Placebo-controlled trial of 13-cis-retinoic acid activity on retinoic acid receptor-beta expression in a population at high risk: Implications for chemoprevention of lung cancer

Journal of Clinical Oncology

Volumn 17, Issue 11, 1999, Pages 3546-3552

  Ayoub, Joseph ^a   Jean Francois R ^a   Cormier, Y ^a   Meyer, D ^a   Ying, Y ^a   Major, P ^a   Desjardins, C ^a   Bradley, W E C ^a  

^a LAVAL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ISOTRETINOIN; RETINOIC ACID RECEPTOR;

ADULT; ARTICLE; BRONCHOSCOPY; BRONCHUS MUCOSA; CANCER PREVENTION; CHEMOPROPHYLAXIS; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; FEMALE; HUMAN; LUNG CANCER; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RANDOMIZED CONTROLLED TRIAL; SMOKING;

EID: 0345466549     PISSN: 0732183X     EISSN: None     Source Type: Journal    
DOI: 10.1200/JCO.1999.17.11.3546     Document Type: Article

References (14)

1. Landis SH, Murray T, Bolden S, et al: Cancer statistics, 1998. CA Cancer J Clin 48:6-29, 1998
2. Shopland DR, Eyre HJ, Pechacek TF: Smoking-attributable cancer mortality in 1991: Is lung cancer now the leading cause of death among smokers in the United States? J Natl Cancer Inst 83:1142-1148, 1991
3. Lee JS, Lippman SM, Benner SE, et al: Randomized placebo-controlled trial of isotretinoin in chemoprevention of bronchial squamous metaplasia. J Clin Oncol 12:937-945, 1994
4. Houle B, Rochette-Egly C, Bradley WEC: Tumor-suppressive effect of the retinoic acid receptor beta in human epidermoid lung cancer cells. Proc Natl Acad Sci USA 90:985-989, 1993
5. Lotan R: Retinoids and chemoprevention of aerodigestive tract cancer. Cancer Metastasis Rev 16:349-356, 1997
6. Lotan R, Xu XC, Lippman SM, et al: Suppression of retinoic acid receptor-beta in premalignant oral lesions and its up-regulation by isotretinoin. N Engl J Med 332:1405-1410, 1995
7. Stambrook J, Fritsch EF, Maniatis T: Molecular Cloning: A Laboratory Manual. Cold Spring Harbor, NY, Cold Spring Harbor Laboratory Press, 1989
8. Houle B, Leduc F, Bradley WEC: Implication of RARβ in epidermoid lung cancer. Genes Chromosom Cancer 3:358-366, 1991
9. Nervi C, Vollberg TM, George MD, et al: Expression of nuclear retinoic acid receptors in normal tracheobronchial cells and in lung carcinoma cells. Exp Cell Res 195:163-170, 1991
10. Xu XC, Sozzi G, Lee JS, et al: Suppression of retinoic acid beta in non-small-cell lung cancer in vivo: implications for lung cancer development. J Natl Cancer Inst 89:624-629, 1997
11. Hong WK, Lippman SM, Itri LM, et al: Prevention of second primary tumors with isotretinoin in squamous-cell carcinoma of the head and neck. N Engl J Med 323:795-801, 1990
12. Pastorino U, Infante M, Maioli M, et al: Adjuvant treatment of stage I lung cancer with high-dose vitamin A. J Clin Oncol 11:1216-1222, 1993
13. Mao L, Lee JS, Kurie JM, et al: Clonal genetic alterations in the lungs of current and former smokers. J Natl Cancer Inst 89:857-862, 1997
14. Xu XC, Lee JS, Lee JJ, et al: Nuclear retinoid acid receptor beta in bronchial epithelium of smokers before and during chemoprevention. J Natl Cancer Inst 91:1317-1321, 1999