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Volumn 14, Issue 5, 2003, Pages 447-457

5-Lipoxygenase and atherosclerosis

Author keywords

5 lipoxygenase; Atherosclerosis; Genetics; Leukotriene biosynthetic pathway

Indexed keywords

APOPTOSIS; ARTERY INTIMA; ARTERY INTIMA PROLIFERATION; ARTERY RUPTURE; ATHEROGENESIS; ATHEROSCLEROSIS; ATHEROSCLEROTIC PLAQUE; BLOOD VESSEL TONE; CELL ADHESION; CELL DIFFERENTIATION; CELL MIGRATION; CELL PROLIFERATION; CHEMOTAXIS; DISEASE COURSE; DISEASE PREDISPOSITION; FOAM CELL; GENE IDENTIFICATION; GENE STRUCTURE; GENETIC ANALYSIS; GENETIC POLYMORPHISM; HUMAN; IMMUNE RESPONSE; INFLAMMATION; LIPID OXIDATION; MONOCYTE; NONHUMAN; PRIORITY JOURNAL; REGULATORY MECHANISM; REVIEW;

EID: 0142093151     PISSN: 09579672     EISSN: None     Source Type: Journal    
DOI: 10.1097/00041433-200310000-00005     Document Type: Review
Times cited : (104)

References (95)
  • 1
    • 0031744790 scopus 로고    scopus 로고
    • Cell biology of the 5-lipoxygenase pathway
    • Peters-Golden M. Cell biology of the 5-lipoxygenase pathway. Am J Respir Crit Care Med 1998; 157:S227-S232.
    • (1998) Am J Respir Crit Care Med , vol.157
    • Peters-Golden, M.1
  • 2
    • 0035127254 scopus 로고    scopus 로고
    • Regulation of leukotrienes in the management of asthma: Biology and clinical therapy
    • Leff AR. Regulation of leukotrienes in the management of asthma: biology and clinical therapy. Annu Rev Med 2001; 52:1-14.
    • (2001) Annu Rev Med , vol.52 , pp. 1-14
    • Leff, A.R.1
  • 3
    • 0037311304 scopus 로고    scopus 로고
    • Extending the understanding of leukotrienes in asthma
    • Coffey M, Peters-Golden M. Extending the understanding of leukotrienes in asthma. Curr Opin Allergy Clin Immunol 2003; 3:57-63. This article reviews recent findings in the regulation of 5LO and cysLTs and their association with cytokines.
    • (2003) Curr Opin Allergy Clin Immunol , vol.3 , pp. 57-63
    • Coffey, M.1    Peters-Golden, M.2
  • 4
    • 0033168592 scopus 로고    scopus 로고
    • Deficiency of 5-lipoxygenase abolishes sex-related survival differences in MRL-lpr/lpr mice
    • Goulet JL, Griffiths RC, Ruiz P, et al. Deficiency of 5-lipoxygenase abolishes sex-related survival differences in MRL-lpr/lpr mice. J Immunol 1999; 163:359-366.
    • (1999) J Immunol , vol.163 , pp. 359-366
    • Goulet, J.L.1    Griffiths, R.C.2    Ruiz, P.3
  • 5
    • 0032985446 scopus 로고    scopus 로고
    • Recent advances in bone biology provide insight into the pathogenesis of bone diseases
    • Boyce BF, Hughes DE, Wright KR, et al. Recent advances in bone biology provide insight into the pathogenesis of bone diseases. Lab Invest 1999; 79:83-94.
    • (1999) Lab Invest , vol.79 , pp. 83-94
    • Boyce, B.F.1    Hughes, D.E.2    Wright, K.R.3
  • 6
    • 0035576010 scopus 로고    scopus 로고
    • Deficiency of 5-lipoxygenase accelerates renal allograft rejection in mice
    • Goulet JL, Griffiths RC, Ruiz P, et al. Deficiency of 5-lipoxygenase accelerates renal allograft rejection in mice. J Immunol 2001; 167:6631-6636.
    • (2001) J Immunol , vol.167 , pp. 6631-6636
    • Goulet, J.L.1    Griffiths, R.C.2    Ruiz, P.3
  • 7
    • 0037178728 scopus 로고    scopus 로고
    • Identification of 5-lipoxygenase as a major gene contributing to atherosclerosis susceptibility in mice
    • Mehrabian M, Allayee H, Wong J, et al. Identification of 5-lipoxygenase as a major gene contributing to atherosclerosis susceptibility in mice. Circ Res 2002; 91:120-126. Using a positional candidate approach, this study demonstrates that 5LO protects against aortic lesion formation in two mouse models, even in the presence of elevated cholesterol levels. It was also shown that 5LO is expressed in the cells of atherosclerotic lesions, particularly in macrophage-rich regions.
    • (2002) Circ Res , vol.91 , pp. 120-126
    • Mehrabian, M.1    Allayee, H.2    Wong, J.3
  • 8
    • 0037417973 scopus 로고    scopus 로고
    • Expanding expression of the 5-lipoxygenase pathway within the arterial wall during human atherogenesis
    • Spanbroek R, Grabner R, Lotzer K, et al. Expanding expression of the 5-lipoxygenase pathway within the arterial wall during human atherogenesis. Proc Natl Acad Sci USA 2003; 100:1238-1243. This study demonstrates that 5LO is expressed in human atherosclerotic lesions and progressively increases with lesion severity, which is consistent with observations in mice.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 1238-1243
    • Spanbroek, R.1    Grabner, R.2    Lotzer, K.3
  • 9
    • 0034648768 scopus 로고    scopus 로고
    • Atherosclerosis
    • Lusis AJ. Atherosclerosis. Nature 2000; 407:233-241.
    • (2000) Nature , vol.407 , pp. 233-241
    • Lusis, A.J.1
  • 10
    • 0032104113 scopus 로고    scopus 로고
    • Genetic loci controlling body fat, lipoprotein metabolism, and insulin levels in a multifactorial mouse model
    • Mehrabian M, Wen PZ, Fisler J, et al. Genetic loci controlling body fat, lipoprotein metabolism, and insulin levels in a multifactorial mouse model. J Clin Invest 1998; 101:2485-2496.
