Intranuclear trafficking of transcription factors: Implications for biological control

Journal of Cell Science

Volumn 113, Issue 14, 2000, Pages 2527-2533

  Stein, G S ^a   van Wijnen, A J ^a   Stein, J L ^a   Lian, J B ^a   Montecino, M ^a   Choi, J Y ^a   Zaidi, K ^a   Javed, A ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

AML CBFA; Chromatin; Gene expression; Nuclear matrix; Nuclear structure; Subnuclear domain

Indexed keywords

LEUKEMIA ANTIGEN; NUCLEAR PROTEIN; NUCLEIC ACID; RNA; TRANSCRIPTION FACTOR;

ACUTE GRANULOCYTIC LEUKEMIA; CELL NUCLEUS; DNA REPLICATION; GENE EXPRESSION; GENE REARRANGEMENT; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; NOTE; PRIORITY JOURNAL; PROMYELOCYTIC LEUKEMIA; PROTEIN DOMAIN; REGULATORY MECHANISM; TRANSCRIPTION REGULATION; TUMOR CELL;

BIOLOGICAL TRANSPORT; CELL NUCLEUS; CHROMATIN; CORE BINDING FACTOR ALPHA 2 SUBUNIT; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION; HUMANS; MACROMOLECULAR SUBSTANCES; MODELS, BIOLOGICAL; MUTATION; NEOPLASMS; NUCLEAR ENVELOPE; NUCLEAR MATRIX; NUCLEAR PROTEINS; PROTEIN STRUCTURE, TERTIARY; PROTO-ONCOGENE PROTEINS; TRANSCRIPTION FACTORS;

MAMMALIA;

EID: 0033885495     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Note

References (63)

1. Runt homology domain proteins in osteoblast differentiation: AML-3/CBFA1 is a major component of a bone specific complex
2. Functional analysis of Tpr: Identification of nuclear pore complex association and nuclear localization domains and a role in mRNA export
3. Connecting nuclear architecture and genomic function
4. The new paradigm: Integrating genomic function and nuclear architecture
5. Actively transcribed genes are associated with the nuclear matrix
6. The organization of replication and transcription
7. Regulation and regulatory parameters of histone modifications
8. A novel macromolecular structure is a target of the promyelocyte-retinoic acid receptor oncoprotein
9. Nuclear export is required for degradation of endogenous p53 by MDM2 and human papillomavirus E6
10. PML-containing nuclear bodies: Their spatial distribution in relation to other nuclear components
11. The nuclear matrix protein NMP-1 is the transcription factor YY1
12. The t(12;21) translocation converts AML-1B from an activator to a repressor of transcription
13. Visualization of glucocorticoid receptor translocation and intranuclear organization in living cells with a green fluorescent protein chimera
14. The path of RNA through nuclear pores: Apparent entry from the sides into specialized pores
15. Energy-dependent chromatin remodelers: Complex complexes and their components
16. Dimer formation by an N-terminal coiled coil in the APC protein
17. Structure and function in the nucleus
18. Intranuclear targeting of DNA replication factors
19. AML1, AML2, and AML3, the human members of the runt domain gene-family: cDNA structure, expression, and chromosomal localization
20. Spatial and temporal dynamics of DNA replication sites in mammalian cells
21. Nucleocytoplasmic transport: The soluble phase
22. Targeting of the YY1 transcription factor to the nucleolus and the nuclear matrix in situ: The C terminus is a principal determinant for nuclear trafficking
23. The t(8;21) chromosomal translocation in acute myelogenous leukemia modifies intranuclear targeting of the AML1/CBFalpha2 transcription factor
24. Deconstructing a disease: RARalpha, its fusion partners, and their roles in the pathogenesis of acute promyelocytic leukemia
25. The tissue-specific nuclear matrix protein, NMP-2, is a member of the AML/CBF/PEBP2/runt domain transcription factor family: Interactions with the osteocalcin gene promoter
26. AML-2 is a potential target for transcriptional regulation by the t(8;21) and t(12;21) fusion proteins in acute leukemia
27. RNA polymerase II targets pre-mRNA splicing factors to transcription sites in vivo
28. Cell biology of transcription and pre-mRNA splicing: Nuclear architecture meets nuclear function
29. t(8;21) breakpoints on chromosome 21 in acute myeloid leukemia are clustered within a limited region of a single gene, AML1
30. Nuclear import and export pathways
31. The nucleus: A target site for parathyroid hormone-related peptide (PTHrP) action
32. PEBP2/CBF, the murine homolog of the human myeloid AML1 and PEBP2B/CBFB proto-oncoproteins, regulates the murine myeloperoxidase and neutrophil elastase genes in immature myeloid cells
33. Half a century of 'the nuclear matrix'
34. Rethinking cell structure
35. The localization of the HRX/ALL1 protein to specific nuclear subdomains is altered by fusion with its eps 15 translocation partner
36. The critical role of chromosome translocations in human leukemias
37. Ataxin-1 with an expanded glutamine tract alters nuclear matrix-associated structures
38. Processing of endogenous pre-mRNAs in association with SC-35 domains is gene specific
39. MLL is fused to CBP, a histone acetyltransferase, in therapy-related acute myeloid leukemia with a t(11;16)(q23;p13.3)
40. Role of covalent modifications of histones in regulating gene expression
41. Functional subnuclear partitioning of transcription factors
42. The language of covalent histone modifications
43. Positive and negative regulation of granulocyte-macrophage colony stimulating factor promoter activity by AML1-related transcription factor, PEBP2
44. Preliminary crystallographic study of the glutathione S-transferase fused with the nuclear matrix targeting signal of the transcription factor AML-1/CBFa2
45. Crystal structure of the nuclear matrix targeting signal of the transcription factor AML-1/PEBP2aB/CBFa2
46. The DNA-binding and t2 transactivation domains of the rat glucocorticoid receptor constitute a nuclear matrix targeting signal
47. Nucleocytoplasmic shuttling of oncoprotein Hdm2 is required for Hdm2-mediated degradation of p53
48. P19(ARF) stabilizes p53 by blocking nucleo-cytoplasmic shuttling of Mdm2
49. Nuclear export receptors: From importin to exportin
50. Domains of the human androgen receptor and glucocorticoid receptor involved in binding to the nuclear matrix
51. Spatial relationship between transcription sites and chromosome territories
52. ATP-dependent chromatin-remodeling complexes
53. Segregation of transcription and replication sites into higher order domains
54. Three-dimensional visualization of transcription sites and their association with splicing factor-rich nuclear speckles
55. Retinoic acid regulates aberrant nuclear localization of PML-RAR alpha in acute promyelocytic leukemia cells
56. Nuclear punctate distribution of ALL-1 is conferred by distinct elements at the N terminus of the protein
57. Identification of a nuclear matrix targeting signal in the leukemia and bone-related AML/CBFα transcription factors
58. Intranuclear targeting of AML/CBFa regulatory factors to nuclear matrix-associated transcriptional domains