메뉴 건너뛰기




Volumn 159, Issue 1, 2002, Pages 55-67

Influence of cargo size on Ran and energy requirements for nuclear protein import

Author keywords

Importin ; Nuclear protein import; Nucleoporin; Ran; Transportin

Indexed keywords

CARRIER PROTEIN; GUANOSINE TRIPHOSPHATE; KARYOPHERIN; KARYOPHERIN BETA; RAN PROTEIN; TRANSPORTIN; UNCLASSIFIED DRUG;

EID: 0037078333     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.200204163     Document Type: Article
Times cited : (78)

References (45)
  • 1
    • 0035800787 scopus 로고    scopus 로고
    • Proteomic analysis ofnucleoporin interacting proteins
    • Allen, N.P., L. Huang, A. Burlingame, and M. Rexach. 2001. Proteomic analysis ofnucleoporin interacting proteins. J. Biol. Chem. 276:29268-29274.
    • (2001) J. Biol. Chem. , vol.276 , pp. 29268-29274
    • Allen, N.P.1    Huang, L.2    Burlingame, A.3    Rexach, M.4
  • 2
    • 0034616910 scopus 로고    scopus 로고
    • Structural basis for the interaction between FxFG nucleoporin repeats and Importin β in nuclear trafficking
    • Bayliss, R., T. Littlewood, and M. Stewart. 2000. Structural basis for the interaction between FxFG nucleoporin repeats and Importin β in nuclear trafficking. Cell. 102:99-108.
    • (2000) Cell , vol.102 , pp. 99-108
    • Bayliss, R.1    Littlewood, T.2    Stewart, M.3
  • 3
    • 0035931750 scopus 로고    scopus 로고
    • Gradient of increasing affinity of importin β for nucleoporins along the pathway of nuclear import
    • Ben-Efraim, I., and L. Gerace. 2001. Gradient of increasing affinity of importin β for nucleoporins along the pathway of nuclear import. J. Cell Biol. 152:411-418.
    • (2001) J. Cell Biol. , vol.152 , pp. 411-418
    • Ben-Efraim, I.1    Gerace, L.2
  • 4
    • 0345647103 scopus 로고    scopus 로고
    • RanBP1 is crucial for the release of RanGTP from Importin β-related nuclear transport factors
    • Bischoff, F.R., and D. Görlich. 1997. RanBP1 is crucial for the release of RanGTP from Importin β-related nuclear transport factors. FEBS Lett. 419:249-254.
    • (1997) FEBS Lett. , vol.419 , pp. 249-254
    • Bischoff, F.R.1    Görlich, D.2
  • 7
    • 0035370948 scopus 로고    scopus 로고
    • Nucleocytoplasmic transport enters the atomic age
    • Conti, E., and E. Izaurralde. 2001. Nucleocytoplasmic transport enters the atomic age. Curr. Opin. Cell Biol. 13:310-319.
    • (2001) Curr. Opin. Cell Biol. , vol.13 , pp. 310-319
    • Conti, E.1    Izaurralde, E.2
  • 8
    • 0030696935 scopus 로고    scopus 로고
    • RanGTP targets p97 to RanBP2, a filamentous protein localized at the cytoplasmic periphery of the nuclear pore complex
    • Delphin, C., T. Guan, F. Melchior, and L. Gerace. 1997. RanGTP targets p97 to RanBP2, a filamentous protein localized at the cytoplasmic periphery of the nuclear pore complex. Mol. Biol. Cell. 8:2379-2390.
    • (1997) Mol. Biol. Cell , vol.8 , pp. 2379-2390
    • Delphin, C.1    Guan, T.2    Melchior, F.3    Gerace, L.4
  • 9
    • 0034761101 scopus 로고    scopus 로고
    • The crystal structure of nucleoplasmin-core: Implications for histone binding and nucleosome assembly
    • Dutta, S., I.V. Akey, C. Dingwall, K.L. Hartman, T. Laue, R.T. Nolte, J.F. Head, and C.W. Akey. 2001. The crystal structure of nucleoplasmin-core: implications for histone binding and nucleosome assembly. Mol. Cell. 8:841-853.
