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Volumn 7, Issue 15, 2000, Pages 1317-1325

Improved safety through tamoxifen-regulated induction of cytotoxic genes delivered by Ad vectors for cancer gene therapy

Author keywords

Adenovirus; Apoptosis; Cancer; E2F1; ER fusion protein; Gene therapy

Indexed keywords

ESTROGEN RECEPTOR; HYBRID PROTEIN; LIGAND; TAMOXIFEN; TRANSCRIPTION FACTOR; VIRUS VECTOR;

EID: 0033869428     PISSN: 09697128     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gt.3301235     Document Type: Article
Times cited : (33)

References (35)
  • 1
    • 0029656105 scopus 로고    scopus 로고
    • Self-contained teracycline-regulated retroviral vector system for gene delivery to mammalian cells
    • (1996) J Virol , vol.70 , pp. 62-67
    • Paulus, W.1
  • 3
    • 0029002136 scopus 로고
    • A modified oestrogen receptor ligand-binding domain as an improved switch for the regulation of heterologous proteins
    • (1995) Nucleic Acids Res , vol.23 , pp. 1686-1690
    • Littlewood, T.D.1
  • 4
    • 0029784962 scopus 로고    scopus 로고
    • Induction of apoptosis by tamoxifen-activation of a p53-estrogen receptor fusion protein expressed in E1A and T24 H-ras transformed p53-/- mouse embryo fibroblasts
    • (1996) Oncogene , vol.13 , pp. 739-748
    • Vater, C.A.1
  • 5
    • 0033254748 scopus 로고    scopus 로고
    • Deregulated c-myc expression in quiescent CHO cells induces target gene transcription and subsequent apoptotic phenotype
    • (1999) Cell Res , vol.9 , pp. 305-314
    • Fang, C.M.1    Shi, C.2    Xu, Y.H.3
  • 6
    • 0344931628 scopus 로고    scopus 로고
    • CDC25A phosphatase is a target of E2F and is required for efficient E2F-induced S phase
    • (1999) Mol Cell Biol , vol.19 , pp. 6379-6395
    • Vigo, E.1
  • 9
    • 0030813584 scopus 로고    scopus 로고
    • Adenovirus-mediated overexpression of the transcription factor E2F1 induces apoptosis in human breast and ovarian carcinoma cell lines and does not require p53
    • (1997) Cancer Res , vol.57 , pp. 4722-4726
    • Hunt, K.K.1
  • 10
    • 0031749470 scopus 로고    scopus 로고
    • Overexpression of E2F-1 in glioma triggers apoptosis and suppresses tumor growth in vitro and in vivo
    • (1998) Nature Med , vol.4 , pp. 685-690
    • Fueyo, J.1
  • 11
    • 0033091228 scopus 로고    scopus 로고
    • Apoptosis induction by E2F-1 via adenoviral-mediated gene transfer results in growth suppression of head and neck squamous cell carcinoma cell lines
    • (1999) Cancer Gene Ther , vol.6 , pp. 163-171
    • Liu, T.J.1
  • 13
    • 0032549487 scopus 로고    scopus 로고
    • Combination therapy with interleukin-2 and wild-type p53 expressed by adenoviral vectors potentiates tumor regression in a murine model of breast cancer
    • (1998) Hum Gene Ther , vol.9 , pp. 707-718
    • Putzer, B.M.1
  • 14
    • 0032549631 scopus 로고    scopus 로고
    • Recombinant E1-deleted adenovirus-mediated gene therapy for cancer: Efficacy studies with p53 tumor suppressor gene and liver histology in tumor xenograft models
    • (1998) Hum Gene Ther , vol.20 , pp. 681-694
    • Nielsen, L.L.1
  • 16
    • 0030931602 scopus 로고    scopus 로고
    • Interleukin-12 and B7-1 costimulatory molecule expressed by an adenovirus vector act synergistically to facilitate tumor regression
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 10889-10894
    • Putzer, B.M.1
  • 18
    • 0000693470 scopus 로고
    • Construction and propagation of human adenovirus vectors
    • Celis JE (ed). Cell Biology: A Laboratory Handbook. Academic Press: San Diego
    • (1994) , pp. 479-490
    • Hitt, M.1    Bett, A.J.2    Prevec, L.3    Graham, F.L.4
  • 19
    • 0039227088 scopus 로고    scopus 로고
    • Induction of S-phase entry by E2F transcription factors depends on their nuclear localization
    • (1997) Mol Cell Biol , vol.17 , pp. 5508-5520
    • Muller, H.1
  • 20
  • 22
    • 0033967137 scopus 로고    scopus 로고
    • A binary adenoviral vector system for expressing high levels of the proapoptotic gene bax
    • (2000) Gene Therapy , vol.7 , pp. 75-79
    • Kagawa, S.1
  • 23
    • 0030860227 scopus 로고    scopus 로고
    • Tumor-selective transgene expression in vivo mediated by an E2F-responsive adenoviral vector
    • (1997) Nature Med , vol.3 , pp. 1145-1149
    • Parr, M.J.1
  • 25
    • 0029793365 scopus 로고    scopus 로고
    • Adenovirus type 5 early region 4 is responsible for E1A-induced p53-independent apoptosis
    • (1996) J Virol , vol.70 , pp. 6207-6215
    • Marcellus, R.C.1
  • 28
    • 0031435461 scopus 로고    scopus 로고
    • Use of a membrane-localized green fluorescent protein allows simultaneous identification of transfected cells and cell cycle analysis by flow cytometry
    • (1997) Cytometry , vol.29 , pp. 286-291
    • Kalejta, R.F.1    Shenk, T.2    Beavis, A.J.3
  • 29
    • 0002025785 scopus 로고
    • Manipulation of adenovirus vectors
    • Murray EJ (ed). Methods in Molecular Biology: Gene Transfer and Expression Protocols. Humana Press: Clifton, NJ
    • (1991) , pp. 109-128
    • Graham, F.L.1    Prevec, L.2
  • 30
    • 0028873133 scopus 로고
    • Expression of the E2F1 transcription factor overcomes type beta transforming growth factor-mediated growth suppression
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 483-487
    • Schwarz, J.K.1
  • 31
    • 0030850752 scopus 로고    scopus 로고
    • E2F1-induced apoptosis requires DNA binding but not transactivation and is inhibited by the retinoblastoma protein through direct interaction
    • (1997) Genes Dev , vol.11 , pp. 1840-1852
    • Hsieh, J.K.1
  • 32
    • 0017184389 scopus 로고
    • A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
    • (1976) Anal Biochem , vol.72 , pp. 248-254
    • Bradford, M.M.1
  • 34
    • 0032504783 scopus 로고    scopus 로고
    • p14ARF links the tumor suppressors RB and p53
    • (1998) Nature , vol.395 , pp. 124-125
    • Bates, S.1
  • 35
    • 0342546018 scopus 로고    scopus 로고
    • E1A is sufficient by itself to induce apoptosis independent of p53 and other adenoviral gene products
    • (2000) Cell Death Diff , vol.7 , pp. 177-188
    • Putzer, B.M.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.