    • (1998) J Clin Invest , vol.101 , pp. 2485-2496
    • Mehrabian, M.1    Wen, P.Z.2    Fisler, J.3
  • 11
    • 0034519043 scopus 로고    scopus 로고
    • Genetic control of HDL levels and composition in an interspecific mouse cross (CAST/Ei x C57BL/6J)
    • Mehrabian M, Castellani LW, Wen PZ, et al. Genetic control of HDL levels and composition in an interspecific mouse cross (CAST/Ei x C57BL/6J). J Lipid Res 2000; 41:1936-1946.
    • (2000) J Lipid Res , vol.41 , pp. 1936-1946
    • Mehrabian, M.1    Castellani, L.W.2    Wen, P.Z.3
  • 12
    • 0034277623 scopus 로고    scopus 로고
    • Genetics of atherosclerosis: The search for genes acting at the level of the vessel wall
    • Villa-Colinayo V, Shi W, Araujo J, Lusis AJ. Genetics of atherosclerosis: the search for genes acting at the level of the vessel wall. Curr Atheroscler Rep 2000; 2:380-389.
    • (2000) Curr Atheroscler Rep , vol.2 , pp. 380-389
    • Villa-Colinayo, V.1    Shi, W.2    Araujo, J.3    Lusis, A.J.4
  • 14
    • 0035920262 scopus 로고    scopus 로고
    • Genetic locus in mice that blocks development of atherosclerosis despite extreme hyperlipidemia
    • Mehrabian M, Wong J, Wang X, et al. Genetic locus in mice that blocks development of atherosclerosis despite extreme hyperlipidemia. Circ Res 2001; 89:125-130.
    • (2001) Circ Res , vol.89 , pp. 125-130
    • Mehrabian, M.1    Wong, J.2    Wang, X.3
  • 15
    • 0025281588 scopus 로고
    • Minimally modified low density lipoprotein induces monocyte chemotactic protein 1 in human endothelial cells and smooth muscle cells
    • Cushing SD, Berliner JA, Valente AJ, et al. Minimally modified low density lipoprotein induces monocyte chemotactic protein 1 in human endothelial cells and smooth muscle cells. Proc Natl Acad Sci USA 1990; 87:5134-5138.
    • (1990) Proc Natl Acad Sci USA , vol.87 , pp. 5134-5138
    • Cushing, S.D.1    Berliner, J.A.2    Valente, A.J.3
  • 16
    • 0035936802 scopus 로고    scopus 로고
    • Atherosclerosis. The road ahead
    • Glass CK, Witztum JL. Atherosclerosis. The road ahead. Cell 2001; 104:503-516.
    • (2001) Cell , vol.104 , pp. 503-516
    • Glass, C.K.1    Witztum, J.L.2
  • 17
    • 0037495055 scopus 로고    scopus 로고
    • Amino acid differences in the deduced 5-lipoxygenase sequence of CAST Atherosclerosis-resistance mice confer impaired activity when introduced into the human ortholog
    • Kuhn H, Anton M, Gerth C, Habenicht A. Amino acid differences in the deduced 5-lipoxygenase sequence of CAST Atherosclerosis-resistance mice confer impaired activity when introduced into the human ortholog. Arterioscler Thromb Vasc Biol 2003; 23:1072-1076. This study demonstrated that substituting the corresponding amino acid from CON6 mice into the human 5LO protein significantly reduced the activity of the enzyme. These results support the observation that CON6 mice have very low levels of 5LO and LTs.
    • (2003) Arterioscler Thromb Vasc Biol , vol.23 , pp. 1072-1076
    • Kuhn, H.1    Anton, M.2    Gerth, C.3    Habenicht, A.4
  • 18
    • 0027945466 scopus 로고
    • Role of leukotrienes revealed by targeted disruption of the 5-lipoxygenase gene
    • Chen XS, Sheller JR, Johnson EN, Funk CD. Role of leukotrienes revealed by targeted disruption of the 5-lipoxygenase gene. Nature 1994; 372:179-182.
    • (1994) Nature , vol.372 , pp. 179-182
    • Chen, X.S.1    Sheller, J.R.2    Johnson, E.N.3    Funk, C.D.4
  • 19
    • 0001488205 scopus 로고
    • Characterization of the human 5-lipoxygenase gene
    • Funk CD, Hoshiko S, Matsumoto T, et al. Characterization of the human 5-lipoxygenase gene. Proc Natl Acad Sci USA 1989; 86:2587-2591.
    • (1989) Proc Natl Acad Sci USA , vol.86 , pp. 2587-2591
    • Funk, C.D.1    Hoshiko, S.2    Matsumoto, T.3
  • 20
    • 0032743539 scopus 로고    scopus 로고
    • The biology of 5-lipoxygenase: Function, structure, and regulatory mechanisms
    • Silverman ES, Drazen JM. The biology of 5-lipoxygenase: function, structure, and regulatory mechanisms. Proc Assoc Am Physicians 1999; 111:525-536.
    • (1999) Proc Assoc Am Physicians , vol.111 , pp. 525-536
    • Silverman, E.S.1    Drazen, J.M.2
  • 21
    • 0033059209 scopus 로고    scopus 로고
    • Pharmacogenetic association between ALOX5 promoter genotype and the response to anti-asthma treatment
    • Drazen JM, Yandava CN, Dube L, et al. Pharmacogenetic association between ALOX5 promoter genotype and the response to anti-asthma treatment. Nat Genet 1999; 22:168-170.
    • (1999) Nat Genet , vol.22 , pp. 168-170
    • Drazen, J.M.1    Yandava, C.N.2    Dube, L.3
  • 22
    • 0037153063 scopus 로고    scopus 로고
    • Intima-media thickness: A tool for atherosclerosis imaging and event prediction
    • O'Leary DH, Polak JF. Intima-media thickness: a tool for atherosclerosis imaging and event prediction. Am J Cardiol 2002; 90:18L-21L.
    • (2002) Am J Cardiol , vol.90
    • O'Leary, D.H.1    Polak, J.F.2
  • 23
    • 0042009818 scopus 로고    scopus 로고
    • A promoter polymorphism of 5-Lipoxygenase is associated with carotid atherosclerosis in the human population
    • Allayee H, Dwyer JH, Fan J, et al. A promoter polymorphism of 5-Lipoxygenase is associated with carotid atherosclerosis in the human population. Am J Hum Genet 2002; 71:S435.