    • (2001) Mol. Cell , vol.8 , pp. 841-853
    • Dutta, S.1    Akey, I.V.2    Dingwall, C.3    Hartman, K.L.4    Laue, T.5    Nolte, R.T.6    Head, J.F.7    Akey, C.W.8
  • 10
    • 0032933745 scopus 로고    scopus 로고
    • Receptor-mediated substrate translocation through the nuclear pore complex without nucleotide triphosphate hydrolysis
    • Englmeier, L., J.-C. Olivo, and I.W. Mattaj. 1999. Receptor-mediated substrate translocation through the nuclear pore complex without nucleotide triphosphate hydrolysis. Curr. Biol. 9:30-41.
    • (1999) Curr. Biol. , vol.9 , pp. 30-41
    • Englmeier, L.1    Olivo, J.-C.2    Mattaj, I.W.3
  • 12
    • 0031454975 scopus 로고    scopus 로고
    • The location of the transport gate in the nuclear pore complex
    • Feldherr, C.M., and D. Akin. 1997. The location of the transport gate in the nuclear pore complex. J. Cell Sci. 110:3065-3070.
    • (1997) J. Cell Sci. , vol.110 , pp. 3065-3070
    • Feldherr, C.M.1    Akin, D.2
  • 13
    • 0029920934 scopus 로고    scopus 로고
    • The nuclear transport factor karyopherin β binds stoichiometrically to RanGTP and inhibits the Ran GTPase activating protein
    • Floer, M., and G. Blobel. 1996. The nuclear transport factor karyopherin β binds stoichiometrically to RanGTP and inhibits the Ran GTPase activating protein. J. Biol. Chem. 271:5313-5316.
    • (1996) J. Biol. Chem. , vol.271 , pp. 5313-5316
    • Floer, M.1    Blobel, G.2
  • 15
    • 0033279841 scopus 로고    scopus 로고
    • Transport between the cell nucleus and the cytoplasm
    • Görlich, D., and U. Kutay. 1999. Transport between the cell nucleus and the cytoplasm. Annu. Rev. Cell Dev. Biol. 15:607-660.
    • (1999) Annu. Rev. Cell Dev. Biol. , vol.15 , pp. 607-660
    • Görlich, D.1    Kutay, U.2
  • 16
    • 0029853631 scopus 로고    scopus 로고
    • Identification of different roles for RanGDP and RanGTP in nuclear protein import
    • Görlich, D., N. Pante, U. Kutay, U. Aebi, and F.R. Bischoff. 1996. Identification of different roles for RanGDP and RanGTP in nuclear protein import. EMBO J. 15:5584-5594.
    • (1996) EMBO J. , vol.15 , pp. 5584-5594
    • Görlich, D.1    Pante, N.2    Kutay, U.3    Aebi, U.4    Bischoff, F.R.5
  • 17
    • 0037017403 scopus 로고    scopus 로고
    • The importin-beta binding domain of snurportin1 is responsible for the Ran- and energy-independent nuclear import of spliceosomal U snRNPs in vitro
    • Huber, J., A. Dickmanns, and R. Luhrmann. 2002. The importin-beta binding domain of snurportin1 is responsible for the Ran- and energy-independent nuclear import of spliceosomal U snRNPs in vitro. J. Cell Biol. 156:467-479.
    • (2002) J. Cell Biol. , vol.156 , pp. 467-479
    • Huber, J.1    Dickmanns, A.2    Luhrmann, R.3
  • 18
    • 0034625427 scopus 로고    scopus 로고
    • Phosphorylation of the nuclear transport machinery down-regulates nuclear protein Import in vitro
    • Kehlenbach, R.H., and L. Gerace. 2000. Phosphorylation of the nuclear transport machinery down-regulates nuclear protein Import in vitro. J. Biol. Chem. 275:17848-17856.
    • (2000) J. Biol. Chem. , vol.275 , pp. 17848-17856
    • Kehlenbach, R.H.1    Gerace, L.2
  • 19
    • 0035958022 scopus 로고    scopus 로고
    • Stimulation of nuclear export and inhibition of nuclear import by a Ran mutant deficient in binding to Ran-binding protein 1
    • Kehlenbach, R.H., R. Assheuer, A. Kehlenbach, J. Becker, and L. Gerace. 2001. Stimulation of nuclear export and inhibition of nuclear import by a Ran mutant deficient in binding to Ran-binding protein 1. J. Biol. Chem. 276:14524-14531.
