Central role of arachidonate 5-lipoxygenase in the regulation of cell growth and apoptosis in human prostate cancer cells

Advances in Experimental Medicine and Biology

Volumn 469, Issue , 2000, Pages 577-582

  Ghosh, J ^a   Myers, C E ^a  

^a UNIVERSITY OF VIRGINIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 [3 TERT BUTYLTHIO 1 (4 CHLOROBENZYL) 5 ISOPROPYL 2 INDOLYL] 2,2 DIMETHYLPROPIONIC ACID; 5 HYDROXYICOSATETRAENOIC ACID; ANDROGEN; ARACHIDONATE 12 LIPOXYGENASE; ARACHIDONATE 5 LIPOXYGENASE; ARACHIDONIC ACID; CYTOCHROME P450; FAT; FATTY ACID; LEUKOTRIENE; PHOSPHOLIPASE A2; PROSTAGLANDIN E2; PROSTAGLANDIN SYNTHASE;

APOPTOSIS; ARACHIDONIC ACID METABOLISM; CANCER INHIBITION; CANCER RISK; CELL GROWTH; CONFERENCE PAPER; FAT INTAKE; HUMAN; NONHUMAN; PRIORITY JOURNAL; PROSTATE CANCER;

APOPTOSIS; ARACHIDONATE 5-LIPOXYGENASE; ARACHIDONIC ACID; CELL DIVISION; DIETARY FATS; HUMANS; INDOLES; LIPOXYGENASE INHIBITORS; MALE; MODELS, BIOLOGICAL; PROSTATIC NEOPLASMS; RISK FACTORS; TUMOR CELLS, CULTURED;

EID: 0034465463     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: None     Document Type: Conference Paper

References (32)

1. Cancer Statistics, 1997
2. Characterization of prostatic carcinoma among blacks: A continuation report
3. Latent carcinoma of prostate at autopsy in seven areas
4. Geographic pathology of latent prostatic cancer
5. Studies of Japanese migrants. I. Mortality from cancer and other diseases among Japanese in the United States
6. Cancers of the prostate and breast among Japanese and white immigrants in Los Angeles County
7. The epidemiology of prostatic cancer: Geographical disribution and time-trends
8. Comparative epidemiology of cacers of the colon, rectum, prostate and breast in Shanghai, China versus the United States
9. Prostate cancer in relation to diet, physical activity and body size, in blacks, white and asians in the U.S. and Canada
10. Beta-carotene and animal fats and their relationship to prostate cancer risk
11. A prospective study of dietary fat and risk of prostate cancer
12. Animal fat consumption and cancer of the prostate: A prospective study in Hawaii
13. Prospective study of plasma fatty acids and risk of prostate cancer
14. Decreased growth of established human prostate LNCaP tumors in nude mice fed a low-fat diet
15. Arachidonic acid meabolism in benign and malignant prostatic tissue in vitro: Effects of fatty acids and cyclooxygenase inhibitors
16. Biochemical, cytogenetic and morphological characteristics of human primary and metastatic prostate cancer cell lines
17. Human PC3 prostate cell line DNA synthesis is suppressed by eicosatetraynoic acid, an in vitro inhibitor of arachidonic acid metabolism
18. Arachidonic acid stimulates prostate cancer cell growth: Critical role of 5-lipoxygenase
19. Arachidonic acid and free fatty acids as second messengers and the role of protein kinase C
20. Synergistic activation of protein kinase C by arachidonic acid and diacyglycerols in vitro: Generation of a stable membrane-bound, cofactor-independent state of protein kinase C activity
21. Regulation of rasGAP and the neurofibromatosis-1 gene product by eicosanoids
22. Arachidonic acid metabolism
23. Leukotrienes and lipoxins: Structures, biosynthesis and biological effects
24. Cyclooxygenase and lipoxygenase inhibitors in cancer therapy
25. Eicosanoids and he immunology of cancer
26. Role of arachidonic acid metabolism in the mitogenic reponse of BALB/c 3T3 fibroblasts to epidermal growth factor
27. Cellular proliferation and lipid metabolism: Importance of lipoxygenases in modulating epidermal growth factor-dependent mitogenesis
28. Mechanisms and genes of cellular suicide
29. Multiple female reproductive failures in cyclooxygenase 2-deficient mice
30. 2 of activation-induced apoptosis of human CD4+8+ T lymphoblasts
31. Bcl-x and Bcl-2 inhibit TNF and FAS-induced apoptosis and activation of phospholipase A2 in breast carcinoma cells
32. Involvement of oxidents and oxident-generating enzyme(s) in tumor-necrosis-factor-alpha-mediated apoptosis: Role for lipoxygenase pathway but not mitochondrial respiratory chain