    • (2002) Am J Hum Genet , vol.71
    • Allayee, H.1    Dwyer, J.H.2    Fan, J.3
  • 24
    • 0027519767 scopus 로고
    • Redistribution of 5-lipoxygenase and cytosolic phospholipase A2 to the nuclear fraction upon macrophage activation
    • Peters-Golden M, McNish RW. Redistribution of 5-lipoxygenase and cytosolic phospholipase A2 to the nuclear fraction upon macrophage activation. Biochem Biophys Res Commun 1993; 196:147-153.
    • (1993) Biochem Biophys Res Commun , vol.196 , pp. 147-153
    • Peters-Golden, M.1    McNish, R.W.2
  • 25
    • 0034014271 scopus 로고    scopus 로고
    • Intracellular compartmentalization of leukotriene biosynthesis
    • Peters-Golden M, Brock TG. Intracellular compartmentalization of leukotriene biosynthesis. Am J Respir Crit Care Med 2000; 161:336-340.
    • (2000) Am J Respir Crit Care Med , vol.161 , pp. 336-340
    • Peters-Golden, M.1    Brock, T.G.2
  • 27
    • 0028566488 scopus 로고
    • The role of leukotrienes in inflammation
    • Henderson Jr WR. The role of leukotrienes in inflammation. Ann Intern Med 1994; 121:684-697.
    • (1994) Ann Intern Med , vol.121 , pp. 684-697
    • Henderson W.R., Jr.1
  • 28
    • 0025164256 scopus 로고
    • Leukotrienes and other products of the 5-lipoxygenase pathway. Biochemistry and relation to pathobiology in human diseases
    • Lewis RA, Austen KF, Soberman RJ. Leukotrienes and other products of the 5-lipoxygenase pathway. Biochemistry and relation to pathobiology in human diseases. N Engl J Med 1990; 323:645-655.
    • (1990) N Engl J Med , vol.323 , pp. 645-655
    • Lewis, R.A.1    Austen, K.F.2    Soberman, R.J.3
  • 29
    • 0032715754 scopus 로고    scopus 로고
    • Determination of the contribution of cysteinyl leukotrienes and leukotriene B4 in acute inflammatory responses using 5-lipoxygenase- and leukotriene A4 hydrolase-deficient mice
    • Byrum RS, Goulet JL, Snouwaert JN, et al. Determination of the contribution of cysteinyl leukotrienes and leukotriene B4 in acute inflammatory responses using 5-lipoxygenase- and leukotriene A4 hydrolase-deficient mice. J Immunol 1999; 163:6810-6819.
    • (1999) J Immunol , vol.163 , pp. 6810-6819
    • Byrum, R.S.1    Goulet, J.L.2    Snouwaert, J.N.3
  • 30
    • 0036070807 scopus 로고    scopus 로고
    • The yin and the yang of 5-lipoxygenase pathway activation
    • Bigby TD. The yin and the yang of 5-lipoxygenase pathway activation. Mol Pharmacol 2002; 62:200-202.
    • (2002) Mol Pharmacol , vol.62 , pp. 200-202
    • Bigby, T.D.1
  • 31
    • 0000747598 scopus 로고
    • Leukotrienes promote plasma leakage and leukocyte adhesion in postcapillary venules: In vivo effects with relevance to the acute inflammatory response
    • Dahlen SE, Bjork J, Hedqvist P, et al. Leukotrienes promote plasma leakage and leukocyte adhesion in postcapillary venules: in vivo effects with relevance to the acute inflammatory response. Proc Natl Acad Sci USA 1981; 78:3887-3891.
    • (1981) Proc Natl Acad Sci USA , vol.78 , pp. 3887-3891
    • Dahlen, S.E.1    Bjork, J.2    Hedqvist, P.3
  • 32
    • 77956851758 scopus 로고
    • The eicosanoids: Cyclooxygenase, lipoxygenase, and epoxygenase pathways
    • Vance DE, and Vance J, editors. Amsterdam: Elsevier Science
    • Smith, WL, Borgeat P, and Fitzpatrick FA. The eicosanoids: cyclooxygenase, lipoxygenase, and epoxygenase pathways. In: Vance DE, and Vance J, editors. Biochemistry of Lipids, Lipoproteins and Membranes, Amsterdam: Elsevier Science, 1991, pp. 297-325.
    • (1991) Biochemistry of Lipids, Lipoproteins and Membranes , pp. 297-325
    • Smith, W.L.1    Borgeat, P.2    Fitzpatrick, F.A.3
  • 33
    • 0028589332 scopus 로고
    • Altered inflammatory responses in leukotriene-deficient mice
    • Goulet JL, Snouwaert JN, Latour AM, et al. Altered inflammatory responses in leukotriene-deficient mice. Proc Natl Acad Sci USA 1994; 91:12852-12856.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 12852-12856
    • Goulet, J.L.1    Snouwaert, J.N.2    Latour, A.M.3
  • 34
    • 0036100383 scopus 로고    scopus 로고
    • Transcellular biosynthesis contributes to the production of leukotrienes during inflammatory responses in vivo
    • Fabre JE, Goulet JL, Riche E, et al. Transcellular biosynthesis contributes to the production of leukotrienes during inflammatory responses in vivo. J Clin Invest 2002; 109:1373-1380.
    • (2002) J Clin Invest , vol.109 , pp. 1373-1380
    • Fabre, J.E.1    Goulet, J.L.2    Riche, E.3
  • 35
    • 0037040256 scopus 로고    scopus 로고
    • The 5-lipoxygenase promoter is regulated by DNA methylation
    • Uhl J, Klan N, Rose M, et al. The 5-lipoxygenase promoter is regulated by DNA methylation. J Biol Chem 2002; 277:4374-4379. This study demonstrates that expression of the 5LO gene can be regulated by the methylation of its promoter. For example, 5LO-negative cell lines expressed 5LO when incubated with a demethylating agent.