    • (2001) J. Biol. Chem. , vol.276 , pp. 14524-14531
    • Kehlenbach, R.H.1    Assheuer, R.2    Kehlenbach, A.3    Becker, J.4    Gerace, L.5
  • 20
    • 0028964821 scopus 로고
    • Interaction of the nuclear GTP-binding protein Ran with its regulatory proteins RCC1 and RanGAP1
    • Klebe, C., F.R. Bischoff, H. Ponstingl, and A. Wittinghofer. 1995. Interaction of the nuclear GTP-binding protein Ran with its regulatory proteins RCC1 and RanGAP1. Biochemistry. 34:639-647.
    • (1995) Biochemistry , vol.34 , pp. 639-647
    • Klebe, C.1    Bischoff, F.R.2    Ponstingl, H.3    Wittinghofer, A.4
  • 21
    • 0034613299 scopus 로고    scopus 로고
    • Constitutive release of ATP and evidence for major contribution of ecto-nucleotide pyrophosphatase and nucleoside diphosphokinase to extracellular nucleotide concentrations
    • Lazarowski, E.R., R.C. Boucher, and T.K. Harden. 2000. Constitutive release of ATP and evidence for major contribution of ecto-nucleotide pyrophosphatase and nucleoside diphosphokinase to extracellular nucleotide concentrations. J. Biol. Chem. 275:31061-31068.
    • (2000) J. Biol. Chem. , vol.275 , pp. 31061-31068
    • Lazarowski, E.R.1    Boucher, R.C.2    Harden, T.K.3
  • 22
    • 0031016658 scopus 로고    scopus 로고
    • RanBP1 forms a ternary complex with Ran and karyopherin β and reduces RanGAP inhibition by karyopherin β
    • Lounsbury, K.M., and I.G. Macara. 1997. RanBP1 forms a ternary complex with Ran and karyopherin β and reduces RanGAP inhibition by karyopherin β. J. Biol. Chem. 272:551-555.
    • (1997) J. Biol. Chem. , vol.272 , pp. 551-555
    • Lounsbury, K.M.1    Macara, I.G.2
  • 23
    • 0035203632 scopus 로고    scopus 로고
    • Transport into and out of the nucleus
    • Macara, I.G. 2001. Transport into and out of the nucleus. Microbiol. Mol. Biol. Rev. 65:570-594.
    • (2001) Microbiol. Mol. Biol. Rev. , vol.65 , pp. 570-594
    • Macara, I.G.1
  • 24
    • 0030932134 scopus 로고    scopus 로고
    • A small ubiquitin-related polypeptide involved in targeting RanGAP1 to nuclear pore complex protein RanBP2
    • Mahajan, R., C. Delphin, T. Guan, L. Gerace, and F. Melchior. 1997. A small ubiquitin-related polypeptide involved in targeting RanGAP1 to nuclear pore complex protein RanBP2. Cell. 88:97-107.
    • (1997) Cell , vol.88 , pp. 97-107
    • Mahajan, R.1    Delphin, C.2    Guan, T.3    Gerace, L.4    Melchior, F.5
  • 25
    • 0027714921 scopus 로고
    • Inhibition of nuclear protein import by nonhydrolyzable analogues of GTP and identification of the small GTPase Ran/TC4 as an essential transport factor
    • Melchior, F., B. Paschal, J. Evans, and L. Gerace. 1993. Inhibition of nuclear protein import by nonhydrolyzable analogues of GTP and identification of the small GTPase Ran/TC4 as an essential transport factor. J. Cell Biol. 123:1649-1659.
    • (1993) J. Cell Biol. , vol.123 , pp. 1649-1659
    • Melchior, F.1    Paschal, B.2    Evans, J.3    Gerace, L.4
  • 26
    • 0032483384 scopus 로고    scopus 로고
    • Ran and nuclear transport
    • Moore, M.S. 1998. Ran and nuclear transport. J. Biol. Chem. 273:22857-22860.
    • (1998) J. Biol. Chem. , vol.273 , pp. 22857-22860
    • Moore, M.S.1
  • 27
    • 0033578298 scopus 로고    scopus 로고
    • The direction of transport through the nuclear pore can be inverted
    • Nachury, M.V., and K. Weis. 1999. The direction of transport through the nuclear pore can be inverted. Proc. Natl. Acad. Sci. USA. 96:9622-9627.
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 9622-9627
    • Nachury, M.V.1    Weis, K.2
  • 28
    • 0033598989 scopus 로고    scopus 로고
    • Transport of proteins and RNAs in and out of the nucleus
    • Nakielny, S., and G. Dreyfuss. 1999. Transport of proteins and RNAs in and out of the nucleus. Cell. 99:677-690.
