C. elegans RAD-5/CLK-2 defines a new DNA damage checkpoint protein

Current Biology

Volumn 11, Issue 24, 2001, Pages 1934-1944

  Ahmed, Shawn ^a,d   Alpi, Arno ^c   Hengartner, Michael O ^b   Gartner, Anton ^c  

^a MRC LABORATORY OF MOLECULAR BIOLOGY   (United Kingdom)

^b UNIVERSITY OF ZURICH   (Switzerland)

^c MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

^d UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CAENORHABDITIS ELEGANS; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES POMBE;

EID: 0035846599     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-9822(01)00604-2     Document Type: Article

References (49)

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7. The human checkpoint protein hRad17 interacts with the PCNA-like proteins hRad1, hHus1, and hRad9
8. Structure-based predictions of Rad1, Rad9, Hus1 and Rad17 participation in sliding clamp and clamp-loading complexes
9. Recruitment of mec1 and ddc1 checkpoint proteins to double-strand breaks through distinct mechanisms
10. Two checkpoint complexes are independently recruited to sites of DNA damage in vivo
11. A Rad3-Rad26 complex responds to DNA damage independently of other checkpoint proteins
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13. Rfc4 interacts with Rpa1 and is required for both DNA replication and DNA damage checkpoints in Saccharomyces cerevisiae
14. Rfc5, in cooperation with rad24, controls DNA damage checkpoints throughout the cell cycle in Saccharomyces cerevisiae
15. A novel Rad24 checkpoint protein complex closely related to replication factor C
16. Replication factor C3 of Schizosaccharomyces pombe, a small subunit of replication factor C complex, plays a role in both replication and damage checkpoints
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30. Tel2p, a regulator of yeast telomeric length in vivo, binds to single-stranded telomeric DNA in vitro
31. Fission yeast genes involved in coupling mitosis to completion of DNA replication
32. Nuclear reorganization and homologous chromosome pairing during meiotic prophase require C. elegans chk-2
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34. Transgene-mediated cosuppression in the C. elegans germ line
35. Genomic analysis of gene expression in C. elegans
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39. The C. elegans maternal-effect gene clk-2 is essential for embryonic development, encodes a protein homologous to yeast Tel2p and affects telomere length
40. C. elegans clk-2, a gene that limits life span, encodes a regulator of telomere metabolism similar to yeast telomere binding protein Tel2p
41. Mutations in recombinational repair and in checkpoint control genes suppress the lethal combination of srs2Delta with other DNA repair genes in Saccharomyces cerevisiae
42. TEL1, a gene involved in controlling telomere length in S. cerevisiae, is homologous to the human ataxia telangiectasia gene
43. TEL1, an S. cerevisiae homolog of the human gene mutated in ataxia telangiectasia, is functionally related to the yeast checkpoint gene MEC1
44. RAD9, RAD17, and RAD24 are required for S phase regulation in Saccharomyces cerevisiae in response to DNA damage
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49. Telomeric repeats (TTAGGC)n are sufficient for chromosome capping function in Caenorhabditis elegans