    • (2002) J Biol Chem , vol.277 , pp. 4374-4379
    • Uhl, J.1    Klan, N.2    Rose, M.3
  • 37
    • 0034665060 scopus 로고    scopus 로고
    • Role for peroxisome proliferator-activated receptor alpha in oxidized phospholipid-induced synthesis of monocyte chemotactic protein-1 and interleukin-8 by endothelial cells
    • Lee H, Shi W, Tontonoz P, et al. Role for peroxisome proliferator- activated receptor alpha in oxidized phospholipid-induced synthesis of monocyte chemotactic protein-1 and interleukin-8 by endothelial cells. Circ Res 2000; 87:516-521.
    • (2000) Circ Res , vol.87 , pp. 516-521
    • Lee, H.1    Shi, W.2    Tontonoz, P.3
  • 38
    • 0242585306 scopus 로고    scopus 로고
    • Covalent binding of leukotriene A4 to DNA and RNA
    • Hankin JA, Jones DN, Murphy RC. Covalent binding of leukotriene A4 to DNA and RNA. Chem Res Toxicol 2003; 16:551-561.
    • (2003) Chem Res Toxicol , vol.16 , pp. 551-561
    • Hankin, J.A.1    Jones, D.N.2    Murphy, R.C.3
  • 39
    • 8944258922 scopus 로고    scopus 로고
    • The Yin and Yang of oxidation in the development of the fatty streak. A review based on the 1994 George Lyman Duff Memorial Lecture
    • Navab M, Berliner JA, Watson AD, et al. The Yin and Yang of oxidation in the development of the fatty streak. A review based on the 1994 George Lyman Duff Memorial Lecture. Arterioscler Thromb Vasc Biol 1996; 16:831-842.
    • (1996) Arterioscler Thromb Vasc Biol , vol.16 , pp. 831-842
    • Navab, M.1    Berliner, J.A.2    Watson, A.D.3
  • 40
    • 0035571606 scopus 로고    scopus 로고
    • Immune mechanisms in atherosclerosis
    • Hansson GK. Immune mechanisms in atherosclerosis. Arterioscler Thromb Vasc Biol 2001; 21:1876-1890.
    • (2001) Arterioscler Thromb Vasc Biol , vol.21 , pp. 1876-1890
    • Hansson, G.K.1
  • 41
    • 0035153824 scopus 로고    scopus 로고
    • Modulation of cell-substrate adhesion by arachidonic acid: Lipoxygenase regulates cell spreading and ERK1/2-inducible cyclooxygenase regulates cell migration in NIH-3T3 fibroblasts
    • Stockton RA, Jacobson BS. Modulation of cell-substrate adhesion by arachidonic acid: lipoxygenase regulates cell spreading and ERK1/2-inducible cyclooxygenase regulates cell migration in NIH-3T3 fibroblasts. Mol Biol Cell 2001; 12:1937-1956.
    • (2001) Mol Biol Cell , vol.12 , pp. 1937-1956
    • Stockton, R.A.1    Jacobson, B.S.2
  • 42
    • 0019491124 scopus 로고
    • The role of the monocyte in atherogenesis: I. Transition of bloodborne monocytes into foam cells in fatty lesions
    • Gerrity RG. The role of the monocyte in atherogenesis: I. Transition of bloodborne monocytes into foam cells in fatty lesions. Am J Pathol 1981; 103:181-190.
    • (1981) Am J Pathol , vol.103 , pp. 181-190
    • Gerrity, R.G.1
  • 43
    • 0025359852 scopus 로고
    • Minimally modified low density lipoprotein stimulates monocyte endothelial interactions
    • Berliner JA, Territo MC, Sevanian A, et al. Minimally modified low density lipoprotein stimulates monocyte endothelial interactions. J Clin Invest 1990; 85:1260-1266.
    • (1990) J Clin Invest , vol.85 , pp. 1260-1266
    • Berliner, J.A.1    Territo, M.C.2    Sevanian, A.3
  • 44
    • 13044265838 scopus 로고    scopus 로고
    • Structurally similar oxidized phospholipids differentially regulate endothelial binding of monocytes and neutrophils
    • Leitinger N, Tyner TR, Oslund L, et al. Structurally similar oxidized phospholipids differentially regulate endothelial binding of monocytes and neutrophils. Proc Natl Acad Sci USA 1999; 96:12010-12015.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 12010-12015
    • Leitinger, N.1    Tyner, T.R.2    Oslund, L.3
  • 45
    • 0033552883 scopus 로고    scopus 로고
    • Atherosclerosis: An inflammatory disease
    • Ross R. Atherosclerosis: an inflammatory disease. N Engl J Med 1999; 340:115-126.
    • (1999) N Engl J Med , vol.340 , pp. 115-126
    • Ross, R.1
  • 46
    • 0032560647 scopus 로고    scopus 로고
    • Differential leukotriene constrictor responses in human atherosclerotic coronary arteries
    • Allen S, Dashwood M, Morrison K, Yacoub M. Differential leukotriene constrictor responses in human atherosclerotic coronary arteries. Circulation 1998; 97:2406-2413.
    • (1998) Circulation , vol.97 , pp. 2406-2413
    • Allen, S.1    Dashwood, M.2    Morrison, K.3    Yacoub, M.4
  • 47
    • 0037180771 scopus 로고    scopus 로고
    • Inflammation in atherosclerosis
    • Libby P. Inflammation in atherosclerosis. Nature 2002; 420:868-874.
    • (2002) Nature , vol.420 , pp. 868-874
    • Libby, P.1
  • 48
    • 0028308423 scopus 로고
    • Oxidized low density lipoprotein increases U937 cell 5-lipoxygenase activity: Induction of 5-lipoxygenase activating protein
    • Fair A, Pritchard KA Jr. Oxidized low density lipoprotein increases U937 cell 5-lipoxygenase activity: induction of 5-lipoxygenase activating protein. Biochem Biophys Res Commun 1994; 201:1014-1020.
    • (1994) Biochem Biophys Res Commun , vol.201 , pp. 1014-1020
    • Fair, A.1    Pritchard K.A., Jr.2
  • 49
    • 0031110839 scopus 로고    scopus 로고
    • Inhibition of 5-lipoxygenase blocks IL-1 beta-induced vascular adhesion molecule-1 gene expression in human endothelial cells
    • Lee S, Felts KA, Parry GC, et al. Inhibition of 5-lipoxygenase blocks IL-1 beta-induced vascular adhesion molecule-1 gene expression in human endothelial cells. J Immunol 1997; 158:3401-3407.