    • (1999) Cell , vol.99 , pp. 677-690
    • Nakielny, S.1    Dreyfuss, G.2
  • 29
    • 0016652057 scopus 로고
    • Nuclear envelope permeability
    • Paine, P.L., L.C. Moore, and S.B. Horowitz. 1975. Nuclear envelope permeability. Nature. 254:109-114.
    • (1975) Nature , vol.254 , pp. 109-114
    • Paine, P.L.1    Moore, L.C.2    Horowitz, S.B.3
  • 30
    • 0029798506 scopus 로고    scopus 로고
    • Nucleotide-specific interaction of Ran/TC4 with nuclear transport factors NTF2 and p97
    • Paschal, B., C. Delphin, and L. Getace. 1996. Nucleotide-specific interaction of Ran/TC4 with nuclear transport factors NTF2 and p97. Proc. Natl. Acad. Sci. USA. 93:7679-7683.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 7679-7683
    • Paschal, B.1    Delphin, C.2    Getace, L.3
  • 31
    • 0028834428 scopus 로고
    • Protein import into nuclei: Association and dissociation reactions involving transport substrate, transport factors, and nucleoporins
    • Rexach, M., and G. Blobel. 1995. Protein import into nuclei: Association and dissociation reactions involving transport substrate, transport factors, and nucleoporins. Cell. 83:683-692.
    • (1995) Cell , vol.83 , pp. 683-692
    • Rexach, M.1    Blobel, G.2
  • 32
    • 0035869022 scopus 로고    scopus 로고
    • Kinetic analysis of translocation through nuclear pore complexes
    • Ribbeck, K., and D. Görlich. 2001. Kinetic analysis of translocation through nuclear pore complexes. EMBO J. 20:1320-1330.
    • (2001) EMBO J. , vol.20 , pp. 1320-1330
    • Ribbeck, K.1    Görlich, D.2
  • 33
    • 0037013954 scopus 로고    scopus 로고
    • The permeability barrier of nuclear pore complexes appears to operate via hydrophobic exclusion
    • Ribbeck, K., and D. Gorlich. 2002. The permeability barrier of nuclear pore complexes appears to operate via hydrophobic exclusion. EMBO J. 21:2664-2671.
    • (2002) EMBO J. , vol.21 , pp. 2664-2671
    • Ribbeck, K.1    Gorlich, D.2
  • 34
    • 0032954291 scopus 로고    scopus 로고
    • The translocation of transportin-cargo complexes through nuclear pores is independent of both Ran and energy
    • Ribbeck, K., U. Kutay, E. Paraskeva, and D. G6rlich. 1999. The translocation of transportin-cargo complexes through nuclear pores is independent of both Ran and energy. Curr. Biol. 9:47-50.
    • (1999) Curr. Biol. , vol.9 , pp. 47-50
    • Ribbeck, K.1    Kutay, U.2    Paraskeva, E.3    Görlich, D.4
  • 35
    • 0035907248 scopus 로고    scopus 로고
    • The nuclear pore complex as a transport machine
    • Rout, M.P., and J.D. Aitchison. 2001. The nuclear pore complex as a transport machine. J. Biol. Chem. 276:16593-16596.
    • (2001) J. Biol. Chem. , vol.276 , pp. 16593-16596
    • Rout, M.P.1    Aitchison, J.D.2
  • 36
    • 0032567524 scopus 로고    scopus 로고
    • Ran-dependent signal-mediated nuclear import does not require GTP hydrolysis by Ran
    • Schwoebel, E.D., B. Talcott, I. Cushman, and M.S. Moore. 1998. Ran-dependent signal-mediated nuclear import does not require GTP hydrolysis by Ran. J. Biol. Chem. 273:35170-35175.
    • (1998) J. Biol. Chem. , vol.273 , pp. 35170-35175
    • Schwoebel, E.D.1    Talcott, B.2    Cushman, I.3    Moore, M.S.4
  • 37
    • 0037054554 scopus 로고    scopus 로고
    • The mechanism of inhibition of Ran-dependent nuclear transport by cellular ATP depletion
    • Schwoebel, E.D., T.H. Ho, and M.S. Moore. 2002. The mechanism of inhibition of Ran-dependent nuclear transport by cellular ATP depletion. J. Cell Biol. 157:963-974.
