PKCα regulates the hypertrophic growth of cardiomyocytes through extracellular signal-regulated kinase1/2 (ERK1/2)

Journal of Cell Biology

Volumn 156, Issue 5, 2002, Pages 905-919

  Braz, Julian C ^a   Bueno, Orlando F ^a   De Windt, Leon J ^a,c   Molkentin, Jeffery D ^a,b  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^b CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

^c MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Cardiac; Hypertrophic growth; MAPK; Protein kinase C; Signal transduction

Indexed keywords

ATRIAL NATRIURETIC FACTOR; LEUCINE; MITOGEN ACTIVATED PROTEIN KINASE 1; PROTEIN KINASE C ALPHA; PROTEIN KINASE C BETA; PROTEIN KINASE C DELTA; PROTEIN KINASE C EPSILON; PROTEIN KINASE C ZETA;

ADENOVIRUS; ANIMAL CELL; ARTICLE; CELL SURFACE; CELL TYPE; CELLULAR DISTRIBUTION; ENZYME ACTIVATION; ENZYME ACTIVITY; GENE OVEREXPRESSION; GENE TRANSFER; HEART HYPERTROPHY; HEART MUSCLE CELL; MARKER GENE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; VIRAL GENE DELIVERY SYSTEM;

ANIMALS; ANIMALS, NEWBORN; ATRIAL NATRIURETIC FACTOR; CARDIOMYOPATHY, HYPERTROPHIC; CELL COMPARTMENTATION; CELL DIFFERENTIATION; CELL MEMBRANE; CYTOSOL; HEART; IMMUNOHISTOCHEMISTRY; ISOENZYMES; MAP KINASE KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; MITOGEN-ACTIVATED PROTEIN KINASES; MYOCARDIUM; PROTEIN KINASE C; PROTEIN KINASE C-ALPHA; PROTEIN-SERINE-THREONINE KINASES; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; TUBULIN;

ADENOVIRIDAE; ANIMALIA; MAMMALIA;

EID: 0037018154     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.200108062     Document Type: Article

References (57)

