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Volumn 59, Issue 2, 2003, Pages 512-519

Mechanism of E2F1-induced apoptosis in primary vascular smooth muscle cells

Author keywords

Apoptosis; Gene expression; Gene therapy; Protein phosphorylation; Restenosis

Indexed keywords

ARF PROTEIN; PROTEIN P53; PROTEIN P73; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR E2F1; UNCLASSIFIED DRUG;

EID: 0142090552     PISSN: 00086363     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0008-6363(03)00392-4     Document Type: Article
Times cited : (14)

References (38)
  • 1
    • 0032146274 scopus 로고    scopus 로고
    • The regulation of E2F by pRB-family proteins
    • Dyson N. The regulation of E2F by pRB-family proteins. Genes Dev. 12:1998;2245-2262.
    • (1998) Genes Dev , vol.12 , pp. 2245-2262
    • Dyson, N.1
  • 2
    • 0031815596 scopus 로고    scopus 로고
    • Toward an understanding of the functional complexity of the E2F and retinoblastoma families
    • Nevins J.R. Toward an understanding of the functional complexity of the E2F and retinoblastoma families. Cell Growth Differ. 9:1998;585-593.
    • (1998) Cell Growth Differ , vol.9 , pp. 585-593
    • Nevins, J.R.1
  • 3
    • 0028061670 scopus 로고
    • Deregulated expression of E2F-1 induces S-phase entry and leads to apoptosis
    • Shan B., Lee W.H. Deregulated expression of E2F-1 induces S-phase entry and leads to apoptosis. Mol Cell Biol. 14:1994;8166-8173.
    • (1994) Mol Cell Biol , vol.14 , pp. 8166-8173
    • Shan, B.1    Lee, W.H.2
  • 4
    • 0028960617 scopus 로고
    • E2F1 overexpression in quiescent fibroblasts leads to induction of cellular DNA synthesis and apoptosis
    • Kowalik T.F., DeGregori J., Schwarz J.K., Nevins J.R. E2F1 overexpression in quiescent fibroblasts leads to induction of cellular DNA synthesis and apoptosis. J Virol. 69:1995;2491-2500.
    • (1995) J Virol , vol.69 , pp. 2491-2500
    • Kowalik, T.F.1    DeGregori, J.2    Schwarz, J.K.3    Nevins, J.R.4
  • 6
    • 0030739355 scopus 로고    scopus 로고
    • Induction of DNA synthesis and apoptosis are separable functions of E2F-1
    • Phillips A.C., Stewart S., Ryan K.M., Helin K., Vousden K.H. Induction of DNA synthesis and apoptosis are separable functions of E2F-1. Genes Dev. 11:1997;1853-1863.
    • (1997) Genes Dev , vol.11 , pp. 1853-1863
    • Phillips, A.C.1    Stewart, S.2    Ryan, K.M.3    Helin, K.4    Vousden, K.H.5
  • 7
    • 0030850752 scopus 로고    scopus 로고
    • E2F-1 induced apoptosis requires DNA binding but not transactivation and is inhibited by the retinoblastoma protein through direct interaction
    • Hsieh J.K., Fredersdorf S., Kouzarides T., Martin K., Lu X. E2F-1 induced apoptosis requires DNA binding but not transactivation and is inhibited by the retinoblastoma protein through direct interaction. Genes Dev. 11:1997;1840-1852.
    • (1997) Genes Dev , vol.11 , pp. 1840-1852
    • Hsieh, J.K.1    Fredersdorf, S.2    Kouzarides, T.3    Martin, K.4    Lu, X.5
  • 8
    • 0031992159 scopus 로고    scopus 로고
    • E2F1-specific induction of apoptosis and p53 accumulation, which is blocked by Mdm2
    • Kowalik T.F., DeGregori J., Leone G., Jakoi L., Nevins J.R. E2F1-specific induction of apoptosis and p53 accumulation, which is blocked by Mdm2. Cell Growth Differ. 9:1998;113-118.
    • (1998) Cell Growth Differ , vol.9 , pp. 113-118
    • Kowalik, T.F.1    DeGregori, J.2    Leone, G.3    Jakoi, L.4    Nevins, J.R.5
  • 9
    • 0032504783 scopus 로고    scopus 로고
    • P14ARF links the tumour suppressors RB and p53
    • Bates S., Phillips A.C., Clark P.A., et al. p14ARF links the tumour suppressors RB and p53. Nature. 395:1998;124-125.