    • (1997) J Immunol , vol.158 , pp. 3401-3407
    • Lee, S.1    Felts, K.A.2    Parry, G.C.3
  • 50
    • 0028937635 scopus 로고
    • 5-Lipoxygenase is located in the euchromatin of the nucleus in resting human alveolar macrophages and translocates to the nuclear envelope upon cell activation
    • Woods JW, Coffey MJ, Brock TG, et al. 5-Lipoxygenase is located in the euchromatin of the nucleus in resting human alveolar macrophages and translocates to the nuclear envelope upon cell activation. J Clin Invest 1995; 95:2035-2046.
    • (1995) J Clin Invest , vol.95 , pp. 2035-2046
    • Woods, J.W.1    Coffey, M.J.2    Brock, T.G.3
  • 51
    • 0030588631 scopus 로고    scopus 로고
    • Stimulating properties of 5-oxoeicosanoids for human monocytes: Synergism with monocyte chemotactic protein-1 and -3
    • Sozzani S, Zhou D, Locati M, et al. Stimulating properties of 5-oxoeicosanoids for human monocytes: synergism with monocyte chemotactic protein-1 and -3. J Immunol 1996; 157:4664-4671.
    • (1996) J Immunol , vol.157 , pp. 4664-4671
    • Sozzani, S.1    Zhou, D.2    Locati, M.3
  • 52
    • 0026331856 scopus 로고
    • JE/MCP-1: An early-response gene encodes a monocyte-specific cytokine
    • Rollins BJ. JE/MCP-1: an early-response gene encodes a monocyte-specific cytokine. Cancer Cells 1991; 3:517-524.
    • (1991) Cancer Cells , vol.3 , pp. 517-524
    • Rollins, B.J.1
  • 53
    • 0036124634 scopus 로고    scopus 로고
    • Leukotriene B4 receptor antagonism reduces monocytic foam cells in mice
    • Aiello RJ, Bourassa PA, Lindsey S, et al. Leukotriene B4 receptor antagonism reduces monocytic foam cells in mice. Arterioscler Thromb Vasc Biol 2002; 22:443-449. This important study demonstrates that pharmacologic antagonism of the BLTR sigificantly reduced atherosclerosis in hyperlipidemic mice, indicating that the proatherogenic role of LTs is modulated through its G-coupled protein receptor.
    • (2002) Arterioscler Thromb Vasc Biol , vol.22 , pp. 443-449
    • Aiello, R.J.1    Bourassa, P.A.2    Lindsey, S.3
  • 54
    • 0036118377 scopus 로고    scopus 로고
    • Leukocyte recruitment into developing atherosclerotic lesions: The complex interaction between multiple molecules keeps getting more complex
    • Rosenfeld ME. Leukocyte recruitment into developing atherosclerotic lesions: the complex interaction between multiple molecules keeps getting more complex. Arterioscler Thromb Vasc Biol 2002; 22:361-363.
    • (2002) Arterioscler Thromb Vasc Biol , vol.22 , pp. 361-363
    • Rosenfeld, M.E.1
  • 55
    • 0033485754 scopus 로고    scopus 로고
    • Endogenous monocyte chemoattractant protein-1 (MCP-1) protects mice in a model of acute septic peritonitis: Cross-talk between MCP-1 and leukotriene B4
    • Matsukawa A, Hogaboam CM, Lukacs NW, et al. Endogenous monocyte chemoattractant protein-1 (MCP-1) protects mice in a model of acute septic peritonitis: cross-talk between MCP-1 and leukotriene B4. J Immunol 1999; 163:6148-6154.
    • (1999) J Immunol , vol.163 , pp. 6148-6154
    • Matsukawa, A.1    Hogaboam, C.M.2    Lukacs, N.W.3
  • 56
    • 0024502040 scopus 로고
    • The molecular control of cell division, differentiation commitment and maturation in haemopoietic cells
    • Metcalf D. The molecular control of cell division, differentiation commitment and maturation in haemopoietic cells. Nature 1989; 339:27-30.
    • (1989) Nature , vol.339 , pp. 27-30
    • Metcalf, D.1
  • 57
    • 0026514827 scopus 로고
    • Macrophage colony-stimulating factor mRNA and protein in atherosclerotic lesions of rabbits and humans
    • Rosenfeld ME, Yla-Herttuala S, Lipton BA, et al. Macrophage colony-stimulating factor mRNA and protein in atherosclerotic lesions of rabbits and humans. Am J Pathol 1992; 140:291-300.
    • (1992) Am J Pathol , vol.140 , pp. 291-300
    • Rosenfeld, M.E.1    Yla-Herttuala, S.2    Lipton, B.A.3
  • 58
    • 0032525907 scopus 로고    scopus 로고
    • Heterozygous osteopetrotic (op) mutation reduces atherosclerosis in LDL receptor-deficient mice
    • Rajavashisth T, Qiao JH, Tripathi S, et al. Heterozygous osteopetrotic (op) mutation reduces atherosclerosis in LDL receptor-deficient mice. J Clin Invest 1998; 101:2702-2710.
    • (1998) J Clin Invest , vol.101 , pp. 2702-2710
    • Rajavashisth, T.1    Qiao, J.H.2    Tripathi, S.3
  • 59
    • 0028240606 scopus 로고
    • Kinetics of 5-lipoxygenase activation, arachidonic acid release, and leukotriene synthesis in human neutrophils: Effects of granulocyte-macrophage colony-stimulating factor
    • Krump E, Borgeat P. Kinetics of 5-lipoxygenase activation, arachidonic acid release, and leukotriene synthesis in human neutrophils: effects of granulocyte-macrophage colony-stimulating factor. Biochim Biophys Acta 1994; 1213:135-139.
    • (1994) Biochim Biophys Acta , vol.1213 , pp. 135-139
    • Krump, E.1    Borgeat, P.2
  • 60
    • 0029068016 scopus 로고
    • Granulocyte-macrophage colony-stimulating factor increases 5-lipoxygenase gene transcription and protein expression in human neutrophils
    • Stankova J, Rola-Pleszczynski M, Dubois CM. Granulocyte-macrophage colony-stimulating factor increases 5-lipoxygenase gene transcription and protein expression in human neutrophils. Blood 1995; 85:3719-3726.
