Cytoplasmic localization is important for transcription factor nuclear factor-κB activation by hepatitis C virus core protein through its amino terminal region

Virology

Volumn 286, Issue 2, 2001, Pages 391-402

  Watashi, Koichi ^a   Hijikata, Makoto ^a   Marusawa, Hiroyuki ^b   Doi, Takahiro ^a   Shimotohno, Kunitada ^a  

^a KYOTO UNIVERSITY   (Japan)

^b KYOTO UNIVERSITY   (Japan)

Author keywords

Endoplasmic reticulum; Hepatitis C virus; NF B; Subcellular localization

Indexed keywords

CORE PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; TRANSCRIPTION FACTOR;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL NUCLEUS; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOPLASM; EMBRYO; ENDOPLASMIC RETICULUM; HEPATITIS C VIRUS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; VIRUS CORE;

HEPATITIS C VIRUS;

EID: 0035421819     PISSN: 00426822     EISSN: None     Source Type: Journal    
DOI: 10.1006/viro.2001.0990     Document Type: Article

References (57)

1. Detection of antibody to hepatitis C virus in prospectively followed transfusion recipients with acute and chronic non-A, non-B hepatitis
2. Hepatitis C virus core protein shows a cytoplasmic localization and associates to cellular lipid storage droplets
3. Identification of a novel cellular cofactor for the Rev/Rex class of retroviral regulatory proteins
4. Hepatitis C virus core from two different genotypes has an oncogenic potential but is not sufficient for transforming primary rat embryo fibroblasts in cooperation with the H-ras oncogene
5. Nuclear localization signals in the core protein of hepatitis C virus
6. Direct interaction of hepatitis C virus core protein with the cellular lymphotoxin-beta receptor modulates the signal pathway of the lymphotoxin-beta receptor
7. Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome
8. Genetic organization and diversity of the hepatitis C virus
9. An amino-terminal domain of the hepatitis C virus NS3 protease is essential for interaction with NS4A
10. Suppression of actinomycin D-induced apoptosis by the NS3 protein of hepatitis C virus
11. Genetic approaches in mice to understand Rel/NF-kappaB and IkappaB function: Transgenics and knockouts
12. Expression and identification of hepatitis C virus polyprotein cleavage products
13. BiP (GRP78), an essential hsp70 resident protein in the endoplasmic reticulum
14. Gene mapping of the putative structural region of the hepatitis C virus genome by in vitro processing analysis
15. Proteolytic processing and membrane association of putative nonstructural proteins of hepatitis C virus
16. A novel method for analysis of viral proteinase activity encoded by hepatitis C virus in cultured cells
17. Prevention of constitutive TNF receptor 1 signaling by silencer of death domains
18. How NF-kappaB is activated: The role of the IkappaB kinase (IKK) complex
19. Molecular cloning of the human hepatitis C virus genome from Japanese patients with non-A, non-B hepatitis
20. Activation of intracellular signaling by hepatitis B and C viruses: C-viral core is the most potent signal inducer
21. An assay for circulating antibodies to a major etiologic virus of human non-A, non-B hepatitis
22. Viral pathogenesis of hepatocellular carcinoma in the United States
23. Processing of the hepatitis C virus E2-NS2 region: Identification of p7 and two distinct E2-specific products with different C termini
24. Use of digitonin-permeabilized cells in studies of steroid receptor subnuclear trafficking
25. Hepatitis C virus core protein inhibits Fas- and tumor necrosis factor alpha-mediated apoptosis via NF-kappaB activation
26. Hepatitis C virus core protein interacts with the cytoplasmic tail of lymphotoxin-beta receptor
27. Signal transduction through NF-kappaB
28. Two hepatitis C virus glycoprotein E2 products with different C termini
29. Analysis of N-terminal processing of hepatitis C virus nonstructural protein 2
30. Molecular mechanisms in cell-mediated cytotoxicity
31. The core protein of hepatitis C virus induces hepatecellular carcinoma in transgenic mice
32. Viruses and apoptosis
33. Activators and target genes of Rel/NF-kappaB transcription factors
34. Expression of influenza virus hemagglutinin activates transcription factor NF-kappa B
35. The ER-overload response: Activation of NF-kappaB
36. Activation of transcription factor NF-kappaB by the adenovirus E3/19K protein requires its ER retention
37. The Dictyostelium essential light chain is required for myosin function
38. Hepatitis C virus core protein cooperates with fas and transforms primary rat embryo fibroblasts to tumorigenic phenotype
39. Suppression of apoptotic cell death by hepatitis C virus core protein
40. Inhibition of tumor necrosis factor (TNF-alpha)-mediated apoptosis by hepatitis C virus core protein
41. Sensitization to Fas-mediated apoptosis by hepatitis C virus core protein
42. The N-terminal region of hepatitis C virus nonstructural protein 3 (NS3) is essential for stable complex formation with NS4A
43. Expression, identification and subcellular localization of the proteins encoded by the hepatitis C viral genome
44. Ectopic expression of hepatitis C virus core protein differentially regulates nuclear transcription factors
45. Persistent activation of NF-kappaB by the tax transforming protein of HTLV-1: Hijacking cellular IkappaB kinases
46. Nuclear localization of the truncated hepatitis C virus core protein with its hydrophobic C terminus deleted
47. Activation of nuclear factor kappaB in hepatitis C virus infection: Implications for pathogenesis and hepatocarcinogenesis
48. Structure and organization of the hepatitis C virus genome isolated from human carriers
49. Hepatitis C and hepatitis B in the etiology of hepatocellular carcinoma in the Japanese population
50. Hepatitis C virus-encoded nonstructural protein NS4A has versatile functions in viral protein processing
51. Hepatitis C virus core protein regulates cell growth and signal transduction pathway transmitting growth stimuli
52. Nuclear transport and transcriptional regulation
53. Identification of a signal for rapid export of proteins from the nucleus
54. Constitutive activation of NF-kappa B is essential for transformation of rat fibroblasts by the human T-cell leukemia virus type 1 tax protein
55. The native form and maturation process of hepatitis C virus core protein
56. Hepatitis C virus core protein enhances NF-kappaB signal pathway triggering by lymphotoxin-beta receptor ligand and tumor necrosis factor alpha
57. Hepatitis C virus core protein binds to the cytoplasmic domain of tumor necrosis factor (TNF) receptor 1 and enhances TNF-induced apoptosis