    • (1998) Nature , vol.395 , pp. 124-125
    • Bates, S.1    Phillips, A.C.2    Clark, P.A.3
  • 10
    • 0036311177 scopus 로고    scopus 로고
    • E2F1 induces phosphorylation of p53 that is coincident with p53 accumulation and apoptosis
    • Rogoff H.A., Pickering M.T., Debatis M.E., Jones S., Kowalik T.F. E2F1 induces phosphorylation of p53 that is coincident with p53 accumulation and apoptosis. Mol Cell Biol. 22:2002;5308-5318.
    • (2002) Mol Cell Biol , vol.22 , pp. 5308-5318
    • Rogoff, H.A.1    Pickering, M.T.2    Debatis, M.E.3    Jones, S.4    Kowalik, T.F.5
  • 11
    • 0036132647 scopus 로고    scopus 로고
    • Novel function of the cyclin A binding site of E2F in regulating p53-induced apoptosis in response to DNA damage
    • Hsieh J.K., Yap D., O'Connor D.J., et al. Novel function of the cyclin A binding site of E2F in regulating p53-induced apoptosis in response to DNA damage. Mol Cell Biol. 22:2002;78-93.
    • (2002) Mol Cell Biol , vol.22 , pp. 78-93
    • Hsieh, J.K.1    Yap, D.2    O'Connor, D.J.3
  • 12
    • 0031886093 scopus 로고    scopus 로고
    • Regulation of cell proliferation by the E2F transcription factors
    • Helin K. Regulation of cell proliferation by the E2F transcription factors. Curr Opin Genet Dev. 8:1998;28-35.
    • (1998) Curr Opin Genet Dev , vol.8 , pp. 28-35
    • Helin, K.1
  • 13
    • 0032537851 scopus 로고    scopus 로고
    • E2F-1 induced p53-independent apoptosis in transgenic mice
    • Holmberg C., Helin K., Sehested M., Karlstrom O. E2F-1 induced p53-independent apoptosis in transgenic mice. Oncogene. 17:1998;143-155.
    • (1998) Oncogene , vol.17 , pp. 143-155
    • Holmberg, C.1    Helin, K.2    Sehested, M.3    Karlstrom, O.4
  • 14
    • 0028861428 scopus 로고
    • Inhibition of apoptosis by the retinoblastoma gene product
    • Haas-Kogan D.A., Kogan S.C., Levi D., et al. Inhibition of apoptosis by the retinoblastoma gene product. EMBO J. 14:1995;461-472.
    • (1995) EMBO J , vol.14 , pp. 461-472
    • Haas-Kogan, D.A.1    Kogan, S.C.2    Levi, D.3
  • 15
    • 0029559027 scopus 로고
    • Cyclin A-kinase regulation of E2F-1 DNA binding function underlies suppression of an S-phase checkpoint
    • Krek W., Xu G., Livingston D.M. Cyclin A-kinase regulation of E2F-1 DNA binding function underlies suppression of an S-phase checkpoint. Cell. 83:1995;1149-1158.
    • (1995) Cell , vol.83 , pp. 1149-1158
    • Krek, W.1    Xu, G.2    Livingston, D.M.3
  • 16
    • 0029856734 scopus 로고    scopus 로고
    • Dual mechanisms of repression of E2F1 activity by the retinoblastoma gene product
    • Zacksenhaus E., Jiang Z., Phillips R.A., Gallie B. Dual mechanisms of repression of E2F1 activity by the retinoblastoma gene product. EMBO J. 15:1996;5917-5927.
    • (1996) EMBO J , vol.15 , pp. 5917-5927
    • Zacksenhaus, E.1    Jiang, Z.2    Phillips, R.A.3    Gallie, B.4
  • 17
    • 0033666776 scopus 로고    scopus 로고
    • Role of the p53 homolog p73 for E2F1-induced apoptosis
    • Stiewe T., Pützer B.M. Role of the p53 homolog p73 for E2F1-induced apoptosis. Nat Genet. 26:2000;464-469.
    • (2000) Nat Genet , vol.26 , pp. 464-469
    • Stiewe, T.1    Pützer, B.M.2
  • 18
    • 0034609798 scopus 로고    scopus 로고
    • Role for the p53 homologue p73 in E2F-1-induced apoptosis
    • Irwin M., Martin M.C., Phillips A.C., et al. Role for the p53 homologue p73 in E2F-1-induced apoptosis. Nature. 407:2000;645-648.
    • (2000) Nature , vol.407 , pp. 645-648
    • Irwin, M.1    Martin, M.C.2    Phillips, A.C.3
  • 19
    • 0034977277 scopus 로고    scopus 로고
    • Apaf-1 is a transcriptional target for E2F and p53
    • Moroni M.C., Hickman E.S., Denchi E.L., et al. Apaf-1 is a transcriptional target for E2F and p53. Nat Cell Biol. 3:2001;552-558.
