajewsky K, Weiss U. Intraclonal generation of antibody mutants in germinal centres. Nature 1991;354:389-92.
5. Küppers R, Zhao M, Hansmann ML, Rajewsky K. Tracing B cell development in human germinal centres by molecular analysis of single cells picked from histological sections. EMBO J 1993;12: 4955-67.
6. Nakamura M, Yagi H, Kayaba S, et al. Death of germinal center B cells without DNA fragmentation. Eur J Immunol 1996;26:1211-16.
7. Pulendran B, van Driel R, Nossal GJV. Immunological tolerance in germinal centres. Immunol Today 1997;18:27-32.
8. Han S, Dillon SR, Zheng B, Shimoda M, Schlissel MS, Kelsoe G. V(D)J recombinase activity in a subset of germinal center B lymphocytes. Science 1997;278:301-5.
9. Papavasiliou F, Casellas R, Suh H, et al. V(D)J recombination in mature B cells: a mechanism for altering antibody responses. Science 1997;278:298-301.
10. Liu YJ, Grouard G, de Bouteiller O, Banchereau J. Follicular dendritic cells and germinal centers, Int Rev Cytol 1996;166:139-79.
11. Oprea M, Perelson AS. Somatic mutation leads to efficient affinity maturation when centrocytes recycle back to centroblasts. J Immunol 1997;158:5155-62.
12. Matsuda F, Honjo T. Organization of the human immunoglobulin heavy-chain locus. Adv Immunol 1996;62:1-29.
13. Corbett SJ, Tomlinson IM, Sonnhammer ELL, Buck D, Winter G. Sequence of the human immunoglobulin diversity (D) segment locus: a systematic analysis provides no evidence for the use of DIR segments, inverted D segments, "minor" D segments or D-D recombinations. J Mol Biol 1997;270:587-97.
14. Tonegawa S. Somatic generation of antibody diversity. Nature 1983;302:575-81.
15. Burke JS. Hodgkin's disease: histopathology and differential diagnosis. In: Knowles DM, ed. Neoplastic hematopathology. Baltimore: Williams & Wilkins, 1992.
16. Harris NL, Jaffe ES, Stein H, et al. A revised European-American classification of lymphoid neoplasms: a proposal from the International Lymphoma Study Group. Blood 1994;84:1361-92.
17. Drexler HG. Recent results on the biology of Hodgkin and ReedSternberg cells.I. Biopsy material. Leuk Lymphoma 1992;8:283-313.
18. Irsch J, Nitsch S, Hansmann M-L, et al. Isolation of viable Hodgkin and Reed-Sternberg cells from Hodgkin disease tissues. Proc Natl Acad Sci USA 1998;95:10117-22.
19. Kanzler H, Hansmann ML, Kapp U, et al. Molecular single cell analysis demonstrates the derivation of a peripheral blood-derived cell line (L1236) from the Hodgkin/Reed-Sternberg cells of a Hodgkin's lymphoma patient. Blood 1996;87:3429-36.
20. Küppers R, Rajewsky K, Zhao M, et al. Hodgkin disease: Hodgkin and Reed-Sternberg cells picked from histological sections show clonal immunoglobulin gene rearrangements and appear to be derived from B cells at various stages of development. Proc Natl Acad Sci USA 1994;91:10962-6.
21. Kanzler H, Küppers R, Hansmann ML, Rajewsky K. Hodgkin and Reed-Sternberg cells in Hodgkin's disease represent the outgrowth of a dominant tumor clone derived from (crippled) germinal center B cells. J Exp Med 1996;184:1495-1505.
22. Vockerodt M, Soares M, Kanzler H, et al. Detection of clonal Hodgkin and Reed-Sternberg cells with identical somatically mutated and rearranged VH genes in different biopsies in relapsed Hodgkin's disease. Blood 1998;92:2899-907.
23. Küppers R, Rajewsky K. The origin of Hodgkin and Reed/ Sternberg cells in Hodgkin's disease. Annu Rev Immunol 1998;16: 471-93.
24. Ohshima K, Suzumiya J, Mukai Y, et al. Classical Hodgkin and Reed-Sternberg cells demonstrate a non-clonal immature B lymphoid lineage: evidence from a single cell assay and in situ hybridization. Hematol Oncol 1996;14:123-36.
25. Hummel M, Ziemann K, Lammert H, Pileri S, Sabattini E, Stein H. Hodgkin's disease with monoclonal and polyclonal populations of Reed-Sternberg cells. N Engl J Med 1995;333:901-6.
26. Roth J, Daus H, Trümper L, Gause A, Salamon-Looijen M, Pfreundschuh M. Detection of immunoglobulin heavy-chain gene rearrangement at the single-cell level in malignant lymphomas: no rearrangement is found in Hodgkin and Reed-Sternberg cells. Int J Cancer 1994;57:799-804.
