Novel estrogen receptor ligands based on an anthranylaldoxime structure: Role of the phenol-type pseudocycle in the binding process

Journal of Medicinal Chemistry

Volumn 46, Issue 19, 2003, Pages 4032-4042

  Minutolo, Filippo ^a   Antonello, Michela ^a   Bertini, Simone ^a   Ortore, Gabriella ^a   Placanica, Giorgio ^a   Rapposelli, Simona ^a   Sheng, Shubin ^b   Carlson, Kathryn E ^c   Katzenellenbogen, Benita S ^b   Katzenellenbogen, John A ^c   Macchia, Marco ^a  

^a UNIVERSITY OF PISA   (Italy)

^b UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^c UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3,4 DIPHENYL N ETHYLANTHRANYLALDOXIME; 3,4 DIPHENYL N METHYLANTHRANYLALDOXIME; 3,4 DIPHENYLANTHRANYLALDOXIME; 3,4 DIPHENYLANTHRANYLALDOXIME DERIVATIVE; 3,4 DIPHENYLBENZALDOXIME; ANTHRANYLALDOXIME DERIVATIVE; ESTRADIOL; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; SELECTIVE ESTROGEN RECEPTOR MODULATOR; UNCLASSIFIED DRUG;

AMINO ACID COMPOSITION; ARTICLE; CANCER CELL CULTURE; DRUG BINDING SITE; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HYDROGEN BOND; LIGAND BINDING; MOLECULAR RECOGNITION; RECEPTOR AFFINITY; STRUCTURE ACTIVITY RELATION;

BENZENE DERIVATIVES; BINDING SITES; BINDING, COMPETITIVE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOMETRIAL NEOPLASMS; ESTRADIOL; FEMALE; GENES, REPORTER; HUMANS; HYDROGEN BONDING; LIGANDS; MODELS, MOLECULAR; OXIMES; PHENOLS; RADIOLIGAND ASSAY; RECEPTORS, ESTROGEN; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSCRIPTION, GENETIC; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 0141790089     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0308390     Document Type: Article

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