    • (1995) Blood , vol.85 , pp. 3719-3726
    • Stankova, J.1    Rola-Pleszczynski, M.2    Dubois, C.M.3
  • 61
    • 0029664424 scopus 로고    scopus 로고
    • Effects of granulocyte-macrophage colony-stimulating factor on eicosanoid production by mononuclear phagocytes
    • Brock TG, McNish RW, Coffey MJ, et al. Effects of granulocyte-macrophage colony-stimulating factor on eicosanoid production by mononuclear phagocytes. J Immunol 1996; 156:2522-2527.
    • (1996) J Immunol , vol.156 , pp. 2522-2527
    • Brock, T.G.1    McNish, R.W.2    Coffey, M.J.3
  • 62
    • 0035162355 scopus 로고    scopus 로고
    • 5-Lipoxygenase regulates malignant mesothelial cell survival: Involvement of vascular endothelial growth factor
    • Romano M, Catalano A, Nutini M, et al. 5-lipoxygenase regulates malignant mesothelial cell survival: involvement of vascular endothelial growth factor. FASEB J 2001; 15:2326-2336.
    • (2001) FASEB J , vol.15 , pp. 2326-2336
    • Romano, M.1    Catalano, A.2    Nutini, M.3
  • 63
    • 0035047885 scopus 로고    scopus 로고
    • Vascular endothelial growth factor enhances atherosclerotic plaque progression
    • Celletti FL, Waugh JM, Amabile PG, et al. Vascular endothelial growth factor enhances atherosclerotic plaque progression. Nat Med 2001; 7:425-429.
    • (2001) Nat Med , vol.7 , pp. 425-429
    • Celletti, F.L.1    Waugh, J.M.2    Amabile, P.G.3
  • 64
    • 0032720993 scopus 로고    scopus 로고
    • The intima: A new soil
    • Schwartz SM. The intima: a new soil. Circ Res 1999; 85:877-879.
    • (1999) Circ Res , vol.85 , pp. 877-879
    • Schwartz, S.M.1
  • 66
    • 0034601753 scopus 로고    scopus 로고
    • Direct evidence for cytokine involvement in neointimal hyperplasia
    • Rectenwald JE, Moldawer LL, Huber TS, et al. Direct evidence for cytokine involvement in neointimal hyperplasia. Circulation 2000; 102:1697-1702.
    • (2000) Circulation , vol.102 , pp. 1697-1702
    • Rectenwald, J.E.1    Moldawer, L.L.2    Huber, T.S.3
  • 67
    • 0037155183 scopus 로고    scopus 로고
    • Cytokine-induced down-regulation of zfm1/splicing factor-1 promotes smooth muscle cell proliferation
    • Cartaruzza M, Schafer K, Hecker M. Cytokine-induced down-regulation of zfm1/splicing factor-1 promotes smooth muscle cell proliferation. J Biol Chem 2002; 277:6582-6589.
    • (2002) J Biol Chem , vol.277 , pp. 6582-6589
    • Cartaruzza, M.1    Schafer, K.2    Hecker, M.3
  • 68
    • 0037388984 scopus 로고    scopus 로고
    • Lack of interleukin-1β decreases the severity of atherosclerosis in ApoE-deficient mice
    • Kirii H, Niwa T, Yamada Y, et al. Lack of interleukin-1β decreases the severity of atherosclerosis in ApoE-deficient mice. Arterioscler Thromb Vasc Biol 2003; 23:656-660.
    • (2003) Arterioscler Thromb Vasc Biol , vol.23 , pp. 656-660
    • Kirii, H.1    Niwa, T.2    Yamada, Y.3
  • 69
    • 0022181066 scopus 로고
    • Leukotrienes augment interteukin 1 production by human monocytes
    • Rola-Pleszczynski M, Lemaire I. Leukotrienes augment interteukin 1 production by human monocytes. J Immunol 1985; 135:3958-3961.
    • (1985) J Immunol , vol.135 , pp. 3958-3961
    • Rola-Pleszczynski, M.1    Lemaire, I.2
  • 70
    • 0032892223 scopus 로고    scopus 로고
    • Alpha-tocopherol decreases interleukin-1 beta release from activated human monocytes by inhibition of 5-lipoxygenase
    • Devaraj S, Jialal I. Alpha-tocopherol decreases interleukin-1 beta release from activated human monocytes by inhibition of 5-lipoxygenase. Arterioscler Thromb Vasc Biol 1999; 19:11215-1133.
    • (1999) Arterioscler Thromb Vasc Biol , vol.19 , pp. 11215-21133
    • Devaraj, S.1    Jialal, I.2
  • 71
    • 17744405988 scopus 로고    scopus 로고
    • Specific cellular responses to alpha-tocopherol
    • Azzi A, Breyer I, Feher M, et al. Specific cellular responses to alpha-tocopherol. J Nutr 2000; 130:1649-1652.
    • (2000) J Nutr , vol.130 , pp. 1649-1652
    • Azzi, A.1    Breyer, I.2    Feher, M.3
  • 72
    • 0031801957 scopus 로고    scopus 로고
    • Signal transduction pathways activated by the IL-1 receptor family: Ancient signaling machinery in mammals, insects, and plants
    • O'Neill LA, Greene C. Signal transduction pathways activated by the IL-1 receptor family: ancient signaling machinery in mammals, insects, and plants. J Leukoc Biol 1998; 63:650-657.
    • (1998) J Leukoc Biol , vol.63 , pp. 650-657
    • O'Neill, L.A.1    Greene, C.2
  • 73
    • 0028063408 scopus 로고
    • Increased expression of matrix metalloproteinases and matrix degrading activity in vulnerable regions of human atherosclerotic plaques
    • Galis ZS, Sukhova GK, Lark MW, Libby P. Increased expression of matrix metalloproteinases and matrix degrading activity in vulnerable regions of human atherosclerotic plaques. J Clin Invest 1994; 94:2493-2503.