27. Delabie J, Tierens A, Gavriil T, Wu G, Weisenburger DD, Chan WC. Phenotype, genotype and clonality of Reed-Sternberg cells in nodular sclerosis Hodgkin's disease: results of a single-cell study. Br J Haematol 1996;94:198-205.
28. Hummel M, Marafioti T, Stein H. Immunoglobulin V genes in Reed-Sternberg cells. Letter to the Editor. N Engl J Med 1996;334.
29. Ohno T, Trenn G, Wu G, Abou-Elella A, Reis HE, Chan WC. The clonal relationship between nodular sclerosis Hodgkin's disease with a clonal Reed-Sternberg cell population and a subsequent B-cell small noncleaved cell lymphoma. Mod Pathol 1998;11: 485-90.
30. Jarret AF, Armstrong AA, Alexander E. Epidemiology of EBV and Hodgkin's lymphoma. Ann Oncol 1996;7(Suppl. 4):S5-10.
31. Herbst H. Epstein-Barr virus in Hodgkin's disease. Semin Cancer Biol 1996:7:183-9.
32. Diebold J, Raphael M, Prevot S, Audouin J. Lymphomas associated with HIV infection. Cancer Surv 1997;30:263-93.
33. Braeuninger A, Küppers R, Strickler JG, Wacker HH, Rajewsky K, Hansmann ML. Hodgkin and Reed-Sternberg cells in lymphocyte predominant Hodgkin disease represent clonal populations of germinal center-derived tumor B cells. Proc Natl Acad Sci USA 1997; 94:9337-42.
34. Klein U, Gossens T, Fischer M, et al. Somatic hypermutation in normal and transformed human B cells, Immunol Rev 1998;162: 261-80.
35. Marafioti T, Hummel M, Anagnostopoulos I, et al. Origin of nodular lymphocyte-predominant Hodgkin's disease from a clonal expansion of highly mutated germinal-center B cells. N Engl J Med 1997;337:453-8.
36. Ohno T, Stribley JA, Wu G, Hinrichs SH, Weisenburger DD, Chan WC. Clonality in nodular lymphocyte-predominant Hodgkin's disease. N Engl J Med 1997;337:459-65.
37. Küppers R, Rajewsky K, Braeuninger A, Hansmann ML. L&H cells in lymphocyte-predominant Hodgkin's disease [letter]. N Engl J Med 1998;338:763-4.
38. Bahler DW, Levy R. Clonal evolution of a follicular lymphoma: evidence for antigen selection. Proc Natl Acad Sci USA 1992;89: 6770-4.
39. Cleary ML, Meeker TC, Levy S, et al. Clustering of extensive somatic mutations in the variable region of an immunoglobulin heavy chain gene from a human B cell lymphoma. Cell 1986;44: 97-106.
40. Chapman CJ, Mockridge CI, Rowe M, Rickinson AB, Stevenson FK. Analysis of VH genes used by neoplastic B cells in endemic Burkitt's lymphoma shows somatic hypermutation and intraclonal heterogeneity. Blood 1995;85:2176-81.
41. Chapman CJ, Zhou JX, Gregory C, Rickinson AB, Stevenson FK. VH and VL gene analysis in sporadic Burkitt's lymphoma shows somatic hypermutation, intraclonal heterogeneity, and a role for antigen selection. Blood 1996;88:3562-8.
42. Du M, Diss TC, Xu C, Peng H, Isaacson PG, Pan L. Ongoing mutation in MALT lymphoma immunoglobulin gene suggests that antigen stimulation plays a role in the clonal expansion. Leukemia 1996;10:1190-7.
43. Qin Y, Greiner A, Hallas C, Haedicke W, Müller-Hermelink HK. Intraclonal offspring expansion of gastric low-grade MALT-type lymphoma: evidence for the role of antigen-driven high-affinity mutation in lymphomagenesis. Lab Invest 1997;76: 477-85.
44. Hsu FJ, Levy R. Preferential use of the VH4 Ig gene family by diffuse large-cell lymphoma. Blood 1995;86:3072-82.
45. Küppers R, Rajewsky K, Hansmann ML. Diffuse large cell lymphomas are derived from mature B cells carrying V region genes with a high load of somatic mutation and evidence of selection for antibody expression. Eur J Immunol 1997;27:1398-1405.
46. Goossens T, Klein U, Küppers R. Frequent occurrence of deletions and duplications during somatic hypermutation: implications for oncogene translocations and heavy chain disease. Proc Natl Acad Sci USA 1998;95:2463-8.
47. Wilson PC, de Bouteiller O, Liu YJ, et al. Somatic hypermutation introduces insertions and deletions into immunoglobulin V genes. J Exp Med 1998;187:59-70.