The oncoprotein Tax binds the SRC-1-interacting domain of CBP/p300 to mediate transcriptional activation

Molecular and Cellular Biology

Volumn 21, Issue 16, 2001, Pages 5520-5530

  Scoggin, K E S ^a   Ulloa, A ^a   Nyborg, J K ^a  

^a Department of Environmental and Radiological Health Sciences   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

STEROID RECEPTOR COACTIVATOR 1; TRANSCRIPTION FACTOR;

ALPHA HELIX; ARTICLE; CARBOXY TERMINAL SEQUENCE; CARCINOGENESIS; DELETION MUTANT; HUMAN T CELL LEUKEMIA VIRUS; POINT MUTATION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN DOMAIN; TRANSACTIVATION; TRANSCRIPTION INITIATION; VIRUS INFECTION;

ANIMALS; E1A-ASSOCIATED P300 PROTEIN; ESCHERICHIA COLI; GENES, PX; HISTONE ACETYLTRANSFERASES; HUMANS; MICE; NUCLEAR PROTEINS; RECOMBINANT PROTEINS; TRANS-ACTIVATION (GENETICS); TRANS-ACTIVATORS; TRANSCRIPTION FACTORS;

EID: 0034941548     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.21.16.5520-5530.2001     Document Type: Article

References (62)