    • (2001) Nat Cell Biol , vol.3 , pp. 552-558
    • Moroni, M.C.1    Hickman, E.S.2    Denchi, E.L.3
  • 20
    • 0033231615 scopus 로고    scopus 로고
    • E2F1 potentiates cell death by blocking antiapoptotic signaling pathways
    • Phillips A.C., Ernst M.K., Bates S., Rice N.R., Vousden K.H. E2F1 potentiates cell death by blocking antiapoptotic signaling pathways. Mol Cell. 4:1999;771-781.
    • (1999) Mol Cell , vol.4 , pp. 771-781
    • Phillips, A.C.1    Ernst, M.K.2    Bates, S.3    Rice, N.R.4    Vousden, K.H.5
  • 21
    • 0029031549 scopus 로고
    • A gene therapy strategy using a transcription factor decoy of the E2F binding site inhibits smooth muscle proliferation in vivo
    • Morishita R., Gibbons G.H., Horiuchi M., et al. A gene therapy strategy using a transcription factor decoy of the E2F binding site inhibits smooth muscle proliferation in vivo. Proc Natl Acad Sci USA. 92:1995;5855-5859.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 5855-5859
    • Morishita, R.1    Gibbons, G.H.2    Horiuchi, M.3
  • 22
    • 0035936506 scopus 로고    scopus 로고
    • Growth suppression of human coronary vascular smooth muscle cells by gene transfer of the transcription factor E2F1
    • Shelat H.S., Liu T.J., Hickman-Bick D.L., et al. Growth suppression of human coronary vascular smooth muscle cells by gene transfer of the transcription factor E2F1. Circulation. 103:2001;407-414.
    • (2001) Circulation , vol.103 , pp. 407-414
    • Shelat, H.S.1    Liu, T.J.2    Hickman-Bick, D.L.3
  • 23
    • 0032578990 scopus 로고    scopus 로고
    • Restoration of E2F expression rescues vascular endothelial cells from tumor necrosis factor-α-induced apoptosis
    • Spyridopoulos J., Principe N., Krasinski K.L., et al. Restoration of E2F expression rescues vascular endothelial cells from tumor necrosis factor-α-induced apoptosis. Circulation. 98:1998;2883-2890.
    • (1998) Circulation , vol.98 , pp. 2883-2890
    • Spyridopoulos, J.1    Principe, N.2    Krasinski, K.L.3
  • 24
    • 0033869428 scopus 로고    scopus 로고
    • Improved safety through tamoxifen-regulated induction of cytotoxic genes delivered by Ad vectors for cancer gene therapy
    • Pützer B.M., Stiewe T., Crespo F., Esche H. Improved safety through tamoxifen-regulated induction of cytotoxic genes delivered by Ad vectors for cancer gene therapy. Gene Ther. 7:2000;1317-1325.
    • (2000) Gene Ther , vol.7 , pp. 1317-1325
    • Pützer, B.M.1    Stiewe, T.2    Crespo, F.3    Esche, H.4
  • 27
    • 0028222124 scopus 로고
    • P53 and E2F1 cooperate to mediate apoptosis
    • Wu X., Levine A.J. P53 and E2F1 cooperate to mediate apoptosis. Proc Natl Acad Sci USA. 91:1994;3602-3606.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 3602-3606
    • Wu, X.1    Levine, A.J.2
  • 28
    • 0027947383 scopus 로고
    • Deregulated E2F1 expression leads to S phase entry and p53-mediated apoptosis
    • Qin X.Q., Livingston D.M., Kaelin W.G., Adams P. Deregulated E2F1 expression leads to S phase entry and p53-mediated apoptosis. Proc Natl Acad Sci USA. 91:1994;10918-10922.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 10918-10922
    • Qin, X.Q.1    Livingston, D.M.2    Kaelin, W.G.3    Adams, P.4
  • 30
    • 0029049577 scopus 로고
    • Cellular targets for activation of E2F1 transcription factor include DNA synthesis- and G1/S-regulatory genes
    • DeGregori J., Kowalik T., Nevins J.R. Cellular targets for activation of E2F1 transcription factor include DNA synthesis- and G1/S-regulatory genes. Mol Cell Biol. 15:1995;4215-4224.
    • (1995) Mol Cell Biol , vol.15 , pp. 4215-4224
    • DeGregori, J.1    Kowalik, T.2    Nevins, J.R.3
  • 31
