The immunomodulatory drugs cyclosporin A, mycophenolate mofetil, and sirolimus (rapamycin) inhibit allergen-induced proliferation and IL-5 production by PBMCs from atopic asthmatic patients

Journal of Allergy and Clinical Immunology

Volumn 108, Issue 6, 2001, Pages 915-917

  Powell, N ^a   Till, S ^a   Bungre, J ^a   Corrigan, C ^a  

^a GUY S HOSPITAL   (United Kingdom)

Author keywords

Allergen; Asthma; Cyclosporin A; Dexamethasone; Interteukin 5; Mycophenolate mofetil; Sirolimus; T cell; Therapy

Indexed keywords

CYCLOSPORIN A; DEXAMETHASONE; IMMUNOMODULATING AGENT; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; RAPAMYCIN;

ALLERGIC ASTHMA; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE SEVERITY; DRUG MECHANISM; HUMAN; HUMAN CELL; IN VITRO STUDY; LUNG FUNCTION; MONONUCLEAR CELL; PRIORITY JOURNAL;

EID: 0035217086     PISSN: 00916749     EISSN: None     Source Type: Journal    
DOI: 10.1067/mai.2001.119742     Document Type: Article

References (10)

1. The relationship between IL-4 and IL-5 mRNA expression and disease severity in atopic asthma
2. Expression of IL-4 and IL-5 mRNA and protein product by CD4+ and CD8+ T cells, eosinophils and mast cells in bronchial biopsies obtained from atopic and non-atopic (intrinsic) asthmatics
3. Allergen-induced proliferation and IL-5 production by bronchoalveolar lavage and blood T cells following segmental allergen challenge
4. IL-5 secretion by allergen-stimulated CD4+ T cells in primary culture: Relationship to expression of allergic disease
5. The topical glucocorticoids beclomethasone dipropionate and fluticasone propionate inhibit human T cell allergen-induced production of IL-5, IL-3 and GM-CSF mRNA and protein
6. IL-5 production by CD4+ T cells of asthmatic patients is suppressed by glucocorticoids and the immunosuppressants FK5S06 and cyclosporin A
7. Double-blind, placebo-controlled study of cyclosporin A as a corticosteroid-sparing agent in corticosteroid-dependent asthma
8. Attenuation of the allergen-induced late asthmatic reaction by cyclosporin A is associated with inhibition of bronchial eosinophils, interleukin-5, granulocyte/macrophage colony-stimulating factor and eotaxin
9. Glucocorticoid-resistant asthma: T-lymphocyte steroid metabolism and sensitivity to glucocorticoids and immunosuppressive agents
10. The effect of dexamethasone, cyclosporin and rapamycin on T-lymphocyte proliferation in vitro: Comparison of cells from patients with glucocorticold-sensitive and glucocorticoid-resistant chronic asthma