1. Distinct regions in human T cell lymphotropic virus type I Tax mediate interactions with activator protein CREB and basal transcription
2. Identification of Poly(ADP-ribose) polymerase as a transcriptional coactivator of the human T-cell leukemia virus type 1 Tax protein
3. Oncogene jun encodes a sequence specific trans-activator similar to AP-1
4. A family of transcriptional adaptor proteins targeted by the E1A oncoprotein
5. HTLV-1 tax oncoprotein represses the p53-mediated trans-activation function through coactivator CBP sequestration
6. x-responsive regulatory sequences within the human T-cell leukemia virus type I long terminal repeat
7. The human T-cell leukemia virus type 1 oncoprotein Tax inhibits the transcriptional activity of c-Myb through competition for the CREB binding protein
8. Twentyone base pair repeat elements influence the ability of a Gal4-Tax fusion protein to transactivate the HTLV-I long terminal repeat
9. Human T-cell leukemia retrovirus-Tax protein is a repressor of nuclear receptor signaling
10. DNase I footprinting as an assay for mammalian gene regulatory proteins
11. Association of p300 and CBP with simian virus 40 large T antigen
12. Molecular mechanisms of human T-cell leukemia/lymphotropic virus type 1 infection
13. Transactivation by the human T-cell leukemia virus Tax protein is mediated through enhanced binding of activating transcription factor-2 (ATF-2) response and cAMP element-binding protein (CREB)
14. Anchoring of CREB binding protein to the human T-cell leukemia virus type 1 promoter: A molecular mechanism of Tax transactivation
15. Conjunction dysfunction: CBP/p300 in human disease
16. p300 and CBP: Partners for life and death
17. The coregulator exchange in transcriptional functions of nuclear receptors
18. CBP/p300 in cell growth, transformation, and development
19. Synergistic activation of transcription by CBP and p53
20. An exposed KID-like domain in human T-cell lymphotropic virus type 1 Tax is responsible for the recruitment of coactivators CBP/p300
21. Saturation mutagenesis of the yeast his3 regulatory site: Requirements for transcriptional induction and for binding by GCN4 activator protein
22. p300/cAMP-responsive element-binding protein interactions with ets-1 and ets-2 in the transcriptional activation of the human stromelysin promoter
23. Transcriptional activation and self-association in yeast: Protein-protein dimerization as a pleiotropic mechanism of HTLV-I Tax function
24. A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors
25. The coactivator CBP stimulates human T-cell lymphotrophic virus type I Tax transactivation in vitro
26. Identification of a human T-cell leukemia virus type I tax peptide in contact with DNA
27. Specific regions of contact between human T-cell leukemia virus type I Tax protein and DNA identified by photocross-linking
28. p300 and estrogen receptor cooperatively activate transcription via differential enhancement of initiation and reinitiation
29. Activator-dependent transcription from chromatin in vitro involving targeted histone acetylation by p300
30. Gene dose-dependent control of hematopoiesis and hematologic tumor suppression by CBP
31. Control of cAMP-regulated enhancers by the viral transactivator Tax through CREB and the co-activator CBP
32. HTLV-I tax repression of p73b is mediated through competition for the C/H1 domain of CBP
33. Human T-cell leukemia virus type 1 Tax requires direct access to DNA for recruitment of CREB binding protein to the viral promoter
34. Molecular mechanisms of viral transcription and cellular deregulation associated with the HTLV-I Tax protein
35. The SRC family of nuclear receptor coactivators
36. Adenoviral E1A-associated protein p300 as a functional homologue of the transcriptional co-activator CBP
37. The human T-cell leukemia virus-1 transcriptional activator Tax enhances cAMP-responsive element-binding protein (CREB) binding activity through interactions with the DNA minor groove
38. Human T-lymphotropic virus type I infection
39. Mice homozygous for a truncated form of CREB-binding protein exhibit defects in hematopoiesis and vasculo-angiogenesis
40. Rubinstein-Taybi syndrome caused by mutations in the transcriptional co-activator CBP
41. Solution structure of the KIX domain of CBP bound to the transactivation domain of CREB: A model for activator: Coactivator interactions
42. All patients with the T(11;16)(q23;p13.3) that involves MLL and CBP have treatment-related hematologic disorders
43. Definition of a minimal activation domain in human T-cell leukemia virus type I Tax
44. Mutational analysis of human T-cell leukemia virus type I Tax: Regions necessary for function determined with 47 mutant proteins
45. Analysis of the steroid receptor coactivator 1 (SRC1)-CREB binding protein interaction interface and its importance for the function of SRC1
46. Identification of HTLV-I tax transactivator mutants exhibiting novel transcriptional phenotypes
47. MLL is fused to CBP, a histone acetyltransferase, in therapy-related acute myeloid leukemia with a t(11;16)(q23;p13.3)
48. The human T-cell leukemia virus (HTLV) transactivator (Tax) protein
49. Tax protein of HTLV-1 inhibits CBP/p300-mediated transcription by interfering with recruitment of CBP/p300 onto DNA element of E-box or p53 binding site
50. Interaction of the human T-lymphotropic virus type I Tax dimer with CREB and the viral 21-base-pair repeat
51. Binding of p53 to the KIX domain of CREB binding protein: A potential link to human T-cell leukemia virus, type I-associated leukemogenesis
52. Insight into the tumor suppressor function of CBP through the viral oncoprotein Tax
53. Binding of the human T-cell leukemia virus Tax protein to the coactivator CBP interferes with CBP-mediated transcriptional control
54. HTLV-1-associated diseases
55. Molecular interactions between the coactivator CBP and the human T-cell leukemia virus Tax protein
56. A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1A
57. Human T cell lymphotropic virus type I genomic expression and impact on intracellular signaling pathways during neurodegenerative disease and leukemia
58. The nuclear hormone receptor coactivator SRC-1 is a specific target of p300
59. Gene dosagedependent embryonic development and proliferation defects in mice lacking the transcriptional integrator p300
60. On the etiology of tropical spastic paraparesis and human T-cell lymphotropic virus-I-associated myelopathy
61. Human T-cell lymphotropic virus type 1 (HTLV-I) transcriptional activator, Tax, enhances CREB binding to HTLV-I 21-base-pair repeats by protein-protein interaction
62. Interaction of the human T-cell lymphotrophic virus type I (HTLV-I) transcriptional activator Tax with cellular factors that bind specifically to the 21-base-pair repeats in the HTLV-I enhancer