    • 0344931628 scopus 로고    scopus 로고
    • CDC25A phosphatase is a target of e2F and is required for efficient E2F-induced S phase
    • Vigo E., Müller H., Prosperini E., et al. CDC25A phosphatase is a target of e2F and is required for efficient E2F-induced S phase. Mol Cell Biol. 19:1999;6379-6395.
    • (1999) Mol Cell Biol , vol.19 , pp. 6379-6395
    • Vigo, E.1    Müller, H.2    Prosperini, E.3
  • 32
    • 0031454026 scopus 로고    scopus 로고
    • Adenoviral delivery of E2F1 directs cell cycle reentry and p53-independent apoptosis in postmitotic adult myocardium in vivo
    • Agah R., Kirshenbaum L.A., Abdellatif M., et al. Adenoviral delivery of E2F1 directs cell cycle reentry and p53-independent apoptosis in postmitotic adult myocardium in vivo. J Clin Invest. 100:1998;2722-2728.
    • (1998) J Clin Invest , vol.100 , pp. 2722-2728
    • Agah, R.1    Kirshenbaum, L.A.2    Abdellatif, M.3
  • 33
    • 0030813584 scopus 로고    scopus 로고
    • Adenovirus-mediated overexpression of the transcription factor E2F1 induces apoptosis in human breast cancer and ovarian carcinoma cell lines and does not require p53
    • Hunt K.K., Deng J., Liu T.J., et al. Adenovirus-mediated overexpression of the transcription factor E2F1 induces apoptosis in human breast cancer and ovarian carcinoma cell lines and does not require p53. Cancer Res. 57:1997;4722-4726.
    • (1997) Cancer Res , vol.57 , pp. 4722-4726
    • Hunt, K.K.1    Deng, J.2    Liu, T.J.3
  • 34
    • 0028361374 scopus 로고
    • Regulation of two E2F-related genes in presenescent and senescent human fibroblasts
    • Dimri G.P., Hara E., Campisi J. Regulation of two E2F-related genes in presenescent and senescent human fibroblasts. J Biol Chem. 296:1994;16180-16186.
    • (1994) J Biol Chem , vol.296 , pp. 16180-16186
    • Dimri, G.P.1    Hara, E.2    Campisi, J.3
  • 35
    • 0036613246 scopus 로고    scopus 로고
    • Suppression of the p53- or pRB-mediated G1 checkpoint is required for E2F-induced S-phase entry
    • Lomarri M., Moroni M.C., Jensen M.R., Frittoli E., Helin K. Suppression of the p53- or pRB-mediated G1 checkpoint is required for E2F-induced S-phase entry. Nat Genet. 31:2002;190-194.
    • (2002) Nat Genet , vol.31 , pp. 190-194
    • Lomarri, M.1    Moroni, M.C.2    Jensen, M.R.3    Frittoli, E.4    Helin, K.5
  • 36
    • 0032856493 scopus 로고    scopus 로고
    • Inhibition of the p53 tumor suppressor gene results in growth of human aortic vascular smooth muscle cells. Potential role of p53 in regulation of vascular smooth muscle cell growth
    • Aoki M., Morishita R., Matsushita H., et al. Inhibition of the p53 tumor suppressor gene results in growth of human aortic vascular smooth muscle cells. Potential role of p53 in regulation of vascular smooth muscle cell growth. Hypertension. 34:1999;192-200.
    • (1999) Hypertension , vol.34 , pp. 192-200
    • Aoki, M.1    Morishita, R.2    Matsushita, H.3
  • 37
    • 0027491775 scopus 로고
    • Expression of transcription factor E2F1 induces quiescent cells to enter S phase
    • Johnson D.G., Schwarz J.K., Cress W.D., Nevins J.R. Expression of transcription factor E2F1 induces quiescent cells to enter S phase. Nature. 365:1993;349-352.
    • (1993) Nature , vol.365 , pp. 349-352
    • Johnson, D.G.1    Schwarz, J.K.2    Cress, W.D.3    Nevins, J.R.4
  • 38
    • 0034306996 scopus 로고    scopus 로고
    • The RB/E2F pathway: Expanding roles and emerging paradigms
    • Harbour J.W., Dean D.C. The RB/E2F pathway: expanding roles and emerging paradigms. Genes Dev. 14:2000;2393-2409.
    • (2000) Genes Dev , vol.14 , pp. 2393-2409
    • Harbour, J.W.1    Dean, D.C.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.