    • (2002) J. Cell Biol. , vol.157 , pp. 963-974
    • Schwoebel, E.D.1    Ho, T.H.2    Moore, M.S.3
  • 38
    • 0032489840 scopus 로고    scopus 로고
    • Major binding sites for the nuclear import receptor are the internal nucleoporin Nup153 and the adjacent nuclear filament protein Tpr
    • Shah, S., S. Tugendreich, and D.J. Forbes. 1998. Major binding sites for the nuclear import receptor are the internal nucleoporin Nup153 and the adjacent nuclear filament protein Tpr. J. Cell Biol. 141:31-49.
    • (1998) J. Cell Biol. , vol.141 , pp. 31-49
    • Shah, S.1    Tugendreich, S.2    Forbes, D.J.3
  • 39
    • 0021806048 scopus 로고
    • A new method of preparing gold probes for multiple-labeling cytochemistry
    • Slot, J.W., and H.J. Geuze. 1985. A new method of preparing gold probes for multiple-labeling cytochemistry. Eur. J. Cell Biol. 38:87-93.
    • (1985) Eur. J. Cell Biol. , vol.38 , pp. 87-93
    • Slot, J.W.1    Geuze, H.J.2
  • 40
    • 0035827319 scopus 로고    scopus 로고
    • Molecular mechanism of translocation through nuclear pore complexes during nuclear protein import
    • Stewart, M., R.P. Baker, R. Bayliss, L. Clayton, R.P. Grant, T. Littlewood, and Y. Matsuura. 2001. Molecular mechanism of translocation through nuclear pore complexes during nuclear protein import. EEBS Lett. 498:145-149.
    • (2001) EEBS Lett. , vol.498 , pp. 145-149
    • Stewart, M.1    Baker, R.P.2    Bayliss, R.3    Clayton, L.4    Grant, R.P.5    Littlewood, T.6    Matsuura, Y.7
  • 41
    • 0029905455 scopus 로고    scopus 로고
    • A GTPase distinct from Ran is involved in nuclear protein import
    • Sweet, D.J., and L. Gerace. 1996. A GTPase distinct from Ran is involved in nuclear protein import. J. Cell Biol. 133:971-983.
    • (1996) J. Cell Biol. , vol.133 , pp. 971-983
    • Sweet, D.J.1    Gerace, L.2
  • 42
    • 0035370938 scopus 로고    scopus 로고
    • Nuclear pores and nuclear assembly
    • Vasu, S.K., and D.J. Forbes. 2001. Nuclear pores and nuclear assembly. Curr. Opin. Cell Biol. 13:363-375.
    • (2001) Curr. Opin. Cell Biol. , vol.13 , pp. 363-375
    • Vasu, S.K.1    Forbes, D.J.2
  • 43
    • 0034718525 scopus 로고    scopus 로고
    • Different structural and kinetic requirements for the interaction of Ran with the Ran-binding domains of RanBP2 and importin β
    • Villa Braslavsky, C., C. Nowak, D. Gorlich, A. Wittinghofer, and J. Kuhlmann. 2000. Different structural and kinetic requirements for the interaction of Ran with the Ran-binding domains of RanBP2 and importin β. Biochemistry. 39:11629-11639.
    • (2000) Biochemistry , vol.39 , pp. 11629-11639
    • Villa Braslavsky, C.1    Nowak, C.2    Gorlich, D.3    Wittinghofer, A.4    Kuhlmann, J.5
  • 44
    • 0030454052 scopus 로고    scopus 로고
    • Characterization of the nuclear protein import mechanism using Ran mutants with altered nucleotide binding specificities
    • Weis, K., C. Dingwall, and A. Lamond. 1996. Characterization of the nuclear protein import mechanism using Ran mutants with altered nucleotide binding specificities. EMBO J. 15:7120-7128.
    • (1996) EMBO J. , vol.15 , pp. 7120-7128
    • Weis, K.1    Dingwall, C.2    Lamond, A.3
  • 45
    • 0033543574 scopus 로고    scopus 로고
    • GTP hydrolysis links initiation and termination of nuclear import on the nucleoporin Nup358
    • Yaseen, N.R., and G. Blobel. 1999. GTP hydrolysis links initiation and termination of nuclear import on the nucleoporin Nup358. J. Biol. Chem. 274:26493-26502.
    • (1999) J. Biol. Chem. , vol.274 , pp. 26493-26502
    • Yaseen, N.R.1    Blobel, G.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.