1. Overproduction of a Ca(2+)-independent protein kinase C isozyme, nPKC epsilon, increases the secretion of prolactin from thyrotropin-releasing hormone-stimulated rat pituitary GH4C1 cells
2. Expression of protein kinase C beta in the heart causes hypertrophy in adult mice and sudden death in neonates
3. The dual-specificity phosphatase MKP-1 limits the cardiac hypertrophic response in vitro and in vivo
4. Differential activation of protein kinase C isozymes by endothelin-1 and phenylephrine and subsequent stimulation of p42 and p44 mitogen-activated protein kinases in ventricular myocytes cultured from neonatal rat hearts
5. Stimulation of phosphatidylinositol hydrolysis, protein kinase C translocation, and mitogen-activated protein kinase activity by bradykinin in rat ventricular myocytes: Dissociation from the hypertrophic response
6. Transgenic Galphaq overexpression induces cardiac contractile failure in mice
7. Calcineurin promotes protein kinase C and c-Jun NH2-terminal kinase activation in the heart. Cross-talk between cardiac hypertrophic signaling pathways
8. Protein kinase C isozymes and the regulation of diverse cell responses
9. Crosstalk between alpha-1A and alpha-1B adrenoceptors in neonatal rat myocardium: Implications in cardiac hypertrophy
10. Localization of protein kinase C isozymes in cardiac myocytes
11. Sustained in vivo cardiac protection by a rationally designed peptide that causes epsilon protein kinase C translocation
12. Myocardial alpha-thrombin receptor activation induces hypertrophy and increases atrial natriuretic factor gene expression
13. Hypoxia alters the subcellular distribution of protein kinase C isozymes in neonatal rat ventricular myocytes
14. A selective epsilon-protein kinase C antagonist inhibits protection of cardiac myocytes from hypoxia-induced cell death
15. Increased protein kinase C and isozyme redistribution in pressure-overload cardiac hypertrophy in the rat
16. Does the nuclear envelope contain two types of ligand-gated Ca2+ release channels?
17. Na(+)influx via Na(+)/H(+)exchange activates protein kinase C isozymes delta and epsilon in cultured neonatal rat cardiac myocytes
18. Critical duration of intracellular Ca2+ response required for continuous translocation and activation of cytosolic phospholipase A2
19. The epidemiology of heart failure: The Framingham Study
20. Induction of mucin gene expression in human colonic cell lines by PMA is dependent on PKC-epsilon
21. Increased contractility and altered Ca(2+) transients of mouse heart myocytes conditionally expressing PKCbeta
22. Adverse effects of chronic endogenous sympathetic drive induced by cardiac GS alpha overexpression
23. PKC translocation without changes in Galphaq and PLC-beta protein abundance in cardiac hypertrophy and failure
24. Endothelin-dependent actions in cultured AT-1 cardiac myocytes. The role of the epsilon isozyme of protein kinase C
25. A protein kinase C translocation inhibitor as an isozyme-selective antagonist of cardiac function
26. An improved permeabilization protocol for the introduction of peptides into cardiac myocytes. Application to protein kinase C research
27. Targeting Pyk2 to beta 1-integrin-containing focal contacts rescues fibronectin-stimulated signaling and haptotactic motility defects of focal adhesion kinase-null cells
28. Protein kinase C alpha activates RAF-1 by direct phosphorylation
29. Prognostic implications of echocardiographically determined left ventricular mass in the Framingham Heart Study
30. Expression of an ATP binding mutant of PKC-delta inhibits Sis-induced transformation of NIH3T3 cells
31. Retinoic acid inhibits cardiac neural crest migration by blocking c-Jun N-terminal kinase activation
32. Left ventricular hypertrophy: Pathogenesis, detection, and prognosis
33. Localization, anchoring, and functions of protein kinase c isozymes in the heart
34. Inhibition of insulin-induced activation of Akt by a kinase-deficient mutant of the epsilon isozyme of protein kinase C
35. Evaluation of the concentration and bioactivity of adenovirus vectors for gene therapy
36. Cardiotrophic effects of protein kinase C epsilon: Analysis by in vivo modulation of PKCepsilon translocation
37. Localization of protein kinases by anchoring proteins: A theme in signal transduction
38. Cytoplasmic signaling pathways that regulate cardiac hypertrophy
39. Signaling mediated by the closely related mammalian Rho family GTPases TC10 and Cdc42 suggests distinct functional pathways
40. Induction of differentiation in normal human keratinocytes by adenovirus-mediated introduction of the eta and delta isozymes of protein kinase C
41. PKCepsilon activation induces dichotomous cardiac phenotypes and modulates PKCepsilon-RACK interactions and RACK expression
42. PKC-dependent activation of p44/p42 MAPKs during myocardial ischemia-reperfusion in conscious rabbits
43. The alpha(1)-adrenoceptor subtype- and protein kinase C isozyme-dependence of norepinephrine's actions in cardiomyocytes
44. PKC-beta is not necessary for cardiac hypertrophy
45. Molecular characterization of the stretch-induced adaptation of cultured cardiac cells
46. Effects of PTH-rP(107-111) and PTH-rP(7-34) on adult cardiomyocytes
47. Activation of the mitogen-activated protein kinase/extracellular signal-regulated kinase pathway by conventional, novel, and atypical protein kinase C isotypes
48. Increased protein kinase C activity in myotrophin-induced myocyte growth
49. Role of protein kinase C-epsilon in hypertrophy of cultured neonatal rat ventricular myocytes
50. Targeted inhibition of calcineurin prevents agonist-induced cardiomyocyte hypertrophy
51. Transgenic overexpression of constitutively active protein kinase C epsilon causes concentric cardiac hypertrophy
52. Effect of angiotensin-converting enzyme inhibition on protein kinase C and SR proteins in heart failure
53. Long-term expression of protein kinase C in adult mouse hearts improves postischemic recovery
54. Requirement of activation of the extracellular signal-regulated kinase cascade in myocardial cell hypertrophy
55. Targeted overexpression of protein kinase C beta2 isozyme in myocardium causes cardiomyopathy
56. Mechanical stress activates protein kinase cascade of phosphorylation in neonatal rat cardiac myocytes
57. C2 region-derived peptides of beta-protein kinase C regulate cardiac Ca2+ channels