    • (1994) J Clin Invest , vol.94 , pp. 2493-2503
    • Galis, Z.S.1    Sukhova, G.K.2    Lark, M.W.3    Libby, P.4
  • 74
    • 0037158892 scopus 로고    scopus 로고
    • Breast cancer cell-derived EMMPRIN stimulates fibroblast MMP2 release through a phospholipase A(2) and 5-lipoxygenase catalyzed pathway
    • Taylor PM, Woodfield RJ, Hodgkin MN, et al. Breast cancer cell-derived EMMPRIN stimulates fibroblast MMP2 release through a phospholipase A(2) and 5-lipoxygenase catalyzed pathway. Oncogene 2002; 21:5765-5772. This study implicates 5LO in the degradation of the fibrotic caps of lesions, leading to plaque destabilization and rupture.
    • (2002) Oncogene , vol.21 , pp. 5765-5772
    • Taylor, P.M.1    Woodfield, R.J.2    Hodgkin, M.N.3
  • 75
    • 0036009043 scopus 로고    scopus 로고
    • Synthesis of interleukin 1beta, tumor necrosis factor-alpha, and interstitial collagenase (MMP-1) is eicosanoid dependent in human osteoarthritis synovial membrane explants: Interactions with antiinflammatory cytokines
    • He W, Pelletier JP, Martel-Pelletier J, et al. Synthesis of interleukin 1beta, tumor necrosis factor-alpha, and interstitial collagenase (MMP-1) is eicosanoid dependent in human osteoarthritis synovial membrane explants: interactions with antiinflammatory cytokines. J Rheumatol 2002; 29:546-553.
    • (2002) J Rheumatol , vol.29 , pp. 546-553
    • He, W.1    Pelletier, J.P.2    Martel-Pelletier, J.3
  • 76
    • 0028940929 scopus 로고
    • Blood pressure regulates platelet-derived growth factor A-chain gene expression in vascular smooth muscle cells in vivo. An autocrine mechanism promoting hypertensive vascular hypertrophy
    • Negoro N, Kanayama Y, Haraguchi M, et al. Blood pressure regulates platelet-derived growth factor A-chain gene expression in vascular smooth muscle cells in vivo. An autocrine mechanism promoting hypertensive vascular hypertrophy. J Clin Invest 1995; 95:1140-1150.
    • (1995) J Clin Invest , vol.95 , pp. 1140-1150
    • Negoro, N.1    Kanayama, Y.2    Haraguchi, M.3
  • 77
    • 0035571668 scopus 로고    scopus 로고
    • Cysteinyl leukotrienes modulate angiotensin II constrictor effects on aortas from streptozotocin-induced diabetic rats
    • Hardy G, Stanke-Labesque F, Peoc'h M, et al. Cysteinyl leukotrienes modulate angiotensin II constrictor effects on aortas from streptozotocin- induced diabetic rats. Arterioscler Thromb Vasc Biol 2001; 21:1751-1758.
    • (2001) Arterioscler Thromb Vasc Biol , vol.21 , pp. 1751-1758
    • Hardy, G.1    Stanke-Labesque, F.2    Peoc'h, M.3
  • 78
    • 0024780913 scopus 로고
    • Endothelium-dependent relaxation of rat aortic rings by leukotriene D4: Importance of the magnitude of preload
    • Lawson DL, Mehta JL, Mehta P, Nichols WW. Endothelium-dependent relaxation of rat aortic rings by leukotriene D4: importance of the magnitude of preload. Eicosanoids 1989; 2:175-181.
    • (1989) Eicosanoids , vol.2 , pp. 175-181
    • Lawson, D.L.1    Mehta, J.L.2    Mehta, P.3    Nichols, W.W.4
  • 79
    • 0033408377 scopus 로고    scopus 로고
    • Increased leukotriene A(4) hydrolase expression in the heart of angiotensin II-induced hypertensive rat
    • Ishizaka N, Nakao A, Ohishi N, et al. Increased leukotriene A(4) hydrolase expression in the heart of angiotensin II-induced hypertensive rat. FEBS Lett 1999; 463:155-159.
    • (1999) FEBS Lett , vol.463 , pp. 155-159
    • Ishizaka, N.1    Nakao, A.2    Ohishi, N.3
  • 80
    • 0021874796 scopus 로고
    • Overall and regional hemodynamic effects of leukotriene D4 in spontaneously hypertensive rats
    • Zukowska-Grojec Z, Bayorh MA, Kopin IJ, Feuerstein G. Overall and regional hemodynamic effects of leukotriene D4 in spontaneously hypertensive rats. Hypertension 1985; 7:507-513.
    • (1985) Hypertension , vol.7 , pp. 507-513
    • Zukowska-Grojec, Z.1    Bayorh, M.A.2    Kopin, I.J.3    Feuerstein, G.4
  • 81
    • 0029936155 scopus 로고    scopus 로고
    • Inhibition of 5-lipoxygenase-activating protein (FLAP) reduces pulmonary vascular reactivity and pulmonary hypertension in hypoxic rats
    • Voelkel NF, Tuder RM, Wade K, et al. Inhibition of 5-lipoxygenase- activating protein (FLAP) reduces pulmonary vascular reactivity and pulmonary hypertension in hypoxic rats. J Clin Invest 1996; 97:2491-2498.
    • (1996) J Clin Invest , vol.97 , pp. 2491-2498
    • Voelkel, N.F.1    Tuder, R.M.2    Wade, K.3
  • 83
    • 0037416754 scopus 로고    scopus 로고
    • Fatty acid release and oxidation are factors in lipoxygenase inhibitor-induced apoptosis
    • La E, Kern JC, Atarod EB, Kehrer JP. Fatty acid release and oxidation are factors in lipoxygenase inhibitor-induced apoptosis. Toxicol Lett 2003; 138:193-203.
    • (2003) Toxicol Lett , vol.138 , pp. 193-203
    • La, E.1    Kern, J.C.2    Atarod, E.B.3    Kehrer, J.P.4
  • 84
    • 0030267528 scopus 로고    scopus 로고
    • Sequential morphologic events during apoptosis of human neutrophils. Modulation by lipoxygenase-derived eicosanoids
    • Hebert MJ, Takano T, Holthofer H, Brady HR. Sequential morphologic events during apoptosis of human neutrophils. Modulation by lipoxygenase- derived eicosanoids. J Immunol 1996; 157:3105-3115.
