Phosphatidylinositol-3 kinase acts in parallel to the ERK MAP kinase in the FGF pathway during Xenopus mesoderm induction

Development

Volumn 128, Issue 1, 2001, Pages 35-44

  Carballada, R ^a   Yasuo, H ^a   Lemaire, P ^a  

^a AIX MARSEILLE UNIVERSITÉ   (France)

Author keywords

Brachyury; Embryo; FGF; MAP kinase; MEK; Mesoderm; P13K; Ras; Xenopus

Indexed keywords

FIBROBLAST GROWTH FACTOR; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; RAS PROTEIN;

ANIMAL EXPERIMENT; ARTICLE; BLASTULA; CATALYSIS; CONTROLLED STUDY; DIFFERENTIATION; ECTODERM; EMBRYO; EMBRYO DEVELOPMENT; EMBRYO PATTERN FORMATION; ENDODERM; ENZYME ACTIVITY; MESODERM; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; XENOPUS;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; EPIDERMAL GROWTH FACTOR; MESODERM; MITOGEN-ACTIVATED PROTEIN KINASES; SIGNAL TRANSDUCTION; XENOPUS;

ANIMALIA; VERTEBRATA;

EID: 0035139038     PISSN: 09501991     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (48)

1. Expression of a dominant negative mutant of the FGF receptor disrupts mesoderm formation in Xenopus embryos
2. Wortmannin is a potent phosphatidylinositol 3-kinase inhibitor: The role of phosphatidylinositol 3,4,5-trisphosphate in neutrophil responses
3. Class II phosphoinositide 3-kinases are downstream targets of activated polypeptide growth factor receptors
4. PDGF signalling is required for gastrulation of Xenopus laevis
5. A beta-catenin/XTcf-3 complex binds to the siamois promoter to regulate dorsal axis specification in Xenopus
6. Comparative effects of insulin on the activation of the Raf/Mos-dependent MAP kinase cascade in vitellogenic versus postvitellogenic Xenopus oocytes
7. Molecular nature of Spemann's organizer: The role of the Xenopus homeobox gene goosecoid
8. Activin-mediated mesoderm induction requires FGF
9. Tyrosine 766 in the fibroblast growth factor receptor-1 is required for FGF-stimulation of phospholipase C, phospholipase D, phospholipase A(2), phosphoinositide 3-kinase and cytoskeletal reorganisation in porcine cells
10. Animal and vegetal pole cells of early Xenopus embryos respond differently to maternal dorsal determinants: Implications for the patterning of the organiser
11. PI 3-kinase: Structural and functional analysis of intersubunit interactions
12. Constitutive activation of protein kinase B and phosphorylation of p47phox by a membrane-targeted phosphoinositide 3-kinase
13. Wnt signaling and transcriptional control of Siamois in Xenopus embryos
14. Antagonizing the Spemann organizer: Role of the homeobox gene Xvent-1
15. Involvement of the MAP kinase cascade in Xenopus mesoderm induction
16. MAP kinase is activated during mesoderm induction in Xenopus laevis
17. Mixer, a homeobox gene required for endoderm development
18. A vegetally localized T-box transcription factor in Xenopus eggs specifies mesoderm and endoderm and is essential for embryonic mesoderm formation
19. Xsox17alpha and beta mediate endoderm formation in Xenopus
20. EFGF regulates Xbra expression during Xenopus gastrulation
21. New perspectives on the role of the fibroblast growth factor family in amphibian development
22. Basic fibroblast growth factor stimulates surface expression and activity of Na(+)/H(+) exchanger NHE3 via mechanism involving phosphatidylinositol 3-kinase
23. Role of MAP kinase in mesoderm induction and axial patterning during Xenopus development
24. Localization of MAP kinase activity in early Xenopus embryos: Implications for endogenous FGF signaling
25. Signalling through phosphoinositide 3-kinases: The lipids take centre stage
26. Expression cloning of Siamois, a Xenopus homeobox gene expressed in dorsal-vegetal cells of blastulae and able to induce a complete secondary axis
27. A role for the vegetally expressed Xenopus gene Mix.1 in endoderm formation and in the restriction of mesoderm to the marginal zone
28. Phosphatidylinositol 3-kinase signals activate a selective subset of Rac/Rhodependent effector pathways
29. Mix.1, a homeobox mRNA inducible by mesoderm inducers, is expressed mostly in the presumptive endodermal cells of Xenopus embryos
30. Identification of phosphorylated proteins associated with the fibroblast growth factor receptor type I during early Xenopus development
31. Use of a recombinant retrovirus to study post-implantation cell lineage in mouse embryos
32. Xenopus chordin: A novel dorsalizing factor activated by organizer-specific homeobox genes
33. Understanding Ras: 'It ain't over 'til it's over'
34. Expression of a Xenopus homolog of Brachyury (T) is an immediate-early response to mesoderm induction
35. Mesoderm-inducing factors and mesodermal patterning
36. Differential expression of VegT and Antipodean protein isoforms in Xenopus
37. Embryonic mesoderm cells spread in response to platelet-derived growth factor and signaling by phosphatidylinositol 3-kinase
38. Mesoderm induction in Xenopus caused by activation of MAP kinase
39. Phosphoinositide 3-kinases: A conserved family of signal transducers
40. Signaling by distinct classes of phosphoinositide 3-kinases
41. Protein kinase B activation and lamellipodium formation are independent phosphoinositide 3-kinase-mediated events differentially regulated by endogenous Ras
42. The Drosophila protein Dof is specifically required for FGF signaling
43. A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002)
44. Induction of the Xenopus organizer: Expression and regulation of Xnot, a novel FGF and activin-regulated homeo box gene
45. Regulation of imaginal disc cell size, cell number and organ size by Drosophila class I(A) phosphoinositide 3-kinase and its adaptor
46. FGF-mediated mesoderm induction involves the Src-family kinase Laloo
47. Involvement of p21ras in Xenopus mesoderm induction
48. Structure and function of phosphoinositide 3-kinases