Frequent 3p allele loss and epigenetic inactivation of the RASSF1A tumour suppressor gene from region 3p21.3 in head and neck squamous cell carcinoma

European Journal of Cancer

Volumn 38, Issue 12, 2002, Pages 1585-1592

  Hogg, R P ^a   Honorio, S ^a   Martinez, A ^a   Agathanggelou, A ^a   Dallol, A ^a   Fullwood, P ^a   Weichselbaum, R ^b   Kuo, M J ^c   Maher, E R ^a   Latif, F ^a  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^b UNIVERSITY OF CHICAGO MEDICAL CENTER   (United States)

^c QUEEN ELIZABETH HOSPITAL   (United Kingdom)

Author keywords

Allele loss; HNSCC; RASSF1A; Tumour suppressor gene

Indexed keywords

ALLELE; ARTICLE; CANCER STAGING; CARCINOGENESIS; CHROMOSOMAL LOCALIZATION; CHROMOSOME 3P; CHROMOSOME LOSS; CLINICAL ARTICLE; CONTROLLED STUDY; CPG ISLAND; DNA METHYLATION; GENE INACTIVATION; GENE LOCATION; GENE LOSS; GENE MUTATION; HUMAN; HUMAN TISSUE; LARYNX CARCINOMA; MICROSATELLITE MARKER; MOLECULAR CLONING; MOUTH CARCINOMA; MUTATIONAL ANALYSIS; PARANASAL SINUS CARCINOMA; PHARYNX CARCINOMA; POLYMORPHIC LOCUS; PRIORITY JOURNAL; PROMOTER REGION; SQUAMOUS CELL CARCINOMA; TUMOR SUPPRESSOR GENE;

CARCINOMA, SQUAMOUS CELL; CHROMOSOMES, HUMAN, PAIR 3; DNA METHYLATION; GENE SILENCING; GENES, TUMOR SUPPRESSOR; HEAD AND NECK NEOPLASMS; HUMANS; LOSS OF HETEROZYGOSITY; MICROSATELLITE REPEATS; MUTATION; NEOPLASM PROTEINS; POLYMERASE CHAIN REACTION; TUMOR SUPPRESSOR PROTEINS;

EID: 0036342284     PISSN: 09598049     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-8049(01)00422-1     Document Type: Article

References (36)

1. Head and neck cancer
2. Molecular lesions in human oral cancer: The Indian scene
3. Allelic loss at chromosomes 3p, 8p, 13q, and 17p associated with poor prognosis in head and neck cancer
4. Allelotype of head and neck squamous cell carcinoma
5. Allelotype of squamous cell carcinoma of the head and neck: Fractional allele loss correlates with survival
6. Deletion mapping of chromosome 4 in head and neck squamous cell carcinoma
7. Location of candidate tumour suppressor gene loci at chromosomes 3p, 8p and 9p for oral squamous cell carcinomas
8. Molecular genetics of head and neck cancer
9. Deletions of the short arm of chromosome 3 in solid tumors and the search for suppressor genes
10. Three discrete regions of deletion at 3p in head and neck cancers
11. Identification of the von Hippel-Lindau disease tumor suppressor gene
12. The VHL tumour-suppressor gene paradigm
13. Frequent allelic loss at chromosome arm 3p is distinct from genetic alterations of the Von-Hippel Lindau tumor suppressor gene in head and neck cancer
14. Construction of a 600kb cosmid clone contig and generation of a transcriptional map surrounding the lung cancer tumour suppressor gene (TSG) locus on human chromosome 3p21.3
15. Cloning of a breast cancer homozygous deletion junction narrows the region of search for a 3p21.3 tumor suppressor gene
16. The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3: Identification and evaluation of the resident candidate tumor suppressor genes
17. Epigenetic inactivation of a RAS association domain family protein from the lung tumour suppressor locus 3p21.3
18. Epigenetic inactivation of RASSF1A in lung and breast cancers and malignant phenotype suppression
19. Methylation associated inactivation of RASSF1A from region 3p21.3 in lung, breast and ovarian tumours
20. Characterization of an 800 kb region at 3p22-p21.3 that was homozygously deleted in a lung cancer cell line
21. The FHIT gene, spanning the chromosome 3p14.2 fragile site and renal carcinoma-associated t(3;8) breakpoint, is abnormal in digestive tract cancers
22. FHIT gene alterations in head and neck squamous cell carcinomas
23. Homozygous deletions at 3p12 in breast and lung cancer
24. Functional evidence for a nasopharyngeal carcinoma tumor suppressor gene that maps at chromosome 3p21.3
25. Functional evidence for involvement of multiple putative tumor suppressor genes on the short arm of chromosome 3 in human oral squamous cell carcinogenesis
26. Deletion mapping on the short arm of chromosome 3 in squamous cell carcinoma of the oral cavity
27. Allelic imbalance on chromosome 3p in oral dysplastic lesions: An early event in oral carcinogenesis
28. Sequential molecular abnormalities are involved in the multistage development of squamous cell lung carcinoma
29. Detailed genetic and physical mapping of tumor suppressor loci on chromosome 3p in ovarian cancer
30. Methylation-specific PCR: A novel PCR assay for methylation status of CpG islands
31. High resolution chromosome 3p allelotyping of human lung cancer and preneoplastic/preinvasive bronchial epithelium reveals multiple, discontinuous sites of 3p allele loss and three regions of frequent breakpoints
32. Computerized polymorphic marker identification: Experimental validation and a predicted human polymorphism catalog
33. Ras uses the novel tumor suppressor RASSF1 as an effector to mediate apoptosis
34. Substrate specificities and identification of putative substrates of ATM kinase family members
35. Identification of Nore1 as a potential Ras effector
36. High frequency of promoter hypermethylation of RASSF1A in nasopharyngeal carcinoma