    • (1996) J Immunol , vol.157 , pp. 3105-3115
    • Hebert, M.J.1    Takano, T.2    Holthofer, H.3    Brady, H.R.4
  • 85
    • 0034465463 scopus 로고    scopus 로고
    • Central role of arachidonate 5-lipoxygenase in the regulation of cell growth and apoptosis in human prostate cancer cells
    • Ghosh J, Myers CE. Central role of arachidonate 5-lipoxygenase in the regulation of cell growth and apoptosis in human prostate cancer cells. Adv Exp Med Biol 1999; 469:577-582.
    • (1999) Adv Exp Med Biol , vol.469 , pp. 577-582
    • Ghosh, J.1    Myers, C.E.2
  • 86
    • 0035458615 scopus 로고    scopus 로고
    • Five-lipoxygenase inhibitors can mediate apoptosis in human breast cancer cell lines through complex eicosanoid interactions
    • Avis I, Hong SH, Martinez A, et al. Five-lipoxygenase inhibitors can mediate apoptosis in human breast cancer cell lines through complex eicosanoid interactions. FASEB J 2001; 15:2007-2009.
    • (2001) FASEB J , vol.15 , pp. 2007-2009
    • Avis, I.1    Hong, S.H.2    Martinez, A.3
  • 87
    • 0037645143 scopus 로고    scopus 로고
    • Creating conditions similar to those that occur during exposure of cells to microgravity induces apoptosis in human lymphocytes by 5-lipoxygenase- mediated mitochondrial uncoupling and cytochrome c release
    • Maccarrone M, Battista N, Meloni M, et al. Creating conditions similar to those that occur during exposure of cells to microgravity induces apoptosis in human lymphocytes by 5-lipoxygenase-mediated mitochondrial uncoupling and cytochrome c release. J Leukoc Biol 2003; 73:472-481.
    • (2003) J Leukoc Biol , vol.73 , pp. 472-481
    • Maccarrone, M.1    Battista, N.2    Meloni, M.3
  • 88
    • 0037407219 scopus 로고    scopus 로고
    • 5-Lipoxygenase-mediated mitochondrial damage and apoptosis of mononuclear cells in ESRD patients
    • Maccarrone M, Taccone-Gallucci M, Finazzi-Agro A. 5-Lipoxygenase- mediated mitochondrial damage and apoptosis of mononuclear cells in ESRD patients. Kidney Int Suppl 2003; 84:33-36.
    • (2003) Kidney Int Suppl , vol.84 , pp. 33-36
    • Maccarrone, M.1    Taccone-Gallucci, M.2    Finazzi-Agro, A.3
  • 89
    • 0033849578 scopus 로고    scopus 로고
    • Reciprocal regulation of LTA(4) hydrolase expression in human monocytes by gamma-interferon and interleukins 4 and 13: Potential relevance to leukotriene regulation in glomerular disease
    • Montero A, Nassar GM, Uda S, et al. Reciprocal regulation of LTA(4) hydrolase expression in human monocytes by gamma-interferon and interleukins 4 and 13: potential relevance to leukotriene regulation in glomerular disease. Exp Nephrol 2000; 8:258-265.
    • (2000) Exp Nephrol , vol.8 , pp. 258-265
    • Montero, A.1    Nassar, G.M.2    Uda, S.3
  • 90
    • 0029665193 scopus 로고    scopus 로고
    • Role of leukotriene B4 in the interleukin-4-induced human mononuclear phagocyte activation
    • Dugas N, Dugas B, Kolb JP, et al. Role of leukotriene B4 in the interleukin-4-induced human mononuclear phagocyte activation. Immunology 1996; 88:384-388.
    • (1996) Immunology , vol.88 , pp. 384-388
    • Dugas, N.1    Dugas, B.2    Kolb, J.P.3
  • 91
    • 18344412674 scopus 로고    scopus 로고
    • New induction of leukotriene A(4) hydrolase by interleukin-4 and interleukin-13 in human polymorphonuclear leukocytes
    • Zaitsu M, Hamasaki Y, Matsuo M, et al. New induction of leukotriene A(4) hydrolase by interleukin-4 and interleukin-13 in human polymorphonuclear leukocytes. Blood 2000; 96:601-609.
    • (2000) Blood , vol.96 , pp. 601-609
    • Zaitsu, M.1    Hamasaki, Y.2    Matsuo, M.3
  • 92
    • 0033595809 scopus 로고    scopus 로고
    • Immunosuppressive effect of leukotriene B(4) receptor antagonist in vitro
    • Morita H, Takeda K, Yagita H, Okumura K. Immunosuppressive effect of leukotriene B(4) receptor antagonist in vitro. Biochem Biophys Res Commun 1999; 264:321-326.
    • (1999) Biochem Biophys Res Commun , vol.264 , pp. 321-326
    • Morita, H.1    Takeda, K.2    Yagita, H.3    Okumura, K.4
  • 93
    • 0032546352 scopus 로고    scopus 로고
    • Dendritic cells and the control of immunity
    • Banchereau J, Steinman RM. Dendritic cells and the control of immunity. Nature 1998; 392:245-252.
    • (1998) Nature , vol.392 , pp. 245-252
    • Banchereau, J.1    Steinman, R.M.2
  • 94
    • 0037163149 scopus 로고    scopus 로고
    • Innate and adaptive immunity in the pathogenesis of atherosclerosis
    • Hansson GK, Libby P, Schonbeck U, Yan ZQ. Innate and adaptive immunity in the pathogenesis of atherosclerosis. Circ Res 2002; 91:281-291.
    • (2002) Circ Res , vol.91 , pp. 281-291
    • Hansson, G.K.1    Libby, P.2    Schonbeck, U.3    Yan, Z.Q.4
  • 95
    • 0034548833 scopus 로고    scopus 로고
    • 5-Lipoxygenase expression in dendritic cells generated from CD34(+) hematopoietic progenitors and in lymphoid organs
    • Spanbroek R, Hildner M, Steinhilber D, et al. 5-lipoxygenase expression in dendritic cells generated from CD34(+) hematopoietic progenitors and in lymphoid organs. Blood 2000; 96:3857-3865.
    • (2000) Blood , vol.96 , pp. 3857-3865
    • Spanbroek, R.1    Hildner, M.2    Steinhilber, D.3


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